Which UTI antibiotic works best? new study compares four options

NCT ID NCT04959331

Completed Disease control Sponsor: Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested four different short antibiotic courses in 1,000 women with uncomplicated lower urinary tract infections. Participants received either a two-day course of fosfomycin, a three-day course of pivmecillinam, a five-day course of nitrofurantoin, or a single dose of fosfomycin. The goal was to see which treatment best relieved symptoms and cleared bacteria from the urine.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fosfomycin, nitrofurantoin, pivmecillinam
What this could lead to: If successful, this could identify the most effective short-course antibiotic for uncomplicated UTIs, reducing treatment duration and side effects.
What could go wrong: This is a completed Phase 4 trial, so results are already in. However, findings may not apply to complicated UTIs or men, and antibiotic resistance could limit real-world effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bacterial urinary tract infection urinary tract infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

URINARY TRACT INFECTIONS

Contacts and locations

Locations

17 de Setembre Center

el Prat de Llobregat, Catalonia, 08820, Spain
Aquitania Health Center

Madrid, Madrid, 28032, Spain
Arrabal Health Center

Zaragoza, Aragon, 50015, Spain
Banyoles Center

Banyoles, Catalonia, 17820, Spain
Buenos Aires Center

Madrid, Madrid, 28038, Spain
Calatayud Center

Calatayud, Aragon, 50300, Spain
Camp Redó Health Center

Palma de Mallorca, Balearic Islands, 07010, Spain
Can Serra Center

L'Hospitalet de Llobregat, Catalonia, 08906, Spain
Can Vidalet Center

Esplugues de Llobregat, Catalonia, 08950, Spain
Corbera Center

Corbera de Llobregat, Catalonia, 08757, Spain
El Puerto Center

Coslada, Madrid, 28821, Spain
Emili Darder Center

Palma de Mallorca, Balearic Islands, 07007, Spain
Florida Center

L'Hospitalet de Llobregat, Catalonia, 08905, Spain
Jaume I Health Center

Tarragona, Catalonia, 43005, Spain
La Gavarra Health Center

Cornellà de Llobregat, Catalonia, 08940, Spain
Las Fuentes Center

Zaragoza, Aragon, 50002, Spain
Los Alpes Health Center

Madrid, Madrid, 28022, Spain
Mar Báltico Center

Madrid, Madrid, 28033, Spain
Molí Nou Center

Sant Boi de Llobregat, Catalonia, 08830, Spain
Montblanc Center

Montblanc, Catalonia, 43400, Spain
Parque Goya Health Center

Zaragoza, Aragon, 50018, Spain
Pere Garau Center

Palma de Mallorca, Catalonia, 07007, Spain
San Fernando Health Center

San Fernando de Henares, Madrid, 28830, Spain
Sant Feliu de Guíxols Center

Sant Feliu de Guíxols, Catalonia, 17220, Spain
Sant Just Desvern Center

Sant Just Desvern, Catalonia, 08960, Spain
Santa Clara Center

Girona, Catalonia, 17001, Spain
Santa Maria del Camí Center

Santa Maria del Camí, Balearic Islands, 07320, Spain
Santa Ponça Health Center

Calvià, Balearic Islands, 07180, Spain
Son Pisà Center

Palma de Mallorca, Balearic Islands, 07011, Spain
Son Serra-La Vileta Health Center

Palma de Mallorca, Balearic Islands, 07013, Spain
Valleaguado Health Center

Coslada, Madrid, 28823, Spain
Vila Vella Center

Sant Vicenç dels Horts, Catalonia, 08620, Spain
Villarejo de Salvanés Health Center

Villarejo de Salvanés, Madrid, 28590, Spain

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