One-Shot radiation for recurrent prostate cancer: game changer or risky bet?

NCT ID NCT06941363

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a single, very high dose of radiation (17 Gy) to the prostate area in men whose prostate cancer has come back after surgery. The goal is to see if this precise, one-time treatment can control the cancer while reducing side effects. Fifty men will be enrolled, and researchers will track side effects and quality of life for up to 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

single high-dose radiation therapy (17 Gy) to the prostate bed

What this could lead to

If successful, this could offer a shorter, more precise radiation option for men whose prostate cancer returns after surgery, potentially with fewer side effects.

What could go wrong

This is a small, early-phase study with only 50 participants, so results may not apply to everyone. The high single dose may still cause bladder or bowel side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

prostate adenocarcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Radiation Oncology, Fondazione IRCCS San Gerardo dei Tintori (University of Milan Bicocca)

    RECRUITING

    Monza, Italy, 20900, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••