Could a smart pacemaker ease a common type of heart failure?
NCT ID NCT05839730
First seen Jan 27, 2026 · Last updated Jun 23, 2026 · Updated 19 times
Summary
This study tests a modified pacemaker designed to improve heart function and quality of life in people with heart failure with preserved ejection fraction (HFpEF). About 105 participants will receive either the active pacing therapy or a non-pacing mode. Researchers will measure changes in heart structure, exercise capacity, and symptoms over 12 months.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HEART FAILURE WITH PRESERVED EJECTION FRACTION are added.
Genom att skicka in godkänner du våra Användarvillkor
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
Genom att skicka in godkänner du våra Användarvillkor
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Duke University
RECRUITINGDurham, North Carolina, 27708, United States
Contact
-
Houston Methodist Research Institute
RECRUITINGHouston, Texas, 77030, United States
Contact
-
NCH Heart Institute
RECRUITINGNaples, Florida, 34102, United States
Contact
-
Oklahoma Heart Hospital
RECRUITINGOklahoma City, Oklahoma, 73120, United States
Contact
-
Prairie Education and Research Cooperative-St. Elizabeth's
RECRUITINGO'Fallon, Illinois, 62269, United States
Contact
-
Prairie Education and Research Cooperative-St. John's
RECRUITINGSpringfield, Illinois, 62769, United States
Contact
-
The University of Vermont Medical Center
RECRUITINGBurlington, Vermont, 05401, United States
Contact
-
University of Kansas Medical Center
RECRUITINGKansas City, Kansas, 66160, United States
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pacemaker with personalized lower rate and tachycardia remodeling therapy
What this could lead to
If it works, this could offer a new way to improve exercise ability and daily life for people with a common type of heart failure.
What could go wrong
This is an early feasibility study with only 105 people, so results may not apply to everyone. The therapy involves a device implant, which carries risks like infection or pacing discomfort.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.