PEDIATRIC

This study tests a medication called aficamten in children aged 12 to 18 with a heart condition that makes the heart muscle too thick and blocks blood flow. The goal is to see if the drug can reduce the pressure gradient across the heart's main pumping chamber and improve symptom…

This study tests the drug rapamycin in children with severe lymphatic malformations in the head and neck area that cannot be safely removed with surgery. The goal is to see if taking rapamycin for 6 months can shrink these growths by at least one-fifth and improve symptoms like p…

This study compares four different surgical methods for treating pilonidal sinus, a painful skin condition at the tailbone. Researchers will enroll 80 teens aged 12-17 to see which surgery leads to fewer complications and less pain. The goal is to find the most effective treatmen…

This study tests whether an opioid-free anesthesia method can better control pain and agitation in children after cleft lip or palate surgery. About 90 children aged 3 months to 7 years will receive either standard opioid or opioid-free drugs. The goal is to improve recovery and …

This study tests whether giving children a medicine called tranexamic acid (TXA) during hip reconstruction surgery can reduce blood loss and the need for blood transfusions. About 400 children scheduled for hip surgery will be randomly assigned to receive TXA or a placebo. The go…

This study looks at whether a mix of two sedatives (dexmedetomidine and ketamine) can work as well as standard general anesthesia for children undergoing heart catheterization. About 150 children under 18 will be observed to see if the new method provides enough sedation without …

This study tests a special video game controller adapter designed for one-handed use in children aged 7 to 17 who have an upper limb difference on one side. Researchers want to see if the adapter improves how well kids play and how much they enjoy gaming. Participants will try th…

This study looks at whether adding dexmedetomidine to a standard numbing medicine (bupivacaine) can give longer and better pain relief for children after open appendix surgery. About 60 children will take part. The goal is to see if the combination reduces pain, helps kids recove…

This study tests whether a natural chitosan-based dressing helps children's burns heal faster and with less scarring than standard silver dressings. About 40 children aged 6 months to 17 years with minor burns will be randomly assigned to one of the two dressings. The goal is to …

This study looks at a new way of doing well-child checkups for Black families. Instead of relying only on a doctor, a community health worker (called a 'Parent's Coach') helps provide many of the services. The goal is to see if this approach improves preventive care, reduces emer…

This study looks at how the brain controls movement in children with dystonia, a condition that causes muscle spasms and twisting. Researchers will use noninvasive tests like EEG to measure brain activity at rest and during simple tasks. Some children with deep brain stimulation …

This study looks at nerve pain in children and teens who had a limb removed before age 15-16. Researchers want to find out how common phantom or stump pain is and how it affects daily life and well-being. About 50 participants will fill out questionnaires during regular check-ups…