PROSTATE ADENOCARCINOMA

This large study aims to personalize treatment for men with high-risk prostate cancer. Based on a genetic test score, patients receive either a shorter course of hormone therapy (to reduce side effects) or a stronger hormone therapy regimen (to better control aggressive cancer), …

This early-stage study is testing the safety of a new two-part radiation treatment for men whose prostate cancer has returned after surgery. First, patients receive a targeted external beam radiation guided by a special PET scan. Then, they receive a radioactive drug designed to …

This study is for men with advanced prostate cancer that has spread and is no longer responding well to standard hormone therapy. It compares a new two-drug combination (cabozantinib and atezolizumab) against a second round of standard hormone therapy. The main goals are to see i…

This study is testing whether a combination of surgery and radiation can control prostate cancer that has returned or spread to a few other places in the body. It involves 20 men whose cancer has come back after initial treatment. The goal is to see if this targeted approach can …

This study is testing whether regular treadmill walking at home affects markers that indicate how aggressive prostate cancer might become. It involves 36 men with low-risk prostate cancer who are being monitored rather than immediately treated. Participants are assigned to either…

This study is testing whether adding two drugs (abiraterone acetate and prednisone) to standard hormone therapy works better than hormone therapy alone for men whose prostate cancer has returned after surgery or radiation. The goal is to keep PSA levels low for longer after the 8…

This study is testing if a shorter, more intense course of radiation is safe and effective for men whose prostate cancer has returned or spread to a few lymph nodes. It compares two radiation methods—proton therapy and standard IMRT—to see which one causes fewer serious side effe…

This study is testing whether adding an anti-inflammatory drug (golimumab) to a standard prostate cancer hormone blocker (apalutamide) can better control a very advanced form of the disease. It's for men whose cancer has spread and stopped responding to standard hormone treatment…

This study is testing a new type of implant that slowly releases a cancer-fighting drug directly into the prostate. The goal is to see if this local treatment can replace the standard body-wide hormone therapy, which often causes difficult side effects. The study will check if th…

This study is testing whether a supplement made from white button mushrooms can help control prostate cancer. It is for men whose cancer has returned after initial treatment (shown by rising PSA levels) and for men with low-risk cancer who are being monitored without treatment. R…

This study is testing whether a combination of three drugs can help control prostate cancer that has spread to other parts of the body. Researchers want to see if they can predict which patients will respond best to this treatment by analyzing tumor characteristics. The trial inv…

This study is testing whether adding an immunotherapy drug (nivolumab) to standard hormone therapy and chemotherapy can better control prostate cancer that has already spread. It is for men newly diagnosed with a high amount of spreading cancer. The goal is to see if this three-d…

This study is testing if a very low dose of the drug apalutamide can help control prostate cancer before surgery. It involves men whose cancer is still confined to the prostate gland. The main goal is to see if this short, low-dose treatment can effectively lower PSA levels, a ke…

This study is testing if taking a hormone therapy drug called apalutamide for 6 months before prostate removal surgery can improve outcomes for men with intermediate-risk prostate cancer. The main goal is to see if this pre-surgery treatment reduces certain high-risk features in …

This study is comparing two different imaging methods used to guide radiation treatment for prostate cancer. It aims to see if using MRI scans to guide the radiation causes fewer side effects, like urinary or bowel problems, compared to the standard CT scan method. About 180 men …

This study is testing whether a daily green tea extract pill can help control early-stage prostate cancer in men who are being monitored instead of immediately treated. 115 men will take either the green tea extract or a placebo pill for two years to see if it slows the cancer's …

This study is testing whether adding a newer drug called enzalutamide to the standard two-drug treatment (androgen deprivation therapy plus docetaxel chemotherapy) works better for men with prostate cancer that has spread. The goal is to see if this three-drug combination is safe…

This study is testing a new type of 3D MRI scan for men with prostate cancer. The goal is to see if this new scan can create clear pictures of the prostate without requiring an uncomfortable rectal coil during the procedure. Researchers will compare the image quality of the new 3…

This study is testing whether a new type of imaging scan, called a PSMA PET scan, is more accurate than standard scans at showing how prostate cancer responds to treatment. Researchers will follow 58 men with progressive prostate cancer. The goal is to see if changes on these spe…

This study is testing a new type of MRI scan to see if it can better find and pinpoint prostate cancer tumors. It uses a special imaging agent called hyperpolarized pyruvate, which may help the scanner see chemical changes in cancer cells. The goal is to develop a more accurate e…

This study is testing a new type of PET scan called 68Ga-PSMA-11 to see if it can better find and track prostate cancer. It enrolled 141 men with different stages of prostate cancer to see if this scan changes how doctors plan their treatment. The goal is to improve how doctors m…

This study is testing new software that combines MRI scans with live ultrasound images during prostate biopsies. The goal is to help doctors more accurately find and diagnose aggressive prostate cancer early. Researchers will enroll 100 men who are already scheduled for a standar…

This study is testing if adding a common water pill (furosemide) to a specialized PET/CT scan can make the images clearer for men whose prostate cancer has returned. The pill may help flush radioactive tracer from the bladder, potentially revealing hidden cancer spots nearby. Res…

This study is testing whether it's practical for men with intermediate-risk prostate cancer to follow a strict Mediterranean diet for four weeks before their scheduled surgery. The main goal is to see if patients can stick to the diet and to measure how it affects their body chem…

This study aims to understand how genetic changes in prostate cancer tumors relate to treatment response. Researchers collect tissue, blood, and urine samples from 92 men with advanced prostate cancer before and during standard treatment. By analyzing these samples, they hope to …

This study is testing whether a genetic test can predict which prostate cancer patients are at high or low risk for serious urinary and bowel side effects from a specific type of radiation therapy. About 208 men with early-stage prostate cancer will take the test, and then discus…

This small, early study aims to understand if standard hormone therapy drugs change how prostate cancer appears on a specialized PSMA PET scan. About 15 men with recurrent prostate cancer will receive a standard hormone pill and have two scans over four weeks. The goal is to gath…