Type 2 diabetes

Many people live with heart disease, kidney disease, and type 2 diabetes at the same time, but care often focuses on each condition separately. This trial tests a primary care model that brings these conditions together under one coordinated plan. Primary care centers receive tra…

Researchers are testing whether a digital behavioral therapy app, added to standard diabetes care, can improve blood sugar control and lower the risk of liver fibrosis in adults with type 2 diabetes. The trial enrolls 180 adults with type 2 diabetes who are at low to moderate ris…

Researchers in Oman are testing whether a structured education program that combines diabetes and oral health advice can improve blood sugar control and gum health in adults with type 2 diabetes. The trial enrolls 290 adults aged 35 and older who have had type 2 diabetes for at l…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This trial tests whether continuous glucose monitoring (CGM) can improve blood sugar control and reduce complications in hospitalized adults with type 2 diabetes, compared to standard finger-prick testing. Participants are randomly assigned to either CGM with a sensor-guided insu…

This 8-week pilot trial tests whether eating at least 56 grams of almonds daily can raise blood levels of vitamin E and improve overall diet quality in adults taking GLP-1 medications like semaglutide or tirzepatide for obesity or type 2 diabetes. Participants are split into two …

This study looks at whether playing active video games can help children and young adults (ages 5-21) with obesity and type 2 diabetes lose weight and lower their blood sugar levels. Participants will play active video games at home, and researchers will track changes in weight a…

This trial tests a shared decision-making program for adults with type 2 diabetes. The program helps patients identify their concerns, learn about their condition and treatment options, and work together with doctors, nurses, and family to create a personalized care plan. Researc…

This trial is testing whether adding dapagliflozin to metformin can improve levels of a growth-related hormone (IGF-1) in men with type 2 diabetes and fatty liver disease. The study will include 84 men aged 30-60 who are already taking metformin. Half will continue metformin alon…

This study looks at whether supervised exercise and the diabetes drug semaglutide, alone or together, can improve thinking and brain health in older adults with type 2 diabetes. About 164 people aged 65 and older will take part. They will be assigned to exercise training, a contr…

This trial tests whether different combinations of rowing and cycling exercise can reduce inflammation and improve blood sugar control in people newly diagnosed with type 2 diabetes. Participants, aged 18-60 and not yet on medication, will be assigned to one of five exercise prog…

This study tests whether a personalized diet plan, guided by a continuous glucose monitor (CGM), can help Chinese and Vietnamese Americans with type 2 diabetes better control their blood sugar. 120 participants will either receive the adaptive diet program or standard care for 12…

This study compares two ways to manage diabetes after hospital discharge: using a continuous glucose monitor (CGM) versus standard fingerstick checks. About 64 adults with type 2 or steroid-induced diabetes who need insulin after leaving the hospital will wear a sensor for 28 day…

This trial tests different ways to start once-weekly insulin icodec in adults with type 2 diabetes who haven't used insulin recently. Participants are randomly assigned to one of three starting-dose methods: a fixed dose, a dose based on their fasting blood sugar, or a dose based…

This study tests whether putting type 2 diabetes into remission through a 24-week lifestyle program can also slow biological aging. Researchers will measure changes in an epigenetic clock called DunedinPACE, which tracks how fast the body is aging. The trial enrolls 100 Chinese a…

This pilot study tests whether a voice-activated smart speaker can help adults aged 50 and older with poorly controlled type 2 diabetes improve their blood sugar levels. Participants receive weekly diabetes education and skills training calls through the smart speaker for 12 week…

This study tests whether using a real-time continuous glucose monitor (CGM) can improve blood sugar control and reduce hospital readmissions in people with type 2 diabetes and acute heart failure. Researchers will follow 140 adults during their hospital stay and for three months …

This pilot study tests whether a family-based, culturally tailored diabetes management program can help Native Hawaiian and Pacific Islander adults with type 2 diabetes. Participants attend group education sessions with a family member and receive help connecting to social servic…

This study explores whether eating durian daily for two weeks changes the gut microbiome, metabolism, and blood sugar levels in adults with type 2 diabetes. Forty participants will eat fresh durian pulp and undergo blood and stool tests, plus continuous glucose monitoring. The go…

This study tests whether a 10-week digital mindfulness program, combined with dietary advice, can help people with type 2 diabetes and obesity lose weight and improve blood sugar control. Participants learn mindful eating techniques through videos and home exercises. The trial me…

This study looks at whether combining peer support with remote patient monitoring can help Black adults with uncontrolled type 2 diabetes improve their blood sugar levels. About 200 participants from Alabama will use the program for 6 months. The goal is to see if this approach l…

This study will test whether eating a diet rich in whole fruit (up to 50% of daily calories) for 17 weeks can improve blood sugar control, reduce liver fat, and lower heart disease risk in adults with type 2 diabetes who do not use insulin. Participants will eat fruit prepared in…

This study tests whether montelukast, a common allergy medication, can reduce damage to the kidneys, eyes, and blood vessels in adults with type 2 diabetes and early kidney disease. The drug works by blocking inflammatory chemicals called leukotrienes, which are linked to diabete…

This study tests whether people with type 2 diabetes can switch from a weekly injection of dulaglutide to a once-monthly shot called PG-102. The trial involves 60 adults whose blood sugar is well-controlled on dulaglutide. Researchers will compare blood sugar levels and safety ov…

This early-stage study tests how the body processes HRS9531 tablets under different dosing conditions. It involves 100 healthy adults aged 18-55 with a BMI between 23 and 35. The goal is to measure drug levels and safety, not yet to treat weight or diabetes.

This study tests whether replacing missing back teeth with dental implants can help people with uncontrolled type 2 diabetes improve their blood sugar levels. The idea is that better chewing leads to healthier eating, which may lower HbA1c. 140 adults will either get implants plu…

This study will test whether replacing breakfast and a snack with a diabetes-specific nutritional drink (Glucerna) helps people with type 2 diabetes and obesity keep their blood sugar in a healthy range more often. About 198 adults will be randomly assigned to either the drink-ba…

This study tests whether a real-time continuous glucose monitor (CGM) helps people with type 2 diabetes and chronic kidney disease keep their blood sugar in a healthy range. Thirty adults will either use the CGM or stick with standard fingerstick checks for three months. The goal…

This study tests a new automated insulin delivery system for people with type 1 or type 2 diabetes in a hospital setting. Six participants will have their blood sugar controlled by the system for 24 hours while eating standard meals. The goal is to see if the system can keep bloo…

This study tests whether a mild electrical stimulation applied to the ear (via a small device) can improve memory and thinking in people with type 2 diabetes who also have mild cognitive impairment. The trial will involve 38 participants who will either receive the active stimula…

This study tests whether a combination of three diabetes drugs (tirzepatide, empagliflozin, and pioglitazone) can help people newly diagnosed with type 2 diabetes achieve remission—meaning their blood sugar stays normal even after stopping medication. About 296 adults will take e…

This study tests whether a device that emits light (biophoton therapy) can help control type 2 diabetes. About 46 adults with diabetes will either receive the real device or a placebo for 4 weeks, then everyone gets the real device for 8 more weeks. Researchers will measure blood…

This study will test an automated insulin delivery system (the Medtronic 780G pump with continuous glucose monitoring) in 20 pregnant women with type 2 diabetes. Participants join before 16 weeks of pregnancy and use the device until delivery. The main goal is to see how much tim…

This study tests whether a 3-month support program, led by a nurse and a community health worker and guided by an AI tool called MEDBRIDGE, can help people with type 2 diabetes manage their medications after leaving the hospital. The program aims to reduce confusion about medicat…

This study will adapt a community health worker-led program to include mental health and digital tools for South Asians with type 2 diabetes who are at risk for depression. Researchers will test whether the program is feasible and acceptable to participants. The study involves 10…

This study will test whether a continuous glucose monitor (CGM) can safely guide insulin therapy in cancer and transplant patients who are not in the ICU but need IV insulin due to steroids and nutrition. About 80 participants will be randomly assigned to CGM-guided care or stand…

This study tests whether a structured nutrition education program can help adults with type 2 diabetes who are not meeting blood sugar goals. About 253 participants will either receive a nutrition booklet alone or the booklet plus four monthly group lessons. The main goal is to s…

This phase 2 trial tests whether a drink called A1Cantus can lower blood sugar levels (HbA1c) in adults with type 2 diabetes. About 50 participants will drink either the active supplement or a placebo twice daily for 3 months. The study is double-blind, meaning neither participan…

This pilot study tests whether starting four approved kidney disease medicines quickly (over about 8 weeks) is safe and effective for people with type 2 diabetes and chronic kidney disease. Researchers will compare this rapid approach to usual care, where medicines are started on…

This early study tests whether adding an experimental drug (CS0159) to a standard diabetes medication (semaglutide) can help people with fatty liver disease, obesity, and type 2 diabetes lose weight and improve their health. About 30 adults will take the combination or a placebo …

This pilot study tests whether a home-based high-intensity interval training (HIIT) program can help people who have reversed their type 2 diabetes keep it from returning. Twenty adults who completed the NHS Path to Remission programme will either do HIIT three times a week or co…

This study compares a new oral diabetes medication, QLG1091, to the existing drug Rybelsus, both taken alongside metformin. About 478 adults with type 2 diabetes will take one of the two pills daily for 26 weeks. The goal is to see if QLG1091 controls blood sugar (HbA1c) as well …

This study looks at whether a program called HEARTS can help people who have both high blood pressure and diabetes get better care. About 1,440 adults in Guatemala will take part, and clinics will either use the HEARTS program or continue their usual care. The program includes tr…

This study looks at whether a probiotic called Lactobacillus paracasei LC19 can help control blood sugar in people recently diagnosed with type 2 diabetes. About 70 adults who have not taken diabetes medication will take the probiotic daily for 12 weeks. Researchers will measure …

This study will test two ways of controlling blood sugar during heart surgery in 3000 elderly patients with type 2 diabetes. One group will have tight control (blood sugar between 5-8 mmol/L) and the other liberal control (11-14 mmol/L). The goal is to see which approach leads to…

This study will test whether a natural fiber called oligofructose, found in foods like onions and bananas, can help improve blood sugar, cholesterol, and inflammation in Saudi adults with type 2 diabetes. A total of 100 people (50 with diabetes and 50 without) will take either th…

This study tests whether an automated insulin delivery system (the Omnipod 5) can help people with type 2 diabetes who are on dialysis achieve better blood sugar control. Half of the 84 participants will use the automated system, while the other half will continue their usual ins…

This study tests whether a new drug, HDM1005, works better than another drug called mazdutide at controlling blood sugar in people with type 2 diabetes. About 912 adults whose diabetes is not well controlled with metformin (alone or with another diabetes pill) will receive one of…

This study tests whether a special education plan using continuous ketone monitoring can lower the risk of diabetic ketoacidosis (DKA) in people with type 1 diabetes who also take SGLT2 inhibitors, a drug class that raises DKA risk. About 75 adults with type 1 diabetes will be en…

This study enrolls 324 adults with type 2 diabetes whose blood sugar is not well controlled on oral medications. All participants will first receive short-term intensive insulin therapy in the hospital. Then, they will be randomly assigned to one of three insulin-based regimens f…

This study tests whether adding denosumab to standard care can strengthen bones and prevent fractures in 358 adults with type 2 diabetes who are at high risk for breaks. Participants will receive the drug or a placebo, and researchers will measure changes in bone density and frac…

This study looks at whether a real-time continuous glucose monitor (CGM) helps people with type 2 diabetes on insulin keep their blood sugar in a healthy range better than an intermittent CGM. About 108 adults with poorly controlled diabetes will use one of the two monitors for a…

This study compares two common diabetes drugs, dapagliflozin and empagliflozin, to see which works better for lowering blood sugar and weight in people with type 2 diabetes and a high body mass index. About 112 adults will take one of the two drugs for six months. Researchers wil…

This study looks at whether adding an SGLT2 inhibitor (a type of diabetes pill) to standard cancer treatment can help people with advanced lung cancer and diabetes live longer or slow their tumor growth. About 200 adults will take either the SGLT2 inhibitor or other diabetes drug…

This study will test whether walking for 20 minutes after each meal helps pregnant women with type 2 diabetes keep their blood sugar in a healthy range. Forty women will be split into two groups: one that walks after meals and one that does not. The goal is to see if this simple …

This study tests an experimental drug called DA-5218 in 238 adults with type 2 diabetes whose blood sugar is not well controlled by metformin alone. Participants will receive either DA-5218 or an active comparator, and researchers will measure changes in HbA1c over time. The tria…

This study will compare two diabetes medications, cofrogliptin and linagliptin, when added to insulin therapy in Chinese adults with type 2 diabetes. About 594 participants will take either a biweekly or daily pill alongside their usual insulin. Researchers will track blood sugar…

This study tests a new drug called cofrogliptin against an older drug, acarbose, in 200 adults with type 2 diabetes who have never taken diabetes medication. The goal is to see which drug better lowers blood sugar levels and has fewer side effects. Participants will take one of t…

This study will test whether using a continuous glucose monitor (isCGM) helps more people with type 2 diabetes achieve remission compared to standard finger-stick testing. Both groups will follow a low-calorie meal replacement plan and receive diabetes education. The trial aims t…

This Phase 3 study tests a new drug called HS-20094, given as a weekly injection, in 204 adults with type 2 diabetes that is not well controlled by diet and exercise alone. Participants will receive either the drug or a placebo for up to 52 weeks. The main goal is to see if the d…

This Phase 3 study tests an experimental drug called HS-20094 against the standard drug dulaglutide, both given as weekly injections. About 546 adults with type 2 diabetes whose blood sugar is not well controlled on metformin or SGLT2 inhibitors will take part. The main goal is t…

This trial tests whether a finger-prick HbA1c test can detect type 2 diabetes better than the standard random blood glucose test in at-risk adults living in rural Dali, China. Researchers will compare detection rates and costs among 720 permanent rural residents with no known dia…

Researchers in South Savo, Finland, invite residents turning 45, 50 or 55 to take a blood test that measures many small molecules at once. The test estimates each person's 10-year risk of type 2 diabetes, heart attack, stroke, chronic kidney disease and fatty liver disease. Peopl…

This study works with First Nations communities in Manitoba to design and test ways to prevent type 2 diabetes in children. Pregnant women with or without diabetes are enrolled, and their children are followed from birth. The approach includes breastfeeding support, nutrition and…

This study tests whether eating all meals within an 8-hour window (between early morning and early afternoon) combined with morning exercise can prevent sarcopenia—age-related muscle loss—in postmenopausal women with obesity and type 2 diabetes. Forty-five women will follow eithe…

This study tests whether two types of fish oil, EPA and DHA, can improve metabolic health in people at high risk for type 2 diabetes. Over 12 weeks, 84 participants will take daily capsules of EPA, DHA, or a placebo (corn oil) and undergo specialized tests to measure insulin func…

Researchers are testing a program that combines mindful eating and yoga-based movement for adults with type 2 diabetes. The trial enrolls 60 people aged 40 and older who have had diabetes for at least six months. Half receive the mindfulness program and half receive standard diet…

Researchers are testing a diabetes education program that combines standard self-management lessons with hands-on activities involving miniature horses. Children and teens ages 8 to 20 with type 1 or type 2 diabetes, along with their caregivers, attend four sessions led by a diab…

This trial tests whether a lidocaine gel applied to the feet can ease painful diabetic neuropathy as well as the oral drug duloxetine. Adults with type 2 diabetes and moderate-to-severe nerve pain will be randomly assigned to one of the two treatments for 8 weeks. Researchers wil…

This pilot study will test whether a remotely delivered mindfulness-based diabetes education program, combined with home blood sugar monitoring, is feasible and acceptable for rural Black adults with type 2 diabetes and high diabetes distress. The program is compared to standard …

This study tests whether taking taurine and beetroot supplements can improve how people with type 2 diabetes regulate their body temperature during extreme heat. Researchers will measure sweating and core temperature in 18 adults during a heat exposure session. The goal is to fin…

This study tests whether adding Eroxon gel to the standard pill tadalafil can improve erections in men aged 18 to 40 with type 2 diabetes. Thirty men who already take tadalafil will use the gel before sex and report changes in erectile function. The goal is to see if the combinat…

This study tests an 8-week mindfulness program for people with type 1 or type 2 diabetes who have trouble sensing when their blood sugar drops too low. The program teaches body awareness techniques like mindful eating and body scanning to help patients catch early warning signs. …

This study tests whether a color-coded rotation training program helps people with diabetes improve their insulin self-management skills. Researchers will teach 112 participants how to rotate injection sites and change needles using a colorful chart and a mannequin. The goal is t…

This study tests a single injection of CIL001 (Paliroden) into the ear to repair nerve damage that causes hearing problems in people with type 2 diabetes. The trial includes 135 adults aged 45-75 with diabetes for at least 5 years. Researchers will check safety and whether the in…

This study tests whether watching interactive videos that teach diabetes self-care skills can help adults with type 2 diabetes improve their blood sugar control and feel more empowered. Sixty participants will be randomly assigned to either receive the video education or standard…

This study tests a drug-free approach for restless leg syndrome (RLS) in people with type 2 diabetes. 42 adults aged 50-65 will receive either vibration, near-infrared light, or both, plus stretching, for 4 weeks. Researchers will measure changes in pain, sleep quality, and RLS s…

This study will test whether a 4-week laughter yoga program can improve self-management and comfort in 80 adults with type 2 diabetes. Participants will attend twice-weekly 40-minute sessions led by a certified facilitator. The goal is to see if this fun, low-cost activity can bo…

This study will test whether combining continuous glucose monitor (CGM) data with information from a smartwatch and a phone app (like meals and activity) can better predict blood sugar levels in people with type 2 diabetes. Thirty-six adults will wear a CGM and smartwatch and log…

Researchers at Kırıkkale University are studying how GLP-1 receptor agonists, drugs prescribed for type 2 diabetes and obesity, affect saliva and oral health. Fifty adults aged 18 to 65 who are newly prescribed these drugs provide saliva samples and undergo dental exams at the st…

This study follows 100 adults with diabetes who are on peritoneal dialysis or about to start it. Researchers use a continuous glucose monitor to track blood sugar levels over time. They will look for links between glucose patterns and health events like hospitalizations, heart pr…

This study is investigating how GLP-1 receptor agonist drugs, commonly used for type 2 diabetes, affect the movement of the entire digestive tract. Researchers will use a special swallowed capsule to measure gut motility in 20 adults before they start the medication and again aft…

This study investigates whether psychological well-being and social support influence how well people with diabetic kidney disease manage their own health. Adults with type 2 diabetes and diabetic kidney disease who are not on dialysis will fill out questionnaires about their emo…

This study tests whether a simple electronic alert in the medical record system can help doctors prescribe guideline-recommended medications for adults with type 2 diabetes and kidney disease. About 600 patients will be randomly assigned to have their doctor receive an alert or n…

This study uses advanced MRI and spectroscopy to track how semaglutide therapy changes muscle strength, volume, and quality over six months. Researchers will measure muscle function and fat infiltration in people with type 2 diabetes and obesity. The goal is to understand whether…

This pilot study will test how easy it is for 20 adults with diabetes to set up and use the Feetsee foot monitoring device at home over 8 weeks. Participants will use the device and app on their own, following the instructions provided. The goal is to see if people can use it cor…

This study tests whether special amino acid-enriched drinks can help people on GLP-1 weight-loss drugs maintain muscle and prevent weight regain. Eight adults aged 30-65 who recently started GLP-1 medication will drink different supplement beverages, and researchers will measure …

This study looks at how a diet high in acid-forming foods (like meat, cheese, and grains) affects kidney function and blood sugar in people with type 2 diabetes and chronic kidney disease. Researchers will ask 80 participants to follow either a high- or low-acid diet for 8 weeks …

This study aims to find early signs of diseases like heart disease, diabetes, and cancer by analyzing blood samples over time. Researchers will collect health data and blood from 15,000 adults aged 40-70 to create personalized health baselines using artificial intelligence. The g…

This study will look at health records of 10,000 patients in Qatar who were hospitalized for heart problems and have diabetes or prediabetes. Researchers will use artificial intelligence to find patterns that predict future heart attacks, strokes, or death. The goal is to create …

This study follows 450 adults with diabetes who were part of an earlier study. Researchers want to see if levels of a nutrient called glutamine in the blood are linked to future heart problems. No new treatments are given—just observation and data collection over time.

This observational study looks at how having type 2 diabetes impacts quality of life in cancer patients receiving immunotherapy. Researchers will compare changes in well-being over six months between patients with and without diabetes. About 920 adults with solid tumors will fill…

This study will check if low vitamin D levels are linked to higher insulin resistance in 165 adults with type 2 diabetes. Researchers will use a simple blood test called the triglyceride-glucose index. The goal is to better understand how vitamin D might affect diabetes control.

This study will analyze medical records of 400 adults with type 2 diabetes or obesity to see how semaglutide affects blood sugar, heart, and kidney health over three years. Researchers will compare those taking semaglutide to those on other diabetes medications. The goal is to un…

This study tests whether a special breathing exercise, called intermittent inspiratory muscle training, can have an immediate effect on blood sugar, heart rate, and blood vessel stiffness. Researchers will compare this breathing workout to normal breathing in 48 healthy, obese, a…

This observational study will look at how cognitive functions—like attention and mental flexibility—relate to balance, fear of falling, and quality of life in 80 adults with type 2 diabetes. Participants will complete thinking tests, balance assessments, and questionnaires. No tr…

This study looks at how fasting during Ramadan impacts treatment adherence, emotional well-being, and blood sugar levels in adults with type 2 diabetes. Researchers will compare those who fast and those who do not, using surveys and HbA1c tests before and after Ramadan. The goal …

This study will follow 154 older adults with type 2 diabetes who are scheduled for liver tumor surgery. Researchers will measure brain glucose metabolism using a PET scan before surgery and then check for delirium (sudden confusion) for a week after. The goal is to see if lower b…

This study compares blood test results from 200 adults with type 2 diabetes to healthy people to see if platelet size and activity are different. Researchers will also check if these changes are linked to inflammation markers and blood sugar control. No treatments or extra proced…

This study aims to create an AI system that combines Traditional Chinese Medicine (TCM) body type data with modern technology to give personalized health advice. Researchers will enroll 195 adults who have all three conditions: high blood pressure, high blood sugar, and high chol…

This study will enroll about 225 adults aged 18-70 who are at risk for or may have early blood sugar problems, but not yet diagnosed with diabetes. Participants will wear a continuous glucose monitor for 10-14 days and take two at-home meal tests, followed by a standard glucose d…

This study will check how common sarcopenia (age-related muscle loss) is in 100 elderly people with type 2 diabetes. Researchers will use bedside muscle ultrasound and handgrip strength tests to measure muscle health, and a questionnaire to see how it affects quality of life. The…

This study investigates how two molecules—glycerol from fat and lactate from the blood—are converted into glucose by the liver, especially in people with type 2 diabetes. Researchers will compare these processes in 48 adults with and without diabetes or obesity. Participants rece…

This study will test whether an AI-powered 'digital twin' can accurately predict how type 2 diabetes progresses in young people aged 10-21. Researchers will create a virtual model of each participant using their health data, then compare predicted changes in blood sugar (HbA1C) t…

This study aims to create a standard list of outcomes that should be measured in type 2 diabetes research. Researchers and people with diabetes will vote on which outcomes matter most through online surveys. The goal is to make future studies more consistent and patient-focused. …

This pilot study will test whether a weekly injection of a GLP-1 receptor agonist (a type 2 diabetes drug) can improve gum health in 30 adults who have both periodontitis and diabetes. Researchers will measure changes in gum pocket depth, bleeding, and tooth mobility. The goal is…

This study looks at a simple blood test called the triglycerides glucose index in people with type 2 diabetes. Researchers want to see if this index can help predict microvascular complications. The study will follow 200 adults aged 18 to 65.

This study will follow 20 adults with type 2 diabetes who are starting on semaglutide or tirzepatide. Researchers will use PET/CT scans and physical tests to track changes in muscle mass, strength, and bone health over one year. The goal is to find early warning signs of muscle o…

This study will compare two groups of people having an endoscopy: those who stopped taking semaglutide for one week beforehand, and those who never took it. The goal is to see if stopping the drug reduces leftover food or liquid in the stomach, which can make the procedure safer …