Precancerous condition

This phase III trial tests whether adding pembrolizumab (Keytruda) after standard chemotherapy can help prevent triple-negative breast cancer from coming back. Over 1,100 patients with residual cancer after chemo are randomly assigned to receive pembrolizumab or placebo. The stud…

This phase III trial compares low-dose tamoxifen to standard hormone therapy (aromatase inhibitors) in postmenopausal women with low-risk, hormone-positive, HER2-negative early breast cancer. The goal is to see if the lower dose works just as well to prevent cancer from coming ba…

This large phase 3 trial studied over 5,000 women with hormone receptor-positive, HER2-negative breast cancer that had spread to 1-3 lymph nodes. Participants received standard hormone therapy (tamoxifen or an aromatase inhibitor) either alone or with chemotherapy. The goal was t…

This phase 2 trial tests whether giving radiation once a day for five days (instead of every other day) can keep the breast looking good after treatment. It includes 48 women aged 40 or older with low-risk, hormone-sensitive breast cancer. The goal is to see if this shorter sched…

This phase 3 trial is testing a drug called ONCOFID-P-B for people with a type of bladder cancer that hasn't responded to standard BCG therapy. The drug is given directly into the bladder weekly for 12 weeks, then monthly for a year if it works. The goal is to see if it can contr…

This phase II trial tests whether adding the hormone-blocking drug relugolix to standard radiation therapy can slow cancer growth in men with prostate cancer that has spread to a few other spots in the body (oligometastatic). About 194 participants will receive either radiation a…

This Phase 2 trial is testing whether linaclotide, a drug currently used for constipation, can slow or prevent colorectal cancer growth. About 150 people with colorectal polyps or early-stage cancer will take the drug or a placebo before surgery. Researchers will measure changes …

This trial tests a sticky patch that releases fenretinide, a vitamin A derivative, directly onto precancerous spots inside the mouth. The goal is to see if the patch can shrink these lesions, reduce their severity under the microscope, and lower genetic changes linked to oral can…

This study tests whether a vitamin D-based gel (calcipotriol) or a light-activated treatment (photodynamic therapy) can shrink or eliminate oral leukoplakia, a precancerous condition. Thirty adults with mild to moderate dysplasia will receive one of the two treatments for four we…

This study tests whether losartan, a drug already used for high blood pressure, can reduce scarring (fibrosis) caused by radiation therapy in breast cancer patients. 43 women who had breast surgery and need radiation will receive either losartan or a placebo. Researchers will mea…

This study tests a shorter course of radiation (hypofractionated) to the breast and nearby lymph nodes in 137 women with node-positive breast cancer. The goal is to see if this approach reduces arm swelling (lymphedema) and other side effects while still preventing cancer from co…

This early-phase trial tests whether injecting the cancer drug nivolumab directly into high-risk precancerous mouth lesions is safe and can shrink them. The study involves 18 adults with untreated oral lesions. The goal is to see if this local approach can reduce the risk of thes…

This study tests a freezing device (CryoBalloon) to treat Barrett's esophagus that hasn't improved after multiple standard heat treatments. About 70 adults with precancerous changes in the esophagus will receive the freezing therapy. The goal is to safely remove all abnormal tiss…

This study tests two experimental treatments—TAR-200 (a drug placed inside the bladder) and cetrelimab (an immunotherapy injection)—alone or together, in people with high-risk bladder cancer that came back after BCG therapy. Participants are those who cannot or choose not to have…

This study is testing a new robotic system, the Medtronic Hugo™, for performing hysterectomies. It includes 70 patients with conditions like uterine fibroids, endometriosis, or certain cancers. The goal is to see if the robot is safe and can complete the surgery without switching…

This study tests a stem cell transplant from a matched unrelated donor for people with advanced blood cancers or blood disorders. Patients get chemotherapy and radiation before the transplant to prepare their body, then take drugs to prevent the donor cells from attacking their o…

This phase II trial tests whether giving the immunotherapy drug cemiplimab before surgery can shrink high-risk skin cancers that have not spread far. The study enrolls 35 people with resectable squamous cell carcinoma. Participants receive cemiplimab intravenously, then undergo s…

This study tests a gel (Ameluz®) plus red light therapy for actinic keratosis, rough precancerous patches on skin. It includes 172 adults with 4-15 spots on arms, legs, neck, or trunk. The goal is to see if the treatment clears these spots better than a placebo gel.

This study tests whether a shorter, more focused radiation treatment (accelerated partial breast irradiation) after breast-conserving surgery can effectively control cancer in the breast and nearby lymph nodes for people with early-stage breast cancer. About 537 participants with…

This phase II trial is testing whether adding the immunotherapy drug pembrolizumab to the chemotherapy drug gemcitabine can help patients with a type of bladder cancer that does not respond to the usual BCG treatment. The study involves 161 participants and looks at how many pati…

This study compares active monitoring (regular checkups without immediate treatment) to surgery for people with low-risk ductal carcinoma in situ (DCIS), a very early form of breast cancer. About 1,000 participants are being followed for two years to see if monitoring is as good …

This study tracks 100 people with pancreatic cysts or tumors who receive a treatment called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA). A thin needle delivers heat directly to the lesion to destroy it. Researchers will monitor how well the procedure works and …

This phase 3 trial compares a standard 3-week radiation course to an experimental 2-week course for women with early-stage breast cancer. About 400 participants who had lumpectomy will receive whole breast radiation plus an extra boost to the tumor site. The study checks if the s…

This study tests a modified radiation schedule for women aged 50 and older with early-stage, low-risk breast cancer. Instead of the standard every-other-day treatment over 10 days, participants receive five daily radiation sessions with a slightly lower dose each day. The goal is…

This early-phase trial is testing a gel form of the drug endoxifen, applied to the skin, in 32 women scheduled for breast surgery. The goal is to see if the gel is safe and how much of the drug gets into breast tissue and blood. If successful, it might offer a gentler way to trea…

This study tests whether a single, focused radiation treatment works as well as five treatments for people with low-risk stage 0 or I breast cancer after a lumpectomy. About 134 participants will be randomly assigned to receive either one or five doses of radiation to the tumor a…

This phase II trial is testing a type of radiation called proton beam therapy for women with early-stage breast cancer (stage 0 to II). The goal is to see if this targeted approach can kill cancer cells while causing less damage to normal tissue, leading to fewer side effects and…

This pilot study tests whether giving a combination of two immunotherapy drugs (nivolumab and ipilimumab) along with chemotherapy and radiation therapy before surgery can help treat stomach cancer that can be surgically removed. The study includes 32 participants and primarily lo…

This phase III trial is testing whether a different strain of BCG (Tokyo-172) works better than the standard TICE strain for high-grade bladder cancer that hasn't spread into muscle. It also looks at whether giving a BCG vaccine under the skin before the usual bladder treatment h…

This study compares a 1-week radiation schedule to the standard 3.1-week schedule for people with early-stage breast cancer who have had lumpectomy. The goal is to see if the shorter course controls cancer just as well while causing fewer side effects. About 72 adults with ductal…

This study is testing whether shorter, more focused radiation treatments after lumpectomy are as safe and effective as the standard six-and-a-half-week course. About 121 women with early-stage breast cancer are receiving one of several accelerated radiation methods, including a s…

This study tests a stem cell transplant using donors who are not a perfect match for patients with blood cancers like leukemia and lymphoma. Doctors give special drugs after the transplant to help prevent the donor cells from attacking the patient's body. The goal is to see if th…

This phase II trial tests a single, high-dose radiation treatment given before surgery for early-stage breast cancer. The goal is to see if this approach leads to good or excellent cosmetic results and reduces the need for multiple radiation sessions. About 110 women with small, …

This phase 3 trial is testing a new treatment called cretostimogene grenadenorepvec for people with a type of bladder cancer (non-muscle invasive) that did not improve after standard BCG therapy. The treatment uses a modified virus to target and destroy cancer cells. About 190 pa…

This early-phase trial tests whether adding a single, focused dose of radiation before surgery can make the immunotherapy drug pembrolizumab work better in people with early-stage breast cancer. About 27 participants will receive both treatments, then have surgery to see if the t…

This study tests whether an inactivated Pseudomonas aeruginosa injection, combined with an iodine wash, can reduce complications like infection and capsular contracture in women undergoing immediate breast reconstruction with implants after cancer surgery. The trial involves 100 …

This study tests whether a shorter, higher-dose radiation schedule (hypofractionation with a concurrent boost) works as well as the standard longer schedule for women with early-stage breast cancer after lumpectomy. Over 2,300 women participated. The goal is to see if the shorter…

This study tests a shorter, more focused radiation treatment (hypofractionated partial breast irradiation) for women with early-stage breast cancer. The goal is to see if targeting only the tumor site can reduce side effects and improve cosmetic outcomes compared to standard whol…

This study looks at women with a very early form of breast cancer called ductal carcinoma in situ (DCIS). After surgery to remove the cancer, all women get radiation to the whole breast. Half also get an extra, stronger dose of radiation right where the cancer was. The goal is to…

This study tests whether a lower dose of the drug cyclophosphamide, given after a stem cell transplant from a partially matched donor, can reduce serious infections in the first 100 days while still preventing graft-versus-host disease (a common complication where donor cells att…

This study tests a precise type of radiation called proton therapy for people with early-stage breast cancer. The goal is to see if it can control the cancer and reduce side effects compared to standard radiation. About 150 adults aged 40 and older who had a lumpectomy are taking…

This study tests a one-time radiation treatment for early-stage breast cancer. After a lumpectomy, tiny radioactive seeds are placed directly into the breast to kill any remaining cancer cells. The goal is to see if this method is safe, works well, and costs less than standard da…

This early-phase trial aimed to test whether curcumin (the active compound in turmeric) could safely help treat cervical precancer (CIN3). It planned to give 500 mg of curcumin twice daily for 12 weeks to women with CIN3. However, the study was withdrawn before enrolling any part…

This study is testing whether women with a very early, low-risk form of breast cancer called DCIS can safely avoid standard treatments like surgery and radiation. Instead, they would simply get a yearly mammogram to monitor the condition. The goal is to see if this 'active survei…

This study looks at whether women aged 50 and older with a very low-risk type of early breast cancer (called DCIS) can avoid radiation therapy after having breast-conserving surgery. The goal is to see if the cancer stays away without radiation, reducing unnecessary treatment and…

This study compares two types of radiation therapy for women with early-stage breast cancer after lumpectomy. One group receives standard CT-guided radiation, while the other receives a newer MRI-guided approach. The goal is to see if MRI-guided radiation works just as well at pr…

This study tests whether giving an extra dose of radiation (a boost) before breast cancer surgery is safe and helpful. About 103 people with early-stage breast cancer that hasn't spread will receive the boost, then standard radiation and surgery. The goal is to see if this approa…

This phase IIb trial is testing whether combining a nightly fast (time-restricted eating) with the diabetes drug metformin can slow the growth of breast cancer cells before surgery. The study includes 120 women with early-stage breast cancer or a precancerous condition called DCI…

This pilot study tested whether a robot-assisted surgical technique (using the daVinci system) can safely remove breast tissue while sparing the nipple in people with early-stage breast cancer or those needing preventive mastectomy. Only 4 participants were enrolled, and the stud…

This study tests whether the drug nivolumab (Opdivo) can reverse early, pre-cancerous changes in the lungs of current or former heavy smokers who are at high risk for lung cancer. Nineteen participants receive nivolumab to see if their lung tissue improves over six months. The go…

This study tests whether giving two drugs (trastuzumab and a taxane) before surgery can shrink HER2-positive breast carcinoma in situ tumors enough to allow breast-conserving surgery instead of mastectomy. About 54 women aged 18-70 with tumors at least 2 cm will receive 4-6 cycle…

This study tests whether giving a short course of radiation to part of the breast before surgery is safe and practical for women with early-stage breast cancer. About 98 women over age 50 with small, hormone-sensitive tumors will receive radiation, then have surgery. Researchers …

This study tests a shorter radiation treatment (partial breast irradiation) for women with early-stage breast cancer or a pre-cancer called DCIS. Instead of treating the whole breast for 5-7 weeks, radiation is given only to the area where the tumor was removed, for just 2 weeks.…

This study compares different HPV tests to find the best way to screen for cervical cancer in women living with HIV in Latin America. Over 1,000 participants will provide cervical, vaginal, and urine samples, plus undergo colposcopy and biopsies. The goal is to identify which tes…

This study aims to create a diagnostic test that can tell the difference between precancerous skin lesions (actinic keratoses) that will turn into skin cancer and those that will go away on their own. Researchers will study tissue samples from 140 patients with skin cancer and pr…

This study looks at whether artificial intelligence can accurately determine the depth of early esophageal cancer from endoscopic images. Researchers will review past records and images from 890 patients who had their tumors removed. The goal is to see if AI can help doctors deci…

This study tests whether special imaging devices can better detect pre-cancerous or cancerous spots in the mouth compared to a standard visual exam. About 63 adults with suspicious mouth lesions or a history of oral cancer will be followed over time. The goal is to see if these a…

This study compares two ways to check for returning cervical pre-cancer after treatment: the standard colposcopy exam versus a high-risk HPV DNA test. Over 2,200 women who were treated for high-grade cervical lesions will be randomly assigned to one of the two follow-up methods. …

This study tests whether special lights and cameras can help find early signs of mouth cancer in people at high risk. About 338 participants with precancerous spots or conditions like Fanconi anemia will have their mouths examined with fluorescence imaging, which makes abnormal c…

This study was designed to compare the standard Pap smear with a new blood test that looks for three proteins linked to cervical cell changes. It planned to include adults aged 18-85 in good health. However, the study was withdrawn before enrolling any participants, so no results…

This study looks at which tests work best to find early signs of HPV-related cancer in the cervix or anus of people living with HIV. About 1,586 participants from Mexico and Puerto Rico will be tested using different methods, including HPV tests and cell samples. The goal is to c…

This study looks at whether combining mammograms with breast MRIs can find breast cancer earlier in women at high risk, such as those with BRCA gene mutations. About 305 participants will get both scans yearly, and researchers will track how well they detect cancer and how the sc…

This large study is testing whether a new laser-based blood test can help screen for breast cancer. Researchers will compare blood samples from women with and without breast cancer to see if the test can accurately spot the disease. If it works, it could offer a less invasive way…

This phase 2 trial tests whether metformin, a widely used diabetes drug, can prevent oral cancer in 26 people with precancerous mouth lesions (leukoplakia or erythroplakia). Participants take metformin by mouth, and researchers check if the lesions shrink or disappear. The goal i…

This phase 3 trial tests whether taking metformin for 12 months can reduce abnormal cells in the breast tissue of women at high risk for breast cancer. Participants have conditions like atypical hyperplasia or a strong family history. Researchers compare metformin to a placebo to…

This study tests whether curcumin, a compound found in turmeric, can prevent stomach cancer in people with chronic atrophic gastritis or gastric intestinal metaplasia. About 50 participants will receive either curcumin or a placebo for a period, and researchers will measure chang…

This study tests whether metformin, a common diabetes drug, can prevent oral cancer in people with precancerous white or red patches in the mouth. About 34 participants will receive either metformin or a placebo for several months. Researchers will check if the patches shrink or …

This pilot study looks at whether adding hunger training to a standard diabetes prevention program helps obese women at high risk for breast cancer lose weight and lower their cancer risk. About 51 participants will learn weight-loss strategies and how to recognize true hunger. T…

This study tests whether a combination of two creams—calcipotriene (a vitamin D cream) and 5-fluorouracil (a chemotherapy cream)—can prevent skin cancer in organ transplant recipients. These patients are at high risk for skin cancer, especially from precancerous spots called acti…

This study tests whether adding a photo guide to standard counseling helps reduce anxiety and depression in women with early-stage breast cancer who are about to start radiation therapy. About 62 participants will either receive standard verbal counseling alone or with a pictoria…

This study tests whether a shorter course of higher-dose radiation (hypofractionated) is as good as or better than standard radiation for early-stage breast cancer. About 300 women with ductal carcinoma in situ or early invasive breast cancer are participating. The main goal is t…

This study looks at whether hypnosis can help women with early-stage breast cancer relax during surgery, possibly reducing the need for general anesthesia. About 50 women will try hypnosedation, a technique that uses words and images to keep them calm and awake while numb. The go…

This phase II trial tests an enhanced recovery after surgery (ERAS) protocol in 52 people with stage 0 to IIIC gastric cancer who are having surgery. The goal is to see if this approach can reduce pain, nausea, and hospital stays while improving quality of life. Participants rece…

This study tests a web-based portal called YES (Young, Empowered & Strong) designed to help adolescent and young adult breast cancer survivors monitor and manage their symptoms. Researchers will compare the quality of life of 400 women who use the portal to those receiving standa…

This study compares two creams, Aquaphor and Miaderm, to see which one better treats skin irritation caused by radiation therapy in breast cancer patients. About 208 women with early-stage breast cancer will use one of the creams during their radiation treatment. The goal is to f…

This study looks at whether a culturally tailored writing program can improve the well-being of Chinese immigrant women who had breast cancer (stages 0 to III). About 256 women who finished their main cancer treatment in the last 5 years will write about their experiences. The go…

This study compares two treatments for actinic keratosis, rough skin spots caused by sun exposure. About 73 adults with at least 10 spots on their head, neck, or limbs will receive both cryotherapy (freezing) and a 5-FU cream on different body areas. Researchers will track which …

This study follows up to 1,000 adults who previously received gene therapy in a National Cancer Institute study. Researchers will contact participants yearly for up to 15 years to check for any long-term side effects, such as new cancers or nerve problems. No new treatments are g…

This study collects blood and tissue samples from 1,000 adults with Barrett's esophagus or esophageal cancer during their routine endoscopy. The goal is to build a biorepository that links clinical data with specimens, enabling future research into these conditions. Participants …

This study is testing whether an artificial intelligence (AI) model can help doctors better detect, diagnose, and treat esophageal cancer. Researchers will feed de-identified data from 12,000 patients receiving routine care into the AI and compare its recommendations to standard …

This study looks at how different breast cancer treatment decisions, like choosing between a lumpectomy or mastectomy, affect women's quality of life and emotional distress. Researchers followed 345 women with early-stage breast cancer and their partners to measure cancer-related…

This study looks at how doctors currently diagnose lung and breast cancer using tissue samples. It will also test whether artificial intelligence (AI) can help analyze these samples faster and more accurately. Researchers will review records from 600 patients to measure diagnosis…

This study follows 500 people who had a malignant colorectal polyp removed. Researchers want to learn how often the cancer stays, comes back, or spreads. They will also study how patients and doctors decide on next steps after removal. Participants share medical records and get f…

This study collects tissue and blood samples from 1,200 adults with known or suspected cancer. The samples are taken during standard surgeries or biopsies, with no extra procedures. Researchers will compare cancerous and normal tissues to identify differences that could lead to n…

This study is a registry that tracks side effects and outcomes in people who have undergone cryoablation (freezing) for early stage breast cancer. It is not testing a new treatment but rather collecting real-world data on symptoms, complications, and follow-up results. Only 2 par…

This study examines how genetic variations (SNPs) in certain genes influence how well the drug raloxifene works and its side effects in 600 patients with lobular carcinoma in situ (LCIS), a high-risk breast condition. Participants take raloxifene daily, and researchers sequence t…

This study follows 204 people with bladder cancer to see how their quality of life changes after treatment like surgery or radiation. Participants fill out surveys about physical function, pain, fatigue, anxiety, and bladder, bowel, and sexual health. The goal is to understand ho…

This study planned to give high doses of vitamin D to women with breast cancer before their surgery. Researchers wanted to see if the vitamin would change certain markers in the cancer cells. However, the study was withdrawn before any participants were enrolled, so no results ar…

This study looks at whether web-based decision support tools can help women with atypical hyperplasia or lobular carcinoma in situ (conditions that raise breast cancer risk) make informed choices about chemoprevention. About 412 women and their healthcare providers will use educa…

This study follows 1,500 women with ductal carcinoma in situ (DCIS), a very early form of breast cancer, who have had breast-conserving surgery. Researchers want to see if a genetic test called DCISionRT helps doctors decide whether to add radiation or hormone therapy after surge…

This study aimed to compare a less invasive procedure called vacuum-assisted excision (VAPE) to standard surgery for removing non-cancerous but high-risk breast lesions. The goal was to see if VAPE worked as well, was safer, and left better cosmetic results. However, the study wa…

This study tests a decision aid designed to help people with early-stage breast cancer become more involved in choosing their surgery. It focuses on patients who face financial or social challenges, to see if the tool helps them feel more confident and speak up during doctor visi…

This study looks at how patients feel physically and emotionally after having a breast biopsy for certain non-cancerous but atypical breast conditions. Over 900 participants from several hospitals answered surveys about pain and quality of life, on average nearly four years after…

This study looks at whether advanced breast MRI can tell the difference between harmless and dangerous breast calcifications, which are often a sign of very early-stage breast cancer called DCIS. About 122 women with suspicious calcifications or recent DCIS diagnosis will get an …

This study gathers information from multiple hospitals about breast cancer in transgender and gender-diverse adults. Researchers want to understand how the cancer is found, what risk factors are involved, and how it is treated. The goal is to find ways to improve care and reduce …

This study collects blood, tissue, and saliva samples from 7,000 people—both those with breast cancer and healthy volunteers. Researchers at Memorial Sloan Kettering will use these samples to study what causes breast cancer and find better ways to prevent, detect, and treat it. N…

This study looks at how normal breast tissue appears on MRI and mammogram to see if it can help predict breast cancer risk. Researchers are comparing images and health information from over 2,000 women, including those with and without breast cancer. The goal is to better underst…

This study looks at whether combining MRI scans with genetic testing can help doctors choose the best treatment for people with ductal carcinoma in situ (DCIS), a very early form of breast cancer that hasn't spread. About 368 participants will have an MRI and a genetic test on th…

This study looks at vitamin A levels in 90 adults with vocal fold leukoplakia, a condition that causes white patches on the vocal cords. Researchers want to see if vitamin A status differs between people with and without precancerous changes. Participants provide blood and tissue…

This study looks at 800 people with a type of breast cancer called lobular breast cancer. Researchers are searching for inherited gene changes that may raise cancer risk. Depending on the gene found, patients may get closer monitoring or preventive surgery. The goal is to tailor …

This study follows 1,000 people with stomach pre-cancer conditions like chronic gastritis and intestinal metaplasia. Researchers will track disease progression over time and analyze biospecimens to find biomarkers linked to cancer development. The goal is to better understand who…

This study searches for new gene changes (mutations) that appear in cancer patients but not in their healthy parents. By comparing DNA from 1,275 people with certain cancers and their families, researchers hope to find genetic clues that increase cancer risk. The goal is to bette…

This study looks at how well a medicated gel (afimoxifene) is absorbed through the skin of the breast in women who have had radiation for breast cancer. Researchers want to understand if differences in skin type or past radiation change how much gel gets into the breast tissue. T…

This study tests whether a single session of a self-corrective exercise can immediately improve muscle activity and spinal alignment in 40 adolescents with idiopathic scoliosis. Participants do both a standard exercise and the self-corrective exercise, and researchers measure cha…