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New blood test algorithm could speed up heart failure diagnosis in ER

NCT ID NCT05518396

Diagnosis Sponsor: University of Edinburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

Acute heart failure is a life-threatening condition where the heart suddenly can't pump blood, but its symptoms often mimic other illnesses, causing delays in diagnosis. Researchers developed a computer algorithm called CoDE-HF that combines a blood test (NT-proBNP) with patient information to estimate the probability of acute heart failure. This study will test the tool in about 2,000 emergency department patients with shortness of breath to see how accurately it identifies those with acute heart failure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
CoDE-HF decision support tool (diagnostic test)
What this could lead to
If successful, this tool could help doctors diagnose acute heart failure faster and more accurately in the emergency room, potentially improving patient outcomes.
What could go wrong
This is a validation study, not a treatment trial. The tool may not perform as well in real-world settings or may not reduce delays in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

3,808 people

The number who actually took part.

Started

Apr 2021

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All consecutive patients presenting to the Emergency Department with acute breathlessness will be included in this study

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients presenting to the Emergency Department with acute breathlessness

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Conditions

The condition(s) this trial relates to.

disease heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute heart failure Diagnosis

Contacts and locations

Locations

  • Centre for Cardiovascular Science, University of Edinburgh

    Edinburgh, EH16 4SB, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.