Tiny virus may hold key to better kidney transplant care

NCT ID NCT05756036

Completed Knowledge-focused Sponsor: Queen Mary University of London Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether levels of a common virus called Torque teno virus (TTV) can help doctors monitor how well a kidney transplant patient's immune system is suppressed. The goal is to find a simple blood test that could predict rejection or infection. Researchers followed 268 kidney transplant recipients and measured TTV levels alongside other markers. If TTV levels prove reliable, this could lead to more personalized immune suppression dosing.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a simple blood test to help doctors balance immune suppression in kidney transplant patients, reducing rejection and infection risks.
What could go wrong: This is an observational study, not a treatment trial, so it cannot prove cause and effect. The virus levels may not reliably predict outcomes in all patients.

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Conditions

The condition(s) this trial relates to.

acute transplant rejection renal infectious disease transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IMMUNOSUPPRESSION RENAL TRANSPLANT FAILURE RENAL TRANSPLANT INFECTION RENAL TRANSPLANT REJECTION

Contacts and locations

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Locations

Royal London Hospital

London, SW4 8FA, United Kingdom

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