TYPE 2 DIABETES

This study tests a new weekly injection called petrelintide in 221 adults who are overweight or obese and have type 2 diabetes. The goal is to see if it helps with weight loss and blood sugar control compared to a placebo. Participants must be on stable diabetes medication like m…

This study compares two diabetes medications, oral semaglutide and sitagliptin, in over 25,000 adults with type 2 diabetes and a specific type of heart failure (preserved ejection fraction). The goal is to see which drug better prevents serious heart events like hospitalizations …

This study tests whether adding a third medication (DA5221-T) to an existing two-drug combination can improve blood sugar control in adults with type 2 diabetes. About 174 participants who still have high blood sugar despite taking two diabetes drugs will receive either the extra…

This study tests a nutrition program designed specifically for African patients with type 2 diabetes. 64 adults in Benin will either receive the tailored program or standard care. The goal is to see if the program helps lower blood sugar and improve eating habits over 6 months, w…

This study tests a culturally tailored, family-based program to help manage type 2 diabetes in Ojibwe communities. Adult caregivers with diabetes and their youth (ages 10-16) participate together, learning healthy habits at home with support from local Family Health Coaches. The …

This study tests a new magnetic device that creates a shortcut in the intestines to help people with obesity and type 2 diabetes lose weight and control blood sugar. Ten adults aged 18-65 with a BMI of 30-35 and diabetes will receive the device. The goal is to see if the procedur…

This study tests a special magnet system that creates a new connection between the stomach and intestine without traditional surgery. The goal is to help adults with obesity and type 2 diabetes lose weight and control blood sugar. About 35 participants will be enrolled to see if …

This study looks at whether combining diabetes nutrition classes with vouchers for fruits and vegetables can improve blood sugar control and quality of life for American Indian and Alaska Native adults with type 2 diabetes. About 67 participants will be split into three groups: s…

This study tests a mobile phone program called MOSAIC that changes over time to fit each person's needs in managing type 2 diabetes. About 547 adults will either get this adaptive phone support or standard printed materials for 16 months. The goal is to see if the phone program i…

This study compares a new medicine called SHR-3167 to insulin glargine in people with type 2 diabetes who are not yet on insulin. Participants take either drug alongside their current metformin or SGLT2 inhibitor pills. The main goal is to see which treatment better lowers blood …

This large Phase 3 trial tests a once-daily tablet called orforglipron against a placebo in 1,200 adults who are obese or overweight, some of whom also have type 2 diabetes. The study is split into two parts: one for people without diabetes and one for those with diabetes. The go…

This study compares tirzepatide, a newer injectable diabetes medication, to other standard treatments in adults who were diagnosed with type 2 diabetes within the last 4 years and are currently taking only metformin. The goal is to see if starting tirzepatide early can better con…

This study looks at two diabetes medications, tirzepatide and semaglutide, in 26,000 adults with type 2 diabetes and a type of heart failure called HFpEF. The goal is to see which drug better prevents hospitalizations for heart failure and death. Participants are already taking o…

This study tests a new digital twin system that creates a virtual copy of each patient to guide personalized treatment for type 2 diabetes. 150 adults with diabetes will be randomly assigned to either the digital twin program or standard care for one year. The goal is to see if m…

This study tests whether the drug semaglutide helps control blood sugar in people with type 2 diabetes who are on dialysis. About 43 participants will be randomly assigned to receive either semaglutide or a placebo injection once a week for about a year. They will wear a continuo…

This study tests a new weekly injection called IBI362 against the existing drug semaglutide in 349 Chinese adults with early type 2 diabetes and obesity. The goal is to see if IBI362 is better at lowering blood sugar and helping people lose weight. Participants will receive eithe…

This study tests whether giving cash payments to inner-city African Americans with poorly controlled type 2 diabetes can improve their blood sugar levels and quality of life. Participants are randomly assigned to receive money for attending virtual diabetes education sessions or …

This study tests a new magnetic system (MagDI) that creates a connection in the small intestine to help with weight loss and type 2 diabetes. About 60 adults with obesity (BMI 30-50) and either diabetes or weight regain after previous surgery will be enrolled. The goal is to see …

This study tests a procedure that reroutes part of the small intestine to help control blood sugar in people with type 2 diabetes and obesity. About 15 participants with a BMI between 30 and 50 will be followed for a year to see if their HbA1c levels improve. The goal is better d…

This study tests different doses of the investigational drug tirzepatide in people with type 2 diabetes and obesity who already take metformin. The main goal is to see how much weight participants lose and how their blood sugar control improves. About 414 adults will take part fo…

This study looks at whether helping adults with type 2 diabetes and high blood pressure or high cholesterol meet their social needs (like food, housing, or transportation) can improve their health. About 4,800 participants will be screened during clinic visits and offered support…

This study tests a once-weekly medicine called retatrutide in about 1000 adults with type 2 diabetes who are overweight or have obesity. The goal is to see if it helps with weight loss and, for a subset with sleep apnea, improves breathing during sleep. Participants receive eithe…

This early-stage study tests an experimental oral drug, ZE63-0302, in 60 adults with type 2 diabetes. The main goal is to check safety and how the body processes the drug. Participants must have had diabetes for at least 7 years and be on stable diabetes medications (excluding in…

This study tests a new magnetic system that creates a connection in the small intestine to help with weight loss and type 2 diabetes. It involves 25 adults with obesity and diabetes who have not had success with other treatments. The goal is to see if the procedure is safe and wo…

This study tests a once-daily pill called orforglipron against a placebo in 600 adults with obesity or overweight who also have type 2 diabetes. The goal is to see if the pill helps lower blood sugar and body weight over about 18 months. Participants must have a BMI of 25 or high…

This study tests a once-weekly injection called retatrutide in adults with type 2 diabetes and moderate to severe kidney problems whose blood sugar is not well controlled with insulin and other medications. The goal is to see if retatrutide can lower blood sugar levels better tha…

This study tests whether eating dried Saskatoon berries every day can improve blood sugar and cholesterol levels in people with untreated prediabetes or new type 2 diabetes. About 92 adults will eat either Saskatoon berries or a control dried fruit for 10 weeks. Researchers will …

This study looks at whether oral semaglutide, a daily pill for type 2 diabetes, can improve bone health in people aged 50-85 who also have weak bones (osteopenia). Over 52 weeks, researchers will measure bone turnover markers, bone density, and strength. The goal is to see if thi…

This study tests whether attending prenatal care in a group setting helps women with type 2 or gestational diabetes control their blood sugar and manage weight after giving birth. About 117 pregnant women will be randomly assigned to either group or traditional one-on-one care. R…

This study tests an experimental medicine called cagrilintide to help people with overweight or obesity and type 2 diabetes lose weight. About 330 adults will receive either cagrilintide or a placebo for around 18 months. The main goals are to see how much weight they lose and ho…

This study looks at whether a mobile app called 'Well Check' can help people with type 2 diabetes better control their blood sugar, blood pressure, and weight. About 471 adults who are starting a new diabetes medication will use the app, which connects to their electronic health …

This study looks at whether wearing a continuous glucose monitor (CGM) after leaving the hospital helps people with type 2 diabetes control their blood sugar. About 108 adults who need insulin will wear a CGM for 12 weeks and get personalized alerts. The goal is to see if this to…

This study tests a procedure called duodenal mucosal resurfacing (DMR) to see if it can improve blood sugar control in people with type 2 diabetes. About 320 adults who are not well-controlled on their current diabetes medications will be randomly assigned to receive the real pro…

This study tests whether a team of doctors, nurses, and other health experts can help African American and Latinx adults with uncontrolled type 2 diabetes lower their blood sugar more than usual care. About 150 participants will either get extra support from the team or continue …

This study looks at whether starting tirzepatide before Ramadan helps adults with type 2 diabetes safely manage their blood sugar while fasting. About 130 participants who plan to fast will take the drug once a week and be monitored for blood sugar control, weight changes, and si…

This study tests whether a team of clinical pharmacists and community health workers can help people with type 2 diabetes improve their blood sugar control using continuous glucose monitors (CGM). About 318 adults aged 25-75 with high blood sugar will be enrolled. The goal is to …

This study tests whether the twiist automated insulin delivery system can help adults with type 2 diabetes who use insulin. About 300 participants will use the system to see if it improves blood sugar control. The goal is to make managing diabetes easier and more effective.

This study tests whether adding two new drugs (prusogliptin and dapagliflozin) to standard metformin can improve blood sugar control in adults with type 2 diabetes. About 815 participants who are not well-controlled on metformin alone will receive either the triple combination or…

This study tests a pre-mixed injection that combines two diabetes drugs (insulin glargine and lixisenatide) in adults with type 2 diabetes whose blood sugar is not well controlled by pills or other injectables. About 105 participants will receive the combo treatment to see if it …

This study tests whether a new tablet form of oral semaglutide (called D) works as safely and effectively as the current approved version for Japanese adults with type 2 diabetes. About 264 participants will be randomly assigned to receive either the new or the standard tablet fo…

This study looks at whether adding motivational interviewing to standard diabetes nutrition therapy helps African American women with type 2 diabetes improve blood sugar control and weight. About 291 women at risk for diabetes complications will take part in group nutrition sessi…

This study tests a lifestyle program at senior centers to help older adults (60+) with type 2 diabetes improve their physical function and quality of life. About 20 participants will take part in the program, which includes education and activity sessions. The goal is to see if t…

This study tests whether tirzepatide, a medication for weight and diabetes management, can improve kidney health in 140 adults with overweight or obesity and chronic kidney disease (with or without type 2 diabetes). Researchers will use MRI scans to measure changes in kidney fat …

This study aimed to see if using an exercise phone app and a continuous glucose monitor could help teenagers with obesity, prediabetes, or type 2 diabetes lose weight and improve their health. Participants would have worn a glucose sensor and used the app with coaching support. H…

This study tests whether using an over-the-counter continuous glucose monitor (CGM) every 30 or 90 days helps people with type 2 diabetes who do not use insulin better manage their blood sugar. About 188 participants will wear the Dexcom Stelo sensor periodically over six months.…

This study tests whether a computer tool that uses continuous glucose monitor (CGM) data can help primary care doctors make better decisions for people with type 2 diabetes who use insulin. About 150 adults with type 2 diabetes and high blood sugar will take part. The goal is to …

This study tests a targeted screening approach to detect undiagnosed heart failure in 706 adults aged 40+ with type 1 or type 2 diabetes who also have additional heart risk factors. Participants are randomly assigned to receive the screening or usual care, and researchers track h…

This study tests whether a family-focused lifestyle program can lower type 2 diabetes risk and improve quality of life in high-risk Latino families. About 132 Latino children aged 10-16 with obesity will take part. The program focuses on healthy eating and physical activity to pr…

This study looks at whether alerting clinical pharmacists about diabetes risk can help prevent type 2 diabetes in younger adults with serious mental illness. People with conditions like schizophrenia or bipolar disorder are at higher risk for diabetes, partly due to medication si…

This study looks at whether a community-based diet and exercise program for pregnant women can lower the chances of obesity and diabetes for both mothers and their children. About 1,000 pregnant women in urban areas will take part during and after pregnancy. The goal is to see if…

This study looks at whether simply seeing real-time blood sugar readings on a continuous glucose monitor (CGM) can help people with type 2 diabetes who don't use insulin improve their blood sugar control. About 120 participants will wear a CGM for two weeks: the first week they c…

This early-phase study tests whether a mobile app that shares continuous glucose monitor data with a care partner can help older adults (65+) with type 2 diabetes and mild cognitive impairment manage their blood sugar. Fourteen participants and their care partners will use the ap…

This study tests a mobile phone program called STRIDE that helps adults with type 2 diabetes and a close friend or family member work together to improve diabetes management and emotional support. About 180 people will join to see if the program is easy to use and helpful. The go…

This pilot study tests whether an enhanced telemedicine program is feasible for adults with type 2 diabetes who use insulin and have other health conditions. Participants will have 2-3 video visits over 6 months, with some receiving extra support like pre-visit calls and educatio…

This study is creating a large biobank of 48,000 people with diabetes in Hong Kong. Researchers will collect blood samples and health data to find genetic markers that predict serious complications like kidney failure, heart disease, and stroke. The goal is to improve early detec…

This study looks at how amino acids change the release of glucagon and insulin compared to glucose alone. Researchers will test 30 people who are healthy, have type 2 diabetes, or are obese. The goal is to better understand hormone regulation in these conditions.

This study follows 135 adults with type 2 diabetes over 75 months to see if MRI scans can predict who will develop kidney, liver, or heart problems. Participants undergo special MRI scans, and the results are compared to healthy people. The goal is to develop a better way to iden…

This study looks at how a specific gene (PDE3B) affects fat tissue and the body's handling of sugar and fats. Researchers will compare two groups of 40 adults—some with a natural gene variant and some without—using detailed metabolic tests. The goal is to understand if targeting …

This study looks at why some people with type 2 diabetes don't get the usual benefits from exercise. Researchers will measure how well cells make energy before and after exercise. The goal is to find factors that cause this 'exercise resistance' in about 84 adults aged 30 to 65.

This study looks at how two different cleaning methods (laser and ultrasonic) affect the body's immune response during root canal retreatment for tooth infections. Researchers will measure certain immune markers in both healthy people and those with type 2 diabetes. The goal is t…

This study re-examines 317 adults with type 2 diabetes who were first checked between 2019 and 2023. Researchers use advanced scans and blood tests to see how many have fatty liver disease (MASLD) and whether it has gotten better or worse over time. The goal is to learn what fact…

This study looks at medical records from 60,000 people with type 2 diabetes and obesity to compare three drugs (dulaglutide, semaglutide, and tirzepatide) against an older drug (sitagliptin). The goal is to see which one is best at preventing heart attacks, strokes, and death. Th…

This study examines whether removing overactive parathyroid glands (parathyroidectomy) improves blood sugar control in people with both primary hyperparathyroidism and type 2 diabetes. Researchers will compare up to 80 adults who have surgery with those who do not, tracking chang…

This study was designed to see if GLP-1 medications change how stiff arteries become after exercise in people with type 2 diabetes. It planned to measure artery stiffness and blood pressure during a treadmill test. The study was withdrawn before enrolling any participants, so no …

This study looks at whether continuous glucose monitors (CGMs) can help underserved adults with type 2 diabetes better manage their blood sugar. About 50 participants with high A1c levels will use a CGM for 6 months, and researchers will track changes in blood sugar control and a…

This study looks at whether young people (ages 8-20) with type 2 diabetes will wear and use a continuous glucose monitor (CGM) and if it helps them manage their blood sugar. About 30 participants will either use the CGM or receive standard care for 6 months. The goal is to see if…

This study looks at health records from about 30,000 people with type 2 diabetes to see if results from a previous clinical trial (REWIND) can be reproduced using real-world data. Researchers compare two diabetes drugs to understand when real-world data can be trusted for medical…

This study looks at how exercise training changes the way muscles and fat tissue respond to insulin in people with type 2 diabetes. Researchers will use special scans and small tissue samples to measure glucose uptake and energy production. The goal is to better understand the be…

This study looks at whether specific genes influence how people respond to a meal and a single dose of metformin, a common diabetes medication. Over 1,000 adults without diabetes will eat a special test meal and take metformin to measure changes in blood sugar and insulin. The go…

This study aims to find out how many people with type 2 diabetes also have non-alcoholic fatty liver disease (NAFLD). Researchers will use a special ultrasound scan (FibroScan) to check the liver health of 385 adults with type 2 diabetes. The goal is to better understand how ofte…