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New daily pill could help millions shed pounds and control diabetes

NCT ID NCT06993792

First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 25 times

Summary

This large Phase 3 trial tests a once-daily tablet called orforglipron against a placebo in 1,200 adults who are obese or overweight, some of whom also have type 2 diabetes. The study aims to see if the drug helps with weight loss and is safe. Participants are split into two groups based on whether they have diabetes or not.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Accel Research Sites - DeLand Clinical Research Unit

    DeLand, Florida, 32720, United States

  • Accel Research Sites - NeuroStudies Clinical Research Unit

    Decatur, Georgia, 30030, United States

  • Activian Clinical Research

    Kingwood, Texas, 77339, United States

  • AmBeNet GmbH

    Leipzig, 04107, Germany

  • Biopharma Informatic, LLC

    Houston, Texas, 77043, United States

  • Boeson Research MSO

    Missoula, Montana, 59804, United States

  • CARE - Centro de Alergia y Enfermedades Respiratorias

    Buenos Aires, 1414, Argentina

  • CIPREC

    Buenos Aires, C1119ACN, Argentina

  • Care Access - Decatur

    Decatur, Georgia, 30030, United States

  • Care Access - Fayetteville

    Fayetteville, North Carolina, 28314, United States

  • Care Access - New Iberia

    New Iberia, Louisiana, 70560, United States

  • Care Access - Tampa

    Tampa, Florida, 33625, United States

  • Care Access - Thousand Oaks

    Thousand Oaks, California, 91360, United States

  • Centro Médico Viamonte

    Buenos Aires, C1120AAC, Argentina

  • Centro de Diagnóstico y Rehabilitación (CEDIR)

    Santa Fe, 3000, Argentina

  • Clinical Research Institute of Arizona (CRI) - Sun City West

    Sun City West, Arizona, 85375, United States

  • Clinical Research of Philadelphia

    Philadelphia, Pennsylvania, 19114, United States

  • Conquest Research

    Winter Park, Florida, 32789, United States

  • Consano Clinical Research, LLC

    Shavano Park, Texas, 78231, United States

  • Diabetes Zentrum Wilhelmsburg

    Hamburg, 21109, Germany

  • Donmed s.r.o.

    Ostrava, 710 00, Czechia

  • Encore Medical Research

    Hollywood, Florida, 33024, United States

  • Endocrine and Metabolic Consultants

    Rockville, Maryland, 20852, United States

  • Frontier Clinical Research, LLC

    Smithfield, Pennsylvania, 15478, United States

  • Fukuwa Clinic

    Chūōku, 104-0031, Japan

  • Gemeinschaftspraxis Dr. Taeschner/Dr. Bonigut

    Leipzig, 04249, Germany

  • Great Lakes Research Group, Inc.

    Bay City, Michigan, 48706, United States

  • Hasegawa Medicine Clinic

    Chitose, 066-0032, Japan

  • Indago Research & Health Center, Inc

    Hialeah, Florida, 33012, United States

  • InnoDiab Forschung Gmbh

    Essen, 45136, Germany

  • Innovation Medical Research Center - Fort Lauderdale

    Fort Lauderdale, Florida, 33316, United States

  • Instituto Centenario

    CABA, 1204, Argentina

  • Instituto Médico Catamarca IMEC

    Rosario, 2000, Argentina

  • Isis Clinical Research Center

    Guaynabo, 00968, Puerto Rico

  • Javara - Nevada Health Centers - Carson City

    Carson City, Nevada, 89706, United States

  • Javara - Privia Medical Group - Silver Spring

    Silver Spring, Maryland, 20901, United States

  • Javara - Privia Medical Group Georgia - Savannah

    Savannah, Georgia, 31406, United States

  • Javara - Tryon Medical Partners

    Charlotte, North Carolina, 28210, United States

  • Jinan Central Hospital

    Jinan, 250013, China

  • MUDr. Alena Vachova

    České Budějovice, 37011, Czechia

  • Medical Corporation Heishinkai OCROM Clinic

    Suita-shi, 565-0853, Japan

  • Medical Corporation Heishinkai ToCROM Clinic

    Shinjuku-ku, 160-0008, Japan

  • Medical Corporation Yuga Tsuruma Kaneshiro Diabetes Clinic

    Yamato-shi, 242-0004, Japan

  • Medical Plus

    Uherské Hradiště, 686 01, Czechia

  • Medicover Neuroendokrinologie

    Munich, 81667, Germany

  • Medizentrum Essen Borbeck

    Essen, 45355, Germany

  • Milan Kvapil s.r.o., Diabetologicka ambulance

    Prague, 14900, Czechia

  • Nemocnice Cesky Krumlov

    Český Krumlov, 381 01, Czechia

  • Norcal Endocrinology & Internal Medicine

    San Ramon, California, 94583, United States

  • Noritake Clinic

    Ushiku, 300-1207, Japan

  • North Georgia Clinical Research

    Woodstock, Georgia, 30189, United States

  • Novak Clinical Research - Tucson - North La Cholla Boulevard

    Tucson, Arizona, 85741, United States

  • Olive Takamatsu Medical Clinic

    Takamatsu, 760-0076, Japan

  • Peking University Third Hospital

    Beijing, 100091, China

  • Puerto Rico Health and Wellness Institute

    Dorado, 00646, Puerto Rico

  • RED-Institut GmbH

    Oldenburg, 23758, Germany

  • Shimokitazawa Tomo Clinic

    Tokyo, 155-0031, Japan

  • Sichuan Provincial People's Hospital

    Chengdu, 610072, China

  • Solaris Clinical Research

    Meridian, Idaho, 83646, United States

  • Southern California Clinical Research

    Santa Ana, California, 92701, United States

  • Texas Valley Clinical Research (TVCR) - Mission

    Mission, Texas, 78572, United States

  • The Corvallis Clinic, P.C.

    Corvallis, Oregon, 97330, United States

  • The First Affiliated Hospital of Henan University of Science &Technology

    Luoyang Shi, 471003, China

  • The Fourth Affiliated Hospital of Harbin Medical University

    Harbin, 150001, China

  • The Institute of Medical Science, Asahi Life Foundation

    Chūōku, 103-0002, Japan

  • The Machuca Foundation

    Las Vegas, Nevada, 89101, United States

  • The Second Affiliated Hospital Chongqing Medical University

    Chongqing, 400010, China

  • The Second Affiliated Hospital of Nanjing Medical University

    Nanjing, 210011, China

  • The Second Hospital of Tianjin Medical University

    Tianjin, 300211, China

  • The Second People's Hospital of Hefei

    Hefei, 230011, China

  • Tokuyama Clinic

    Mihama-ku,Chiba City, 261-0004, Japan

  • Tokyo-Eki Center-building Clinic

    Chūōku, 103-0027, Japan

  • Tsuchiura Medical & Health Care Center

    Tsuchiura, 300-0012, Japan

  • University of North Carolina Medical Center

    Chapel Hill, North Carolina, 27514, United States

  • Velocity Clinical Research, Dallas

    Dallas, Texas, 75230, United States

  • West Orange Endocrinology P.A.

    Ocoee, Florida, 34761, United States

  • Xuanwu Hospital Capital Medical University

    Beijing, 100053, China

  • Yokohama Minoru Clinic

    Yokohama, 232-0064, Japan

  • Zhongda Hospital Southeast University

    Nanjing, 210009, China

  • Zhujiang Hospital

    Guangzhou, 510280, China

Conditions

Explore the condition pages connected to this study.