Can a simple HPV test replace colposcopy for cervical cancer Follow-Up?
NCT ID NCT01051895
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two ways to check for returning cervical pre-cancer after treatment: the standard colposcopy exam versus a high-risk HPV DNA test. Over 2,200 women who were treated for high-grade cervical lesions will be randomly assigned to one of the two follow-up methods. The goal is to see which approach is more sensitive at detecting persistent or recurrent disease, potentially making follow-up care simpler and more accessible.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- high risk HPV DNA testing
- What this could lead to
- If successful, this could show that a simple HPV test is better than a colposcopy for catching returning cervical pre-cancer, potentially making follow-up easier and more accurate.
- What could go wrong
- This is a diagnostic comparison, not a treatment. The results may not change practice if HPV testing proves less effective or too costly. Also, the study is observational in nature, so it cannot prove that one strategy improves long-term health outcomes.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre de recherche du CHUM
Montreal, Quebec, H2X 0A9, Canada
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