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Safer anesthesia for kids? study hunts for ideal ciprofol dose

NCT ID NCT07697404

Knowledge-focused Sponsor: Huazhong University of Science and Technology Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study aims to find the best dose of ciprofol, a new anesthetic similar to propofol but with fewer side effects, for placing a laryngeal mask airway (a type of breathing tube) in children aged 1 to 12. Children undergoing short surgeries will receive ciprofol along with a standard dose of fentanyl. The goal is to determine the dose that works 95% of the time, minimizing movement, coughing, or gagging during tube insertion.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ciprofol
What this could lead to
If successful, this could establish a safer, more comfortable anesthesia method for children undergoing short surgeries.
What could go wrong
This is a small, early-phase dose-finding study, not a large trial. The results may not apply to all children or surgeries, and side effects like low blood pressure or breathing problems are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 180 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

1 year to 12 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status I or II * Aged 1 to 12 years * Scheduled for elective surgery requiring general anesthesia with laryngeal mask airway (LMA) insertion (e.g., ophthalmic surgery, skin lesion excision, minor abdominal or urological procedures, with expected surgical duration ≤ 2 hours) * Written informed consent obtained from parents or legal guardians Exclusion Criteria: * Known allergy or hypersensitivity to ciprofol, fentanyl, or any study-related drugs * Intellectual disability, cognitive-affective disorders, psychiatric or neurological diseases * Inability to cooperate with peripheral intravenous cannulation * History of reactive airway disease or suspected difficult airway * Body mass index (BMI) ≥ 30 kg/m² or ≤ 15 kg/m² * History of sedative medication use * Inability to understand the study protocol or participation in another clinical trial within the past 30 days

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Conditions

The condition(s) this trial relates to.

channelopathy-associated congenital insensitivity to pain, autosomal recessive

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia induction Ciprofol Laryngeal mask airway Pediatric

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Tongji Hospital

    RECRUITING

    Wuhan, Hubei, 430030, China

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