PEDIATRIC

This trial tests whether a new robotic system that uses only one small incision (single port) can safely perform common abdominal surgeries in children. The study includes children aged 1 to 17 who need procedures like pyeloplasty or reflux treatment. The goal is to see if the si…

This phase 2 trial tests whether a single injection of DNX-2401, a virus designed to kill cancer cells, can shrink or stabilize recurrent high-grade brain tumors in 39 children and young adults. Participants receive the virus directly into the tumor during a biopsy procedure. The…

This study tests whether the drug rapamycin can shrink large, hard-to-treat lymphatic malformations in the head and neck area of children. Over 6 months, 28 kids will take oral rapamycin, and doctors will measure changes using MRI scans and quality-of-life surveys. The goal is to…

This trial compares four different surgical techniques for treating pilonidal sinus, a painful skin condition near the tailbone, in adolescents aged 12 to 18. The goal is to find which method causes the least pain, fewest complications, and lowest chance of the sinus coming back.…

This study tests a medicine called aficamten in children aged 12 to 18 with a heart condition that makes it hard for blood to pump out. The goal is to see if the drug can reduce pressure inside the heart and improve symptoms like shortness of breath. About 55 participants will re…

This study tests whether giving tranexamic acid (TXA) during hip reconstruction in children reduces blood loss and the need for blood transfusions. About 400 children will be randomly assigned to receive TXA, a nerve block, or standard care. The goal is to make surgery safer and …

This study compares two ultrasound-guided nerve blocks—external oblique intercostal plane block and erector spinae plane block—for controlling pain in children aged 6 to 12 undergoing upper abdominal surgery. Forty children will be enrolled, and their pain levels, heart rate, and…

This study tests a 3D-printed adapter that snaps onto an Xbox controller, allowing children aged 7 to 17 with a one-sided upper limb difference to use almost all buttons with one hand. Researchers want to see if it improves gaming performance and enjoyment. Twenty participants wi…

This study looks at whether adding dexmedetomidine to the standard numbing drug bupivacaine in a caudal block (a type of pain shot near the tailbone) can give children longer pain relief after open appendix surgery. Sixty children will be randomly assigned to get either the combo…

This study compares a new sedation method using dexmedetomidine and ketamine (KETADEX) to standard general anesthesia for children undergoing heart catheterization. The goal is to see if the new method is as safe and effective, but without needing a breathing tube. Researchers wi…

This study tests whether an opioid-free anesthesia approach using ketamine and dexmedetomidine can control pain and reduce agitation just as well as standard opioid anesthesia in 90 children aged 3 months to 7 years undergoing cleft lip or palate repair. Researchers will measure …

This study tests whether a chitosan-based gel (made from natural sources) helps children's burns heal faster and with less scarring than standard silver-based dressings. About 40 children aged 6 months to 17 years with mild to moderate burns will be randomly assigned to one of th…

This study looks at how the brain's motor networks change over time in children with dystonia, a movement disorder. Researchers will use noninvasive tests like EEG and EMG to measure brain activity at rest and during simple tasks. Children with deep brain stimulation (DBS) will b…

This study compares a redesigned well-child care approach, where a community health worker (called a 'Parent's Coach') helps deliver checkup services, to traditional care for Black families. The goal is to see if this team-based model improves receipt of preventive services, redu…

This study looks at children and teens who had a limb removed before age 15-16 to see if they experience nerve pain (phantom limb or stump pain). Researchers will review medical records and use questionnaires during regular check-ups. The goal is to better understand how common t…