PROSTATE ADENOCARCINOMA

This phase II trial tests whether adding a targeted radiation drug (177Lu-PSMA-617) to standard hormone therapy, with or without additional hormone-blocking pills, can better control low-volume metastatic hormone-sensitive prostate cancer. The study enrolls men whose cancer has s…

This study tests a new way to give radiation for prostate cancer using only 2 treatments instead of the usual 39. Doctors will use MRI scans to see how the tumor responds after the first dose, then adjust the second dose to target the cancer more precisely. The goal is to see if …

This study tests a personalized radiation approach for men whose prostate cancer has returned after surgery. Using PSMA PET scans, doctors will give higher radiation doses to active cancer spots and lower doses to healthy areas, all in just 5 treatments over two weeks. The goal i…

This study tests whether the drug rezvilutamide, combined with standard hormone therapy, can prevent high-risk prostate cancer from coming back after surgical removal. About 33 participants will take the pills and get injections for up to 2 years. The main goal is to see how many…

This study looks at men with high-risk prostate cancer who will receive radiation therapy along with hormone therapy for either 6 months or 18 months. The goal is to see if the shorter treatment works as well at preventing cancer from coming back or getting worse over 5 years. Pa…

This phase 2 trial tests whether adding darolutamide (a pill that blocks male hormones) to standard hormone therapy after prostate removal can keep cancer from coming back in high-risk patients. About 40 men will take the combination for 12 months and be followed for 2 years. The…

This trial tests a new imaging system that combines PSMA-PET, MRI, and ultrasound to guide robot-assisted prostate surgery. The goal is to help surgeons remove all cancer while sparing healthy tissue, nerves, and urinary control. About 98 men with prostate cancer will take part t…

This study looks at giving the drug rezvilutamide to men with high-risk or locally advanced prostate cancer before their surgery. The goal is to see if it can completely clear cancer cells from the removed tissue and reduce the chance of the cancer coming back. About 115 particip…

This study compares a precise, focused radiation treatment (stereotactic body radiotherapy) to simply watching the cancer (active surveillance) in men with low-to-intermediate risk prostate cancer. The goal is to see if the radiation can reduce the number of men who later need st…

This study tests a new PET/CT imaging agent called 68Ga-NYM032 in 232 men with suspected prostate cancer recurrence after initial treatment. Participants have rising PSA levels, and the scan aims to accurately locate any remaining cancer. The goal is to see how well the scan dete…

This phase 2 trial tests whether a new radioactive imaging agent, 61Cu-NU101, can detect prostate cancer spread as well as or better than the current standard, Pylarify. 34 men with confirmed prostate cancer and visible disease on a prior Pylarify scan will receive one dose of 61…

This phase 3 trial is testing a new radioactive imaging agent called 68Ga-NYM032, given as an injection before a PET/CT scan, in 365 men newly diagnosed with prostate cancer. The goal is to see if this scan can accurately detect whether the cancer has spread to pelvic lymph nodes…

This phase 2 trial will test whether a special PET scan using Flotufolastat F18 can accurately detect any remaining prostate cancer after focal therapy (like cryotherapy or HIFU). About 60 men with prostate cancer who haven't had prior treatment will get the scan before and after…

This study compares two types of radiation therapy for prostate cancer: one that boosts the whole prostate gland and one that boosts only the main tumor. About 186 men will be randomly assigned to one of the two treatments. The goal is to see which approach causes fewer urinary a…

This study tests whether a procedure called prostate artery embolization (PAE) can reduce urinary side effects from radiotherapy in men with prostate cancer. Participants have large prostates or existing urinary symptoms. They will receive PAE before starting radiation, and resea…

This study compares the side effects of two radiation treatments for men with low-to-intermediate risk prostate cancer: low dose rate brachytherapy (radioactive seeds placed in the prostate) and ultra-hypofractionated radiotherapy (5 sessions of external radiation over 2 weeks). …

This study tests whether injecting a radioactive tracer directly into the prostate artery improves imaging compared to standard arm injection in 10 men with high-risk prostate cancer. The goal is to see if this method gives clearer pictures and helps predict the right radiation d…