Skin disorder caused by infection

This study tests the Shingrix vaccine in people with HIV and healthy volunteers to see how well it boosts immunity against shingles. Participants receive two shots two months apart and are followed for a year. The goal is to understand if the vaccine works safely in those with di…

This study tests a new chickenpox vaccine in 600 healthy toddlers aged 12-15 months. The children receive two doses, and the new vaccine is compared to the current standard, Varivax. The goal is to see if the new vaccine produces a strong immune response and is safe.

This study tests a new chickenpox vaccine in 750 healthy children aged 12-15 months. Researchers will compare its safety to the existing Varivax vaccine. The goal is to see if the new vaccine causes similar side effects like injection site pain, fever, or rash.

This study tests a new chickenpox vaccine given as a muscle injection in healthy children aged 12 to 15 months. It compares the immune response and safety of this vaccine to the standard shot given under the skin. The study also looks at combining it with the MMR vaccine. About 9…

This study tests a new chickenpox vaccine in healthy children aged 12 to 15 months who have never had chickenpox or the vaccine. Researchers want to see if the new vaccine works as well as the approved Varivax vaccine and if different batches of the new vaccine produce consistent…

This study tests a new chickenpox vaccine called MG1111 in healthy children aged 1 to 12 years. About 474 kids will receive either the new vaccine or the current one (Varivax) to compare safety and immune response. Participants will be followed for 42 days after each dose, and up…

This study looks at how well the shingles vaccine (Shingrix) works in adults with kidney failure who are waiting for a kidney transplant. Researchers want to see if giving an extra dose after the transplant boosts the immune response. About 132 participants will be followed for u…

This study tests the shingles vaccine (SHINGRIX) in 160 people: transplant recipients on different immunosuppressant drugs and their healthy housemates. Researchers will measure immune responses at five time points over a year to see if the vaccine works well in these groups. The…

This study looks at how well a second dose of the chickenpox vaccine works and if it is safe for healthy children aged 15 months to 12 years. About 300 children who already had one dose at 12 months old will get a second dose made by Sinovac. Researchers will measure antibody lev…

This study is testing a new shingles vaccine (PED-HZ/su) in children aged 1 to 17 who have had a kidney transplant and have weakened immune systems. The vaccine is given as two shots in the arm. Researchers are checking how safe it is, what side effects occur, and how well it boo…

This study is testing a new mRNA vaccine to prevent shingles (herpes zoster) in adults aged 40 and older. The vaccine uses mRNA technology, similar to some COVID-19 vaccines, and is freeze-dried for easier storage. Researchers will compare different doses against existing vaccine…

This study looks at how well the shingles vaccine Shingrix works in people who have had a stem cell transplant. About 55 adults who received the vaccine at least a year after their transplant will have their immune responses measured. Researchers want to see if the timing of the …

This study tests a new recombinant shingles vaccine in healthy adults aged 40 and above. Researchers will give two doses and monitor for side effects and immune response. The trial involves 645 participants and compares the new vaccine to an existing one (Shingrix) and placebo.

This early-phase study tests whether Mozobil, a drug already used to boost stem cells for transplants, can safely raise white blood cell counts in people with WHIMS. WHIMS is a rare genetic condition that traps infection-fighting cells in the bone marrow, leading to frequent infe…

This study tests whether giving patients special donor immune cells (called CD45RA-depleted DLI) can treat viral infections that persist after a stem cell transplant. The trial involves 30 participants who have not improved with standard antiviral drugs. Researchers will measure …

This study investigates whether reducing calories to lower fat in the liver and muscles can improve how the body responds to insulin. Researchers will measure changes in insulin sensitivity and fat levels in 250 healthy but insulin-resistant adults with a family history of type 2…

This study tests a new shampoo (X92001483) that works by physically trapping and removing head lice, comparing it to a standard medicated rinse (Nix Cream Rinse with 1% permethrin). The goal is to see if the new shampoo is safe, effective at killing lice, and can prevent reinfest…

This study tests a new gel called OCF001 for treating acute yeast infections in women. About 36 women with a confirmed yeast infection will use the gel or a placebo for 7 days. Researchers will check if the infection clears up and if the gel is safe and well-tolerated.

This study tests whether using a device that heats skin lesions to 50°C for 30 seconds can effectively treat cutaneous leishmaniasis in primary health centers in Ethiopia. 103 patients aged 12 to 60 with up to four lesions will receive thermotherapy and be monitored for 90 days. …

This study tests whether boric acid vaginal inserts (600 mg) taken for 7 or 14 days can safely and effectively treat yeast infections. About 400 women aged 12 and older with active symptoms will participate. The goal is to see if all signs and symptoms disappear without needing m…

This study tests whether lactoferrin, a natural prebiotic from cow's milk, can be a good alternative to antibiotic tablets for women with bacterial vaginosis (BV) or thrush. Researchers will recruit 114 women and give half lactoferrin vaginal pessaries for 3 weeks, while the othe…

This phase 3 trial compares a 5-day course of the antibiotic flucloxacillin to the standard 7-day course for adults with leg cellulitis. About 334 participants will receive either 5 days of active drug plus 2 days of placebo, or 7 days of active drug. The goal is to see if the sh…

This study follows people who already took part in earlier YCANTH wart studies. It tests whether up to 4 more treatments, applied every 21 days, can safely clear common warts. About 600 adults and children will be monitored for a year. The goal is to see if the medicine continues…

This study compares two treatments for recurrent plantar warts: a topical adapalene gel (a type of retinoid cream) and cryotherapy (freezing with liquid nitrogen). Researchers will enroll 98 adults aged 18-60 with recurring warts on the soles of their feet. The goal is to see whi…

This study tests a cream called tirbanibulin on hand warts in children aged 8 to 18. Warts are common but current treatments like freezing can be painful and scary for kids. The cream is applied at home and may clear warts with less discomfort. Only 10 children will take part to …

This study tests whether adding low dose isotretinoin (a vitamin A drug) or excimer light to standard itraconazole pills works better for nail fungus. 36 adults with onychomycosis will be split into three groups: itraconazole alone, itraconazole plus isotretinoin, or itraconazole…

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This study tests whether adding a microneedle patch soaked in hydrogen peroxide to local heat therapy can clear viral warts better than heat alone. About 210 people aged 6–65 with common or plantar warts will be split into three groups: heat only, heat plus a plain patch, or heat…

This phase 3 trial tests whether a plant-based tincture made from arnica flowers can safely and effectively heal skin ulcers caused by cutaneous leishmaniasis, a parasitic disease spread by sandflies. About 96 people aged 12 and older with confirmed infection will receive either …

This study tests whether injecting acyclovir (an antiviral drug) or vitamin D3 directly into skin warts can clear them. Forty people aged 12 and older with common, plantar, flat, or nail warts will receive injections every two weeks for up to four sessions. The main goal is to se…

This study tests whether giving oral antibiotics instead of IV antibiotics is just as safe and effective for patients with common infections like pneumonia, urinary tract infections, and cellulitis. About 4,000 adults in Danish emergency rooms will be randomly assigned to start o…

This study tests an experimental eye drop called GLK-321 in 250 adults with Demodex blepharitis, a condition where tiny mites cause debris at the base of eyelashes. Participants will receive either a low, mid, or high dose of the drug, or a placebo, for 6 weeks. The main goal is …

This early study tests whether a lactic acid gel (Phexxi) used twice weekly can change the vaginal microbiome to help prevent recurrent bacterial vaginosis and yeast infections. 22 premenopausal women with a history of these infections will use the gel for 4 weeks. Researchers wi…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method adjusts the dose based on the patient's kidney function, using only standard doses. The main goal is to see if this approach is easy for doctors to use and …

This study is testing a new cooling device placed in the vagina to treat yeast infections. Researchers want to see if it can relieve symptoms and clear the infection within 7 days. The study involves 55 women aged 22-49 with uncomplicated yeast infections. It is an early-stage tr…

This study tests a special hydrogel patch applied daily to toenails for three months. It is designed for people with nail fragility, fungal infections, or nail psoriasis. The trial includes 72 adults and compares the active patch to a placebo to see if it safely improves nail hea…

This study tests a gel called YCANTH on common warts caused by HPV. About 300 people aged 2 and older with at least one wart will apply the gel or a fake version. The goal is to see if the gel can clear all warts by day 84.

This study compares two common oral antifungal pills—fluconazole and itraconazole—in adults with ringworm that hasn't cleared up with creams. 126 people aged 18-70 with persistent infection for at least 6 months will be randomly assigned to one of the two drugs for 4 weeks. The g…

This study tests a new device that uses cold plasma (a type of energized gas) to treat moderate-to-severe athlete's foot, a stubborn fungal infection. About 220 adults with confirmed infection will receive either the plasma treatment or a fake one to see if it safely reduces skin…

This clinical trial compares two drugs for shingles (herpes zoster): brivudine and famciclovir. The study will enroll 140 adults with acute shingles to see which drug better reduces pain and speeds up healing. Researchers will track pain levels for up to 90 days and monitor for l…

This pilot study is testing whether injecting the MMR vaccine directly into skin lesions can help treat hard-to-clear fungal infections (tinea cruris and corporis). The study will enroll 50 people aged 10-60 who have not improved with standard antifungal treatments. Participants …

This study tests whether giving zinc supplements along with standard antibiotics can reduce deaths and improve recovery in young infants (0-59 days old) hospitalized with severe infections like sepsis or pneumonia. About 3,250 babies in Tanzania will receive either zinc or a plac…

This Phase 2 trial tests three different stick formulations of the antifungal drug tolnaftate (1%) for treating athlete's foot (tinea pedis). About 150 people aged 16 and older with a confirmed diagnosis will apply the stick twice daily for 4 weeks. The main goal is to see if the…

This study compares two drugs, ivermectin and moxidectin, to see which works better at controlling river blindness and other common infections like intestinal worms and scabies in Angola. Over 52,000 people in 20 village groups will receive one of the drugs once a year for four y…

This early study tests a cream made from cassia alata, a plant, on 20 adults with tinea versicolor (light or dark patches on skin). Participants apply the cream to one area and leave another area untreated for comparison. Researchers check if the treated skin clears up better and…

This study tests a gel device called Multi-Gyn FemiTotal in 80 women with bacterial vaginosis or vaginal yeast infections. Participants use the gel for 7 days, and if symptoms clear, they are followed for 4 months to see if the infection returns. The goal is to see if the gel can…

This study tests whether injecting the antibiotic ciprofloxacin directly into skin sores caused by leishmaniasis works as well as the standard treatment, sodium stibogluconate. Eighty people with one to seven sores will be randomly assigned to receive weekly injections of one dru…

This study tests whether injecting the antibiotic levofloxacin directly into skin sores caused by leishmaniasis can cure them. Forty adults with up to seven sores will receive weekly injections for up to six weeks and be monitored for 90 days. The goal is to see if the sores heal…

This study compares a new head lice lotion (Elimax Green Lotion with Emogreen) to a standard lice-killing shampoo (Walgreens Lice Killing Shampoo). About 86 people aged 6 months and older with active head lice will use one of the two treatments. Researchers will check how well ea…

This study compares two treatment schedules for oral itraconazole in children aged 5 to 18 with tinea capitis (scalp ringworm). One group takes the drug daily, the other takes it in pulses (intermittent doses). Researchers will check cure rates using clinical exams, lab tests, an…

This study compares a new medical device called ENRICHED to a standard nail fungus treatment (Loceryl) in 88 adults with nail fungus. Participants will use one of the two treatments for 9 months. Doctors will measure how much healthy nail grows back by analyzing photos. The goal …

This study tests a smartphone app that uses artificial intelligence to detect 16 different eye diseases from photos taken with the phone. The AI works entirely on the device, so no internet is needed. Researchers will compare its accuracy to eye doctors and see if non-medical use…

This study is testing a software tool called Belle.ai that uses artificial intelligence to help doctors diagnose common skin diseases. About 400 patients at dermatology clinics will have three photos taken of their skin condition. The AI will analyze the photos and suggest possib…

This study looks at how well a live shingles vaccine prevents shingles over 6 years in adults aged 40 and older. It follows about 24,740 people who were in an earlier vaccine trial, comparing those who got the vaccine first to those who got it later. Researchers will track new sh…

This study is testing whether the Shingrix vaccine, already used to prevent shingles, can also lower the risk of dementia in adults aged 76 and older. Over 33,000 participants in Finland will receive either the vaccine or a placebo. Researchers will track new dementia diagnoses o…

This large study in Denmark is testing whether the shingles vaccine (Shingrix) can do more than prevent shingles—it may also lower the risk of heart attacks, strokes, and dementia. About 162,000 adults aged 65 and older will either get the vaccine or no vaccine, and researchers w…

This study tests whether the oral medication venlafaxine, typically used for depression, can prevent postherpetic neuralgia—a persistent nerve pain that often follows a shingles rash. Researchers will enroll 832 adults who have had a shingles rash for less than 30 days and are ex…

This study is testing whether the shingles vaccine (RZV) works and is safe for adults with autoimmune rheumatic diseases like rheumatoid arthritis or lupus who are taking immune-suppressing drugs. Two hundred participants will receive two doses of the vaccine. Researchers will me…

This study tests whether using a mobile app that gives visual feedback can help lung cancer patients do breathing exercises more effectively after having part of a lung removed. Forty patients will try both standard breathing training and app-guided training on the same day. Rese…

This study looks at whether electroacupuncture (a type of acupuncture with mild electric pulses) can help relieve pain from shingles and reduce the chance of long-term nerve pain. About 228 adults with shingles will be split into three groups: one gets electroacupuncture plus sta…

This study tests whether adding a probiotic supplement (Bioithas WOMAN®) to standard antifungal medicine helps relieve symptoms of vaginal yeast infections faster. About 60 women with suspected yeast infections will take either antifungal treatment alone or with the probiotic for…

This study tests two different nerve blocks to control pain after video-assisted lung surgery. One block targets a muscle plane, the other targets individual nerves. Researchers will measure pain levels, opioid use, and breathing problems in 80 adults aged 18-80. The goal is to f…

This study tests whether combining heat therapy (hyperthermia) with a common antiseptic (3% hydrogen peroxide) can clear stubborn viral warts that haven't responded to other treatments. About 80 adults with warts lasting two years or more will receive either the combination treat…

This study tests whether pulsed electromagnetic field (PEMF) therapy can improve sports performance and speed up recovery in athletes. Thirty active adults will receive either real or fake PEMF treatments twice a week for 8 weeks. Researchers will measure cycling power, fatigue, …

This study tests whether adding a bone stimulator to standard care helps athletes aged 16–40 with a spine stress fracture (spondylolysis) heal faster, reduce pain, and return to sport sooner. About 48 participants will use the device alongside physical therapy. The goal is to see…

This study tests whether adding a newer pain medication called mirogabalin to standard treatment provides better pain relief for people with shingles. About 750 adults with moderate to severe shingles pain will receive either standard care alone or standard care plus mirogabalin.…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce pain and improve daily life for people with post-herpetic neuralgia (long-term nerve pain after shingles). About 34 adults aged 35-65 with persistent pain will receive the sti…

This study tests whether a lower dose (6%) or a higher dose (8%) of sevoflurane gas works better and causes fewer side effects when putting children aged 1 to 6 years to sleep for minor eye surgery. The main goal is to see which dose leads to less agitation and confusion when the…

This study compares two treatments for long-lasting nerve pain after shingles (postherpetic neuralgia). Researchers will give 50 adults either a nerve block or a radiofrequency treatment and measure pain levels. The goal is to find which option works better for easing this stubbo…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This study tests whether a loxoprofen patch can safely reduce pain from shingles (herpes zoster). Researchers will compare standard treatment alone to standard treatment plus the patch in 750 adults with moderate to severe pain. The goal is to see if the patch provides better pai…

This study tests whether adding the muscle relaxant baclofen to standard shingles treatment can better reduce moderate to severe pain. Researchers will enroll 750 adults with shingles rash for less than 90 days. Participants will receive either baclofen plus usual care or usual c…

This study tests whether adding the antidepressant tulodesvenlafaxine to standard shingles treatment can better relieve pain. It includes 750 adults with moderate to severe shingles pain. The goal is to see if this drug reduces pain scores more than usual care alone.

This study tests whether a flurbiprofen patch can safely reduce pain in people with shingles (herpes zoster). About 750 adults with moderate to severe pain will either receive the patch plus standard treatments (antivirals, opioids) or standard treatments alone. The goal is to se…

This study tests whether the antidepressant desvenlafaxine can reduce pain from shingles (herpes zoster) better than standard treatments alone. Researchers will enroll 750 adults with moderate to severe pain and compare those taking desvenlafaxine plus usual care to those receivi…

This study tests whether a new oral medication called crisugabalin can provide better pain relief for people with shingles (herpes zoster) compared to standard treatments. The trial will enroll 750 adults with moderate to severe shingles pain. Participants will receive either cri…

This study tests whether a cream containing two medicines (5-fluorouracil and calcipotriol) can safely and effectively treat warts on the palms and soles of children aged 4 to 18. About 60 children will receive either the active cream or a placebo for several weeks. The goal is t…

This study looks at how leishmaniasis infections progress and respond to treatment. It involves up to 289 people aged 3 to 100 with known or suspected leishmaniasis. Researchers will collect blood and tissue samples to learn more about the disease and test different treatments. T…

This study looks at how the immune system changes with age and how that affects the risk of infections in people 60 and older. Researchers will collect blood, urine, stool, and other samples from elderly patients with infections and healthy older adults. By analyzing immune cells…

This study follows 950 people with idiopathic CD4+ lymphocytopenia (ICL), a rare condition where low CD4+ white blood cells raise infection risk. Researchers will track participants for up to 10 years, collecting medical history, blood samples, and infection data. The goal is to …

This study aims to improve how doctors evaluate and manage people who have been exposed to bioterrorism agents (like anthrax) or emerging infectious diseases (like SARS or new flu strains). Up to 200 participants, including patients and healthcare workers, will be monitored and t…

This study looks at how well the shingles vaccine (Shingrix) works in people with lupus compared to healthy people of the same age and sex. Researchers will measure immune cell responses after two doses and follow participants for up to 5 years. The goal is to understand if the v…

This study collects biological samples—like blood, skin biopsies, and swabs—from people with or at risk for skin diseases, as well as healthy volunteers. Researchers will use these samples to study the causes of skin conditions and explore potential treatments. Up to 700 particip…

This study looks at how natural menstrual cycles and birth control pills affect strength, hydration, and energy balance in 40 female athletes. Researchers will measure muscle strength, body water, and energy use at different times of the month. The goal is to better understand ho…

This study is observing how doctors manage complicated infections of the ears, nose, throat, and neck in both children and adults. Researchers will track standard treatments like surgery or medication to understand current practices. No new treatments are being tested; the goal i…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study looks at how the Shingrix vaccine (for shingles) works in people with psoriasis or myelofibrosis who are taking drugs that weaken their immune system. Researchers will compare their immune response to that of similar patients not on these drugs. The goal is to understa…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study looks at whether giving athletes real-time feedback during shoulder exercises helps them generate more force and do it faster. Twenty healthy, active adults will train their shoulder muscles with and without feedback to see if it makes a difference. The goal is to unde…

This study tracks 200 children in Italy with leishmaniasis, a parasitic infection that can affect the skin or internal organs. Researchers will look at how quickly the disease is diagnosed and treated, and how that affects recovery, relapse, and death rates. The goal is to identi…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and respond to moderate exercise. Participants will do strength and aerobic exercises while their pain tolerance and sensitivity are measured. The goal is to understan…

This study looks at how the antibiotic ceftazidime avibactam behaves in 30 children with severe infections who are in intensive care, some on life support. Researchers will measure drug levels in the blood to understand the right dose. The goal is to improve treatment for life-th…

This study looks at whether screening college athletes for low energy availability and providing personalized nutrition advice from a sports dietitian can prevent Relative Energy Deficiency in Sport (RED-S). About 300 Division III athletes at Case Western Reserve University will …

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing needs. About 60 children in intensive …

This study will collect data from 2,000 children admitted to pediatric intensive care units (PICUs) with severe infections across major Chinese cities. Over 10 years, researchers will track which germs cause these infections, how they are treated, and patient outcomes. The goal i…

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam, or vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury than the other, using more sensitive markers …

This study looks at how well a blood test can predict a person's fitness level, measured by VO₂max. Researchers will collect blood samples and fitness data from 250 healthy adults. The goal is to see if certain molecules in the blood can accurately estimate how fit someone is, an…

This study looks at how electroacupuncture might affect immune cells in people with shingles (herpes zoster). Researchers will compare standard medication alone versus medication plus electroacupuncture in 8 women aged 50-70. The goal is to see if electroacupuncture changes immun…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study follows 150 pregnant women infected with parvovirus B19 to see how often the virus passes to the fetus and what complications may occur. Researchers will track pregnancy outcomes, newborn health, and long-term effects. No treatments are tested; the goal is to better un…

This study is creating a data bank to better understand vaginal conditions like vulvodynia, yeast infections, bacterial vaginosis, and preterm labor. Researchers will look at proteins, immune markers, and vaginal bacteria in 550 women, including healthy volunteers and those with …

This study looks at how skin conditions related to cancer or cancer treatments affect the well-being of cancer patients and survivors. About 1,025 participants will fill out questionnaires about their skin condition. The goal is to better understand these effects and improve trea…

This observational study looks at whether people with shingles (herpes zoster) have a higher risk of vascular dementia—memory loss from reduced blood flow to the brain. Researchers will analyze tiny particles called exosomes in blood samples from 375 participants over 12 months. …

This study looks at whether scheduling automatic follow-up appointments after a child leaves the hospital is better than only seeing a doctor when needed. About 2,674 children hospitalized for pneumonia, urinary tract infections, skin infections, or stomach bugs will take part. T…

This study compares two types of visual cues during treadmill walking in 36 athletes who had ACL reconstruction. One cue is a steady beat (isochronous), the other has natural fluctuations (fractal). The goal is to see which better restores natural walking patterns and brain activ…

This study looks at how different warm-up exercises affect the performance of young competitive swimmers. Fifteen athletes will try three different warm-up routines, and researchers will measure their jump height and swim times for 25, 50, and 100 meters. The goal is to find the …

This pilot study is testing whether a smart wristband can accurately measure drug levels in sweat compared to standard blood tests. Researchers will collect sweat, saliva, and blood samples from 100 patients with chronic or infectious diseases who are taking medications like cycl…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…

This study looks at how families feel about antibiotic use and whether a Garmin smartwatch can track symptoms in children aged 4-17 with common infections like UTIs, tonsillitis, or skin infections. About 300 children from the Royal Children's Hospital Emergency Department will w…

This study tests two different preparation designs (bevel vs. butt) for Peek endocrowns, which are tooth-colored caps for molars that have had root canals. Researchers will check how precisely each design fits the tooth, using a replica technique and microscope. The goal is to se…