Preneoplastic lesion
MONDO:1060215A precancerous condition characterized by accumulation of some molecular alterations necessary for malignant transformation in a clonal proliferation of cells, representing an intermediate stage in carcinogenesis with increased risk of progression to invasive neoplasia.
16 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Could a shot stop mouth cancer before it starts?
Disease control Recruiting nowThis study tests if injecting the cancer drug nivolumab directly into high-risk precancerous mouth lesions can stop them from turning into cancer. About 45 adults with these lesions will receive either the drug or a placebo injection. The goal is to see if the treatment is safe a…
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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AI eye on stomach cancer: 6,000-Person trial tests smarter scopes
Diagnosis Recruiting nowThis study tests whether artificial intelligence (AI) can help doctors better detect H. pylori infection and precancerous stomach changes during routine endoscopy. The goal is to see if AI assistance can reduce deaths from stomach cancer. The trial will enroll 6,000 adults aged 2…
Sponsor: National Taiwan University Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 14:02 UTC
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Simple blood test could spot cancer early
Diagnosis Recruiting nowThis study is testing a new blood test called PanTum Detect to see how well it can find early signs of cancer or pre-cancer. The test looks for certain markers in immune cells. Researchers will compare the blood test results with standard PET/CT scans in 134 adults—half with susp…
Phase: NA • Sponsor: Comenius University • Aim: Diagnosis
Last updated Jun 27, 2026 08:11 UTC
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Scientists launch massive tumor repository to unlock cancer secrets
Knowledge-focused Recruiting nowThis study collects extra blood, urine, and tumor samples from children and adults with certain cancers to build a large tissue repository. Researchers will analyze these samples to learn more about the genetic and molecular makeup of these tumors. The goal is to support future s…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Jul 03, 2026 23:00 UTC
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Massive cancer gene mapping project aims to unlock new treatments
Knowledge-focused Recruiting nowThis study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…
Sponsor: Avera McKennan Hospital & University Health Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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5000 volunteers help hunt for hidden cancer clues
Knowledge-focused Recruiting nowThis study collects tissue, blood, urine, and stool samples from 5000 people undergoing colonoscopy or endoscopy, including those with cancer, polyps, or inflammatory bowel disease, as well as healthy volunteers. The goal is to find new biomarkers that could improve early detecti…
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Simple blood test could predict stomach cancer risk
Knowledge-focused Recruiting nowThis study is looking for markers in the blood that might show early signs of stomach cancer or conditions that can lead to it. Researchers will follow about 192 adults who are already getting stomach function tests. The goal is to see if changes in these markers over time can he…
Sponsor: Centro di Riferimento Oncologico - Aviano • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Robot vs. laparoscopic: which pancreas surgery is better?
Knowledge-focused Recruiting nowThis study compares two minimally invasive surgical techniques—laparoscopic and robot-assisted—for removing the left side of the pancreas in people with benign or pre-cancerous growths. About 256 participants will be randomly assigned to one of the two procedures. The goal is to …
Phase: NA • Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:56 UTC