New antibiotic cocktails take on tough UTIs and kidney infections

NCT ID NCT05887908

Completed Disease control Sponsor: Meiji Seika Pharma Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tested two new antibiotic combinations—cefepime/nacubactam and aztreonam/nacubactam—against a standard antibiotic (imipenem/cilastatin) in 614 adults with complicated urinary tract infections or acute kidney infections. The goal was to see if the new combos are safe and effective at clearing both symptoms and bacteria. Results are pending.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

cefepime/nacubactam and aztreonam/nacubactam (antibiotic combinations)

What this could lead to

If successful, these new antibiotic combos could offer effective treatment options for complicated urinary tract and kidney infections, especially against drug-resistant bacteria.

What could go wrong

This is a phase 3 trial, but results are not yet published. The new drugs may not prove superior or even non-inferior to the existing antibiotic, and side effects or resistance could limit their use.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

acute pyelonephritis bacterial urinary tract infection cutis laxa

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE PYELONEPHRITIS AP COMPLICATED URINARY TRACT INFECTION CUTI

Contacts and locations

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Locations

Meiji Research Site

Pleven, Bulgaria
Meiji Research Site

Rousse, Bulgaria
Meiji Research Site

Silistra, Bulgaria
Meiji Research Site

Sofia, Bulgaria
Meiji Research Site

Beijing, China
Meiji Research Site

Changchun, China
Meiji Research Site

Chongqing, China
Meiji Research Site

Fuyang, China
Meiji Research Site

Ganzhou, China
Meiji Research Site

Huaian, China
Meiji Research Site

Huzhou, China
Meiji Research Site

Nanchang, China
Meiji Research Site

Nanning, China
Meiji Research Site

Quanzhou, China
Meiji Research Site

Shanghai, China
Meiji Research Site

Shantou, China
Meiji Research Site

Shijiazhuang, China
Meiji Research Site

Taian, China
Meiji Research Site

Tianjin, China
Meiji Research Site

Xuancheng, China
Meiji Research Site

Yunnan, China
Meiji Research Site

Zhejiang, China
Meiji Research Site

Zhengzhou, China
Meiji Research Site

Hradec Králové, Czechia
Meiji Research Site

Liberec, Czechia
Meiji Research Site

Prague, Czechia
Meiji Research Site

Ústí nad Labem, Czechia
Meiji Research Site

Meegomäe, Võrumaa, Estonia
Meiji Research Site

Kohtla-Järve, Estonia
Meiji Research Site

Tallinn, Estonia
Meiji Research Site

Tartu, Estonia
Meiji Research Site

Kutaisi, Georgia
Meiji Research Site

Rustavi, Georgia
Meiji Research Site

Tbilisi, Georgia
Meiji Research Site

Fukuyama, Japan
Meiji Research Site

Gifu, Japan
Meiji Research Site

Ibaraki-Town, Higashiibaraki-County, Japan
Meiji Research Site

Iwakuni, Japan
Meiji Research Site

Kanazawa, Japan
Meiji Research Site

Kawachi-Nagano, Japan
Meiji Research Site

Kofu, Japan
Meiji Research Site

Kumamoto, Japan
Meiji Research Site

Matsumoto, Japan
Meiji Research Site

Mizumaki-Town, Onga-County, Japan
Meiji Research Site

Nagasaki, Japan
Meiji Research Site

Nankoku, Japan
Meiji Research Site

Ōita, Japan
Meiji Research Site

Ōtake, Japan
Meiji Research Site

Sagamihara, Japan
Meiji Research Site

Sapporo, Japan
Meiji Research Site

Shinjuku-ku, Japan
Meiji Research Site

Toyota, Japan
Meiji Research Site

Ueda, Japan
Meiji Research Site

Yokohama, Japan
Meiji Research Site

Riga, Latvia
Meiji Research Site

Valmiera, Latvia
Meiji Research Site

Kaunas, Lithuania
Meiji Research Site

Vilnius, Lithuania
Meiji Research Site

Galanta, Slovakia
Meiji Research Site

Rimavská Sobota, Slovakia
Meiji Research Site

Svidník, Slovakia