Skin disorder caused by infection

This study tested whether miconazole oil can cure fungal ear infections (otomycosis). 112 adults with ear fungus received either the active oil or a placebo for 14 days. Neither patients nor doctors knew who got the real treatment. After two weeks, doctors checked if the infectio…

This study compared two oral antifungal medications—itraconazole and terbinafine—for treating scalp ringworm (tinea capitis) in 164 children aged 1 to 13 years. The goal was to see which drug more effectively clears the fungal infection, confirmed by lab tests. Both treatments ai…

This study tested a single oral dose of acoziborole in 208 adults with sleeping sickness, a deadly parasitic disease. Participants took three tablets once and were monitored for 18 months. The goal was to see if this simple treatment could cure both early and late stages of the d…

This clinical trial tested a new vaccine designed to protect against two viruses (EV71 and CA16) that cause hand, foot, and mouth disease and herpangina. The study involved 744 healthy adults and children, including kids as young as 6 months. Researchers checked the vaccine's saf…

This study looked at how safe and effective two shingles vaccines (Zostavax and Shingrix) are in people with rheumatoid arthritis who are taking the drug abatacept. About 154 adults took part, and researchers measured their immune response and any side effects. The goal was to se…

This early-stage study tested a new mRNA vaccine called IN001 for preventing shingles in 150 healthy adults aged 50 to 69. The main goals were to check the vaccine's safety, side effects, and how well it triggers the immune system. Researchers gave different doses to find the bes…

This study tested a new vaccine designed to protect against hand, foot, and mouth disease and herpangina, which are common viral infections in children. The trial involved 552 healthy adults and children aged 6 months to 12 years. Participants received either a low, medium, or hi…

This study followed over 7,500 older adults who received the shingles vaccine to see how well it prevents shingles over many years. Researchers also tested giving extra doses to some participants. The goal was to understand how long protection lasts and whether booster shots are …

This study tested a two-dose shingles vaccine (HZ/su) in 1,430 adults aged 50 and older who had already experienced shingles. The goal was to see if the vaccine could prevent the virus from coming back and to check its safety and immune response. Participants received either the …

This study tested whether giving the RSV vaccine (Abrysvo) and the shingles vaccine (Shingrix) at the same doctor's visit is safe and works as well as giving them separately. About 526 adults aged 50 and older took part. Researchers measured immune responses and tracked side effe…

This study tested two drugs, plerixafor and G-CSF, in 20 people with WHIM syndrome, a rare genetic condition that causes frequent infections and warts. Participants received each drug for a year and tracked their infections. The goal was to see which drug better reduced infection…

This completed study tested two topical serums for treating toenail fungus (onychomycosis). 44 adults with mild to moderate infection applied one or both serums daily for 112 days. Researchers measured the change in healthy nail area using photos. The goal was to see if using bot…

This study tested whether a single dose of an oral drug called moxidectin can cure scabies, a skin condition caused by tiny mites. 200 adults with confirmed scabies received either 8 mg, 16 mg, or 32 mg of moxidectin or a placebo. The main goal was to see if the drug could comple…

This study tested a drug called sonelokimab, given as a shot under the skin, in 422 adults with moderate to severe hidradenitis suppurativa (a painful skin condition causing boils and abscesses). Participants were randomly assigned to receive either the drug or a placebo for up t…

This study tested a drug called sonelokimab in 418 adults with moderate to severe hidradenitis suppurativa, a skin condition that causes painful lumps and abscesses. Participants received either the drug or a placebo injection for 16 weeks. The goal was to see if sonelokimab redu…

This study tested a new clinic that sees emergency room patients the next day for conditions like pneumonia, heart failure, and kidney injury. The goal was to avoid hospital stays and improve patient care. About 570 adults took part, and researchers measured how many days they we…

This study tested two treatments for toenail fungus in 27 Asian adults: a light-activated dye (methylene blue photodynamic therapy) and a medicated nail polish (amorolfine). The goal was to see which worked better and was safer. Participants received either the light treatment or…

This study tested a light therapy device called ToeFX for mild to moderate toenail fungus. 126 people with fungal infection in one big toenail used the device. Researchers measured new clear nail growth after 12 months to see if the treatment worked and was safe.

This study looked at how well the shingles vaccine works and how safe it is for people living with HIV. Researchers compared the immune response based on participants' CD4+ T-cell counts and age. The goal was to provide evidence to help guide vaccination recommendations for this …

This study compared two ear drop treatments for otomycosis, a fungal infection of the outer ear that causes itching, discharge, and blockage. Sixty patients were randomly assigned to receive either clotrimazole or 2% salicylic acid drops three times daily for two weeks. The main …

This study tested whether an oral antibiotic (moxifloxacin) works as well as a standard intravenous (IV) antibiotic (cefazolin) for treating moderate skin infections (cellulitis) in the emergency department. 390 patients with moderate cellulitis were treated either with daily IV …

This study tested a single dose of the oral drug acoziborole in 35 children aged 1 to 14 with sleeping sickness (g-HAT). The goal was to see how the drug works in the body and if it is safe and effective. This simpler treatment could help control the disease in remote areas where…

This study tested a special gel, CGB-400, on 15 adults with toenail fungus. The goal was to see if the gel could clear the fungus and make the nails look better. Participants applied the gel for 12 weeks, with follow-up visits to check progress.

This study tested a new ankle training machine in 14 athletes with chronic ankle instability. The machine allows for multi-directional strengthening while sitting. Researchers compared it to standard resistance band training over six weeks, measuring muscle strength, balance, and…

This study tested whether cleaning the eyelids with wipes containing chlorhexidine can treat blepharitis caused by Demodex mites. 106 adults with the condition used the wipes twice daily for four weeks. Researchers measured mite counts and eyelash debris before and after treatmen…

This study tested two antifungal creams—oxiconazole and clotrimazole—against each other in 386 adults with jock itch (tinea cruris). The goal was to see which one better relieved itching and redness. Both creams are already used for fungal skin infections, so this trial aimed to …

This study tested whether adding isotretinoin (a retinoid that changes skin oil and growth) to the standard antifungal itraconazole works better than itraconazole alone for adults with resistant Trichophyton fungal skin infections. 148 adults aged 18-65 with confirmed infection w…

This study tested a new oral medication, oteseconazole, to see if it can prevent recurrent yeast infections in women who have had at least three infections in the past year. Over 400 participants took either the study drug or a placebo for 12 weeks after an initial treatment, and…

This study tested a new oral medication, oteseconazole, to see if it can prevent recurrent yeast infections in women who have had at least three infections in the past year. Participants first received standard treatment for their current infection, then took either oteseconazole…

This study tested a device that uses UVA and blue light to treat bacterial vaginosis and yeast infections. 38 women received one or two light treatments. Researchers checked if symptoms improved and if the vaginal microbiome became healthier. The goal is to find an alternative to…

This study tested whether an ultrasound-guided nerve block, using a steroid and local anesthetic, could better control pain from shingles and prevent postherpetic neuralgia (long-term nerve pain). 100 adults with acute shingles and moderate to severe pain were randomly assigned t…

This study tested three ways to treat warts: a topical acid solution, injections of candida antigen (a yeast extract), and a combination of both. 126 people with warts took part. The goal was to see which approach cleared warts best, including warts not directly treated, and how …

This study tested two different injections for treating skin warts caused by HPV. One group received a mix of furosemide and digoxin (drugs usually used for heart conditions), while the other got polidocanol, a standard treatment. Researchers tracked how well each cleared the war…

This study tested two common treatments for fungal ear infections: boric acid and povidone iodine. Sixty patients were treated with one of the two solutions applied directly to the ear canal. The goal was to see which one clears the infection better and reduces symptoms like pain…

This study tested a new way to do lung cancer surgery without using a breathing tube or ventilator. Instead, patients breathe on their own during the operation. The goal was to see if this 'tubeless' method causes less lung injury, helps patients recover faster, and reduces pollu…

This study tested the safety and effectiveness of oral ivermectin for treating scabies in children weighing 5 to less than 15 kilograms. 240 children participated, receiving either ivermectin, a standard permethrin cream, or a placebo. The goal is to see if ivermectin can be a sa…

This completed Phase 2 trial tested oral ivermectin minitablets in 13 children aged 3 months and older weighing 5 to less than 15 kilograms who had scabies. The study aimed to check the safety, how the drug works in the body, and how well it treats the infection. Results will hel…

This study compared two common antibiotics, doxycycline and TMP-SMX, for treating uncomplicated skin infections like boils and cellulitis. 269 people aged 9 to 85 took one of the drugs for 7 days. Researchers checked if the infection cleared up early, at the end of treatment, and…

This study tested a single dose of the antibiotic oritavancin in 118 children aged 3 months to 12 years with acute bacterial skin infections. The goal was to see if it is safe and tolerable. Researchers also looked at how the drug works in the body and whether it cures the infect…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested a vaginal pessary (Gedea) in 26 women with yeast infections. Participants used the device daily for 6 days. Researchers checked if symptoms like itching and burning went away by day 7 to 14. The goal was to see if the device could safely treat the infection with…

This study tested an eyedrop called TP-03 in 39 people with meibomian gland dysfunction (a common cause of dry eye) linked to Demodex mites. The goal was to compare two dosing schedules (twice vs. three times daily) for safety and effectiveness. The results could lead to a new tr…

This small pilot study tested whether injecting the Gardasil 9 HPV vaccine directly into genital warts could reduce their size and number. Only 2 adults with at least 3 warts each took part. The goal was to see if this approach is safe and worth studying further.

This study tested whether injections of Candin, a yeast extract, can clear common warts better than a placebo. 330 people aged 12 and older with 3 to 20 warts received injections every two weeks until their wart disappeared. The goal was to see if Candin leads to complete wart cl…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study is adapting and testing a French version of the Athletic Disordered Eating (ADE) scale, a 17-question screening tool designed specifically for athletes. Researchers will enroll 229 athletes aged 15 to 70 who exercise more than 6 hours per week. Participants complete th…

This study tested whether a rapid point-of-care test (Xpert® Xpress MVP) helps doctors diagnose vaginal infections more accurately than usual methods. 351 women with symptoms like discharge or itching were randomly assigned to either usual care or the rapid test. Researchers then…

This completed study tested whether an AI device could help 16 doctors (10 general practitioners and 6 dermatologists) more accurately diagnose 13 different skin conditions, including melanoma, psoriasis, and acne. The doctors reviewed 29 medical images, first giving a diagnosis …

This study evaluated a new rapid test called CL Detect™ for diagnosing cutaneous leishmaniasis, a skin infection caused by parasites. Researchers tested 150 adults with skin ulcers to see how well the rapid test works compared to the standard method of looking at samples under a …

This completed study tested a new rapid diagnostic tool to quickly identify antibiotic-resistant bacteria in wounded warriors and veterans. Over 2,200 participants provided samples from blood, lungs, or skin. The goal was to see if the test could accurately detect resistant bacte…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study looked at 120 people with suspected fungal skin infections (like athlete's foot or nail fungus). Researchers compared two different PCR test kits to see how well they could detect the fungus compared to standard lab methods. The goal was to find a faster and more relia…

This study tested whether combining personal hygiene (using medicated washes and ointments) with household cleaning can prevent MRSA skin infections. Over 800 people from households with a recent MRSA infection took part. The goal was to see if this combined approach reduces the …

This study tested whether applying medical-grade honey after bone-anchored hearing aid surgery could prevent skin breakdown better than the usual bacitracin ointment. Seventeen adults were randomly assigned to receive either honey or bacitracin for two weeks after surgery. Resear…

This study tested whether giving mothers a single 2-gram dose of the antibiotic azithromycin during labour could reduce the risk of skin and soft tissue infections in their babies during the first three months of life. Over 2,000 pregnant women in Fiji took part, receiving either…

This study tests whether ALIDYA, a gel injected into the skin, can improve the appearance of cellulite on the back of the thighs. Thirty women aged 20 to 45 with mild to moderate cellulite received six weekly treatments. Researchers used photos, ultrasound, and other imaging to m…

This completed Phase 4 study tested multiple doses of Qwo, a drug made from bacterial enzymes, for treating mild to moderate cellulite in adult women. Five participants received injections in their buttocks and thighs over three sessions. The goal was to see if the treatment impr…

This study tested a device called AVELI to safely reduce cellulite and fibrous tissue in 130 people undergoing body contouring surgery. Researchers measured safety, patient satisfaction, and appearance improvements over 9 months. The goal was to see if adding AVELI to standard li…

This study tested whether caffeine helps elite weightlifters perform better in competition. Fourteen athletes took either caffeine or a placebo before a simulated weightlifting meet. The results suggest caffeine can provide a small performance boost, but the effect is modest and …

This study tests whether biofield therapy, a type of energy healing or magnetism, can make common warts on hands and feet disappear. Sixty-two adults with warts for at least 3 months will be randomly assigned to receive either real biofield therapy from a recognized healer or fak…

This study looked at whether taking sodium bicarbonate (baking soda) before exercise helps well-trained cyclists perform better during a long, intense ride. Nineteen athletes did two lab sessions: three hours of moderate cycling followed by a max-effort time trial. They took eith…

This study compared two types of nerve blocks (serratus anterior plane block and serratus posterior superior intercostal plane block) for pain after video-assisted lung surgery. 60 adults aged 18-65 were enrolled. Researchers measured pain levels and patient satisfaction to see w…

This study tested a treatment called Complex Decongestive Therapy (CDT) for people with venous insufficiency, a condition where leg veins struggle to send blood back to the heart. Twenty-one adults received either CDT plus exercises or exercises alone. The goal was to see if CDT …

This pilot study tested whether kinesio taping, applied weekly for four weeks, can improve skin structure and reduce stage II cellulite in women aged 18-45 with normal BMI. Researchers compared a group receiving the tape on thighs and buttocks to a no-treatment control group. The…

This study tested a device that uses tiny needles and radiofrequency energy to treat cellulite on the legs. 48 women received the treatment to reduce the appearance of dimples and improve skin tightness. The goal was to see if the treatment is safe and effective for smoothing ski…

This study tested a medicated patch containing 40% salicylic acid to treat common and plantar warts. Thirty people aged 6 and older used the patch for up to 21 days. The goal was to see if the patch safely shrinks or removes warts by softening and peeling off the affected skin.

This study looked at whether doing drop jumps during warm-up helps young basketball players jump higher, sprint faster, and land more stably. Twenty-two athletes were split into two groups: one added drop jumps to their warm-up for 8 weeks, the other did not. Researchers measured…

This study looked at whether adding strength training to regular cycling workouts helps competitive cyclists improve performance and muscle function. Twenty-four male cyclists either did strength training plus endurance training or just endurance training for 10 weeks. Researcher…

This study looked at how patients recover right after two different types of chest surgery: open surgery (thoracotomy) and keyhole surgery (VATS). Researchers measured fear of movement, pain, breathing difficulty, fatigue, and anxiety in 18 adults before they left the hospital. T…

This completed study looked at scalp ringworm, a common fungal infection in children, across 11 French centers in 2023. Researchers collected 701 fungal samples to identify the species and test their sensitivity to common antifungal drugs. The goal was to understand which fungi c…

This study tested whether 40 sessions of hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) could improve aerobic and anaerobic fitness in healthy athletes. 59 participants, aged 18-25 or 40-50, underwent either real or sham treatment over two months. Rese…

This study looked at 60 adults having lung surgery (VATS) to see how three different anesthesia methods affect stress markers in the blood. The goal was to measure changes in oxidative stress, not to treat a disease. Results may help doctors choose the best anesthesia for future …

This study looked at 134 competitive runners to see if advanced footwear technology (AFT) — the springy, carbon-fiber shoes many elite athletes wear — is linked to more muscle and tendon injuries. Researchers surveyed athletes about their training habits and injury history over t…

This completed study looked at hand and wrist injuries in professional hockey players in the Swedish Hockey League over three seasons. Researchers analyzed injury data from about 2,300 games to understand what types of injuries happen, when they occur, and which players are most …

This study tested whether thermal imaging (a camera that measures body heat) can reliably assess injury risk in volleyball players. Researchers compared thermal images with standard performance tests like vertical jumps and balance assessments in 33 amateur and professional playe…

This study looked at whether having a dermatologist review a patient's skin condition remotely (teledermatology) could help emergency room doctors correctly identify true cellulitis (a bacterial skin infection) versus pseudocellulitis (a condition that looks like cellulitis but i…

This study tested whether full-body suits made with far-infrared (FIR) emitting fibers affect body temperature, heart rate, oxygen use, and power output in young competitive cyclists. Nine cyclists rode a stationary bike for 40 minutes at a steady pace, then did a 5-second sprint…

Cellulitis is a painful skin infection that often requires antibiotics, but the ideal treatment length is unknown. This study followed 230 adults hospitalized with cellulitis to identify factors that predict a good recovery, such as medical history and early response to treatment…

This completed Italian study looked at over 1,300 people with scabies to see how often the first treatment cured them. Researchers also tracked how many scabies cases occurred over three years and analyzed patterns by age and ethnicity. The study did not test a new drug but colle…

This study compared High-Intensity Interval Training (HIIT) and Medium-Intensity Interval Training (MIIT) in 36 athletes aged 20-30. Participants trained three times a week for six weeks. Researchers measured changes in heart-lung fitness, strength, and agility to see which metho…

This study tested whether an artificial intelligence (AI) tool could help doctors diagnose rare and tricky skin conditions like generalized pustular psoriasis (GPP). Fifteen doctors, including both general practitioners and dermatologists, looked at 100 skin images. They first ga…

This study looked at health records of nearly 69,000 adults aged 40 and older to see if those who develop lasting nerve pain after shingles (postherpetic neuralgia) have a higher chance of getting dementia later. Researchers compared people with and without this nerve pain, match…

This pilot study tested whether it is possible to collect and analyze small RNA molecules from a person's breath. Researchers took breath samples from 25 volunteers (healthy people and a few with lung disease) at rest and after intense exercise. They successfully extracted and se…

This study tested whether wearing special stroboscopic glasses during volleyball drills could improve how players' brains and bodies react. 42 female volleyball players aged 10-16, from beginners to elite, took part. They did 8 weeks of extra drills with or without the glasses. R…

This completed study looked at how much anxiety people feel about artificial intelligence, comparing athletes (who exercise regularly) with sedentary individuals (who don't). Over 660 participants filled out a questionnaire measuring their AI-related worries. The goal was to see …

This study looked at whether lower-body plyometric training changes levels of certain muscle damage markers in the blood of female college volleyball players. Sixty players were split into two groups: one did plyometric exercises twice a week for 8 weeks, while the other stuck to…

This study looked at whether having a dermatologist see patients within 24 hours of being admitted to the hospital for cellulitis (a skin infection) could improve their care. Researchers compared patients who got a dermatology consult to those who only saw their regular hospital …

This study tested an artificial intelligence algorithm designed to help primary care doctors decide whether a patient with a skin condition really needs to see a dermatologist. Researchers enrolled 200 adults with skin problems and had their doctors take photos of the affected ar…

This study looked at whether adding more legumes (like beans, lentils, and chickpeas) to a Mediterranean diet could improve hydration, heart rate balance, and swimming performance in competitive swimmers. Thirty-nine adolescent and young adult swimmers were split into groups base…

This study looked at how a 10-week complex training program—mixing heavy weights with explosive jumps—affects the physical fitness, balance, and shooting of Chinese national korfball players. Twenty-four athletes completed the program, and researchers measured changes in strength…

This pilot study gave 20 professional football players either a single high dose of vitamin D or a placebo before a match. Researchers measured how vitamin D levels changed in their blood. The goal was to see how exercise affects vitamin D metabolism, not to treat any disease.

This study looked at 114 healthy adults (athletes and non-athletes) to see if core muscle endurance is linked to pelvic width and movement. Participants did simple holding exercises like wall sits and planks while researchers measured their pelvis. The goal was to understand how …

This study looked at how many medical students have immunity against hepatitis B and varicella-zoster (chickenpox) viruses. Researchers tested 401 students to see their protection levels and vaccination rates. The goal was to understand if current immunization programs are workin…

This study examined 86 professional e-athletes aged 18-35 to understand what factors are linked to pain, fatigue, and poor sleep quality. Researchers assessed pain severity, fatigue levels, sleep quality, and physical activity. The goal is to identify health risks in esports and …

This study looked at 151 adults with shingles to find clues that might predict who will develop lasting nerve pain (postherpetic neuralgia). Researchers collected blood samples and health information at the start and checked for pain three months later. The goal was to create a r…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This study looked at how different music volumes affect balance in athletes. 48 healthy athletes listened to soft, medium, and loud music while standing on a virtual reality balance system. The goal was to see if sound intensity changes how well they can keep steady.

This study translated an English questionnaire into Turkish to help athletes with low back pain measure how their pain affects sports and daily activities. 120 Turkish athletes with low back pain filled out three questionnaires. The goal was to make sure the Turkish version is ac…

This study followed 198 runners in the 2015 Ultra-Trail Mont-Blanc to see if drinking only when thirsty ("at thirst") keeps blood sodium levels more stable compared to other drinking plans. The goal is to understand how hydration affects health during extreme endurance events. Re…

This study looked at whether a four-week mental training program could help athletes feel more motivated to achieve their goals. Fifty licensed athletes took part, with half receiving the training and half not. The training included techniques like goal setting, positive self-tal…

This study looked at 30 people with shingles (herpes zoster) to measure levels of inflammatory proteins and nerve-related chemicals in their blood. Researchers wanted to understand how these substances change over time and relate to pain. The study did not test any new treatment,…

This study followed 603 pregnant women in South Africa to see if infections or bacteria in the vagina are linked to how early they give birth. Researchers tested for sexually transmitted infections, yeast, and other germs at the start of pregnancy and again at 30-34 weeks. The go…

This completed trial with 66 participants compared two methods for marking small lung nodules before minimally invasive surgery: navigational bronchoscopy using a green dye (ICG) and CT-guided radioisotope injection. The goal was to see which method helps surgeons find and remove…