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Withdrawn study planned to test diabetes drugs before surgery

NCT ID NCT03816488

Disease control Sponsor: McMaster University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study was designed to see if taking metformin or salsalate on the morning of surgery could help control blood sugar and reduce complications in people with type 2 diabetes. It planned to enroll patients having elective surgery who regularly take metformin. However, the trial was withdrawn before any participants were enrolled, so no data were collected.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Metformin or salsalate
What this could lead to
If this approach were tested and worked, it could point toward a simple way to reduce high blood sugar and infections after surgery in people with type 2 diabetes.
What could go wrong
This trial was withdrawn before enrolling anyone, so no results exist. Even if run, it was a small early feasibility study, not designed to prove effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Started

Dec 2023

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Elective surgical patients requiring a general anesthetic at HHS requiring at least an overnight admission; * Using metformin regularly for control of T2D; * American Society of Anesthesiologists (ASA) physical classification I, II and III; * Less than 1000 mL of blood loss is expected. Exclusion Criteria: * Procedures for which non-steroidal anti-inflammatory drugs are contraindicated; * Diagnosis of renal failure (estimated glomerular filtration rate \<60 mL/min/1.73m2); * Liver failure; * Previous episodes of congestive heart failure; * Severe hypoglycemia in the past year; * Conditions masking hypoglycemia (e.g. autonomic neuropathy); * Low random blood glucose during pre-screening (≤4.0 mmol/L); * Received contrast within 48h prior to, or during, surgery.

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Conditions

The condition(s) this trial relates to.

hyperglycemia Postoperative Complications type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes mellitus type 2 Hyperglycemia Perioperative/postoperative complications Salsalate to improve non-cardiac surgery glucose control

More trials for these conditions

Other studies related to the condition(s) this trial covers.