TYPE 2 DIABETES

This study tests a new medicine called CagriSema to help people with obesity lose weight, whether or not they also have type 2 diabetes. About 2500 adults with a BMI of 35 or higher will get either CagriSema or the existing drug semaglutide for 83 weeks. The goal is to see which …

This early study will test whether adding a new drug (CS0159) to a standard diabetes medication (semaglutide) can help people with fatty liver disease, obesity, and type 2 diabetes lose weight and improve their health. About 30 adults will take the combination or a placebo for 12…

This study looks at whether a probiotic called Lactobacillus paracasei LC19 can improve blood sugar control in people recently diagnosed with type 2 diabetes. About 70 adults who have not taken diabetes medication will take the probiotic daily for 12 weeks. Researchers will measu…

This study compares two common diabetes medications, dapagliflozin and empagliflozin, to see which works better for lowering blood sugar, reducing weight, and improving overall health in people with type 2 diabetes and a high body mass index. About 112 adults will take one of the…

This study will adapt a community health worker-led program to include mental health support for South Asians with type 2 diabetes who are at risk for depression. About 100 participants will try the program, which includes digital tools and a trauma-informed approach. The goal is…

This study will test a special insulin pump and continuous glucose monitor in 20 pregnant women with type 2 diabetes. The goal is to keep blood sugar in a safe range for pregnancy and improve health for both mother and baby. Participants will be followed from early pregnancy thro…

This study compares a new drug, QLG1091, to an approved drug, Rybelsus, in adults with type 2 diabetes who are already taking metformin. About 478 participants will take either QLG1091 or Rybelsus for 26 weeks to see if the new drug works as well at lowering blood sugar. The goal…

This study tests a personalized diet program for Chinese and Vietnamese Americans with type 2 diabetes. Participants use a continuous glucose monitor to track blood sugar, and those who don't improve after 4 weeks get extra dietary coaching. The goal is to see if this approach he…

This study looks at whether supervised exercise and the diabetes drug semaglutide can improve thinking and memory in older adults with type 2 diabetes. About 164 people aged 65 and older will be placed into four groups: exercise only, semaglutide only, both, or standard care. The…

This study tests whether a home-based high-intensity interval training (HIIT) programme can help people who have reversed their type 2 diabetes keep it from returning. Twenty adults who completed the NHS Path to Remission programme will either do HIIT three times a week or contin…

This study tests whether an automated insulin delivery system can help people with type 2 diabetes and kidney failure who are on dialysis. About 84 participants will use either the automated system or their usual insulin routine with a continuous glucose monitor for 12 weeks. The…

This study looks at whether eating whole fruit can improve blood sugar control, reduce liver fat, and lower heart disease risk in adults with type 2 diabetes who do not use insulin. About 25 participants will be monitored using continuous glucose monitors and other tests. The goa…

This study tests an investigational injection called HS-20094 in people with type 2 diabetes whose blood sugar is not well controlled by diet and exercise alone. About 204 participants will receive either the drug or a placebo for up to 52 weeks. The main goal is to see if the dr…

This study looks at whether walking for 20 minutes after each meal can improve blood sugar control in pregnant women with type 2 diabetes. About 40 participants will be split into two groups: one that walks after meals and one that does not. The goal is to see if this simple acti…

This study looks at whether playing active video games can help children and young adults (ages 5-21) with obesity and type 2 diabetes lose weight and lower their blood sugar (HbA1c). Participants will play active video games at home, and researchers will track changes in weight,…

This study looks at people with type 2 diabetes whose pills are no longer controlling their blood sugar well. All participants will first get a short course of intensive insulin in the hospital. Then, they will be split into three groups to try different drug combinations for 24 …

This study looks at the safety and performance of the Endogenex System in 50 adults with type 2 diabetes. Participants previously received a sham (fake) procedure in an earlier study. The goal is to see if the device is safe and works well for managing diabetes.

This study tests a new drug called cofrogliptin against an older drug, acarbose, in 200 adults with type 2 diabetes who have never taken diabetes medication. The goal is to see which drug better controls blood sugar and has fewer side effects. Participants will take one of the tw…

This study tests whether using a continuous glucose monitor (CGM) helps more people with type 2 diabetes achieve remission compared to standard finger-prick testing. All participants follow a low-calorie meal replacement plan and attend diabetes education sessions. The trial invo…

This study tests if a drink called A1Cantus can lower blood sugar levels in people with type 2 diabetes. Fifty adults with high blood sugar will drink either the test drink or a placebo daily for 3 months. Researchers will measure changes in A1C, blood pressure, weight, and chole…

This study tests montelukast, an asthma drug, in 50 teens and young adults (ages 14–24) with type 2 diabetes. The goal is to see if it can reduce inflammation that damages kidneys and blood vessels. Participants will take the drug for 6 months, and researchers will measure change…

This study tests whether a structured nutrition education program can help people with type 2 diabetes who are not meeting their blood sugar goals. About 253 adults aged 16-70 will either receive a nutrition booklet alone or the booklet plus four monthly lessons. The goal is to s…

This study tests a new weekly injection called HS-20094 against an existing drug, dulaglutide, for people with type 2 diabetes whose blood sugar is not well controlled with metformin alone or with another diabetes pill. About 546 adults will receive one of the two injections for …

This study will test a program that combines peer support with remote patient monitoring to help Black adults with uncontrolled type 2 diabetes. Researchers will enroll 200 participants from primary care clinics in Alabama and track changes in blood sugar (A1C) and blood pressure…

This study tests whether two types of fish oil, EPA and DHA, can improve how the body handles blood sugar and cholesterol in people at high risk for type 2 diabetes. Over 12 weeks, 84 adults with obesity will take daily capsules of EPA, DHA, or a placebo (corn oil). Researchers w…

This study tests whether starting four approved kidney disease medicines within 8 weeks is safe and effective for people with type 2 diabetes and chronic kidney disease. About 64 adults will be randomly assigned to either the rapid-start approach or usual care. Researchers will t…

This study tests whether denosumab, a bone-strengthening drug, can help prevent fractures in people with type 2 diabetes who are at high risk for broken bones. About 358 adults aged 45 and older with long-standing diabetes or related complications will receive denosumab plus stan…

This study compares two telehealth programs—digital health coaching and remote patient monitoring—to see which better helps people with physical disabilities manage type 2 diabetes and other chronic conditions. About 5,000 participants will be followed for 12 months to measure ch…

This study compares two types of continuous glucose monitors—real-time and intermittent—in people with type 2 diabetes who use insulin. About 108 participants will be randomly assigned to one monitor type to see which helps keep blood sugar in a healthy range more effectively. Th…

This study tests a new injectable medicine called iGlarLixi (a mix of insulin and a GLP-1 drug) against standard diabetes treatments in 1,316 adults in China whose type 2 diabetes is not well controlled with oral pills. The goal is to see if iGlarLixi lowers blood sugar better an…

This study tests a new medicine called HDM1005 against an existing drug, mazdutide, in about 900 adults with type 2 diabetes whose blood sugar is not well controlled by metformin alone or with another diabetes pill. The goal is to see which drug works better at lowering blood sug…

This study tests whether a natural dietary fiber called oligofructose (found in onions, garlic, and bananas) can help improve blood sugar control, reduce inflammation, and support healthy gut bacteria in adults with type 2 diabetes. 100 Saudi adults (50 with diabetes and 50 witho…

This study looks at two diabetes medications, cofrogliptin and linagliptin, when added to insulin treatment in Chinese adults with type 2 diabetes. The goal is to see which one works better at controlling blood sugar and is safer. About 594 participants will be followed in real-w…

This study tests whether a special education plan using continuous ketone monitoring can lower the risk of diabetic ketoacidosis (DKA) in people with type 1 diabetes who also take SGLT2 inhibitors. About 75 adults with type 1 diabetes will be enrolled. The study compares the spec…

This study will see if a program called HEARTS helps people who have both high blood pressure and diabetes get better care. About 1,440 adults in Guatemala will take part. Some clinics will use the HEARTS program, while others will continue their usual care. The study will check …

This study tests a program that delivers fresh produce to the homes of pregnant women with type 1 or 2 diabetes who also struggle to get enough healthy food. Participants will also receive group education on diabetes, nutrition, and cooking, plus ongoing support for other needs. …

This study compares two ways to manage diabetes after hospital discharge: a continuous glucose monitor (CGM) that checks sugar levels automatically versus traditional fingerstick checks. About 64 adults with type 2 or steroid-induced diabetes will wear a sensor for 28 days and ha…

This study tests whether an interactive video-based education program helps adults with type 2 diabetes improve their blood sugar control, self-care skills, and confidence. Sixty participants will be randomly assigned to either the video program or standard care. The goal is to s…

This study tests a remotely delivered program that combines mindfulness training with diabetes education for rural Black adults who have type 2 diabetes and high stress about their condition. Participants will either get this program plus remote blood sugar monitoring or standard…

This study looks at how the body makes new sugar from fat and blood molecules in people with and without type 2 diabetes. Researchers will give special tracers and take blood samples to track this process. The goal is to find new ways to lower blood sugar more effectively. About …

This study looks at 20 adults with type 2 diabetes who are starting weight-loss drugs like semaglutide or tirzepatide. The goal is to use advanced PET/CT scans and physical tests to detect early signs of muscle or bone loss. Findings will help doctors identify who is at risk and …

This study looks at how thinking abilities (like attention and memory) relate to physical function, balance, fear of falling, and quality of life in people with type 2 diabetes. Researchers will test 80 adults aged 40–65 using cognitive tests, balance machines, and walking assess…

This observational study looks at how type 2 diabetes impacts quality of life in 920 cancer patients receiving immunotherapy. Participants will fill out surveys at the start, 3 months, and 6 months to track changes. The goal is to see if those with diabetes experience a greater d…

This study looks at whether low vitamin D levels are linked to higher insulin resistance in people with type 2 diabetes. Researchers will measure vitamin D and a simple blood test called the triglyceride-glucose index in 165 adults. The goal is to better understand how vitamin D …

This study aims to collect health information and blood samples from 15,000 adults aged 40-70 over time. Researchers will use artificial intelligence to analyze molecular patterns in the blood to find early signs of diseases like heart disease, diabetes, cancer, and lung disease.…

This study looks at how a diet high in acid-forming foods (like meat, cheese, and grains) affects kidney function and blood sugar in people with type 2 diabetes and chronic kidney disease. Researchers will ask 80 participants to follow either a high- or low-acid diet for 8 weeks …

This early-stage study tests a new drug called DWRX5003 in 72 healthy adults to see if it is safe and how the body processes it compared to similar drugs. Participants must be between 19 and 65 years old with a healthy weight. The study does not aim to treat any disease, but to g…

This study looks at how fasting during Ramadan affects treatment adherence, emotional well-being, and blood sugar control in adults with type 2 diabetes. Researchers will compare those who fast and those who do not, using surveys and HbA1c tests before and after Ramadan. The goal…

This study aims to build an AI-powered 'digital twin' for 50 young people (ages 10-21) with type 2 diabetes. The digital twin will simulate how their disease might progress and how they might respond to treatments. Researchers will then test whether sharing these predictions with…

This study looks at whether measuring how the brain uses sugar (glucose) before surgery can help predict if older adults with type 2 diabetes will become confused or delirious after their operation. Researchers will scan the brains of 154 people aged 65 and older before liver tum…

This study looks at how the body controls blood sugar in people who may be at risk for type 2 diabetes. About 225 adults aged 18 to 70 without a diabetes diagnosis will wear a continuous glucose monitor for 10-14 days and take two at-home meal tests, followed by a standard glucos…

This study is a registry that collects long-term safety information from people with type 2 diabetes who have already been treated with the Endogenex System. Researchers will track device- and procedure-related side effects over time. About 500 participants will provide their med…

This study will look at the medical records of 100,000 Chinese adults with type 2 diabetes to compare heart and kidney outcomes between those who took Ozempic and those who took other diabetes medications. The goal is to see if Ozempic leads to fewer heart attacks, strokes, heart…

This study aims to create a standard list of outcomes that matter most in type 2 diabetes research. It will involve 300 participants, including healthcare professionals, researchers, and people living with diabetes, who will vote on which outcomes are most important through onlin…

This study compares blood tests from 200 adults with type 2 diabetes and healthy volunteers to see if platelet size and activity are linked to inflammation and blood sugar control. Participants give one blood sample during a routine clinic visit. No treatments or follow-up are in…

This study will look at medical records from 10,000 adults in Qatar who have heart disease and diabetes or prediabetes. Researchers will use artificial intelligence to find patterns that predict future heart attacks, strokes, or death. The goal is to create better risk prediction…

This study will analyze medical records from 400 adults with type 2 diabetes or obesity to see how well semaglutide works over three years for heart, kidney, and metabolic health. Researchers will compare blood sugar control in people taking semaglutide versus other diabetes medi…