Heart failure clue: blood test may forecast therapy success
NCT ID NCT07469137
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether a substance called YKL-40 in the blood can help predict how well heart failure patients will respond to cardiac resynchronization therapy (CRT), a special pacemaker. About 51 adults with severe heart failure will have blood samples taken during their routine CRT procedure. Researchers will then check their heart function 6 months later to see if YKL-40 levels are linked to improvement. The goal is to find a simple way to identify who will benefit most from CRT.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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51 people
The number who actually took part.
- Started
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Mar 2025
- Expected to finish
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Aug 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with heart failure who have been decided to undergo CRT treatment at Trakya University Cardiology Clinic
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients diagnosed with heart failure, with an EF ≤35, who remain in heart failure stages 2-3-4 despite optimal medical therapy, and who have LBBB and a QRS duration of at least 130 msec. * Those who agreed to participate in the study * Patients diagnosed with heart failure and who have been monitored, and for whom a permanent pacemaker has been decided due to the presence of a high-degree heart block Exclusion Criteria: * Patients under the age of 18 * Patients not receiving optimal medical treatment * Those who declined to participate in the study * Malignancy patients with an expected survival period of less than 1 year * Patients with chronic inflammatory and rheumatological diseases
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Trakya University
Edirne, Edirne, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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