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One pill to cure sleeping sickness? new trial raises hopes

NCT ID NCT03087955

Completed ⭐️ CURE ⭐️ Sponsor: Drugs for Neglected Diseases Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested a single oral dose of acoziborole in 208 adults with sleeping sickness, a deadly parasitic disease. Participants took three tablets once and were monitored for 18 months. The goal was to see if this simple treatment could cure both early and late stages of the disease, potentially replacing difficult injections.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
acoziborole (a single-dose oral pill)
What this could lead to
If successful, this could provide a simple, one-time oral cure for sleeping sickness, replacing current complex treatments.
What could go wrong
This is a combined Phase 2/3 trial, so results are promising but not yet confirmed in larger populations. Relapse or side effects remain possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

human African trypanosomiasis infection by Trypanosoma gambiense trypanosomiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GAMBIENSE TRYPANOSOMIASIS SLEEPING SICKNESS TRYPANOSOMIASIS, AFRICAN

Contacts and locations

Locations

  • Centre de Traitement de Kimpese

    Kimpese, Bas-Congo Province, Democratic Republic of the Congo

  • Centre de Traitement de Nkara

    Nkara, Bandundu, Democratic Republic of the Congo

  • Centre de Traitement de la THA de Dubreka

    Dubréka, Dubreka, Guinea

  • Hopital Général de Réference de Bandundu

    Bandundu Province, Democratic Republic of the Congo

  • Hôpital Général de Référence Roi Baudouin

    Kinshasa, Democratic Republic of the Congo

  • Hôpital Général de Référence de Bagata

    Bagata, Kwilu, Democratic Republic of the Congo

  • Hôpital Général de Référence de Kwamouth

    Kwamouth, Mai Ndombe, Democratic Republic of the Congo

  • Hôpital Général de Référence de Masi-Manimba

    Masi-Manimba, Kwilu, Democratic Republic of the Congo

  • Hôpital Général de Référence de Ngandajika

    Gandajika, East Kasai, Democratic Republic of the Congo

  • Hôpital Secondaire de Katanda

    Katanda, East Kasai, Democratic Republic of the Congo

  • Hôpital de Dipumba

    Mbuji-Mayi, East Kasai, Democratic Republic of the Congo

  • Hôpital de Référence d'Isangi

    Isangi, Democratic Republic of the Congo

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