Could a chemo drug shrink prostate tumors in men with BRCA mutations?

NCT ID NCT05806515

Recruiting now Disease control Sponsor: SWOG Cancer Research Network Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is for men with high-risk prostate cancer who have inherited BRCA1 or BRCA2 gene mutations. It tests whether giving the chemotherapy drug carboplatin before surgery can shrink tumors more effectively. About 44 participants will receive carboplatin, and researchers will check if the cancer disappears completely after surgery.

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Conditions

The condition(s) this trial relates to.

prostate adenocarcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE ADENOCARCINOMA STAGE IIIB PROSTATE CANCER AJCC V8 STAGE IIIC PROSTATE CANCER AJCC V8

Contacts and locations

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Locations

Alaska Breast Care and Surgery LLC
RECRUITING

Anchorage, Alaska, 99508, United States
Alaska Oncology and Hematology LLC
RECRUITING

Anchorage, Alaska, 99508, United States
Alaska Women's Cancer Care
RECRUITING

Anchorage, Alaska, 99508, United States
Alegent Health Bergan Mercy Medical Center
RECRUITING

Omaha, Nebraska, 68124, United States

Contact Email: •••••@•••••
Alegent Health Immanuel Medical Center
RECRUITING

Omaha, Nebraska, 68122, United States

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Alegent Health Lakeside Hospital
RECRUITING

Omaha, Nebraska, 68130, United States

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Alegent Health Mercy Hospital
RECRUITING

Council Bluffs, Iowa, 51503, United States

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Anchorage Associates in Radiation Medicine
RECRUITING

Anchorage, Alaska, 98508, United States
Anchorage Oncology Centre
RECRUITING

Anchorage, Alaska, 99508, United States
Anchorage Radiation Therapy Center
RECRUITING

Anchorage, Alaska, 99504, United States
Bay Area Hospital
RECRUITING

Coos Bay, Oregon, 97420, United States
Benefis Healthcare- Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

Contact Email: •••••@•••••
Bethesda North Hospital
RECRUITING

Cincinnati, Ohio, 45242, United States

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Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

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Billings Clinic-Cody
RECRUITING

Cody, Wyoming, 82414, United States

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Bozeman Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

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CHI Health Good Samaritan
RECRUITING

Kearney, Nebraska, 68847, United States

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Cancer Center at Saint Joseph's
RECRUITING

Phoenix, Arizona, 85004, United States

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City of Hope Comprehensive Cancer Center
RECRUITING

Duarte, California, 91010, United States

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City of Hope at Irvine Lennar
RECRUITING

Irvine, California, 92618, United States
Clackamas Radiation Oncology Center
RECRUITING

Clackamas, Oregon, 97015, United States

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Commonwealth Cancer Center-Corbin
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Corbin, Kentucky, 40701, United States

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Community Hospital of Anaconda
RECRUITING

Anaconda, Montana, 59711, United States

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Community Medical Hospital
SUSPENDED

Missoula, Montana, 59804, United States
Creighton University Medical Center
RECRUITING

Omaha, Nebraska, 68131, United States

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FHCC South Lake Union
RECRUITING

Seattle, Washington, 98109, United States
Flaget Memorial Hospital
RECRUITING

Bardstown, Kentucky, 40004, United States

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Fred Hutchinson Cancer Research Center
RECRUITING

Seattle, Washington, 98109, United States
Garnet Health Medical Center
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Middletown, New York, 10940, United States
Good Samaritan Hospital - Cincinnati
RECRUITING

Cincinnati, Ohio, 45220, United States

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Great Falls Clinic
RECRUITING

Great Falls, Montana, 59405, United States

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Harrison Medical Center
RECRUITING

Bremerton, Washington, 98310, United States

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Idaho Urologic Institute-Meridian
RECRUITING

Meridian, Idaho, 83642, United States
Kadlec Clinic Hematology and Oncology
RECRUITING

Kennewick, Washington, 99336, United States

Contact Email: •••••@•••••
Kalispell Regional Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

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Katmai Oncology Group
RECRUITING

Anchorage, Alaska, 99508, United States
Kootenai Cancer Clinic
RECRUITING

Sandpoint, Idaho, 83864, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

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Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

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LSU Healthcare Network / Metairie Multi-Specialty Clinic
RECRUITING

Metairie, Louisiana, 70006, United States
Littleton Adventist Hospital
RECRUITING

Littleton, Colorado, 80122, United States

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Longmont United Hospital
RECRUITING

Longmont, Colorado, 80501, United States

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Louisiana State University Health Science Center
RECRUITING

New Orleans, Louisiana, 70112, United States
Mercy Cancer Center - Elk Grove
RECRUITING

Elk Grove, California, 95758, United States

Contact Email: •••••@•••••
Mercy Cancer Center - Rocklin
RECRUITING

Rocklin, California, 95765, United States

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Mercy Cancer Center - Sacramento
RECRUITING

Sacramento, California, 95816, United States

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Mercy Cancer Center �� Carmichael
RECRUITING

Carmichael, California, 95608, United States
Mercy Medical Center
RECRUITING

Durango, Colorado, 81301, United States

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Mercy San Juan Medical Center
RECRUITING

Carmichael, California, 95608, United States

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Midlands Community Hospital
RECRUITING

Papillion, Nebraska, 68046, United States

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Mission Hope Medical Oncology - Arroyo Grande
RECRUITING

Arroyo Grande, California, 93420, United States

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Mission Hope Medical Oncology - Santa Maria
RECRUITING

Santa Maria, California, 93444, United States

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North Shore Medical Center
RECRUITING

Skokie, Illinois, 60076, United States
NorthShore University HealthSystem-Evanston Hospital
RECRUITING

Evanston, Illinois, 60201, United States
NorthShore University HealthSystem-Glenbrook Hospital
RECRUITING

Glenview, Illinois, 60026, United States
NorthShore University HealthSystem-Highland Park Hospital
RECRUITING

Highland Park, Illinois, 60035, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States

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Pacific Central Coast Health Center-San Luis Obispo
RECRUITING

San Luis Obispo, California, 93401, United States

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Parker Adventist Hospital
RECRUITING

Parker, Colorado, 80138, United States

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PeaceHealth Saint John Medical Center
RECRUITING

Longview, Washington, 98632, United States
PeaceHealth Saint Joseph Medical Center
RECRUITING

Bellingham, Washington, 98225, United States
PeaceHealth Southwest Medical Center
RECRUITING

Vancouver, Washington, 98664, United States
PeaceHealth United General Medical Center
RECRUITING

Sedro-Woolley, Washington, 98284, United States
Penrose-Saint Francis Healthcare
RECRUITING

Colorado Springs, Colorado, 80907, United States

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Porter Adventist Hospital
RECRUITING

Denver, Colorado, 80210, United States

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Providence Alaska Medical Center
RECRUITING

Anchorage, Alaska, 99508, United States
Providence Cancer Institute Clackamas Clinic
RECRUITING

Clackamas, Oregon, 97015, United States

Contact Email: •••••@•••••
Providence Medical Foundation - Santa Rosa
RECRUITING

Santa Rosa, California, 95403, United States
Providence Newberg Medical Center
RECRUITING

Newberg, Oregon, 97132, United States

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Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

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Providence Queen of The Valley
RECRUITING

Napa, California, 94558, United States
Providence Regional Cancer Partnership
RECRUITING

Everett, Washington, 98201, United States
Providence Regional Cancer System-Aberdeen
RECRUITING

Aberdeen, Washington, 98520, United States
Providence Regional Cancer System-Centralia
RECRUITING

Centralia, Washington, 98531, United States
Providence Regional Cancer System-Lacey
RECRUITING

Lacey, Washington, 98503, United States
Providence Regional Cancer System-Shelton
RECRUITING

Shelton, Washington, 98584, United States
Providence Regional Cancer System-Yelm
RECRUITING

Yelm, Washington, 98597, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center
RECRUITING

Burbank, California, 91505, United States
Providence Saint Mary Regional Cancer Center
RECRUITING

Walla Walla, Washington, 99362, United States
Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

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Providence Santa Rosa Memorial Hospital
RECRUITING

Santa Rosa, California, 95405, United States
Providence Willamette Falls Medical Center
RECRUITING

Oregon City, Oregon, 97045, United States

Contact Email: •••••@•••••
Rocky Mountain Cancer Centers-Penrose
RECRUITING

Colorado Springs, Colorado, 80907, United States

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Saint Alphonsus Cancer Care Center-Boise
RECRUITING

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell
RECRUITING

Caldwell, Idaho, 83605, United States
Saint Alphonsus Cancer Care Center-Nampa
RECRUITING

Nampa, Idaho, 83687, United States

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Saint Alphonsus Medical Center-Baker City
RECRUITING

Baker City, Oregon, 97814, United States

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Saint Alphonsus Medical Center-Ontario
RECRUITING

Ontario, Oregon, 97914, United States

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Saint Anthony Hospital
RECRUITING

Lakewood, Colorado, 80228, United States

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Saint Charles Health System
RECRUITING

Bend, Oregon, 97701, United States
Saint Charles Health System-Redmond
RECRUITING

Redmond, Oregon, 97756, United States
Saint Elizabeth Regional Medical Center
RECRUITING

Lincoln, Nebraska, 68510, United States

Contact Email: •••••@•••••
Saint Francis Cancer Center
RECRUITING

Colorado Springs, Colorado, 80923, United States

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Saint Joseph Hospital
RECRUITING

Lexington, Kentucky, 40504, United States
Saint Joseph Hospital East
RECRUITING

Lexington, Kentucky, 40509, United States

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Saint Joseph London
RECRUITING

London, Kentucky, 40741, United States

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Saint Joseph Mount Sterling
RECRUITING

Mount Sterling, Kentucky, 40353, United States
Saint Joseph Radiation Oncology Resource Center
RECRUITING

Lexington, Kentucky, 40504, United States

Contact Email: •••••@•••••
Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland
RECRUITING

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian
RECRUITING

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa
RECRUITING

Nampa, Idaho, 83686, United States
Saint Luke's Cancer Institute - Twin Falls
RECRUITING

Twin Falls, Idaho, 83301, United States
Saint Mary Corwin Medical Center
RECRUITING

Pueblo, Colorado, 81004, United States

Contact Email: •••••@•••••
Saint Patrick Hospital - Community Hospital
RECRUITING

Missoula, Montana, 59802, United States
Smilow Cancer Center/Yale-New Haven Hospital
RECRUITING

New Haven, Connecticut, 06510, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital Care Center - Guilford
RECRUITING

Guilford, Connecticut, 06437, United States

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Smilow Cancer Hospital Care Center - Waterford
RECRUITING

Waterford, Connecticut, 06385, United States

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Smilow Cancer Hospital Care Center - Westerly
RECRUITING

Westerly, Rhode Island, 02891, United States

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Smilow Cancer Hospital Care Center at Glastonbury
RECRUITING

Glastonbury, Connecticut, 06033, United States

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Smilow Cancer Hospital Care Center at Greenwich
RECRUITING

Greenwich, Connecticut, 06830, United States

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Smilow Cancer Hospital Care Center at Long Ridge
RECRUITING

Stamford, Connecticut, 06902, United States

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Smilow Cancer Hospital Care Center at Saint Francis
RECRUITING

Hartford, Connecticut, 06105, United States

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Smilow Cancer Hospital Care Center-Fairfield
RECRUITING

Fairfield, Connecticut, 06824, United States

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Smilow Cancer Hospital Care Center-Trumbull
RECRUITING

Trumbull, Connecticut, 06611, United States

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Smilow Cancer Hospital-Derby Care Center
RECRUITING

Derby, Connecticut, 06418, United States

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Smilow Cancer Hospital-Torrington Care Center
RECRUITING

Torrington, Connecticut, 06790, United States

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Smilow Cancer Hospital-Waterbury Care Center
RECRUITING

Waterbury, Connecticut, 06708, United States

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Southwest Oncology PC
RECRUITING

Durango, Colorado, 81301, United States

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Swedish Cancer Institute-Edmonds
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Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah
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Issaquah, Washington, 98029, United States
Swedish Medical Center-Ballard Campus
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Seattle, Washington, 98107, United States
Swedish Medical Center-Cherry Hill
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Seattle, Washington, 98122-5711, United States
Swedish Medical Center-First Hill
RECRUITING

Seattle, Washington, 98122, United States
TriHealth Cancer Institute-Anderson
RECRUITING

Cincinnati, Ohio, 45255, United States

Contact Email: •••••@•••••
TriHealth Cancer Institute-Westside
RECRUITING

Cincinnati, Ohio, 45247, United States

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University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Washington Medical Center - Montlake
RECRUITING

Seattle, Washington, 98195, United States
Walter Knox Memorial Hospital
RECRUITING

Emmett, Idaho, 83617, United States
Welch Cancer Center
RECRUITING

Sheridan, Wyoming, 82801, United States

Contact Email: •••••@•••••
Woodland Memorial Hospital
RECRUITING

Woodland, California, 95695, United States

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Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

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Yale-New Haven Hospital North Haven Medical Center
RECRUITING

North Haven, Connecticut, 06473, United States

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