Heart failure

This study tests whether using urine sodium levels to guide diuretic dosing improves outcomes for emergency department patients with acute heart failure. About 474 adults with fluid overload will be randomly assigned to either the urine-guided protocol or standard care. The goal …

This early study is testing a device that uses ultrasound to ablate (calm) nerves in the pulmonary artery. The goal is to see if this procedure can improve quality of life for 50 people with heart failure and a specific type of pulmonary hypertension (Group 2). Participants will …

This study tests whether Empagliflozin (Jardiance), a drug used for diabetes and heart failure, can help adults born with heart defects who now have a weakened heart. Forty participants will receive either the drug or a placebo for one year. Researchers will measure changes in he…

This study offers continued access to an oral medication called levosimendan for people with pulmonary hypertension (high blood pressure in the lungs) and a type of heart failure where the heart pumps normally but is stiff. About 800 participants who completed a previous levosime…

This trial tests whether an AI system that flags at-risk Medicare Advantage members and suggests care actions, reviewed by a nurse, can reduce overall healthcare spending over a year. About 9,900 participants in Utah are assigned to either this AI-supported navigation or usual ca…

This first-in-human trial tests a small device called the FIRE1 System, which is implanted in a major vein to monitor fluid buildup in people with heart failure. The study enrolls up to 50 adults who have recently needed hospital care for heart failure. Researchers check whether …

This study tests whether a personalized 12-week cardiac rehabilitation program, offered in a safety net clinic, helps more heart patients attend rehab compared to the usual referral to an outside program. Researchers will enroll 100 adults who have had a heart attack, surgery, or…

This early study tests a new device called the NORM™ system in 25 adults with heart failure. The device is placed inside a large vein near the heart to send health information to doctors. The goal is to see if the implant is safe and can reliably transmit data, which may help man…

This study compares two ways of delivering cardiac rehabilitation: in-person sessions and telehealth sessions. Cardiac rehab includes exercise training, health education, and counseling for people with heart conditions like heart attack, heart failure, or after heart surgery. The…

This study tests whether a program using community health workers and medication can lower blood pressure and prevent heart failure in 364 adults from Detroit and Cleveland. Participants with high blood pressure or risk factors will receive personalized support and medication. Th…

This study tests whether the drug sacubitril/valsartan can reduce scarring in the heart muscle of people with a type of heart failure called HFpEF (stiff heart). The trial will enroll 36 adults aged 50 and older with heart failure and a normal pumping function. Participants will …

This study is testing a new driving system for the EXCOR Pediatric heart pump, which helps children with severe heart failure while they wait for a heart transplant. About 40 children will take part to see if the new driver works safely and effectively. The goal is to keep patien…

This trial tests a device called the TricValve system in people with severe tricuspid regurgitation, a condition where the heart's tricuspid valve leaks blood backward. The device is implanted through a catheter into the veins leading to the heart, aiming to reduce symptoms witho…

This trial tests whether a dietary supplement called Endocalyx Pro can reduce excess sodium and water in people with chronic heart failure. Participants will take either the supplement or a placebo daily for 8 weeks, with follow-up for 12 weeks. The study measures changes in a bl…

This early trial is testing a small, implantable sensor that measures pressure inside the heart for people with heart failure who are getting a mechanical heart pump (LVAD). The goal is to see if the sensor can be safely and accurately placed and whether it can provide reliable p…

This early study tests the safety and performance of a new implantable defibrillator (the CorSky ICD) in 52 people who need one for heart failure or dangerous fast heart rhythms. Participants will be followed for 12 months to check for device-related problems. The device is progr…

This study compares two approaches for replacing an infected aortic valve: using a cryopreserved aortic homograft (a preserved human donor valve) versus conventional mechanical or tissue prosthetic valves. The goal is to see which method leads to fewer complications, such as deat…

This study looks at a new way to keep donor hearts healthy during transport for transplantation. It involves 141 adults with heart failure who are on the transplant list. The goal is to see if this method is safe and effective for using hearts from extended criteria donors.

This study tests a device that electrically stimulates the vagus nerve to help manage heart failure. About 118 patients with moderate-to-severe heart failure received the implant. The goal is to see if this stimulation can improve heart function and exercise capacity over six mon…

This trial tests whether a digital tool that prompts doctors to adjust heart failure medications can improve care. The tool uses home monitoring and patient data to suggest medication changes. The study includes over 1,300 adults with heart failure and will measure hospitalizatio…

This study looks at whether opening a completely blocked heart artery with a procedure called PCI, on top of taking standard heart medications, helps people live longer and feel better compared to medications alone. About 2000 adults with stable heart disease and symptoms like ch…

This study tests a small device, called the Coronary Sinus Reducer, in 35 people with a type of heart failure where the heart pumps well but still has trouble filling with blood. The device is placed in a vein of the heart to help lower pressure during exercise. The goal is to se…

This study tests if adding a tiny shunt (a small passage) between the upper chambers of the heart can lower pressure after a standard valve repair procedure called MitraClip. Ten people with heart failure and a leaky mitral valve will receive the shunt right after their MitraClip…

This trial tests whether a personalized exercise prescription, based on a graded exercise test and target heart rate, improves fitness more than standard perceived exertion-based exercise in older adults (60+) recovering from heart events like heart attacks or heart surgery. Part…

This study tests a new method to preserve hearts from donors after circulatory death. The hearts are kept cool and oxygenated using a special machine during transport. The goal is to see if this helps more people get heart transplants and survive. The study involves 20 adults alr…

This study tests a modified pacemaker designed to improve heart function and quality of life in people with heart failure with preserved ejection fraction (HFpEF). About 105 participants will receive either the active pacing therapy or a non-pacing mode. Researchers will measure …

This study tests whether adding vericiguat to standard heart failure care can improve heart function in people with breast cancer who developed heart problems after cancer treatment. Participants will be randomly assigned to receive either vericiguat plus usual care or usual care…

This early-stage trial is testing whether stem cells from a donor can help control heart failure in people whose hearts were weakened by a type of chemotherapy called anthracyclines. About 72 participants will either receive standard care alone or standard care plus stem cells gi…

This study tests an experimental drug (BMS-986435/MYK-224) in people with a specific type of heart failure where the heart pumps normally but is too stiff (HFpEF). The main goal is to check the drug's safety and how the body processes it. About 208 adults with stable symptoms wil…

This study tests whether using the Impella heart pump during a high-risk stenting procedure helps people with weak hearts and blocked arteries. About 1,250 participants will be randomly assigned to get either Impella-supported stenting or standard care. The goal is to see if the …

This study tests a small sensor implanted in the lung artery that sends daily pressure readings to doctors. It involves 81 adults with advanced heart failure (NYHA Class III). The goal is to see if the device is safe and accurate, helping patients avoid hospital stays by catching…

This study tests an oral medication called levosimendan in people who have both pulmonary hypertension (high blood pressure in the lungs) and a type of heart failure where the heart pumps normally but is stiff. The goal is to see if the drug helps them walk farther in 6 minutes c…

This study tested a small sensor placed in the lung artery to help doctors monitor heart failure patients remotely. 738 people with advanced (NYHA Class III) heart failure took part. The goal was to see if using the sensor could reduce hospitalizations and deaths compared to a ta…

This pilot study tests whether a new pacing method called LOT-CRT, which paces two areas of the heart at once, works better than standard pacing alone in people with heart failure. Ten patients will each receive a special pacemaker and try both pacing settings for 6 months each. …

This study is testing a new heart valve device (JenaValve Trilogy) placed through a tube in an artery, without open surgery. It is for 50 adults who have a mechanical heart pump (LVAD) and also a leaky aortic valve that makes the pump work less effectively. The goal is to see if …

This study looks at the long-term safety of a drug called sotatercept for people with a specific type of pulmonary hypertension caused by heart failure with preserved ejection fraction. About 130 people who completed a prior study will receive sotatercept injections and be monito…

This study investigates whether a specific leg exercise program can improve how blood vessels, muscles, and nerves work during exercise in people over 65 with heart failure with preserved ejection fraction (HFpEF). The trial focuses on peripheral problems—like reduced blood flow …

This study tests an investigational drug called COR-1167 in 300 people hospitalized with worsening heart failure. Participants receive either the drug or a placebo for 28 days. Researchers measure how well the body removes fluid, changes in weight, heart function, and symptoms. T…

This trial tests a procedure called pulmonary arterial denervation (PADN) for people with heart failure who also have high blood pressure in the lungs. A special catheter delivers radiofrequency energy to nerves in the pulmonary artery, which may help lower pressure and improve h…

This study investigates whether diagnosing and treating obstructive sleep apnea with CPAP therapy early, while patients are still in the hospital for heart problems, can reduce the chance of being readmitted within 30 days. The trial enrolls adults with heart failure, heart attac…

This study tests whether giving oral salt tablets alongside standard IV diuretics helps hospitalized heart failure patients lose more fluid and maintain better kidney function. About 67 adults with acute decompensated heart failure will receive either salt or placebo three times …

This study tests whether a fully online exercise program is practical and acceptable for people with heart failure. Participants are randomly assigned to either a supervised online exercise group or a self-managed home exercise program for 8 weeks. The goal is to see if people st…

This study follows 2,500 people with moderate heart failure (NYHA Class II or III) who already have a CardioMEMS sensor implanted in their lung artery. The sensor wirelessly sends pressure readings to doctors, who use the data to adjust medications. Researchers will track surviva…

This trial investigates whether intravenous infusions of tiny particles (extracellular vesicles) from heart progenitor cells can safely improve heart function in people with severe dilated cardiomyopathy and heart failure. Participants receive three infusions and are monitored fo…

This study tests a transitional care model for older adults (65+) hospitalized with heart failure, COPD, or pneumonia. The model provides extra education, social services, and coordination among doctors after discharge. Researchers compare this to usual care to see if it reduces …

This was a planned Phase 2 study testing a drug called CDR132L in about 130 people with heart failure and a preserved or mildly reduced ejection fraction. The drug aimed to reverse harmful changes in the heart muscle. However, the trial was withdrawn before any participants were …

This study tests an experimental drug called TX000045 in 180 adults with pulmonary hypertension (high blood pressure in the lungs) caused by a type of heart failure where the heart pumps normally but doesn't relax properly. Participants will receive either the drug or a placebo f…

This study tests whether strengthening the muscles used for breathing can improve exercise capacity, heart function, and quality of life in people with chronic heart failure. Participants with reduced or mildly reduced heart pumping ability will be randomly assigned to one of two…

This study tests whether a mechanical heart pump called the HeartMate III (an LVAD) helps people with end-stage heart failure live longer and with fewer strokes compared to taking standard heart failure medications. About 80 adults with severe heart failure are randomly assigned …

This study investigates whether empagliflozin, a drug typically used for diabetes, can help people with worsening heart failure get rid of extra fluid. Researchers will give 60 participants either empagliflozin or a placebo for six weeks, alongside their usual diuretic medication…

This study tests whether hearts from donors who died from circulatory death (DCD) are as safe for transplant as hearts from brain-dead donors (DBD). About 40 adult heart transplant recipients will receive either a DCD or DBD heart. The goal is to see if using DCD hearts can safel…

This study tests whether a supplement called sulforaphane, found in broccoli sprouts, can help prevent age-related declines in heart function. Researchers will give the supplement or a placebo to adults over 60 with a type of heart failure called HFpEF. They will measure heart fu…

This study monitors the safety of the intravenous drug Samtasu (tolvaptan sodium phosphate) in people with heart failure who have fluid overload. Researchers will track side effects, including serious events and off-label use, in about 1,600 patients. The goal is to confirm the d…

This study tests a new way to help people with heart failure in Uganda manage their condition. It combines a standard care program with a mobile app that tracks symptoms and gives advice. The goal is to see if this approach improves self-care and reduces deaths or hospital stays.…

This phase 3 trial studies 1,200 people with severe coronary artery disease and a weak heart pump (ejection fraction 40% or less). Participants are randomly assigned to receive either guideline-directed medical therapy, bypass surgery, or stenting. The study tracks survival, hear…

This study tests a device called the Edwards APTURE shunt, which is implanted in the heart to create a small opening that lowers pressure. The goal is to see if it can improve symptoms and quality of life for 100 people with a certain type of heart failure. Half of the participan…

This study tests whether a ketone ester supplement, taken three times a day for 12 weeks, can improve heart function in people with heart failure. Fifty participants will be randomly assigned to receive the supplement or a placebo. Heart function will be measured using cardiac MR…

This study tests a device called AccuCinch that is placed around the heart to help it pump more effectively. It is for people with heart failure and a weakened heart muscle. The goal is to see if the device improves quality of life, exercise ability, and reduces serious heart eve…

This study tests a smartphone app called Medly that helps heart failure patients monitor their health after a hospital stay. The app reminds patients to check their weight and symptoms, and sends the information to their care team. The goal is to see if using the app improves pat…

This study tests a nurse-led program that uses home monitoring devices to help older adults with conditions like heart failure, diabetes, and depression manage their health after leaving the hospital. The goal is to improve care coordination and reduce hospital readmissions. Abou…

This study tests a new device that combines two heart therapies: one to strengthen heartbeats and another to stop dangerous rhythms. About 300 adults with heart failure and a weak heart pump will get the device. Researchers will check if it safely converts life-threatening heart …

This Phase 2 trial tests JK07, a lab-made protein designed to help heart cells repair and pump better. About 282 adults with chronic heart failure will receive either JK07 or a placebo. The study looks at safety and whether JK07 can improve heart function in two groups: those wit…

This study tests whether a minimally invasive procedure to repair a leaky tricuspid valve can help people with right-sided heart failure. About 360 participants will either receive the valve repair plus standard medications or medications alone. The goal is to see if the repair r…

This Phase 3 trial tests whether dapagliflozin (Forxiga), a drug originally for diabetes, can reduce the risk of death, kidney failure, and heart failure hospitalization in 1750 people with severe chronic kidney disease. Unlike earlier studies, this trial includes patients on dia…

This study tests whether a wearable sensor that measures lung fluid can help doctors better treat fluid buildup in patients hospitalized for acute heart failure. About 216 adults will be randomly assigned to either standard care or care guided by the sensor. The goal is to see if…

This study looks at whether measuring blood pressure inside the heart's left upper chamber during a procedure for atrial fibrillation (an irregular heartbeat) can spot patients with hidden heart failure. If the pressure is high, patients get a heart failure checkup and medication…

This large study compares two popular diabetes drugs, tirzepatide and semaglutide, in 26,000 people who have both type 2 diabetes and a type of heart failure. Researchers will track who ends up in the hospital for heart failure or dies, to see if one drug works better. The goal i…

This study looks at whether doing a preventive heart ablation (a procedure to destroy small areas of heart tissue causing irregular rhythms) before LVAD surgery can reduce serious problems like dangerous heart rhythms, death, blood clots, or heart failure in the first 30 days aft…

This study tests whether a special heart pacing technique (left bundle branch pacing) combined with standard heart failure drugs can improve heart function better than drugs alone. It includes 50 adults with non-ischemic heart failure and a specific heart block. The main goal is …

This study was designed to test the safety and tolerability of a new drug called JK07 in people with heart failure and a specific type of high blood pressure in the lungs. It planned to enroll about 20 to 30 adults aged 18 to 85. However, the study was withdrawn before any partic…

This study is tracking 500 heart failure patients in Germany who receive a small device called the InterAtrial Shunt. The device is implanted to create a tiny passage between the heart's upper chambers, which may help lower pressure and improve breathing and quality of life. Rese…

This trial aimed to test whether umbilical cord stem cells, delivered through a catheter into heart arteries, could safely improve heart function in people with severe heart damage after a major heart attack. It was designed for patients with very weak hearts (ejection fraction b…

This study tests whether a drug called anakinra, which reduces inflammation, can help prevent heart failure in people who have just had a heart attack. About 84 participants will receive daily injections of anakinra or a placebo for up to 14 days. The goal is to see if blocking i…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…

This study is testing whether a special pacemaker (cardiac resynchronization therapy, or CRT) can improve heart function and symptoms in people with mild heart failure and a specific type of heart block called left bundle-branch block. About 21 participants will receive a CRT dev…

This study tests whether a newer pacing method (conduction system pacing) is as good as or better than standard biventricular pacing in heart failure patients with atrial fibrillation who need a heart ablation. About 82 participants will be randomly assigned to one of the two pac…

This study is testing the Carmat Total Artificial Heart in 104 people with severe, irreversible heart failure who are waiting for a heart transplant. The device is designed to replace both heart chambers and keep patients alive until a donor heart becomes available. Researchers a…

This study was designed to test an experimental drug called OPC-131461 in people hospitalized for worsening heart failure who still had fluid buildup after standard treatment. The goal was to see if the drug could improve a key blood marker of heart strain over 30 days. However, …

This study tests whether a small sensor implanted in the lung artery can help doctors remotely monitor heart failure and adjust treatments. About 554 patients with advanced heart failure will either receive standard care or the sensor plus standard care. The goal is to see if the…

This phase 2 trial is testing whether a patient's own bone marrow stem cells can improve heart function and ease symptoms in people with dilated cardiomyopathy and heart failure. Twenty participants will have stem cells collected from their hip and then infused into their heart a…

This trial aimed to test whether infusions of stem cells from donated fat tissue could improve heart function in people recently diagnosed with non-ischemic heart failure. Participants would have received two infusions a month apart. However, the study was withdrawn before enroll…

This study compares a special pacemaker procedure called left bundle branch pacing (LBBP) plus standard heart failure drugs against drugs alone in 36 people with mild heart failure. The goal is to see if early pacing improves the heart's pumping ability more than medication. Part…

This study compares a new heart pump (EVAHEART®2) to a current pump in 399 adults with severe heart failure. The goal is to see if the new pump helps people survive until a heart transplant or recover enough to have the pump removed, without suffering a disabling stroke or severe…

This study compares two types of cardiac rehabilitation for heart failure patients: a home-based program using spot-jogging (jogging in place) and a standard outpatient program at a medical center. Forty adults with heart failure will be assigned to one of the two groups. Researc…

This study tests a new device called the Cardiovalve, which is threaded through a blood vessel in the leg to fix a leaky mitral valve without open-heart surgery. It includes 30 people with severe mitral regurgitation who are too high-risk for traditional surgery. The goal is to s…

This study looks at whether treating patients at home for conditions like infections, heart failure, diabetes, and COPD can lead to better health outcomes and satisfaction compared to traditional hospital stays. Nearly 10,000 adults will receive hospital-level care at home, inclu…

This study tests a new type of wire (lead) for implantable heart devices like ICDs or CRT-Ds. The lead is designed to pace the heart's natural conduction system, which may work better than standard pacing. About 414 adults who need these devices will be followed for 3 months to c…

This early study tests a device that keeps donor hearts alive outside the body for longer periods before transplant. The goal is to see if hearts preserved this way work well within 15 days after surgery. Twenty adults with severe heart failure who cannot get a standard transplan…

This study tests a small device called the Corvia Atrial Shunt in 750 people with heart failure where the heart pumps normally but doesn't fill properly. The device creates a tiny passage between heart chambers to relieve pressure. Participants are randomly assigned to get the sh…

This study tests whether a nurse practitioner-led team can improve care for adults with two or more chronic conditions like heart failure, diabetes, or kidney disease. Participants are randomly assigned to either the nurse-led team or usual care. The team reviews medications to e…

This UK study tests a device that scans your feet each day to detect fluid buildup, a key sign of worsening heart failure. The goal is to catch problems early so doctors can adjust treatment and prevent hospital stays. About 186 adults with heart failure are taking part, using th…

This study looks at whether starting empagliflozin early in patients with cardiogenic shock (a severe heart pump failure) can reduce deaths and hospital readmissions within 3 months. Researchers compared 418 patients who received the drug plus usual care against those who got usu…

This study tests whether a drug called finerenone can reduce scarring and fat buildup in the heart muscle of people with diabetic kidney disease and heart failure. About 40 adults will take the pill daily for 6 months and get advanced heart scans to see if their heart structure i…

This study tests a new device called EVOQUE that replaces the tricuspid valve in people with severe leakage (tricuspid regurgitation). The goal is to see if it is safe and can reduce leakage, improve symptoms, and enhance quality of life compared to standard medical therapy alone…

This study tests whether a newer type of blood thinner (DOA) works better than the standard one (VKA) for dissolving dangerous blood clots inside the heart. About 340 adults with such clots will be randomly assigned to one of the two treatments. The goal is to see which drug redu…

This study looks at whether deep cleaning for gum disease can lower a key heart failure marker in the blood. About 80 adults with or without heart failure will receive dental scaling and root planing. Researchers will track changes in NT-proBNP levels and gum health over 6 months…

This study tests a temporary heart pump called the Supira System in 71 people with severe coronary artery disease who need a high-risk procedure to open blocked arteries. The pump supports the heart for up to 4 hours during the procedure to prevent dangerous drops in blood pressu…

This study tests whether injecting lab-grown heart muscle cells (HiCM-188) into the heart during bypass surgery can safely help people with severe chronic heart failure. About 36 adults with damaged heart tissue and reduced pumping function will receive the cell injection. The ma…

This trial is testing a new mechanical heart pump called the Corheart 6 in 50 people with end-stage heart failure. The pump is implanted to help the heart circulate blood. Researchers are checking if the device works safely and effectively at 3 months and 2 years after implantati…

This study tests a digital platform that collects health data from heart failure patients, heart transplant recipients, and those with heart pumps. 390 participants will use sensors and a mobile app to track vital signs, activity, and more. Doctors in the intervention group can s…

This study is checking the long-term safety of a special heart lead (Attain Stability Quad) used with a pacemaker-like device to help heart failure patients. Over 1,000 people are being followed for 5 years to see how often the lead causes problems. The goal is to make sure the l…

This study is testing a device called the APTURE shunt, which is implanted in the heart to create a small passage that may help relieve pressure. It involves 45 people with symptomatic heart failure who are already on standard medications. The goal is to see if the device is safe…

This study tests a dual GIP/GLP-1 drug (a type of diabetes medication) in 120 adults in Kazakhstan who have both chronic heart failure and type 2 diabetes. Participants take the drug for 40 weeks and have regular heart tests, blood work, and genetic checks. The goal is to see if …

This study tests a procedure that uses ultrasound and a catheter to deliver a low dose of a clot-dissolving drug directly to blood clots in the lungs. The goal is to quickly reduce the strain on the heart and improve blood flow, while keeping the risk of serious bleeding low. The…

This study tests whether adding Thymoglobulin to standard anti-rejection drugs helps prevent complications after a first heart transplant. About 60 adults will receive either standard therapy alone or standard therapy plus five days of Thymoglobulin. Researchers will check for si…

This early study tests a temporary heart pump called Impella BTR in 10 adults with severe heart failure. The pump is placed inside the body to help the heart pump blood for up to 28 days. The goal is to see if the device is safe and can support patients until they recover or rece…

This early study is testing a new device called the Cardiovalve system in 10 people with severe mitral regurgitation (a leaky heart valve) who are at high risk for open-heart surgery. The valve is delivered through a vein in the leg, avoiding a large chest incision. The main goal…

This study tests whether enavogliflozin, a diabetes drug, can improve outcomes in people with heart failure and a leaky tricuspid valve. About 541 participants will receive either the drug or a placebo for 18 months. Researchers will track heart-related events, valve worsening, a…

This trial studies whether a special pacing feature called SyncAV, used in heart devices, can improve heart function in people with congestive heart failure. About 1,686 participants will get a new or upgraded heart device and be randomly assigned to have SyncAV on or a standard …

This study tests if stem cells from donated bone marrow can help people with heart failure. The cells are delivered directly into the heart using a special catheter. The goal is to see if this treatment is safe and can improve heart function, reduce hospital stays, and help patie…

This study tests whether giving people free fruits and vegetables (a produce prescription) along with culturally tailored cooking classes can improve their nutrition and help manage chronic conditions like diabetes and high blood pressure. Thirty adults who already take medicatio…

This study tests whether a combination of anti-inflammatory and heart-protecting drugs can reduce symptoms and heart damage in people with Long COVID who have ongoing heart inflammation. About 279 adults with heart inflammation seen on MRI will receive either the drug combo or a …

This study tests a one-time gene therapy called AB-1002, given directly into the heart arteries, for people with advanced heart failure (NYHA Class III). The goal is to see if it can improve heart function, reduce symptoms, and lower the risk of death or hospitalization. About 15…

This Phase 2 study tests an injectable drug called HRS9531 in 203 obese adults with a type of heart failure where the heart pumps normally but is stiff. Participants receive either the drug or a placebo for 52 weeks. The main goals are to see if the drug helps with weight loss an…

This study is testing a device called the OPTIMIZER Smart, which is implanted in the chest to send mild electrical signals to the heart. It is for people with moderate-to-severe heart failure (NYHA class III) and a weakened heart pump (ejection fraction 25-45%). The goal is to se…

This study tests the safety and performance of a new pacemaker system (Amvia pacemaker and Solia CSP S lead) for people who need help with their heart's electrical system. The device is designed to pace a specific part of the heart's natural wiring to improve efficiency. 152 part…

This study looks at how vericiguat, a recently approved heart failure drug, improves heart function during activity and at rest. Researchers will give 30 adults with heart failure either vericiguat or a placebo for about three months, then measure heart performance using catheter…

This study tests a less invasive way to replace a failing mitral valve in the heart. About 53 people who already have a surgical valve that is not working well will receive a new valve placed inside the old one using a thin tube. The goal is to see if this procedure is safe and h…

This registry follows 350 adult heart transplant patients whose donor hearts were kept alive and beating using the OCS Heart System before transplant. The goal is to see how well patients do one year after surgery. The device may allow more donor hearts to be used, especially tho…

This study tests whether a nurse-led remote monitoring program can help heart failure patients after they leave the hospital. About 200 patients will use a digital platform or phone to report symptoms and medication adherence for three months. The goal is to see if this reduces h…

This study tests the Impella 5.5 heart pump in 123 high-risk patients with weak hearts (ejection fraction 25% or less) who need complex cardiac surgery. The pump supports the heart during and after surgery to prevent failure, stroke, and other complications. The goal is to confir…

This early-phase trial is testing whether heart muscle cells grown from stem cells can be safely injected into the hearts of 10 people with severe heart failure caused by blocked arteries. The main goal is to check for side effects over 26 weeks, while also measuring whether the …

This early study tests a device that creates a small opening between the upper chambers of the heart to relieve pressure in people with symptomatic heart failure. The study includes 71 participants and focuses on safety and whether the device works as intended. It is not a cure b…

This study compares three catheter ablation strategies in 300 adults with persistent atrial fibrillation and heart failure. The goal is to see which approach best reduces the risk of death, hospitalization, or urgent visits due to worsening heart failure. Participants are randoml…

Researchers are testing whether an artificial intelligence system can analyze echocardiogram images and draft reports as accurately as experienced sonographers in patients with heart failure. The trial enrolls adults with new or worsening heart failure symptoms and elevated heart…

Researchers are testing whether artificial intelligence can combine ultrasound images with routine health data to track changes in a person's physiology over time. The study enrolls adults with heart, lung, kidney, or blood vessel conditions, as well as healthy volunteers. The go…

This trial tests whether actively screening adults with obesity for early signs of heart failure can improve their health outcomes. Adults aged 45 and older with a BMI of 30 or higher, who have no known heart disease, will be randomly assigned to receive either standard care or a…

This study asks whether tiny RNA molecules in the blood can signal a higher risk of dangerous heart rhythms in people who have heart failure after a heart attack and use an implanted defibrillator. Researchers collect blood samples from 57 participants and compare RNA patterns be…

This trial tests whether a point-of-care blood test for NT-proBNP, which gives results at the bedside in about 12 minutes, can help doctors diagnose new heart failure faster in hospital patients with unexplained breathlessness. Researchers will compare time to diagnosis, time to …

This study will test if artificial intelligence (AI) can spot a rare heart condition called ATTR-CM in people with heart failure. Researchers will use AI to analyze electrocardiograms (ECGs) and echocardiograms (Echo) from 150 adults. The AI's findings will be checked against a s…

This trial evaluates an AI-assisted tool that measures the heart's pumping efficiency (ejection fraction) from ultrasound clips. The AI's measurements will be compared to those made by a panel of expert cardiologists to see if they are equally accurate. The study uses previously …

This study enrolls about 4,000 adults aged 60 and older with heart failure who are at high risk for ATTR amyloidosis, a rare disease that stiffens the heart. Doctors receive special training on how to spot and diagnose the condition using standard tests. The goal is to see if thi…

This study tests whether a non-invasive device called Vivio can accurately track heart failure status by measuring blood pressure in the lungs. Researchers will compare Vivio readings to those from an implanted CardioMEMS sensor in 500 adults over age 21 who already have or will …

This trial tests whether an artificial intelligence tool can improve the accuracy and speed of measuring heart wall thickness on echocardiograms compared to standard sonographer measurements. About 4,000 adults receiving a transthoracic echocardiogram will have their images asses…

This early-phase trial tests a radioactive imaging agent called 18F-mFBG to see how well it can show the nerves in the heart. Researchers will give the agent to 10 adults—some with heart disease and some without—and take PET scans over time. The goal is to measure how the agent m…

This study looks at whether existing blood markers can accurately identify the underlying cause of heart failure in 511 patients. Researchers aim to improve diagnosis and potentially reduce healthcare costs by avoiding unnecessary tests. Participants were recently diagnosed with …

This study tests a new, non-invasive method called ezCVP to measure central venous pressure (a key heart health indicator) in 30 adults with heart failure in the ICU. It compares ezCVP to the standard invasive method that uses a catheter. The goal is to see if ezCVP can accuratel…

Acute heart failure is a life-threatening condition where the heart suddenly can't pump blood, but its symptoms often mimic other illnesses, causing delays in diagnosis. Researchers developed a computer algorithm called CoDE-HF that combines a blood test (NT-proBNP) with patient …

This study looks at better ways to find heart failure in people with pacemakers. About 1 in 3 pacemaker patients may have undiagnosed heart failure, but current tests are expensive and time-consuming. Researchers will test if a handheld ultrasound with artificial intelligence or …

This study is testing a device that reads wrist pulses to help diagnose heart failure. Heart failure is often missed in primary care because its symptoms overlap with other conditions. The device uses a sensor and AI to detect pulse patterns linked to heart failure. Researchers w…

This study explores whether fluid from the skin can be used to detect signs of heart disease. Researchers will collect skin fluid and blood samples from 30 volunteers, including older adults with heart failure and younger healthy adults. The goal is to see if certain biomarkers i…

This study tests whether a blood test for NT-proBNP can spot undiagnosed heart failure in 706 people with diabetes who are at high risk. Those with elevated levels get a heart ultrasound and exam. The goal is to see if this screening strategy leads to more early diagnoses and pro…

This study looks at whether a simple blood test (NT-proBNP) can help find heart failure earlier in adults who take water pills (loop diuretics) but haven't been diagnosed with heart failure. About 400 people from GP practices in Jersey will take part. Some GP practices will offer…

This study looks at better ways to diagnose a type of heart failure called HFpEF in people who have unexplained shortness of breath. Researchers will compare non-invasive tests to the standard invasive method in 30 adults aged 18-90. The goal is to make diagnosis easier and more …

This study looks at 80 people with heart failure to find better ways to diagnose sarcopenia, a condition where muscles weaken and shrink. Researchers will use body scans, blood tests, and simple physical tests like walking speed and grip strength. The goal is to catch muscle loss…

This study tests whether a smartwatch-based monitoring system can help prevent sudden worsening of heart failure. Researchers will enroll 250 adults with stable heart failure and use wearable data to predict and avoid hospitalizations. The goal is to catch problems early and redu…

Researchers are testing whether Azerbaijani national dance sessions can improve cardiorespiratory fitness and quality of life in older adults with chronic heart failure. The trial enrolls 120 people aged 65 to 85 whose heart failure is confirmed by an ejection fraction between 40…

Researchers are testing whether dapagliflozin, a daily oral drug, helps people with refractory heart failure who are on peritoneal dialysis remove more salt and fluid. The trial compares two 12-week periods: one with dapagliflozin added to usual care and one without. About 31 adu…

This study tests whether a 14-week elastic band exercise program can improve muscle mass, strength, and physical function in heart failure patients aged 50 and older who also have sarcopenia (age-related muscle loss). Researchers will measure changes in muscle, symptoms, and qual…

This study tests a digital program called TPA4You for older adults (50+) who care for a family member with heart failure. The program uses a Fitbit, video coaching, and text messages to encourage physical activity. The goal is to see if it's feasible and helps improve caregivers'…

This study tests a new medicine called ziltivekimab in 680 adults with heart failure and signs of inflammation. Participants will receive either the drug or a placebo for up to 16 months. The goal is to see if the drug improves heart failure symptoms and physical function, like b…

Many Veterans with heart failure or COPD struggle with breathlessness, fatigue, depression, and anxiety that routine care often misses. This study tests whether a virtual team—a nurse and a social worker—can improve quality of life by helping Veterans manage their most bothersome…

This study tests whether a single intravenous dose of iron (ferric derisomaltose) can improve symptoms, exercise ability, and quality of life in 150 adults with a type of heart failure called HFpEF who also have iron deficiency. Participants will receive either the iron infusion …

This pilot study is testing whether providing medically tailored meals to heart failure patients after they leave the hospital is practical and helpful. Researchers will enroll 85 adults who are on Medicaid or Medicare and recovering from a heart failure hospitalization. The meal…

This trial tests whether nurse-guided breathing exercises can reduce shortness of breath and anxiety in people with advanced heart failure who come to the emergency department. Participants are randomly assigned to receive either standard care plus guided diaphragmatic and pursed…

This study tests whether 8 weeks of phone-based mindfulness training can improve self-care and thinking skills in 176 adults with heart failure and mild cognitive impairment. Participants practice techniques like breath awareness and body scanning for 20 minutes daily. The goal i…

This trial tests whether a structured therapeutic education program, delivered by general practitioners, can improve quality of life for people with heart failure. Around 200 patients in primary care will be randomly assigned to receive the program or usual care, and their qualit…

This study looks at whether exercise training and dietary counseling can help cancer survivors who have heart failure. About 85 participants will either receive usual care or join a program with exercise three times a week and low-salt diet guidance. The goal is to see if this li…

This study tests a program called CHAT for people aged 60 and older with a type of heart failure called HFpEF. Participants get up to four sessions with a health coach and watch seven educational videos, all from home. The goal is to see if this helps them manage their condition …

This study looks at whether gradually stopping beta-blockers (medicines often used for heart failure) can improve symptoms and daily function in adults aged 60 and older with a specific type of heart failure called HFpEF. About 240 participants will either taper off their beta-bl…

This study tests a program called UPHOLDS to improve quality of life for 64 older adults with advanced heart failure. Participants receive different combinations of coaching, financial help, and a palliative care consultation. The goal is to see which parts of the program are mos…

This pilot study looks at whether following the DASH diet (a heart-healthy eating plan) can improve the health of people with heart failure. Researchers will track diet, blood pressure, and heart failure markers in 26 adults over time. The goal is to see if medical nutrition coun…

This early study tests a device that creates a small, temporary opening in the wall of the heart to relieve pressure and improve symptoms in people with advanced heart failure. The main goal is to see if the procedure is safe. About 20 participants who have not responded well to …

This study tests whether 10 weeks of supervised exercise training can improve heart function, oxygen use, and quality of life in people with heart failure and pulmonary hypertension. Forty participants will do three sessions per week at a cardiac rehab clinic. The goal is to see …

This study tests whether exercise delivered through immersive virtual reality can improve physical performance, muscle strength, fatigue, and quality of life in 32 adults with idiopathic pulmonary arterial hypertension. Participants will do virtual reality exercises and be measur…

This study planned to compare two versions of the water pill torsemide (immediate release vs extended release) in people with stable heart failure. The goal was to see which form helps the body get rid of extra salt more effectively after a salty meal. However, the trial was with…

This study tests whether a 12-week yoga program can improve thinking and brain health in people aged 55+ who have both heart failure and mild cognitive impairment. Participants will be split into a yoga group and a control group to compare changes in brain scans, memory tests, an…

This early-stage study tests whether the drug atibuclimab (IC14) is safe and helpful for adults hospitalized with sudden worsening heart failure. Ten participants receive one IV dose of the drug and are monitored for side effects, drug levels, and heart failure markers. The goal …

This study tests whether a combination of virtual reality exercises and computer-based cognitive training can improve memory and thinking in 172 older adults (55+) who have both heart failure and mild cognitive impairment. Participants will use VR and computer programs designed t…

This study tests whether empagliflozin, a drug typically used for diabetes, can help people with hypertrophic cardiomyopathy (a thickened heart muscle) who do not have diabetes. About 250 adults will receive either the drug or a placebo daily for 12 months. The main goals are to …

This study tests whether high-flow oxygen therapy can prevent low oxygen levels (hypoxemia) in patients at higher risk during sedated digestive endoscopy. The trial includes 326 adults with obesity, sleep apnea, or stable lung or heart conditions. Researchers will compare high-fl…

This study tests whether special 'kinesthetic brain exercises'—simple movements that connect body and mind—can improve thinking and memory in adults with heart failure. Forty participants aged 30-65 will be split into two groups: one gets standard care plus these exercises twice …

This study aimed to see if a single dose of bumetanide given as a nasal spray could quickly lower blood pressure in the lungs and reduce blood volume in people with heart failure. Participants would have had a heart monitor implanted. However, the trial was withdrawn before enrol…

This study tests whether adding a traditional Japanese herbal medicine called Goreisan to standard heart failure treatment can help reduce fluid buildup (edema) in the body. About 1,179 adults with worsening heart failure and signs of fluid overload are being randomly assigned to…

This study tests whether adding a team of specialists—physical therapy, occupational therapy, palliative care, and social work—to standard clinic visits helps people with a ventricular assist device (VAD) feel better and function better. About 110 participants, including newly im…

This study aimed to see if making physical activity into a game could help older hospital patients move more. Participants would have received daily text messages, set step goals, earned points, and worn a Fitbit to track their steps. The study was withdrawn before any patients w…

This study tests a personalized, remotely monitored exercise program for 150 people with a type of heart failure called HFpEF. The goal is to see if the program improves heart function, muscle health, and quality of life. Participants will follow a structured exercise plan and be…

This study tests whether a 9-month program that encourages people with heart failure to gradually increase their daily steps and walking speed can improve their physical function and symptoms. Two hundred participants will either receive standard care or the step-based program, w…

This study looks at whether taking ketone or hawthorn supplements for 8 weeks can improve exercise ability and heart function in people with congestive heart failure. About 45 adults with mild to moderate heart failure will be randomly assigned to receive one of the supplements o…

This study tests whether a ketone drink can improve exercise capacity in people with heart failure with preserved ejection fraction (HFpEF). Twenty participants will receive either the ketone drink or a placebo for 8 weeks, then switch. The main goal is to see if the drink helps …

This study tests a personalized approach to find the best beta-blocker dose for older adults with heart failure. Fifty participants will either receive the N-of-1 intervention (testing different doses in 2-week cycles) or enhanced usual care. The goal is to see if this patient-dr…

This study will collect blood, urine, stool, and DNA samples from 2000 adults with heart failure to better understand how the disease progresses. Researchers will analyze proteins and other factors linked to declining heart function. Participants will be followed for up to 5 year…

This study explores whether artificial intelligence (AI) combined with data from a smartwatch can predict serious heart failure events, such as hospitalizations or worsening symptoms. Adults with heart failure will wear a smartwatch for six months and take weekly ECG readings. Th…

Researchers at University Hospital Freiburg are studying how blood levels of hsCRP and Lp(a), two markers linked to heart disease, change over time in patients who have had these tests more than once. The study asks whether a high result on a first test often returns to normal la…

This Phase 1 trial investigates how the drug HRS-9057 is absorbed, processed, and eliminated in healthy men. Six participants receive a single dose, and researchers measure the drug and its breakdown products in blood, urine, and stool. The goal is to understand the drug's behavi…

This study monitors heart rate variability in 150 adults with type 2 diabetes who also have heart failure, chronic kidney disease, or both. Participants will wear a 24-hour heart monitor before and after starting a standard SGLT2 inhibitor medication. The goal is to understand ho…

This observational study follows 95 people with heart failure and preserved ejection fraction who are already receiving weight loss treatment as part of their standard care. Researchers will measure muscle blood flow, fat content, and inflammation before and after at least 7% wei…

This study tracks how paramedics use the ZOLL 731 ventilator when helping people with serious conditions like cardiac arrest, sepsis, or heart failure before they reach the hospital. Researchers will record which ventilator modes and settings are used, and how often alarms go off…

This study follows 200 adults in Western Denmark who are having a transcatheter aortic valve implantation, a procedure to replace a narrowed heart valve. Researchers will measure quality of life before the procedure and at follow-up using a standard questionnaire. They will also …

This study follows 250 people with high blood pressure and 60 healthy volunteers over several years. Researchers use heart imaging and blood tests to track changes in heart structure and function. The goal is to understand why some people with hypertension develop heart failure, …

This study looks at why standard heart failure medications may not fully block a hormone called aldosterone. Researchers will give 20 adults with stable heart failure either a placebo or the drug spironolactone, then measure how the body handles salt and water. The goal is to und…

This study is testing whether a wearable ECG patch, combined with AI analysis, can help doctors identify a wide range of heart conditions and risks from a single recording. The Cor360 system looks at many aspects of heart health at once, such as heart failure, rhythm problems, an…

This study looks at whether training doctors on quickly starting and adjusting heart failure medications (called GDMT) during a hospital stay leads to better treatment after discharge. About 438 adults with heart failure and reduced ejection fraction will be observed across multi…

This observational study aims to capture a real-world snapshot of how heart failure is managed across Europe and worldwide. Researchers will collect data from about 4,000 adults with chronic or acute heart failure, looking at whether routine care aligns with the 2021 ESC guidelin…

This study looks at whether sensors inside implanted heart devices can warn of worsening heart failure. Researchers will track 500 adults with heart failure or cardiomyopathy who have a Boston Scientific ICD or CRT-D equipped with HeartLogic, Sleep Incline, and Apnea Scan functio…

This study aims to improve how doctors communicate with patients facing serious illnesses like cancer, heart failure, COPD, or dementia. Researchers will give doctors detailed feedback on their conversations about goals of care. The goal is to help patients receive care that matc…

This study looks at whether standard blood tests for heart failure show different results in African American and Caucasian patients. Researchers will compare levels of cardiac biomarkers in 400 adults newly diagnosed with heart failure. The goal is to see if current tests miss o…

This study tests new strategies to make sure that decisions about who gets a heart transplant or a heart pump are fair and based on objective medical criteria, not bias. Researchers will work with over 1,400 patients and doctors at heart centers across the U.S. to reduce racial a…

This study looks at how dapagliflozin, a diabetes drug, affects heart function and metabolism in people with chronic kidney disease. Researchers will measure heart strain, oxygen use during exercise, and blood chemicals in 60 adults. The goal is to understand how the drug works b…

This pilot study at the Cleveland Clinic is testing whether a simple, non-invasive retinal camera can detect signs of heart failure severity. Researchers will compare eye images from 250 people with and without heart failure to see if blood vessel changes in the retina match dise…

This study looks at whether a quick, simple test—standing up and sitting down from a chair as many times as possible in one minute—can help predict how heart failure patients will fare after leaving the hospital. Researchers will follow 68 adults hospitalized for decompensated he…

This study looks at how people with both cancer and heart failure feel day-to-day. Researchers will ask 100 participants about their symptoms and quality of life using simple questionnaires. No new treatments are tested—the goal is to better understand the challenges these patien…

This study follows over 800 heart failure patients in Germany who are starting dapagliflozin, a drug recently approved for heart failure. Researchers will track how long patients stay on the drug, any side effects, and changes in symptoms and quality of life. The goal is to under…

This study looks at how data from wearable devices (like activity trackers and heart monitors) relates to heart and muscle function in people with a type of heart failure called HFpEF. Researchers will compare 60 adults with and without HFpEF using tests like MRI, exercise testin…

This pilot study investigates whether a continuous remote ECG monitor, worn as a chest patch, can predict hospital readmission or death within 30 days after discharge in patients with heart failure and atrial fibrillation. Fifty participants will wear the Vivalink ECG patch at ho…

This study looks at how different levels of pressure from a breathing machine (called PEEP) affect the heart's pumping ability in 28 adults having heart surgery. Doctors will use special imaging and monitors to measure heart function at four different pressure settings. The goal …

This study compares two ways of delivering a health and wellness program to people with chronic conditions like diabetes and high blood pressure. One group gets a kit with a tablet and home monitors for blood pressure and blood sugar; the other gets standard phone calls. The goal…

This study looks at how inflammation and oxidation (chemical reactions in the body) might damage the heart and lead to heart failure. Researchers are tracking over 1,200 healthy adults aged 40+ (or 18+ with a family history of heart failure) to see if waste products in blood or u…

This study looks at why people who have had an organ transplant are more likely to get cancer. Researchers will combine existing health records from over 85,000 transplant patients in England to track cancer cases and deaths. The goal is to better understand risks and improve car…

This study looks at how high blood pressure changes the heart's structure in people who work rotating shifts in the Arctic. Researchers will track 550 workers over a year using heart ultrasounds and blood tests. The goal is to understand why some develop heart failure, not to tes…

This study uses two advanced MRI techniques to measure muscle health in heart failure patients with and without sarcopenia (age-related muscle loss). Researchers will scan 70 participants to compare muscle composition and energy recovery. The goal is to find better ways to detect…

This study looks at whether using a simple bedside ultrasound exam on all hospitalized patients can shorten their hospital stay. Researchers will check the heart, kidneys, liver, and lungs for common problems. The goal is to see if this routine check helps doctors make faster dec…

This study looks at tiny pieces of RNA in the blood of people with congestive heart failure. Researchers want to see if these RNA levels change with treatment and if they can predict heart health or future heart problems. About 400 adults with heart failure will be followed durin…

This study tests a machine-learning tool built into electronic health records to help emergency doctors quickly assess risk in adults with acute heart failure. The tool predicts which patients are at high risk of complications and likely need hospital admission, and which low-ris…

This study tracks 130 people with chronic heart failure to understand how taking multiple medications (polypharmacy) affects their safety, adherence, and health outcomes. Researchers will look for patterns of over- or under-prescribing and factors linked to low medication adheren…

This study tests a questionnaire called NECPAL to see if it can spot patients with serious long-term illnesses like cancer, heart failure, or kidney disease who might benefit from palliative care. Researchers will check 200 adults in the hospital or day clinic to see how many are…

This study looks at how SGLT2 inhibitors, a type of diabetes drug also used for heart failure, affect the body's metabolism. About 40 adults with mild to moderate heart failure will have blood tests, walking tests, and calf MRIs before and after starting the medication. The goal …

This study is for heart failure patients who do not have a specific heart rhythm pattern called left bundle branch block (non-LBBB). These patients often get a device called CRT-D, which combines a pacemaker and a defibrillator, but not everyone responds well. Researchers will fo…

This study tests a redesigned clinical decision support tool for heart failure patients during virtual visits. The tool gives doctors medication recommendations and tips for patients to upload their vitals at home. Researchers will compare it to the usual tool in a small pilot wi…

This study looks at medical records from over 600 Indian adults with chronic heart failure who were prescribed vericiguat between 2022 and 2023. Researchers want to see how the drug is used in routine care, how well it works, and what side effects occur. No new tests or visits ar…

This study tests a new computer tool that gives doctors personalized reminders when prescribing heart failure medications. The goal is to help doctors follow treatment guidelines more closely. About 764 doctors from cardiology and primary care clinics are taking part.

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This early study is testing whether the diabetes and heart failure drug empagliflozin (Jardiance) is safe for people on dialysis for kidney failure. The drug is already approved for other uses but has not been studied in dialysis patients. Researchers will give 24 participants ei…

This study tests whether a wearable sensor can accurately estimate the heart's pumping ability (LVEF) compared to standard ultrasound. Researchers will enroll 500 adults already scheduled for an echocardiogram. The goal is to develop a simpler, more accessible way to monitor hear…

This study analyzes data from over 4,200 heart failure patients to create a tool that uses biomarkers to guide diuretic dosing. Researchers aim to develop a machine-learning algorithm that could personalize treatment and improve outcomes. The study is observational and does not t…

This study aimed to validate several blood biomarkers (like NT-proBNP and IL-6) to help doctors assess atrial fibrillation burden and track treatment effectiveness. Researchers planned to analyze samples from 266 patients before and after treatment. However, the study was withdra…

This study looks at 50 adults hospitalized with acute decompensated heart failure who need intravenous diuretics (water pills). Researchers want to see if a non-invasive monitor called the Starling System can accurately measure changes in heart function as fluid is removed. The g…

This study looks at whether measuring salt levels in the kidneys using a special MRI can help doctors predict which heart failure patients will not respond well to water pills (diuretics). About 50 adults with heart failure and kidney disease will be scanned to compare salt conte…

This study is testing a new type of clinic that screens people with prediabetes and type 2 diabetes for several hidden health problems at the same time, including fatty liver disease, sleep apnea, and heart failure. The goal is to see how common these undiagnosed conditions are a…

This study looks at over 1,200 adults with type 2 diabetes and heart muscle problems to see if diabetic cardiomyopathy is a unique condition. Researchers will use detailed medical tests, imaging, and biological data to find patterns. The goal is to better understand and diagnose …

This large real-world study will follow 10,000 Italian patients with COPD to see how their treatments, flare-ups, and other health conditions affect their risk of death. Researchers will collect data on medications, lung function, and heart problems over time. The goal is to bett…

This study aimed to compare two versions of the water pill torsemide (extended release vs immediate release) in adults with stable heart failure. Participants would have taken each version for a week, then had their sodium excretion measured after a single dose and a salty lunch.…

This study looks at real-world data from 6,000 heart failure patients to compare a newer pacing method (conduction system pacing) with the standard method (biventricular pacing). The goal is to see if the newer approach is just as safe and effective at reducing heart failure hosp…

This study looks at whether giving doctors early results from heart biomarker tests (NT-proBNP and hs-cTnT) along with a structured interpretation note can improve outcomes for patients admitted with rapid breathing (tachypnea). About 574 adults will be randomly assigned to recei…

This study looks at 2,000 people who had a heart attack to see if checking the stiffness of their blood vessels one month later can help predict future heart failure, another heart attack, or bleeding. Researchers will track participants for several years to identify which measur…

This study tests a web-based platform called 'My Voice' that helps heart failure patients learn about their illness, decide on end-of-life care goals, and share those wishes with doctors and caregivers. About 244 patients in Singapore will use the tool to see if it increases adva…

This study was designed to compare a newer pacing method (left bundle branch area pacing) with the standard method (right ventricular pacing) in patients who developed heart block after TAVR valve replacement. The goal was to see which method better preserves heart function and r…

This trial aimed to see if an AI program could help doctors choose better heart failure treatments for each patient. It planned to compare standard care with AI-generated treatment advice. However, the study was withdrawn before enrolling any participants, so no results are avail…

This study collects tissue and blood samples from 200 people with advanced heart failure who are getting a heart pump or transplant. Researchers will use these samples to learn more about the disease. No new treatments are being tested, and the study does not change how patients …

This study tests whether using an ultrasound measure of heart muscle coordination (mechanical dyssynchrony) can better select heart failure patients for cardiac resynchronization therapy (CRT) than current guidelines. About 500 patients will receive a CRT device, but pacing will …

This study tests whether using game-like rewards and personal coaching can encourage older adults to walk more after leaving the hospital. About 350 people aged 50 and older with conditions like high blood pressure or heart failure will wear a Fitbit to track their steps. The goa…

This study enrolls 80 people with implanted heart devices to see if collecting extra health data from wearables and a phone app can improve care. Participants must have had a heart failure event in the past year. The goal is simply to gather data, not to test a new treatment.

This study tests whether an AI-powered speech-to-text tool can accurately capture health information from heart failure patients. Researchers at Stanford will enroll 100 adults with heart failure to see if the tool's summaries match expert reviews. The goal is to improve communic…

This study planned to use a machine learning algorithm to estimate blood potassium levels from a single-lead ECG in hospitalized patients. It was designed as a retrospective analysis of existing data from a home hospital program. However, the study was withdrawn before enrolling …

This study tests whether a small device placed under the skin can detect hidden atrial fibrillation (an irregular heartbeat) in people with heart failure who are at high risk for stroke. About 477 participants either received the implant or standard care. The goal is to see if th…

This study uses a special MRI technique that tracks oxygen levels in the heart and brain of people with heart failure. Participants practice breathing exercises before the scan to see how their organs respond to changes in oxygen. The goal is to find a link between low oxygen res…

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study examines whether SGLT2 inhibitors, a type of diabetes drug, can improve red blood cell production and heart/kidney function in people with chronic heart failure. Researchers will compare blood tests, heart ultrasound measures, and clinical outcomes between 85 patients …

This study looks at why Veterans with heart failure with preserved ejection fraction (HFpEF) get tired so easily during exercise. Researchers will block nerve signals from leg muscles to see how that affects blood flow and fatigue, both before and after a regular exercise program…

This study looks at whether a substance called YKL-40 in the blood can help predict how well heart failure patients will respond to cardiac resynchronization therapy (CRT), a special pacemaker. About 51 adults with severe heart failure will have blood samples taken during their r…

This study looks at whether giving pharmacists extra education plus monthly feedback on their performance helps them adjust heart failure medications more often than just education alone. About 400 pharmacists across 22 VA sites will take part. The goal is to see if simple change…

This study tests whether a noninvasive procedure called remote ischemic preconditioning can improve blood vessel function in people with suspected heart failure with preserved ejection fraction. Participants will have a blood pressure cuff inflated around their arm in cycles, whi…

This study looks at whether a special PET scan can help doctors better predict sudden cardiac arrest in people with heart failure and blocked arteries. About 300 participants who already have a defibrillator will be followed to see if heart nerve damage, heart size, or blood mark…

This study planned to test a new way to program cardiac resynchronization therapy (CRT) devices for heart failure patients who didn't get enough benefit from standard settings. Researchers would use ECG and cardiac MRI to find the best device settings and measure changes in heart…

This study tests a smartphone app that listens to your voice to catch early signs of heart failure getting worse. 123 people who were in the hospital for heart failure will record their voice daily for 6 months. The app looks for voice changes that might signal a problem, but doc…

This study looks at blood gas levels taken from a vein near the heart during a pacemaker-like procedure called CRT. The goal is to see if these measurements can help predict which heart failure patients will respond well to the therapy. Researchers are following 65 patients to tr…

This study follows 1,599 people who had a first heart attack to see how their hearts remodel over time. Researchers want to link these changes to later heart failure. Participants are from several Minnesota counties and will be monitored for heart failure and death. No new drug o…

This study tests whether a phone app called StudyU can help people with heart failure reach their recommended beta blocker dose. Five adults aged 65 and older with heart failure will use the app to track their medication. The goal is to see if the app is practical and acceptable …

This study follows over 3,000 heart failure patients who have a BIOTRONIC CRT device implanted. Researchers will track hospitalizations, deaths, and device issues over time to understand how well the devices work in real life. The goal is to find ways to improve treatment and dev…

This study looks at how the heart changes after a procedure to replace a leaky tricuspid valve in people with severe heart failure who cannot have open-heart surgery. It focuses on patients who develop unstable blood pressure right after the procedure. Researchers will track surv…

This study follows about 3,000 adults in Port-au-Prince, Haiti, to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other heart problems. Researchers will track participants for about…

This study is a registry that will follow 700 heart failure patients whose heart pumping ability has either improved significantly or is naturally very high. Researchers will collect medical data and track outcomes like death, heart-related death, and worsening heart failure over…

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related health problems. Researchers aimed to identify risks and understand what leads to disability or death after a heart event. The study did not test a new treat…

This study looks at whether special heart MRI scans can help predict serious events like death or hospital stays in people with a type of heart failure called HFpEF (heart failure with preserved ejection fraction). Researchers will scan 3000 patients with HFpEF and 500 healthy vo…

This study planned to test whether an electromagnetic resonator could change how the autonomic nervous system works in people with heart failure. It would have included 20 heart failure patients and 20 healthy volunteers. However, the study was withdrawn before enrolling any part…

This study uses advanced heart MRI scans to better understand early-stage heart failure in people with risk factors like diabetes, high blood pressure, or obesity. Researchers will follow 3,000 participants over time to see how the heart changes and who develops serious problems.…

This study creates a registry of 240 patients hospitalized with decompensated heart failure with preserved ejection fraction. Researchers will track medical history, body composition, imaging, and blood markers to see how these factors relate to short- and long-term outcomes. The…

This study tests a new digital platform that helps doctors and nurses share important patient information when a person is moved from one hospital to another. About 1,000 adults being transferred to a major hospital will take part. The goal is to see if better information sharing…

This study followed over 6,800 adults from different racial and ethnic backgrounds to understand how heart disease develops over time. Participants were healthy at the start and were monitored for risk factors and heart-related events like heart attacks and strokes. The goal is t…

This study looks at balance and thinking skills in middle-aged and older adults with heart failure compared to healthy people of the same age. Researchers will track changes one and three months after hospital discharge. The goal is to understand if balance problems are linked to…

This pilot study looks at how the diabetes drug sitagliptin (Januvia) affects people who naturally have lower levels of a protein called DPP4 due to their genes. Researchers will compare 20 adults with and without this genetic trait to see how sitagliptin changes blood sugar and …

This study looks at whether a special training program can help family doctors use focused heart ultrasound (FoCUS) to accurately detect common heart conditions like heart failure and valve disease. About 500 patients will get both a family doctor's FoCUS and a cardiologist's ful…

This study tests whether adding video-call education (via WhatsApp) to standard teaching helps heart failure patients improve self-care. 100 adults with heart failure will be split into two groups: both get usual in-person education, but one group also gets a video call three mon…

This study uses advanced MRI techniques to measure changes in heart muscle tissue in 8,000 adults with heart failure, heart muscle disease, inflammation, coronary artery disease, or chronic kidney disease. The goal is to see if these measurements can help doctors better diagnose …

This study looks at people with rare adrenal tumors (pheochromocytomas and paragangliomas) that do not produce excess hormones. Researchers want to see if these 'silent' tumors still cause heart problems, blood pressure changes, or metabolic issues like diabetes and high choleste…

This study follows 10,000 people with both obstructive sleep apnea and high blood pressure over many years. Researchers will track how well patients use CPAP machines and blood pressure medications, and whether this reduces the chance of heart attacks, strokes, heart failure, or …

This study looks at 180 adults newly diagnosed with heart failure and a weak heart pump. Researchers use multiple types of heart scans and tests to see if they can predict whose heart function will improve over 3-12 months. A smaller part of the study tests a higher dose of a dru…

This study was designed to measure levels of a protein called SGLT2 in heart muscle samples taken during valve replacement surgery in people with aortic stenosis. Researchers wanted to compare SGLT2 levels between those with and without diastolic heart failure to better understan…

This study aimed to see if simple electronic reminders could help doctors reduce risky medication combinations in older patients. It planned to enroll primary care clinicians and use behavioral nudges in the electronic health record. However, the trial was withdrawn before any pa…

This study tests whether sending cardiologists regular emails about quality goals helps them prescribe recommended medications for heart failure and atrial fibrillation. Researchers will track prescribing rates for 7,000 patients. The goal is to see if simple feedback can improve…

This study aims to improve exercise prescription in cardiac rehabilitation by using machine learning to analyze data from the autonomic nervous system. Researchers will enroll 90 patients with coronary artery disease or non-ischemic heart failure. They will measure nerve activity…

This study looks at 120 adults getting a left ventricular assist device (LVAD) to see how often infections happen and how their immune system changes after surgery. The goal is to find what makes some patients more likely to get infections. This research does not test a new treat…

This study tests whether offering heart patients extra support—like a $50 incentive, text messages, case management, and coaching—helps more of them attend cardiac rehabilitation, a program that only 30% of eligible patients currently use. Researchers will also try different ways…

This study explores whether MRI scans can help doctors predict which heart failure patients will respond well to a special pacemaker treatment called cardiac resynchronization therapy (CRT). Researchers will analyze MRI images from 110 adults scheduled for CRT and use computer mo…

This study will observe 72 adults with heart failure and implanted cardiac devices (ICD or CRT) to understand what affects their arm function. Researchers will measure arm strength and endurance using simple tests like throwing a medicine ball and lifting objects. The goal is to …

This study looks at whether long-term use of a breathing device called adaptive servo-ventilation (ASV) can improve how the heart uses energy and how nerves work in people with heart failure and sleep apnea. Researchers will use PET scans to measure heart metabolism and nerve fun…

This study was designed to measure how stiff the arteries are in intensive care patients receiving drugs to support their heart or blood pressure. The goal was to see if a simple monitor reading could help doctors adjust treatment. However, the study was withdrawn before any pati…

This study looks at tiny RNA molecules in the blood of 200 people hospitalized with acute congestive heart failure. Researchers want to see if these RNA levels change as patients receive decongestive therapy and if they can help predict who will respond well to treatment. The goa…

This study looks at how well a feature called TriageHF, built into Medtronic heart devices, can predict when heart failure might get worse. About 2200 people with these devices are being followed in regular doctor visits. The goal is to see if the high-risk alerts correctly ident…

This study was designed to find out if treating obstructive sleep apnea with a CPAP machine could help improve insulin resistance and heart function in people with heart failure. It planned to enroll adults aged 18 to 75 with moderate to severe sleep apnea and reduced heart pumpi…

This study looks at how two drugs, Sacubitril/Valsartan (Entresto) and MANP, affect people with a type of heart failure called HFpEF, which also involves chronic kidney disease or shortness of breath during exercise. Researchers will measure changes in body chemicals and kidney f…

This study follows over 5,700 people with coronary artery disease and mild heart damage to see if blood tests and ECGs can better predict who is at risk for sudden cardiac death. The goal is to find inexpensive markers that could help doctors decide who needs a defibrillator. Par…

This study looks at whether a common diabetes medicine (SGLT2 inhibitor) can help prevent future heart problems in people with type 2 diabetes who have had a heart attack. Researchers will compare health records of 200,000 adults in Korea who took either an SGLT2 inhibitor or ano…

This study was designed to see if helping heart patients with social problems like food, housing, and mental health could keep them out of the hospital. The researchers planned to screen patients and connect them to community resources. However, the study was withdrawn before enr…