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Pill power: oral antibiotic could replace IV for tough UTIs

NCT ID NCT06059846

Completed Disease control Sponsor: Spero Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an oral antibiotic (tebipenem pivoxil hydrobromide) against a standard IV antibiotic in 1,690 hospitalized adults with complicated urinary tract infections or kidney infections. The goal was to see if the oral pill works as well as the IV treatment in curing the infection and clearing bacteria. Results could offer a more convenient, needle-free option for patients.

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Conditions

The condition(s) this trial relates to.

acute pyelonephritis bacterial urinary tract infection urinary tract infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE PYELONEPHRITIS URINARY TRACT INFECTION

Contacts and locations

Locations

  • Medical Facility

    Miami, Florida, 33176, United States

  • Medical Facility

    Buenos Aires, Argentina

  • Medical Facility

    Córdoba, Argentina

  • Medical Facility

    La Plata, Argentina

  • Medical Facility

    Mendoza, Argentina

  • Medical Facility

    San Miguel de Tucumán, Argentina

  • Medical Facility

    Villa Regina, Argentina

  • Medical Facility

    Banja Luka, Bosnia and Herzegovina

  • Medical Facility

    Sarajevo, Bosnia and Herzegovina

  • Medical Facility

    Tuzla, Bosnia and Herzegovina

  • Medical Facility

    Barueri, Brazil

  • Medical Facility

    Campinas, Brazil

  • Medical Facility

    Curitiba, Brazil

  • Medical Facility

    Porto Alegre, Brazil

  • Medical Facility

    São José do Rio Preto, Brazil

  • Medical Facility

    Blagoevgrad, Bulgaria

  • Medical Facility

    Dobrich, Bulgaria

  • Medical Facility

    Gabrovo, Bulgaria

  • Medical Facility

    Pleven, Bulgaria

  • Medical Facility

    Plovdiv, Bulgaria

  • Medical Facility

    Sliven, Bulgaria

  • Medical Facility

    Varna, Bulgaria

  • Medical Facility

    Čakovec, Croatia

  • Medical Facility

    Slavonski Brod, Croatia

  • Medical Facility

    Split, Croatia

  • Medical Facility

    Zagreb, Croatia

  • Medical Facility

    Kohtla-Järve, Estonia

  • Medical Facility

    Pärnu, Estonia

  • Medical Facility

    Tallinn, Estonia

  • Medical Facility

    Tartu, 50406, Estonia

  • Medical Facility

    Võru, Estonia

  • Medical Facility

    Alexandroupoli, Greece

  • Medical Facility

    Athens, Greece

  • Medical Facility

    Ioannina, Greece

  • Medical Facility

    Pátrai, Greece

  • Medical Facility

    Thessaloniki, Greece

  • Medical Facility

    Budapest, Hungary

  • Medical Facility

    Eger, Hungary

  • Medical Facility

    Kistarcsa, Hungary

  • Medical Facility

    Nyíregyháza, Hungary

  • Medical Facility

    Belagavi, Karnataka, 590010, India

  • Medical Facility

    Bangalore, India

  • Medical Facility

    Jaipur, India

  • Medical Facility

    Lucknow, India

  • Medical Facility

    Varanasi, India

  • Medical Facility

    Daugavpils, Latvia

  • Medical Facility

    Liepāja, Latvia

  • Medical Facility

    Riga, Latvia

  • Medical Facility

    Valmiera, Latvia

  • Medical Facility

    Chisinau, Moldova

  • Medical Facility

    Krakow, Poland

  • Medical Facility

    Lodz, Poland

  • Medical Facility

    Warsaw, Poland

  • Medical Facility

    Łęczna, Poland

  • Medical Facility

    Brasov, Romania

  • Medical Facility

    Iași, Romania

  • Medical Facility

    Oradea, Romania

  • Medical Facility

    Timișoara, Romania

  • Medical Facility

    Bratislava, Slovakia

  • Medical Facility

    Galanta, Slovakia

  • Medical Facility

    Lučenec, Slovakia

  • Medical Facility

    Malacky, Slovakia

  • Medical Facility

    Poprad, Slovakia

  • Medical Facility

    Pretoria, South Africa

  • Medical Facility

    Tongaat, South Africa

  • Medical Facility

    Umhlanga, South Africa

  • Medical Facility

    Ankara, Turkey (Türkiye)

  • Medical Facility

    Diyarbakır, Turkey (Türkiye)

  • Medical Facility

    Istanbul, Turkey (Türkiye)

  • Medical Facility

    Izmir, Turkey (Türkiye)

  • Medical Facility

    Samsun, Turkey (Türkiye)

  • Medical facility

    Miami, Florida, 33144, United States

  • Medical facility

    Lom, Bulgaria

  • Medical facility

    Rousse, Bulgaria

  • Medical facility

    Shumen, Bulgaria

  • Medical facility

    Sofia, Bulgaria

  • Medical facility

    Tbilisi, Georgia

  • Medical facility

    Bucharest, Romania

  • Medical facility

    Craiova, Romania

  • Medical facility

    Belgrade, Serbia

  • Medical facility

    Kragujevac, Serbia

  • Medical facility

    Niš, Serbia

  • Medical facility

    Novi Sad, Serbia

  • Medical facility

    Benoni, South Africa

  • Medical facility

    Durban, South Africa

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