TYPE 2 DIABETES

This study follows about 470 adults with type 2 diabetes who are starting oral semaglutide as part of their regular care. Researchers will track changes in blood sugar (HbA1c) and body weight over about 6 months. The goal is to see how well the medicine works in everyday practice…

This study tests a new medicine called HDM1005 in people with type 2 diabetes whose blood sugar is not well controlled by diet and exercise alone. About 240 adults will receive either HDM1005 or a placebo for up to 52 weeks. The main goal is to see if HDM1005 safely lowers blood …

This study tests whether adding a digital lifestyle program to standard care helps adults with type 2 diabetes who are at high risk for complications. About 200 participants will use apps that support healthy eating, activity, and weight loss, while others receive usual care. The…

This study tests a new drug, CMG190303, in 240 adults with type 2 diabetes and high cholesterol. It compares the drug's effect on blood sugar and cholesterol levels against standard treatments. The goal is to see if the new drug works better and is safe.

This study tests a lifestyle program for adults recently diagnosed with type 2 diabetes. Participants use a continuous glucose monitor and follow a personalized plan to minimize blood sugar spikes after meals. The goal is to see if this approach lowers blood sugar as well as or b…

This study tests whether community pharmacists can safely prescribe medications that protect the kidneys in people with type 2 diabetes and early kidney disease. About 120 adults without a family doctor will be randomly assigned to either pharmacist-led care using a step-by-step …

This study tests a new medicine called MET097, given as a weekly shot, to help adults who are overweight or have obesity and type 2 diabetes lose weight. About 1,000 people will take part; two-thirds get the real medicine and one-third get a placebo. The study lasts about 21 mont…

This study looks at whether meals designed for a person's ethnic background can improve blood sugar control in adults with type 2 diabetes. About 30 Asian Indian or Filipino participants will wear a continuous glucose monitor for one month while eating their usual diet and then s…

This study aims to help Native Hawaiians manage type 2 diabetes, high blood pressure, and obesity by promoting traditional diets and cooking skills. About 210 adults from Hawaiian homesteads will take part in a program that includes dietary guidance, cooking demonstrations, and g…

This study tests if nurse home visits help people with high blood pressure and type 2 diabetes manage their conditions better than standard clinic visits. Researchers will track blood pressure and blood sugar changes over 6 months in 100 adults aged 18-60. The goal is to see if h…

This study tests a new drug called HRS9531 to see if it helps people with type 2 diabetes who are not getting enough blood sugar control from their current insulin. About 300 adults will receive either HRS9531 or a placebo for 40 weeks. The main goal is to measure changes in bloo…

This study tests two ways to help Chinese immigrants with type 2 diabetes control their blood sugar. One group gets educational videos, another gets videos plus a community health worker, and a third group gets usual care. The goal is to see which approach works best for 540 part…

This study tests whether helping couples with type 2 diabetes walk more—by giving step counters and step prescriptions—can improve blood sugar control. Half of the 200 couples will also get counseling to improve communication and teamwork. Researchers will track steps and blood s…

This 12-month study tests whether a nurse-led smartphone app can help people with type 2 diabetes who use insulin and are on Medicaid better manage their blood sugar. Participants will use the app to track glucose, get education, and receive phone support from nurses. The goal is…

This study tests whether replacing some animal protein with plant protein can improve blood sugar control in people with type 2 diabetes who are overweight. About 146 adults will follow either a plant-based diet or a standard healthy diet for 24 weeks. The main goal is to see if …

This study tests an experimental supplement called HP-211, made from herbs and vegetables, to see if it helps people with type 2 diabetes control their blood sugar. About 300 adults with type 2 diabetes will take different doses of HP-211 or a placebo for 90 days. The main goal i…

This study looks at whether giving people with type 2 diabetes a Fitbit and sending them personalized text messages can help them become more active and better manage their condition. Researchers will enroll 36 adults who are not very active. Participants will wear a Fitbit and r…

This study looks at how well a new diabetes pill (Proline Plus Empagliflozin) works in everyday medical practice. About 3,000 adults with type 2 diabetes will take the pill, either alone or with other medicines, and doctors will check their blood sugar control after 24 weeks. The…

This study looks at whether a low-carbohydrate diet can improve blood sugar control in teenagers with type 2 diabetes compared to a standard diet. About 40 teens aged 12-18 will follow one of the two diets for 24 weeks. The goal is to see if the low-carb approach leads to better …

This study tests whether a mobile app that scans food barcodes and shows easy-to-read nutrition labels can help 900 adults with type 2 diabetes improve their blood sugar control. Participants either use the app plus get standard advice, or just get standard advice. The main goal …

This study tests a program that gives fresh fruits and vegetables to Native American adults aged 55 and older who have food insecurity and are at risk for type 2 diabetes. Participants receive vouchers to buy healthy foods at local centers, along with nutrition education. The goa…

This study explores whether repeated cold exposure that causes shivering can improve how the body uses insulin in people with type 2 diabetes. Fifteen adults aged 40-75 will undergo 10 days of cold acclimation. The goal is to see if this approach can lower blood sugar and improve…

This early-stage study tests a new medicine (NNC9733-0001) to see if it is safe and well-tolerated in healthy volunteers and people with type 2 diabetes. Participants receive either the study drug or a placebo as a single injection. The study lasts about 10 months and will monito…

This study tests whether higher doses (3.0 mg and 4.5 mg) of the diabetes drug dulaglutide are safe and work well in teens aged 10 to 17 with type 2 diabetes. About 55 participants will take the drug for around 8 months while doctors monitor side effects, blood sugar control, and…

This study looks at how fat cells work in people with normal-weight type 2 diabetes compared to those with overweight diabetes or no diabetes. Researchers will test two drugs, pioglitazone and tirzepatide, to see if they improve insulin resistance and fat storage. About 104 adult…

This study provides free continuous glucose monitors (CGMs) to 17 adults with poorly controlled type 2 diabetes. Researchers want to see if easier access to real-time blood sugar data improves glucose control and quality of life. Participants will wear the device for 14-day perio…

This study looks at whether a class of diabetes drugs called GLP-1 receptor agonists (like semaglutide) can improve nerve damage in the heart caused by type 2 diabetes. About 60 adults with type 2 diabetes will receive either standard care or standard care plus a weekly injection…

This study tests whether short, controlled low-oxygen breathing sessions (intermittent hypoxia) can improve blood flow to the brain and thinking skills in adults aged 60-85 with type 2 diabetes. Researchers will compare the breathing training to a placebo in 80 participants. The …

This study tests a program called PILI 'Āina to help Native Hawaiians better manage common health problems like type 2 diabetes, high blood pressure, and obesity. About 1,780 adults who are overweight and have at least one of these conditions will take part. The program focuses o…

This study tests a method called physiologic insulin resensitization (PIR) in 120 adults with advanced chronic kidney disease and type 2 diabetes. The goal is to see if PIR can improve kidney function and blood sugar control better than standard care. Participants will be randoml…

This study tests whether limiting all food intake to a 10-hour window each day for one year can help people with type 2 diabetes better manage their blood sugar. About 100 adults with type 2 diabetes will follow this time-restricted eating plan. Researchers will track changes in …

This study tests whether a special screening and a tailored exercise program (RYMA) can reduce falls, fractures, and heart risks in people aged 65+ with type 1 or type 2 diabetes. About 490 participants will be assigned to either the exercise program or usual care and followed fo…

This study looks at whether high-intensity interval training (HIIT) can improve how muscles use sugar in people with type 2 diabetes. The goal is to see if HIIT helps the body store sugar as glycogen and reduces fat in the liver. The study will involve 36 adults aged 45-75 who ha…

This study tests whether a fully automated insulin pump (closed-loop system) can improve kidney oxygen levels in people with type 2 diabetes and moderate chronic kidney disease. About 76 adults will use either the automated pump or standard insulin therapy for 26 weeks. The main …

This study tests a new medicine called HM11260C in adults with type 2 diabetes whose blood sugar is still too high despite taking metformin and dapagliflozin. About 118 people will receive either the new drug or a placebo for 36 weeks. The main goal is to see if the drug lowers H…

This study tests whether a structured lifestyle program can help Malaysian adults with early type 2 diabetes achieve remission—meaning blood sugar returns to normal without medication. About 92 participants will either follow an intensive diet and exercise plan or receive usual c…

This study tests whether adding a continuous glucose monitor (CGM) and nutrition counseling to a food assistance program helps adults with type 2 diabetes better control their blood sugar. About 60 participants will be split into two groups: one gets the food program alone, the o…

This study tests a new digital tool called iMatter2 that uses artificial intelligence to help people with type 2 diabetes manage their condition. About 353 patients will use the tool to track their symptoms and receive text message support, while others receive usual care. The go…

This study tests an experimental weekly injection (LY3457263) for adults with type 2 diabetes who are already taking semaglutide or tirzepatide but still have high blood sugar. About 240 participants will receive either the new drug or a placebo for roughly 9 months. The main goa…

This study compares two medications, enavogliflozin and pioglitazone, when added to metformin (with or without another diabetes drug) in adults with type 2 diabetes whose blood sugar is not well controlled. The goal is to see which drug better lowers blood sugar and improves hear…

This study tests a 24-week program called Black Impact to improve heart health and reduce stress in Black men. About 340 Black men with below-ideal heart health will either join the program right away or be placed on a waitlist. The program includes weekly exercise, health educat…

This early-stage study tests a new drug called TLC-6740 in healthy volunteers and people with obesity, with or without type 2 diabetes. The goal is to check the drug's safety, how the body processes it, and its potential to help with weight and blood sugar control. About 564 part…

This pilot study tests whether having a pharmacist guide the use of a continuous glucose monitor (CGM) helps people with type 2 diabetes improve their blood sugar control and adopt healthier behaviors. About 40 participants with poorly controlled diabetes will use a CGM for 12 we…

This study compares using a continuous glucose monitor (CGM) periodically versus traditional finger-prick testing in 400 adults with type 2 diabetes. The goal is to see if CGM leads to better blood sugar control and improved patient well-being during doctor visits. Participants m…

This study tests whether a special high-protein drink can help overweight or obese adults with type 2 diabetes preserve lean muscle mass while they start taking weight-loss medications like Ozempic or Mounjaro. About 60 participants will be randomly assigned to receive the protei…

This study tests whether a 12-month program of diet and exercise can help people with type 2 diabetes achieve remission. It includes 24 adults who are overweight and not on insulin. The goal is to see if the program is practical and acceptable before a larger trial.

This study tests whether two common blood thinners, clopidogrel and cilostazol, can slow the buildup of plaque in the neck arteries of people with type 2 diabetes. About 120 adults with diabetes and early signs of artery thickening will take one of the two drugs for a year. The g…

This pilot study tests whether personalized nutrition advice, guided by continuous glucose monitoring (CGM), is more effective than standard dietary care for adults with type 2 diabetes. Twenty participants will follow a 12-week diet plan while using a CGM device to track blood s…

This early-stage study tests a new medicine called HMS1005 in 40 adults with type 2 diabetes. The main goal is to check its safety and how the body processes it. Participants will receive either the drug or a placebo, and researchers will monitor blood sugar levels and any side e…

This study tests whether changing from one diabetes medication combination to another can better control blood sugar in adults with type 2 diabetes. About 204 participants will either stay on their current drugs or switch to a new combination. The main goal is to see if the switc…

This study tests whether a 4-week online education program about continuous glucose monitors (CGMs) helps youth aged 8-21 with type 2 diabetes improve their blood sugar control compared to standard care. Participants wear a CGM and attend virtual sessions with a diabetes educator…

This study tests a new daily pill, icovamenib, for people with type 2 diabetes whose blood sugar is still too high despite using Ozempic. About 60 adults will receive either the study drug or a placebo for 12 weeks. The main goal is to see if icovamenib lowers HbA1c (a measure of…

This study is testing whether a higher-than-normal dose of metformin is acceptable and feasible for youth aged 10-21 with type 2 diabetes. Participants will take either the standard dose or a higher dose for 3 months. The goal is to see if the higher dose is well-tolerated and he…

This study tests whether a 24-week food and fitness program helps 200 post-menopausal women with type 2 diabetes and heart-kidney problems stick to their new GLP-1 medication. The program includes exercise sessions, nutrition counseling, and home food deliveries. Researchers will…

This study tests a new tablet called HDM1002 in 360 adults with type 2 diabetes whose blood sugar is not well controlled by diet and exercise alone. Participants will take either the study drug or a placebo for 40 weeks to see if it safely lowers blood sugar levels. The goal is t…

This study compares a smart insulin pump called the iLet Bionic Pancreas to usual diabetes care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the pump or continue their routine care for 13 weeks to see if the pump improves blood sugar …

This study tests whether time-restricted eating (eating only during a set window each day) can help preserve insulin-making cells and improve blood sugar control in people with type 2 diabetes who are overweight. About 112 adults will be assigned to either a time-restricted eatin…

This early-stage study tests a new injection called SHR-3167 in 55 adults with type 2 diabetes. The goal is to see how the drug moves through the body and how well it controls blood sugar. Participants will be monitored for side effects and low blood sugar events.

This study tests if a mobile app called PortionSize Ed can help 40 adults who recently had a stroke and have prediabetes or type 2 diabetes follow a Mediterranean diet. Participants will either use the full app with dietitian support or a basic version. The goal is to see if the …

This study compares two triple-drug combinations to achieve blood sugar control and diabetes remission in people newly diagnosed with type 2 diabetes. 240 participants aged 18-65 with high blood sugar (HbA1c ≥ 9%) will receive either an injectable or an oral medication, both comb…

This study tests a weekly injection called mazdutide in 420 people with type 2 diabetes who also have mild memory problems or early dementia. The goal is to see if the drug can slow down or improve thinking and memory decline over 76 weeks. Participants are randomly assigned to r…

This study tests a new medication called icovamenib in people with type 2 diabetes whose blood sugar is not well controlled with their current medicines. About 60 adults will receive either the study drug or a placebo for 12 weeks. The goal is to see if icovamenib can safely lowe…

This study provides families on Medi-Cal who have a child with type 2 diabetes with a prescription for free fresh fruits and vegetables. The goal is to help families eat healthier, reduce food insecurity, and improve the child's blood sugar and overall health. About 200 children …

This study tests whether a combination of three drugs (THP-00101, THP-00102, and THP-00103) works better than taking just one or two of them for people with both type 2 diabetes and high blood pressure. About 221 adults will take the pills daily for 12 weeks. The goal is to see i…

This study tests whether personalized marketing and discounts in an online grocery store can encourage people with prediabetes or type 2 diabetes to buy more whole grains instead of refined grains. About 216 adults aged 45-70 from Pennsylvania who already shop online for grocerie…

This study tests a new medicine called clofutriben for people with type 2 diabetes that is hard to manage, especially if they may have high cortisol levels. About 1500 adults will first be screened for cortisol issues, then receive either clofutriben or a placebo daily for 24 wee…

This study tests whether shared medical appointments—where teens with type 2 diabetes attend clinic visits and group activities together—are a good way to deliver care. Researchers will compare this approach to standard care in 160 teens aged 12-18. The goal is to see if group vi…

This study looks at whether drinking whey protein before meals can help older adults (ages 75-90) with type 2 diabetes keep their blood sugar levels steadier throughout the day. Over two 7-day periods, participants will take either a whey protein drink or a placebo before each me…

This study tests whether weekly diabetes education videos sent by text, plus help from a community health worker, can improve blood sugar control in Chinese immigrants with type 2 diabetes. 270 participants will be randomly assigned to get the video program right away or to wait …

This study tests whether semaglutide, a common diabetes drug, works well for people with spinal cord injury (SCI) who also have type 2 diabetes. SCI increases the risk of diabetes, but standard treatments may not work the same. The study will measure how the drug affects blood su…

This study from the University of Oxford is testing whether a simple finger-prick test done at home can replace the standard oral glucose tolerance test (OGTT) for diagnosing type 1 and type 2 diabetes in children and young people. The standard OGTT requires a vein drip and multi…

This study tests whether a special camera with artificial intelligence can help screen more young people with diabetes for a condition called diabetic retinopathy, which can lead to vision loss. The study will include 500 children and teens with type 1, type 2, or cystic fibrosis…

This study tests an online program to help at-risk UCLA students prevent type 2 diabetes. About 80 students with prediabetes or high risk will take part. The program focuses on weight loss and healthy habits, and researchers will see if it works and is easy to use.

This study tests a new virtual program called Diabetes Body Project 2, designed to prevent eating disorders in women with type 2 diabetes. Researchers want to see if it helps improve body image, reduce unhealthy eating behaviors, and control blood sugar. The program is adapted fr…

This study tests a new way to prevent heart failure in people with type 2 diabetes. Doctors will use a blood test (NT-proBNP) and a risk score to find high-risk patients and then start them on proven preventive medications. The goal is to see if this approach reduces heart failur…

This study tests a family-oriented program to help Black families in Southwest Georgia lower their risk for type 2 diabetes. Parents with prediabetes and their children aged 8-15 will take part in a 20-month healthy lifestyle program. The goal is to see if parents can achieve a 4…

This study tests whether a ketone ester supplement can improve heart function and exercise ability in people with type 2 diabetes. About 30 adults with diabetes will take either the supplement or a placebo and undergo heart scans and treadmill tests. The goal is to see if this si…

This small study in Uganda looks at how meals made with local fruits and vegetables affect blood sugar and fat levels in people with type 2 diabetes. Eight participants will eat five different test meals over five weeks. The goal is to find which local foods help lower blood suga…

This study looks at whether adding a special light therapy (antimicrobial photodynamic therapy) to standard gum cleaning can better reduce bad breath in people with type 2 diabetes and advanced gum disease. About 32 adults will receive either standard care or standard care plus t…

This study tests if walking on a treadmill with a special cuff that slightly limits blood flow is safe and helpful for people with type 2 diabetes. Sixty adults will either walk with or without the cuff for 6 weeks. Researchers will check if this method improves fitness, blood su…

This early study is testing whether using focused ultrasound on the abdomen can help people with type 2 diabetes manage their blood sugar. About 30 adults on stable oral diabetes medications will receive the ultrasound treatment. The main goal is to check for side effects, especi…

This study tests a virtual health coaching program for 160 adults with type 2 diabetes and mental health struggles. Participants get weekly coaching calls, support from a care team, and online tools. The goal is to see if this approach improves quality of life and reduces diabete…

This study looks at whether extra counseling sessions can help people with type 2 diabetes become more physically active and reduce sitting time. About 123 adults will be split into three groups: standard care, informational talks, or talks plus supervised exercise sessions. The …

This study looks at whether adding a self-massage technique called myofascial release to a regular exercise program can help people with type 2 diabetes have better foot function, balance, and walking ability. Forty adults aged 30 to 65 with controlled diabetes will be split into…

This study tests whether limiting eating to specific hours of the day (early or late) helps control blood sugar and improve heart health in people who are overweight and have normal blood sugar, prediabetes, or type 2 diabetes. Researchers will monitor 30 participants' glucose le…

This early-stage study tests a new medicine called LY4086940 in healthy people and those with overweight, obesity, or type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. About 216 participants will take part in different parts of the study …

This study is creating a questionnaire called the Active Health Behavior Scale for people with type 2 diabetes. Researchers will test the scale on 600 adults to make sure it accurately measures how patients manage their health. The goal is to identify different patterns of behavi…

This study looks at how the amino acid arginine works in the bodies of young people with type 2 diabetes. Researchers will compare 30 teens with diabetes to healthy teens to see if arginine affects insulin release. The goal is to learn more about the disease and test if arginine …

This study looks at how controlling blood sugar and using a GLP-1 drug (liraglutide) changes the way special cells in the pancreas work in people with type 1 or type 2 diabetes. Researchers will measure hormone levels during fasting and high blood sugar. The goal is to understand…

This study looks at how well people with type 2 diabetes can produce insulin after drinking a meal replacement shake. Researchers will take blood samples over two hours to measure insulin and blood sugar levels. The goal is to understand how recent weight gain might affect the bo…

This study looks at how a 12-week exercise program changes the way older adults (65+) with type 2 diabetes use protein from their diet. Researchers will measure body composition, fitness, and protein efficiency using special tests. The goal is to understand if exercise can improv…

This study looks at how antipsychotic drugs change the way the brain responds to insulin in women, and whether this varies with menstrual cycle phase. Fifteen healthy women will receive the antipsychotic olanzapine or a placebo, plus insulin nasal spray, and undergo MRI scans. Th…

This study looks at how tiny particles called extracellular vesicles (EVs) affect blood vessel function in people with type 2 diabetes. Researchers want to understand if exercise can change how these particles influence blood flow and metabolism. The study involves 60 adults aged…

This study aims to understand how type 2 diabetes and obesity in young people (ages 12-25) affect heart and blood vessel health over time. Researchers will follow 930 participants for up to 25 years, using yearly checkups, scans, and stress tests. No treatments or drugs are being…

This study follows 40 liver transplant patients after they leave the hospital, using a continuous glucose monitor to track their blood sugar levels. The goal is to see how well blood sugar is controlled and whether that affects transplant outcomes like wound healing or complicati…

This study follows 300 people having weight-loss (metabolic) surgery to see how their gut bacteria change and how that affects heart health and diabetes. Researchers collect stool, blood, and tissue samples before and up to 3 years after surgery. The goal is to learn which gut mi…

This study follows 1,000 people with type 2 diabetes who have already had a heart CT scan. Researchers will repeat the scan to see how fatty plaque in heart arteries changes over time. The goal is to better understand who is at highest risk for heart attacks and other problems.

This study looks at whether high or moderate intensity exercise is better for the brain in people with type 2 diabetes. 75 participants will exercise three times a week for six months and have brain scans, thinking tests, and blood tests before and after. The goal is to see how e…

This study looks at how taking a new medicine (CX11) with or without food changes the way the body absorbs it. It involves 32 healthy adults who will take the drug twice under different conditions. The results will help doctors decide the best way to take this drug in future stud…

This study looks at how well different doses and forms of aspirin work in people with type 2 diabetes. About 30 participants will first take a standard dose of coated aspirin. Those whose blood platelets are not fully blocked will then try three other aspirin regimens to see whic…

This study looks at how eating a lot of fructose (a type of sugar) changes the bacteria in your gut and affects your risk for diabetes and fatty liver. Thirty adults who have trouble digesting fructose will eat special diets for 12 days each. Researchers will measure changes in g…

This study is a registry that collects information from 3000 adults with type 2 diabetes who visit heart or internal medicine clinics in Italy. The goal is to see how well doctors follow current guidelines for managing heart disease risk. No new treatments are given; it simply ob…

This study looks at how a person's genetic makeup influences their body's response to oral semaglutide, a medication used for type 2 diabetes. Researchers will give 125 people with normal to prediabetic blood sugar levels the drug for two weeks and measure changes in blood sugar …

This study uses a new type of MRI scan with a special dye to look at how the heart works in people with heart failure with preserved ejection fraction (HFpEF), especially those who also have type 2 diabetes. The goal is to understand why this combination is so harmful. Researcher…

This study looks at whether the drug pioglitazone can block the increase in ketones and sugar production caused by another diabetes drug, empagliflozin. Researchers will give both drugs to 64 adults with type 2 diabetes and measure changes in the body. The goal is to understand h…

This study looks at how common memory problems are in people aged 65 and older with type 2 diabetes. It also tests whether a program that combines healthy habits, exercise, and mental activities can help prevent or slow down memory decline. The study involves 420 participants fro…

This early-phase study looks at how a natural cell process called autophagy affects small blood vessel function in adults with type 2 diabetes. Researchers will compare 60 participants with and without diabetes, giving some a supplement called trehalose (thought to boost autophag…

This study looks at different methods to help teenagers and young adults with type 2 diabetes and their families address social needs like food, housing, and transportation. About 104 participants will try approaches such as connecting with community resources, working with healt…

This study looks at the diet, heart health, body composition, and mental well-being of 600 U.S. Army soldiers. Researchers will collect information through surveys, physical tests, and blood samples. The goal is to understand how nutrition and health affect soldier performance an…

This study is looking for early warning signs in the blood that could predict chronic heart failure in people with type 2 diabetes. Researchers will follow 500 adults over age 50 with type 2 diabetes, but no history of heart problems. They will use blood tests and heart ultrasoun…

This study looks at how insulin resistance in type 2 diabetes harms blood flow to the heart and muscles, leading to poor exercise ability. Researchers will test if 15 weeks of exercise training can improve insulin sensitivity and restore blood flow. The study involves 150 sedenta…

This study tracks muscle and fat changes in 50 adults starting semaglutide for type 2 diabetes or weight loss. Over 12 months, participants undergo MRI scans, physical tests, and blood draws. The goal is to understand how the drug affects muscle health, especially in people at ri…

This early-stage study tests whether a new drug called PATAS is safe for people. It involves 56 healthy volunteers who receive either the drug or a placebo. The main goal is to check for side effects and measure how the drug moves through the body. This is a first step before tes…

This study looks at whether teaching digital skills to Latino adults with type 2 diabetes during a hospital stay helps them use patient portals and telehealth after discharge. Participants get one-on-one training from a digital navigator, while others receive standard care. The g…

This study looks at why having low LDL (bad) cholesterol might actually increase the risk of type 2 diabetes. Researchers think LDL entering fat tissue may cause problems that lead to diabetes. They will test if taking omega-3 (fish oil) for 6 months can reduce that risk in 48 ad…

This study looks at how much people with type 2 diabetes know about nutrition and how closely they follow the Mediterranean diet. Researchers will ask 500 patients to fill out questionnaires. The goal is to understand the link between food knowledge and healthy eating habits.

This study looks at how two natural gut hormones, GIP and GLP-1, affect how the body takes up sugar and moves blood through organs. Researchers will use a special full-body PET scanner to measure these effects in healthy volunteers and people with type 2 diabetes. The goal is to …

This study looks at how exercise changes the amount of sugar the liver makes in people with type 2 diabetes and fatty liver. Researchers will compare sugar production during rest and exercise in 12 adults aged 25-55. The goal is to better understand how exercise helps control blo…

This study is a large registry that collects information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers will observe how these conditions are managed in everyday medical practice, including treatments, hospi…

This study looks at how losing weight can reverse type 2 diabetes by reducing fat in the pancreas. Researchers will follow 104 people, including those without diabetes, with prediabetes, and with short- or long-term diabetes. Participants will follow a very low-calorie diet for 8…

This study looks at whether taking metformin before being admitted to the intensive care unit (ICU) affects survival in people with type 2 diabetes who develop severe lactic acidosis. Researchers will review records of 100 adults admitted to a French hospital ICU between 2014 and…

This study looks at how sleep duration relates to blood sugar control in 90 adolescents (ages 12-20) with type 2 diabetes. Researchers will measure sleep with a wrist monitor for 14 days and check blood sugar levels. They will also test if offering rewards for meeting sleep goals…

This study aims to find early warning signs of heart failure in people with type 2 diabetes and metabolic syndrome. Researchers will analyze blood cells from 175 participants to see if certain signals can predict heart problems before they become serious. The goal is to improve d…

This study looks at how liver cells produce energy in people who have both type 2 diabetes and nonalcoholic fatty liver disease. Researchers will measure liver metabolism before and after 16 weeks of treatment with the diabetes drug pioglitazone. The goal is to understand how the…

This small early-phase study is testing whether a drink containing ketone esters can improve how the heart works in people who have both type 2 diabetes and heart failure with reduced pumping ability. Ten adults will take the drink for seven days, and researchers will use heart s…

This study looks at why people with pre-diabetes or type 2 diabetes feel more tired and weak in their legs during exercise. Researchers think it may be due to blood vessel problems. They will test a special exercise program that uses blood flow restriction to better understand th…