PEDIATRIC

This study tests a treatment called DNX-2401, a virus that is injected directly into brain tumors to kill cancer cells. It is for children and young adults (up to age 39) whose high-grade brain tumors have come back or not responded to standard treatments. The goal is to see if t…

This study tests two medicines, dexmedetomidine and lidocaine, to see which one helps place a breathing mask (laryngeal mask) more easily in children aged 2-12 having elective surgery. The goal is to improve first-attempt success and reduce coughing or other breathing problems. S…

This study compares two types of nerve blocks—erector spinae plane block and caudal block—to see which provides better pain relief for children aged 1 to 8 years after lower abdominal surgery. About 78 children will be enrolled, and their pain levels, safety, and parent satisfact…

This study looks at whether using special cards—distractor cards with pictures or thermochromic cards that change color with heat—can help children aged 4 to 6 feel less pain, fear, and anxiety while receiving inhaler therapy for respiratory infections. About 90 children will tak…

This study compares two types of nerve blocks (External Oblique Intercostal block and Transversus Abdominis Plane block) for pain control after laparoscopic spleen removal in children aged 8 to 16. The goal is to see which block provides better pain relief right after surgery. Th…

This study looks at whether a visit from a specially trained facility dog can help children ages 8 to 17 feel less afraid and anxious while staying in the hospital. Some children will get a dog visit with a child life specialist, some will get a child life specialist alone, and o…

This study watches how blood flow and oxygen levels in the brain change during laparoscopic (keyhole) hernia repair in children aged 2-10. Researchers use ultrasound and light sensors to measure these changes without any extra procedures. The goal is to better understand how the …

This study follows 330 infants aged 0-6 months with congenital hydronephrosis (a common kidney condition) over 3 years to see how it naturally progresses or resolves. Researchers will use ultrasounds to track changes and identify factors that influence outcomes. The goal is to pr…

This study will follow 400 children and teens who have survived blood cancers like leukemia and lymphoma. Researchers want to understand the long-term health problems these survivors face and create a structured follow-up plan using an electronic platform. The goal is to improve …

This study aims to find normal blood clotting values in children under 18 who are having surgery or a procedure requiring anesthesia. About 240 children will participate. The results will help doctors better understand and interpret blood clotting tests in pediatric patients.

This study checks if children who had a moderate to severe head injury develop long-term hormone problems that affect growth. Researchers will call about 90 past participants for a 15-minute phone interview to measure their current height and ask about symptoms. The goal is to un…

This study looks at two techniques used to safely put children under anesthesia for urgent surgery when they have a full stomach. One method uses no breathing help until the tube is in, while the other uses gentle air pressure to keep oxygen levels up. The goal is to find out whi…