Urinary tract infection

This study tested two DNA vaccines designed to prevent hemorrhagic fever with renal syndrome caused by Hantaan and Puumala viruses. A total of 132 healthy adults received up to four doses of vaccine using a needle-free jet injector. The main goal was to see if the vaccines trigge…

This study looks at whether an extra cleaning step before a routine bladder check during laparoscopic hysterectomy can lower the chance of urinary tract infections after surgery. About 98 women having the surgery for non-cancer reasons will be observed. The goal is to see if this…

This study tested whether transplanting healthy gut bacteria (washed microbiota transplantation) could help people who get frequent urinary tract infections (UTIs). Thirty adults with recurrent UTIs received the treatment through a tube into the gut. Researchers tracked how many …

This study tested whether switching from one immunosuppressant to everolimus, along with lowering overall immunosuppression, helps clear BK virus better than just lowering immunosuppression alone. The trial involved 130 kidney transplant recipients with BK virus in their blood. T…

This study tested a new antibiotic combination, cefepime-zidebactam, against a standard antibiotic (meropenem) in adults hospitalized with complicated urinary tract infections or kidney infections. About 530 participants received either the new drug or the standard one for 7 to 1…

This study tested a new clinic that sees emergency room patients the next day for conditions like pneumonia, heart failure, and kidney injury. The goal was to avoid hospital stays and improve patient care. About 570 adults took part, and researchers measured how many days they we…

This study looked at 38 kidney transplant patients who had CMV infection. Researchers wanted to see if measuring a type of immune cell (γδ T cells) could help decide who needs extra medication to prevent the virus from coming back. The goal is to avoid unnecessary drugs while sti…

This study tested whether a visual storytelling sticker on antibiotic packaging helps adults with urinary tract infections (UTIs) take all their medicine. 358 adults in Pakistan were randomly assigned to get either the sticker or usual care. The goal was to see if the sticker imp…

This study tested a new type of urinary catheter coated with copper nanoparticles to see if it could lower the risk of urinary tract infections in hospitalized adults. 256 patients who needed a catheter for a long time took part. The goal was to compare this new catheter to stand…

This study tested two new antibiotic combinations (cefepime/nacubactam and aztreonam/nacubactam) against the best available treatments for adults with serious infections like urinary tract infections, pneumonia, and abdominal infections caused by carbapenem-resistant bacteria. Th…

This study tested whether tamsulosin (Flomax) can reduce the risk of urinary retention and catheter-related infections in men aged 50 and older after elective surgery. Participants received either tamsulosin or a placebo after their catheter was removed. The goal was to see if th…

This early-phase trial tested whether putting heparin directly into the bladder can reduce the number of urinary tract infections (UTIs) in women who get them often. 34 women with recurrent UTIs received either heparin or a placebo (saline) bladder wash. The study measured how ma…

This study tested a closed-system bladder irrigation device designed to reduce urinary tract infections after endoscopic urologic surgery. 240 patients undergoing prostate or bladder tumor surgery were randomly assigned to use the new device or standard irrigation. The device all…

This study looked at whether deep cleaning of the gums (non-surgical periodontal therapy) could reduce prostate-specific antigen (PSA) levels and urinary tract infections in men with both gum disease and chronic prostatitis or recurrent UTIs. Sixty men were split into three group…

This early-stage trial tested an experimental antibiotic called GSK3882347 in 140 women with uncomplicated urinary tract infections (UTIs). Participants received either the new drug, a standard antibiotic (nitrofurantoin), or a placebo for 5 days. The study measured how well the …

This study tested an oral antibiotic (tebipenem pivoxil hydrobromide) against a standard IV antibiotic in 1,690 hospitalized adults with complicated urinary tract infections or kidney infections. The goal was to see if the oral pill works as well as the IV treatment in curing the…

This study tested the safety and how the body processes the antibiotic cefiderocol in hospitalized children aged 3 months to 18 years with serious bacterial infections. The goal was to see if the drug is safe and how it works in the body. 53 children participated, and the study i…

This study looked at whether giving pomegranate seed oil supplements for 24 weeks could help prevent urinary tract infections and pneumonia in people with advanced dementia who are in palliative care. It also checked if the supplement helped reduce or stop antipsychotic medicatio…

This study tested whether an over-the-counter vaginal moisturizing gel, called BioNourish, could reduce recurrent urinary tract infections (UTIs) in menopausal women. The idea is that the gel helps restore a healthy vaginal microbiome, which may protect against UTIs. Eight post-m…

This phase 3 trial tested two new antibiotic combinations—cefepime/nacubactam and aztreonam/nacubactam—against a standard antibiotic (imipenem/cilastatin) in 614 adults with complicated urinary tract infections or acute kidney infections. The goal was to see if the new combos are…

This study tested a vaccine called Bilhvax, given alongside a standard treatment (praziquantel), to see if it could delay the return of schistosomiasis (a parasitic infection) in children aged 6 to 9 in Senegal. The vaccine was given as three shots plus a booster one year later. …

This study tested if the antibiotic temocillin works as well as a stronger antibiotic (carbapenem) for treating urinary tract infections caused by resistant bacteria. 29 hospitalized adults took part. The goal was to see if both treatments could clear the infection and symptoms. …

This study looked at 140 children aged 4 to 14 who had kidney stones and underwent a procedure called flexible ureteroscopy. Researchers compared giving antibiotics before surgery versus using extra preventive steps to see which better reduces urinary tract infections after the p…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested an antibody drug called AntiBKV in 95 kidney transplant patients with BK virus infection. The virus can damage the new kidney if not controlled. Patients received four doses of the drug or a placebo over four months. The goal was to see if the drug could clear t…

This completed Phase 2 trial tested fecal microbiota transfer (FMT) – a freeze-dried product made from healthy donor stool – in 40 women with recurrent urinary tract infections (UTIs). The goal was to see if FMT could prevent future UTIs by restoring healthy gut bacteria. Researc…

This study tested whether using a special cleaning product called organosilane, in addition to standard cleaning, could lower the number of infections patients get in intensive care units (ICUs). Over 10,000 adult patients in ICUs took part. Researchers compared infection rates w…

This study tested whether taking a probiotic called Lactobacillus reuteri could reduce the number of repeat urinary tract infections (UTIs) in adult women who had recently finished antibiotic treatment for a UTI. 140 women with a history of recurrent UTIs took either the probioti…

This pilot study tested whether women with kidney infections could safely stop antibiotics once their symptoms resolved, instead of taking a full 10-day course. 35 women were randomly assigned to either standard treatment or a patient-directed approach. The main goal was to see i…

This study tested four different short antibiotic courses in 1,000 women with uncomplicated lower urinary tract infections. Participants received either a two-day course of fosfomycin, a three-day course of pivmecillinam, a five-day course of nitrofurantoin, or a single dose of f…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested whether a rapid point-of-care test (Xpert® Xpress MVP) helps doctors diagnose vaginal infections more accurately than usual methods. 351 women with symptoms like discharge or itching were randomly assigned to either usual care or the rapid test. Researchers then…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested whether a rapid 30-minute desktop test for gonorrhea and chlamydia could help doctors make better treatment decisions compared to the current standard (a gram stain). 98 adults with symptoms of urethritis or cervicitis took part. The goal was to see if the rapid…

This completed study in Pemba, Tanzania, compared several diagnostic tests for Schistosoma haematobium, a parasitic worm that causes a debilitating disease. Researchers tested 801 schoolchildren using methods like urine filtration, AI microscopy, and molecular tests. The goal was…

This completed study tested whether a DNA-based PCR test works better than the usual lab culture for diagnosing complicated urinary tract infections (cUTIs) in adults. Over 770 participants across six U.S. sites were randomly assigned to have their treatment guided by either PCR …

This early-phase trial tests whether taking a daily probiotic (Saccharomyces boulardii) and using a targeted antibiotic (ciprofloxacin) only when a UTI occurs can reduce the number of repeat infections in children aged 2 to 17. Participants have had at least three UTIs in the pas…

This study tested whether D-mannose, a natural sugar, can prevent urinary tract infections (UTIs) in people who need a catheter for a long time. Nineteen participants with recurrent UTIs were followed to see if D-mannose reduced the number of infections needing treatment. The goa…

This study tested whether giving intravenous immunoglobulins (IVIG) could prevent BK virus infection in kidney transplant recipients. The virus often causes graft problems. Researchers enrolled 359 patients with low antibody levels against their donor's virus strain and gave some…

This study tested whether putting the antibiotic gentamicin directly into the bladder can prevent recurrent urinary tract infections (UTIs) in postmenopausal women. Twenty women were split into two groups: one received gentamicin via a catheter into the bladder, and the other too…

This study tested whether taking a specific probiotic (Lactobacillus crispatus M247) along with another probiotic blend could help prevent repeat urinary tract infections (UTIs) in women. 84 women with a history of frequent UTIs took either the probiotic combo or a standard probi…

This study tested whether a supplement made from bovine colostrum (the first milk from cows) can prevent repeated urinary tract infections (UTIs) in children. Sixty children with a history of recurrent UTIs took part. The goal was to see if this natural prebiotic could reduce the…

This study tested whether taking a different antibiotic once a week, rotating between two drugs, could prevent urinary tract infections in people with neurogenic bladder. The 45 participants had at least four infections per year and used a catheter. The goal was to see if this ap…

This completed study tested whether taking nettle and cranberry capsules twice daily for 8 weeks could prevent recurrent urinary tract infections (UTIs) in adults aged 30 to 75. Sixty participants with a history of frequent UTIs were given either the supplement or a placebo. Rese…

This study tested whether a shared decision-making tool could help women with uncomplicated cystitis (bladder infection) and their doctors decide together about antibiotic use. 169 women aged 18-65 participated. The goal was to see if the tool reduced antibiotic use without harmi…

This completed Phase 3 trial tested the antibiotic gepotidacin in 97 adolescent and adult women with uncomplicated urinary tract infections (UTIs). The goal was to see if symptoms like pain and urgency improved within 24 hours. Researchers measured symptom scores and safety. The …

This study looked at whether women who had surgery for prolapse or incontinence could safely remove their urinary catheter at home one day after surgery, instead of waiting 3-4 days. 128 women who failed a voiding trial before leaving the hospital took part. The main goal was to …

This study tested a fractional carbon dioxide laser treatment for women with vaginal and urinary symptoms like dryness, burning, pain during sex, and incontinence. One hundred women received three laser sessions about six weeks apart. The main goal was to see if symptoms improved…

This study tested whether hygiene education using the 'teach-back' method (where women explain what they learned) improves genital hygiene behaviors and reduces symptoms in pregnant women diagnosed with urinary tract infections. 36 pregnant women participated, with half receiving…

This completed study looked at 378 kidney transplant patients to see if measuring antibodies against BK virus before transplant could predict whether the virus would reactivate after surgery. Researchers used a lab-made virus-like particle to test for five different BK virus type…

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This completed study looked at antibiotic resistance in bacteria causing urinary tract infections (UTIs) in Uganda. Researchers compared resistance patterns in patients who sought care at community drug shops versus hospitals. By studying 890 participants, they aim to understand …

This study looked at whether giving antibiotics before a kidney drainage procedure (called percutaneous nephrostomy) prevents urinary tract infections in cancer patients whose urinary tract is blocked by a tumor. Researchers reviewed records of 320 cancer patients who had the pro…

This study tested a program where rural hospitals connect with an infectious disease expert through video calls to improve antibiotic use. The goal was to reduce unnecessary antibiotics and fight drug-resistant infections. Eight VA medical centers participated, and the approach h…

This study looked at 172 kidney transplant recipients who were on stable anti-rejection medication for at least 3 months. Researchers measured levels of a common, harmless virus (Torque Teno Virus) in their blood to see if it could predict serious infections or organ rejection. T…

This study looked at whether information from national health insurance cards—like past antibiotic use and hospital stays—can predict if a person's urinary tract infection will be resistant to common antibiotics. Researchers analyzed data from over 1,100 patients with community-a…

This study checks if men who had a treated urethritis infection still have signs of long-term inflammation and cell damage in their genital tract. Researchers measured a protein called elastase and markers of oxidative stress in semen 6 and 12 months after treatment. They compare…

This study looked at whether a blood test that measures immune response to CMV can predict infection risk in children who have received a heart, kidney, or liver transplant. Researchers tested blood samples from 161 children within the first year after transplant. The goal is to …

This study looks at whether a set of steps to prevent urinary tract infections and bladder swelling in older hip fracture patients still works 9 years after it was first put in place. Researchers will compare infection and bladder problem rates from year 9 to earlier years in 750…

This study tested whether adding infectious disease experts to primary care teams helps reduce unnecessary antibiotic use. Over 1,300 patients from six clinics in Spain took part. Doctors in the expert-advised group could call or meet with specialists to discuss tricky cases. The…

This study looked at 27 postmenopausal women with frequent urinary tract infections (UTIs) to understand why vaginal estrogen therapy prevents UTIs in only about half of them. Researchers examined changes in bacteria in the vagina and bladder, as well as immune responses, before …

This study looked at whether levels of a common virus called Torque teno virus (TTV) can help doctors monitor how well a kidney transplant patient's immune system is suppressed. The goal is to find a simple blood test that could predict rejection or infection. Researchers followe…

This study looked at how antibiotics used to treat urinary tract infections (UTIs) affect the bacteria in the gut. Researchers collected stool samples from 61 hospitalized patients before and after antibiotic treatment to see if resistant bacteria increased. The goal was to under…

This study reviewed 575 adults admitted to intensive care for a severe kidney infection called acute obstructive pyelonephritis. Researchers aimed to identify factors that lead to poor outcomes such as death or lasting kidney damage. The goal is to better understand which patient…

This study tested whether watching a video about genital hygiene helps women take better care of themselves. Sixty-six women with urinary tract infections took part. Researchers measured their self-care skills and hygiene habits before and after the video.

This study looked at whether a special blood test could predict BK virus infection in people who had a kidney transplant. The test measured how certain immune cells (T cells) react to the virus. Researchers studied 80 kidney transplant recipients to see if this test could help ca…

This study looked at whether a routine urine culture before removing a ureteral stent (a small tube from kidney to bladder) helps prevent urinary infections. Over 2200 adults were split into two groups: one got the standard urine test, the other did not. Researchers then tracked …

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This study looked at whether a nurse-led education program based on the Health Belief Model could improve genital hygiene behaviors and attitudes toward preventing urinary tract infections (UTIs). The study involved 122 health science students, split into two groups. The goal was…

This study looked at 147 kidney stone patients who had a positive urine culture before a minimally invasive surgery called mini-PCNL. Doctors gave them antibiotics and then checked if a follow-up urine culture was needed to predict infections after surgery. The goal was to see if…

This study examined 346 adults who had kidney stone surgery to see if changes in their urine white blood cells and nitrite levels before the operation could predict serious infections like fever or sepsis afterward. The goal was to find a faster, simpler way to identify high-risk…

This study followed 94 adults who have both recurrent urinary tract infections and kidney stones that are not blocking the kidney. Researchers wanted to see if surgically removing these stones reduces the number of future UTIs compared to just monitoring them. Patients chose with…

This study looked at the bacteria living in the bladder (urinary microbiota) of 108 women, some with urinary tract infections (UTIs) and some healthy. Researchers used advanced DNA sequencing to find bacteria that standard lab tests miss. The goal was to understand how changes in…

This study tested a new system (PA-100 AST) to help doctors quickly choose the right antibiotic for women with urinary tract infections (UTIs). About 199 non-pregnant women with UTI symptoms provided urine samples, which were tested with the new system. The goal was to see if usi…

This study followed 603 pregnant women in South Africa to see if infections or bacteria in the vagina are linked to how early they give birth. Researchers tested for sexually transmitted infections, yeast, and other germs at the start of pregnancy and again at 30-34 weeks. The go…

This completed study followed over 18,000 Taiwanese Buddhists to see if a vegetarian diet is linked to a lower risk of chronic diseases like dementia, depression, heart disease, stroke, gout, cataracts, gallstones, and urinary tract infections. Researchers compared health records…