New drug combo may beat BK virus in kidney transplants

NCT ID NCT03216967

Completed Disease control Sponsor: University Hospital, Strasbourg, France Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether switching from one immunosuppressant to everolimus, along with lowering overall immunosuppression, helps clear BK virus better than just lowering immunosuppression alone. The trial involved 130 kidney transplant recipients with BK virus in their blood. The goal was to see if more patients cleared the virus after 6 months while keeping their kidney function stable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: everolimus
What this could lead to: If successful, this could offer a safer way to clear BK virus after kidney transplant, reducing the risk of kidney damage without increasing rejection.
What could go wrong: This is a completed Phase 4 trial with 130 participants, so results are available but may not apply to all patients. Everolimus can cause side effects like mouth sores, infections, or metabolic issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

BK-virus nephropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BK VIRUS NEPHROPATHY AFTER KIDNEY TRANSPLANTATION

Contacts and locations

Locations

AP-HP - Hôpital Georges Pompidou

Paris, 75908, France
AP-HP Hôpital Necker

Paris, 75743, France
CHRU - Hôpital Bretonneau

Tours, 37044, France
CHRU d'Angers

Angers, 49033, France
CHU - Hôpital Dupuytren

Limoges, 87042, France
CHU - Hôpital Maison Blanche

Reims, 51092, France
CHU - Hôpital Sud

Amiens, 80054, France
CHU - Hôpital de la Cavale Blanche

Bois-Guillaume, 76230, France
CHU - Hôpital de la Cavale Blanche

Brest, 29609, France
CHU Côte de Nacre

Caen, 14033, France
CHU Hôpital Gabriel Montpied

Clermont-Ferrand, 63000, France
CHU Poitiers - Hôpital Jean Bernard

Poitiers, 86021, France
CHU Rennes - Hôpital Pontchaillou

Rennes, 35033, France
Hôpital Edouard Herriot

Lyon, 69003, France
Les Hôpitaux Universitaires

Strasbourg, 67000, France