PROSTATE ADENOCARCINOMA

This study is testing a new, highly focused radiation treatment for men with early-stage prostate cancer that is confined to one spot in the prostate. The goal is to see if delivering a high dose of radiation directly to the tumor in just two sessions can effectively control the …

This study is testing whether giving a targeted radiation drug called Lu-177-PSMA-617 (Pluvicto) before surgery can shrink or eliminate high-risk prostate cancer. Men with a specific type of high-risk prostate cancer that shows up on a special PSMA scan will receive two doses of …

This study is for men whose prostate cancer has returned and spread to a few sites after initial radiation treatment. It aims to see if adding a 12-month course of hormone-blocking therapy to targeted radiation treatments works better than targeted radiation alone at keeping the …

This study is testing if a special 5-day monthly fasting diet can help improve the effectiveness of standard prostate cancer treatment. It will involve 138 men with metastatic prostate cancer who are starting hormone therapy. Participants will either follow the fasting diet for 6…

This study is testing if using a fluorescent green dye during robotic prostate cancer surgery helps surgeons better see and preserve the nerves needed for sexual function. The goal is to improve men's recovery of sexual function one year after surgery. The study will involve 400 …

This study is testing whether a shorter, two-session radiation treatment is as effective as the standard five-session treatment for men with low-risk prostate cancer. The main goal is to see if the shorter treatment can better preserve patients' sexual quality of life and cause f…

This study is comparing two hormone therapies for prostate cancer to see if one is better for heart health. Men with intermediate-risk prostate cancer will receive standard radiation and be randomly assigned to take either a daily pill (relugolix) or get an injection every 3 mont…

This study is testing if two advanced types of PET scans can help doctors see exactly where prostate cancer has spread after initial treatment. For men whose cancer has returned and spread to only a few spots, the scans will guide targeted treatment like radiation or surgery to t…

This study aims to find out which treatment is better for men with high-risk prostate cancer that hasn't spread: surgery to remove the prostate or radiation combined with hormone therapy. Researchers will follow about 840 men in the Netherlands to compare side effects, quality of…

This study is for men whose prostate cancer has spread to nearby lymph nodes after surgery. It tests if adding a drug called apalutamide to the usual hormone and radiation therapy can better control the cancer and prevent it from spreading further. The goal is to see if this stro…

This study is testing whether doctors can safely give less hormone-blocking therapy to men with high-risk prostate cancer. Researchers will group patients by risk level and give them radiation plus a shorter course of hormone therapy. The goal is to see if this personalized appro…

This study is testing whether a dietary supplement called Urolithin A can help reduce cellular stress in prostate cancer tumors. It involves 90 men with prostate cancer who are scheduled for surgery to remove their prostate. Participants will take either the supplement or a place…

This is the first study in people to test a new drug called BL-B01D1. It aims to find a safe dose and see if it can help control advanced cancers that have spread or cannot be removed by surgery. The trial will enroll about 470 adults with various solid tumors, including lung, br…

This study is testing if giving the chemotherapy drug carboplatin before surgery can help shrink tumors in men with high-risk prostate cancer who have specific inherited BRCA gene mutations. The goal is to see if this approach leads to better outcomes by reducing or eliminating c…

This large study is testing if using a PET scan to guide treatment decisions helps control prostate cancer that returns after surgery. For about 800 men, the scan will determine if they receive standard radiation and hormone therapy alone, or if stronger drug therapy and targeted…

This study tests a combination treatment for men with advanced prostate cancer that has spread to bones and stopped responding to standard hormone therapy. Participants receive monthly testosterone injections along with a targeted radiation drug that goes to bone areas. The goal …

This study is testing whether combining two hormone-blocking drugs with radiation therapy works better than standard treatments for men with very high-risk prostate cancer. The goal is to more aggressively control the cancer and prevent it from returning. Researchers will follow …

This study is for men whose prostate cancer has spread to a limited number of other body sites but still responds to hormone therapy. It compares standard radiation treatment alone to radiation combined with a daily pill (relugolix) that lowers testosterone. The goal is to see if…

This early-stage study is testing whether small implants called Enolen can safely deliver prostate cancer medication directly into the prostate gland. The study involves 56 men who are already scheduled for prostate removal surgery. Researchers will place the implants into the pr…

This large trial is testing if a gene test (Decipher) can help personalize treatment for men with intermediate-risk prostate cancer. Men with a low-risk gene score will be randomly assigned to receive either radiation alone or the standard combination of radiation plus hormone th…

This large trial is comparing two different radiation schedules for men with high-risk prostate cancer. It will test if a much shorter, more intense treatment (5 sessions over 2 weeks) is as effective at preventing the cancer from spreading as the standard, longer course (20-45 s…

This study is testing a new technique called 'Spot Delete' during proton beam therapy for prostate cancer. Researchers want to see if carefully controlling where the proton beams stop in the body can reduce common and painful side effects like diarrhea, rectal bleeding, and urina…

This study is testing new computer software designed to help doctors better analyze prostate MRI scans. The software creates detailed maps showing areas most likely to contain cancer, which could help guide biopsy procedures more accurately. Researchers will compare the software'…

This study is testing a new type of MRI scan that uses a special form of sugar (called hyperpolarized pyruvate) to create detailed pictures of prostate cancer cells. The goal is to see if this scan can help doctors better monitor 60 men with low-to-intermediate risk prostate canc…

This study is testing a new, personalized method for performing prostate biopsies that aims to use fewer needle sticks. Researchers want to see if this 'reduced-core' method can find prostate cancer just as well as the standard method, while causing less pain, bleeding, and risk …

This study is testing a new type of PET/CT scan that uses a radioactive tracer to look for prostate cancer that may have spread. It aims to see if this scan is more accurate than current methods at finding cancer in lymph nodes before a patient has surgery to remove the prostate.…

This study is testing whether a new type of PET scan can find aggressive prostate cancer better than the standard MRI scan in men who are being monitored instead of immediately treated. About 120 men with low-risk prostate cancer on active surveillance will get both the new PET s…

This study is testing if a short course of hormone-blocking pills can make prostate cancer cells 'light up' more brightly on a special imaging scan. The goal is to help doctors see smaller or hidden areas of cancer that have spread, particularly to lymph nodes, in men with high-r…

This study is testing whether personalized nutrition and exercise advice can help prostate cancer survivors who are receiving hormone therapy. The goal is to reduce frailty, improve strength, and enhance quality of life. Participants will receive a 6-month program including diet …

This study is testing whether a medication called fezolinetant can safely reduce the frequency and severity of hot flashes in men with prostate cancer who are undergoing hormone-blocking therapy. Researchers will compare the drug to a placebo in 60 participants over 4 weeks to se…

This study explores whether providing cancer care at home is a practical and preferred option for Black men with advanced prostate cancer. Researchers want to understand if home care can reduce healthcare disparities and improve quality of life. The study involves surveys, interv…

This study aims to understand how hormone therapy changes what doctors see on a special prostate cancer scan (PSMA PET). Researchers will track 80 men with prostate cancer, taking scans before treatment and again 8 and 28 days after starting hormone therapy. The goal is to learn …

This study aims to see if a simple blood test can predict which hormone therapies will work for men with advanced prostate cancer that has spread. Researchers will follow 120 men receiving standard treatment, checking their blood for cancer cells to look for genetic clues linked …