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Prostate cancer showdown: which hormone therapy plus radiation delays progression best?

NCT ID NCT02799706

Ongoing Disease control Sponsor: European Organisation for Research and Treatment of Cancer - EORTC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial compares two hormone therapies (GnRH antagonist vs GnRH agonist) given alongside radiation for men with very high-risk localized or locally advanced prostate cancer. The main goal is to see which combination better delays cancer progression. The study enrolled 885 participants and is no longer recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Degarelix (GnRH antagonist) or approved GnRH agonist plus anti-androgen flare protection, combined with radiotherapy
What this could lead to
If successful, this could show that one hormone therapy works better than the other at delaying cancer progression when combined with radiation.
What could go wrong
This is a large Phase 3 trial, but results may not apply to all prostate cancer patients. Both treatments have side effects, and the study is not designed to prove a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

prostate adenocarcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

Locations

  • AUSL Romagna - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

    Meldola, 47014, Italy

  • AZ Groeninge Kortrijk - Campus Kennedylaan

    Kortrijk, 8500, Belgium

  • Assistance Publique - Hopitaux de Paris - La Pitie Salpetriere

    Paris, 75651, France

  • Azienda Ospedaliero-Universitaria Careggi

    Florence, 50134, Italy

  • CHU Ucl Namur - Site Sainte-Elisabeth

    Namur, 5000, Belgium

  • CHU de Grenoble - La Tronche - Hôpital A. Michallon

    Grenoble, 38043, France

  • Centre D'Onco. & Radioth. De Haute Energie Du Pays Basque

    Bayonne, 64100, France

  • Centre Hospitalier Privé Saint-Grégoire

    Saint-Grégoire, 35760, France

  • Centre Leon Berard

    Lyon, 69008, France

  • Centre de radiotherapie Marie Curie

    Arras, 6200, France

  • Charite - Universitaetsmedizin Berlin - Campus Benjamin Franklin

    Berlin, 12200, Germany

  • Clinica IMQ Zorrotzaurre

    Bilbao, 48014, Spain

  • Clinique Pasteur-Toulouse-Atrium

    Toulouse, BP27617, France

  • Clinique de l'Europe

    Amiens, 80090, France

  • Cliniques Universitaires Saint-Luc

    Brussels, 1200, Belgium

  • Complejo Hospitalario A

    Pamplona, Spain

  • Complejo Hospitalario Universitario de Vigo -CHUVI - Hospital Alvaro Cunqueiro

    Vigo, 36312, Spain

  • Corporacio Sanitaria Parc Tauli

    Sabadell, 08208, Spain

  • Fundacion Hospital Alcorcon

    Alcorcón, 28922, Spain

  • Gasthuiszusters van Antwerpen - GasthuisZusters Antwerpen - Sint-Augustinus

    Wilrijk, 2610, Belgium

  • Groupe Radiopole Artois - Centre de Radiotherapie Pierre Curie

    Beuvry, 62660, France

  • Hopital De Jolimont

    Haine-Saint-Paul, 7100, Belgium

  • Hopitaux Universitaires Bordet-Erasme - Hopital Universitaire Erasme

    Brussels, 1070, Belgium

  • Hopitaux Universitaires Bordet-Erasme - Hopitaux Universitaires Bordet- Institut Jules Bordet

    Brussels, 1000, Belgium

  • Hospital Consorci Sanitari De Terrassa

    Terrassa, 08227, Spain

  • Hospital General Universitario Santa Lucia

    Cartagena, 30202, Spain

  • Hospital Universitario Reina Sofia

    Córdoba, 14004, Spain

  • Hospital Universitario de Gran Canaria Doctor Negrin

    Las Palmas de Gran Canaria, 35010, Spain

  • Hospital Universitario de Salamanca

    Salamanca, 37007, Spain

  • Hôpitaux universitaires de Genève - HUG - site de Cluse-Roseraie

    Geneva, Switzerland

  • Inselspital

    Bern, 3010, Switzerland

  • Institut Catala d'Oncologia - ICO Badalona - Hospital Germans Trias i Pujol (Institut Catala D'Oncologia)

    Barcelona, 08916, Spain

  • Institut de Cancerologie de l'Ouest (ICO) - Centre Rene Gauducheau

    Nantes, 44805, France

  • Nottingham University Hospitals NHS Trust - City Hospital

    Nottingham, NG5 1PB, United Kingdom

  • Oncology Institute of Southern Switzerland (IOSI) - Oncology Institute of Southern Switzerland - Ospedale Regionale Bellinzona e Valli

    Bellinzona, 6500, Switzerland

  • Otto-Von-Guericke-Universitaet Magdeburg - Universitaetsklinik

    Magdeburg, 39120, Germany

  • Universitaetsklinikum Freiburg

    Freiburg im Breisgau, 79106, Germany

  • Universitair Ziekenhuis Brussel

    Brussels, 1090, Belgium

  • University Hospitals Copenhagen - Rigshospitalet

    Copenhagen, 2100, Denmark

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