Coronaviridae infectious disease

This early-stage trial tests a new booster vaccine called Boost-2867 in 140 healthy adults who have already been vaccinated against COVID-19. The vaccine is given either as a shot with or without adjuvants (ingredients that boost immune response) or as a nasal spray without adjuv…

This study tests an experimental oral COVID-19 vaccine tablet (VXA-CoV2-3.3) against approved mRNA booster shots in about 5,500 adults who have already been vaccinated. The goal is to see if the tablet can prevent symptomatic COVID-19 as well as or better than the injectable vacc…

This early-stage trial tests a new COVID-19 booster vaccine called Prime-2-CoV_Beta, made from a modified orf virus. It involves 96 healthy adults aged 18-55 who have already been vaccinated or infected. The main goal is to check safety and how well the vaccine boosts the immune …

This study tests whether training popular community leaders to share vaccine information can increase COVID-19 booster shots among Black individuals with rheumatic conditions like lupus. About 60 people will take part, including leaders and their social network members. The goal …

This early-stage trial tests a new type of COVID-19 booster vaccine called PepGNP-COVID19. It uses tiny gold nanoparticles to train the immune system's T cells to recognize and fight the virus. The study involves 60 healthy adults aged 18-64 who will receive one of three doses to…

This study tests a single dose of an updated Novavax COVID-19 vaccine designed to target the JN.1 variant. About 6,500 healthy adults aged 50 to under 65 who are not at high risk for severe COVID will receive either the vaccine or a placebo. Researchers will track how well the va…

This study tests two updated mRNA COVID-19 vaccines (mRNA-1283 and mRNA-1273 variant formulation) in 30,000 healthy adults aged 50 to 64 who are not at high risk for severe COVID-19. The goal is to see if these vaccines prevent symptomatic COVID-19 compared to a placebo. Research…

This large study is testing updated mRNA vaccines designed to protect against newer Omicron variants of COVID-19 in healthy children aged 6 months to 12 years. Over 4,000 participants will receive one or more doses depending on their age and vaccination history. Researchers are m…

This study tests a variant-adapted COVID-19 vaccine in about 5,240 healthy adults aged 50 to 64. Half receive the vaccine, half a placebo, to see if it safely prevents COVID-19 caused by new virus variants. The goal is to find out how well the updated shot works in this age group…

This early-stage trial tests a new vaccine designed to protect against multiple coronaviruses, not just COVID-19. 51 healthy adults aged 18-55 will receive two doses to check safety and immune response. The vaccine uses a protein nanoparticle to target the virus's spike protein, …

This large study tests whether an updated Moderna COVID-19 vaccine can prevent severe COVID-19 in adults aged 50 to 64 who have no health conditions that raise their risk. About 285,000 participants will be randomly assigned to get the vaccine or not. The main goal is to see if t…

This Phase 3 trial tests an updated COVID-19 vaccine (BNT162b2, 2025/2026 formulation) in 343 children aged 5 to 11 who have medical conditions that put them at high risk for severe COVID-19. All participants receive one dose and are monitored for about 6 months to check safety a…

This study tests a new COVID-19 vaccine (GEO-CM04S1) in 63 adults with blood cancers like leukemia or lymphoma who have had a stem cell transplant or cell therapy. The goal is to see if this vaccine triggers a stronger immune response than standard mRNA vaccines, potentially offe…

This study tests two different COVID-19 vaccines—Moderna's bivalent mRNA and Novavax's protein-based—as a fourth booster dose in healthy adults who have already had three doses. Researchers will check how well each vaccine boosts the immune system and track any side effects. The …

This study tests a single-dose nasal spray COVID-19 vaccine (CVXGA) against a standard mRNA shot in about 432 healthy adults who have already had a primary COVID-19 vaccine series. The goal is to see if the nasal vaccine is safer and better at preventing symptomatic COVID-19 over…

This study tests a new COVID-19 vaccine given as a nasal spray. It aims to see if the spray is safe and helps the body fight the virus. About 227 healthy adults aged 18 to 80 will take part. The vaccine is designed to boost immunity in the nose, where the virus often enters.

This study tests whether extra COVID-19 vaccine doses are safe and work well for people with weakened immune systems, such as those with HIV, organ transplants, or blood cancers. Around 960 participants will receive different booster schedules to see which one boosts their protec…

This was an early safety study for a personalized COVID-19 vaccine. The vaccine would have been made using each participant's own immune cells, trained in a lab to recognize the coronavirus. The study was withdrawn before any participants were enrolled, so no results are availabl…

This study tests whether a single infusion of hyperimmune immunoglobulin (hIVIG) — concentrated antibodies from recovered COVID-19 patients — can help adults at high risk (age 55+ or with weakened immune systems) who have early COVID-19. Participants receive either the antibody i…

This study tests a non-invasive pneumatic vest designed to apply pressure to the chest wall in patients with acute respiratory distress syndrome (ARDS) caused by COVID-19 who are on mechanical ventilators. The goal is to see if the vest can improve oxygen levels in the blood. Up …

This study was designed to see if corticosteroids (prednisone or hydrocortisone) could help COVID-19 patients who need extra oxygen. It planned to enroll adults with confirmed COVID-19 and pneumonia, using CT scans to identify those likely to benefit. However, the trial was withd…

This early-stage trial tests a biologic treatment for 20 people with moderate COVID-19 who also have controlled cancer. The treatment aims to help the immune system recognize and kill the virus. Researchers will check if the virus clears and if the immune response improves.

This study tests whether intravenous immunoglobulin (IVIG) can reduce symptoms of autonomic dysfunction—such as dizziness, rapid heartbeat, and fatigue—in people with long COVID. Two hundred participants will receive either IVIG or a placebo (saline) for 9 months, plus coordinate…

This phase 2 trial tests a nasal spray called Optate in 24 adults with mild COVID-19. The spray aims to lower virus levels in the nose and improve symptoms like congestion. Participants receive either Optate or a placebo, and researchers measure changes in virus levels and sympto…

This study tests whether infusions of cord blood stem cells can help people with moderate to critical COVID-19 pneumonia. The trial includes 65 adults with COVID-19-related acute respiratory distress syndrome (ARDS). Researchers will compare stem cell treatment plus standard care…

This phase 2 trial tests a new COVID-19 booster vaccine (GEO-CM04S1) in 80 people with chronic lymphocytic leukemia (CLL). The goal is to see if this vaccine triggers a stronger immune response than standard mRNA boosters. Participants will receive either the new vaccine or a sta…

This study was designed to test whether an inhaled drug called ZYESAMI could help people with severe COVID-19 avoid getting worse and needing a ventilator. It was a Phase 3 trial, meaning it was in the final stage of testing. However, the study was withdrawn before any participan…

This study was designed to test whether the drug itolizumab could help hospitalized COVID-19 patients recover faster. The trial was planned for 18 years and older with confirmed COVID-19 pneumonia and low oxygen levels. However, the study was withdrawn before enrolling any partic…

This early-stage trial tests whether a new drug called PDI204, an antibody that targets the COVID-19 virus, is safe and tolerable in healthy adults. 32 participants will receive a single dose of PDI204 or a placebo and be monitored for side effects and how the drug behaves in the…

This phase 2 trial tests whether N-acetylcysteine, a drug already used for acetaminophen overdose and lung mucus, can help severe COVID-19 patients by boosting their immune system. About 48 critically ill adults will receive the drug alongside standard care. The goal is to see if…

This study tests whether a probiotic called Lactobacillus plantarum 299v (Lp299v) can improve blood vessel function in people with Long COVID (PASC). The trial includes 80 adults who had COVID-19 30-180 days ago and have ongoing symptoms. Participants take either the probiotic or…

This trial tests a device called Seraph 100, a blood filter used to treat severe COVID-19. The goal is to see if filtering the blood can reduce organ failure in patients with COVID-19 who are in the intensive care unit. The study enrolled 42 adults with confirmed COVID-19 and org…

This phase 2 trial tests whether a single, low dose of radiation to the chest can reduce lung inflammation in hospitalized COVID-19 pneumonia patients. Researchers compare two radiation doses (35 cGy and 100 cGy) to standard care. The goal is to see if this treatment lowers the n…

This study tests whether repeated doses of the BCG vaccine (originally for tuberculosis) can help adults with long-standing type 1 diabetes lower their blood sugar levels. About 150 participants receive either BCG or a placebo over 5 years, with follow-up for 10 years. The goal i…

This study tests whether the drug tocilizumab can help people with severe or critical COVID-19 who have serious lung problems (ARDS). About 200 adults will receive one or two doses and be followed for 30 days. The goal is to see if the drug improves survival and recovery. There i…

This study tests several experimental treatments at once in critically ill COVID-19 patients who need high-flow oxygen or a ventilator. The goal is to quickly find which treatments can reduce deaths and shorten the time patients need breathing support. About 1,500 adults in the h…

This study looks at whether a special team of doctors and nurses can treat adults with suspected infections at home, instead of sending them to the hospital. About 500 people will be randomly assigned to either standard hospital care or home-based care from a mobile response team…

This study tests whether giving inhaled anesthetics (isoflurane or sevoflurane) to sedate COVID-19 patients on ventilators can improve survival and reduce time on the breathing machine compared to standard IV sedatives. About 800 adults in the ICU with lung failure will be random…

This study planned to test whether putting a thyroid hormone (T3) directly into the lungs could help people with severe COVID-19 who need a breathing machine. The goal was to reduce fluid in the lungs and shorten time on a ventilator. However, the trial was withdrawn before any p…

This study planned to test a new stem cell product (BX-U001) in people with severe COVID-19 pneumonia and moderate to severe lung failure (ARDS). The goal was to check safety and find the best dose. However, the study was withdrawn before enrolling any participants, so no results…

This study planned to give blood plasma from recovered COVID-19 patients to people in the ICU with severe COVID-19. The goal was to see if it could help them breathe better and survive. However, the trial was withdrawn before enrolling any participants, so no results are availabl…

This study tests whether the drug sirolimus can prevent lung scarring (fibrosis) in people hospitalized with severe COVID-19 pneumonia. About 60 adults who need extra oxygen will receive sirolimus to see if it reduces the chance of long-term lung damage. The goal is to find a way…

This study tests if inhaling a protein called interferon beta 1b can help hospitalized COVID-19 patients who need oxygen. The goal is to see if the treatment reduces the amount of oxygen they need over 15 days. The study includes 74 adults with confirmed COVID-19 who are on oxyge…

This study provides early access to an experimental stem cell treatment called remestemcel-L for children aged 2 months to 17 years with MIS-C, a severe inflammatory condition linked to COVID-19. The treatment aims to calm the immune system and reduce inflammation. Participants r…

This study tests whether a single dose of the monoclonal antibody AER002 can safely improve physical health in adults with Long COVID. The idea is that lingering virus or spike protein may cause ongoing symptoms, and the antibody might clear it. 36 participants will receive eithe…

This study tested whether using a baby shampoo nasal wash and Listerine mouthwash for 4 days could lower the amount of COVID-19 virus in the nose and throat of recently infected adults aged 18-65. Participants were randomly assigned to different wash combinations, including plain…

This phase 2 study tests whether fisetin, a natural compound found in fruits and vegetables, can reduce dangerous inflammation and improve oxygen levels in hospitalized COVID-19 patients. About 80 adults aged 60+ (or younger with certain health conditions) will receive either fis…

This study aimed to see if the drug sarilumab could help hospitalized COVID-19 patients with severe breathing distress. It planned to compare one or two doses of sarilumab against a placebo. However, the study was withdrawn before enrolling any participants, so no results are ava…

This study tested an experimental stem cell treatment (HB-adMSCs) added to standard care for people aged 18-65 with Post-COVID-19 syndrome. Participants had not fully recovered weeks or months after a positive COVID-19 test. The goal was to see if the treatment is safe and helps …

This study planned to test an inhaled medicine called Virazole (ribavirin) in adults hospitalized with COVID-19 who had serious breathing trouble. The goal was to see if the drug was safe and could improve oxygen levels. However, the trial was withdrawn before enrolling any volun…

This trial tests whether a single infusion of stem cells from donated umbilical cords can help people with acute respiratory distress syndrome (ARDS), a severe lung condition often seen in intensive care. The study first finds a safe dose, then randomly gives either stem cells or…

This study planned to compare a rapid antigen detection test against the standard PCR test for diagnosing COVID-19 in people who were close contacts of infected patients but had no symptoms. The goal was to see if the quick, inexpensive antigen test could reliably identify contag…

This study tests a simple, at-home smell test to see if it can detect COVID-19 infection and track how smell recovers over time. About 1000 adults, including those with known smell loss and healthy volunteers, will use smell cards to rate odor intensity, identification, and discr…

This study tests two new devices (imPulse Una and TOR) that use sound waves to detect COVID-19, flu, and RSV without needles or swabs. About 300 adults with or without symptoms will have a quick, painless scan. The goal is to see if these e-stethoscopes can accurately identify th…

This study uses advanced PET and MRI scans to look for brain inflammation and blood vessel problems in 30 people with long COVID who have brain fog, anxiety, or depression. The goal is to develop better ways to diagnose these lingering symptoms, not to test a treatment. Participa…

This study tests a new drug called VYD2311, a monoclonal antibody that blocks the COVID-19 virus from entering cells. About 1,770 adults and teens aged 12 and older receive either VYD2311 or a placebo as a monthly shot for 3 months. The goal is to see if it safely prevents COVID-…

This study aimed to see if hydroxychloroquine could prevent COVID-19 hospitalizations in adults on dialysis for kidney failure. It was designed as a randomized trial but was withdrawn before enrolling any participants. No results are available.

This study aimed to see if the BCG vaccine, originally for tuberculosis, could reduce the severity of COVID-19 in healthcare workers in Medellín, Colombia. It planned to give a single dose of BCG or a placebo to 0 participants (doctors, nurses, and nursing assistants) who were di…

This study aims to see if health communication campaigns and added community support can increase COVID-19 vaccination rates in 15 rural Kentucky counties. About 2,250 adults will take part, with some counties getting only messages and others getting extra help like transportatio…

This phase 3 trial tests whether taking Paxlovid (nirmatrelvir/ritonavir) during acute COVID-19 can prevent long COVID. About 2,000 adults aged 18-64 with a recent positive test and symptoms will receive either Paxlovid or a placebo for 5 days. Researchers will track long COVID s…

This study aimed to see if hydroxychloroquine could prevent COVID-19 in older adults living in long-term care homes. It planned to give either the drug or a placebo to high-risk residents after they were exposed to the virus. However, the trial was withdrawn before enrolling anyo…

This study tests whether breathing techniques and meditation can help healthcare workers at MD Anderson Cancer Center reduce stress and improve lung health during the COVID-19 pandemic. One hundred participants will learn these techniques through videos and practice them at home.…

This study tests whether a treatment called IVIG (intravenous immunoglobulin) can help with ongoing neurological symptoms after COVID-19, like dizziness, trouble walking, or memory problems. About 45 adults who had COVID-19 at least 12 weeks ago will receive either IVIG or a plac…

This study tests whether a diet rich in fermented foods (like yogurt and kimchi) is tolerable and can improve quality of life for survivors of critical illness, including severe COVID-19. The goal is to help restore gut health and reduce inflammation. The study involves 40 partic…

This study tests a drug called bezisterim (NE3107) in 203 adults with long COVID who struggle with brain fog and fatigue. Participants take either the drug or a placebo twice daily for 84 days, and researchers measure changes in thinking, memory, and energy levels. The goal is to…

This study tests whether a 10-week aerobic exercise program can improve physical function and reduce symptoms in adults still struggling after a COVID-19 infection. Participants will exercise three times a week and attend weekly education classes. The goal is to see if exercise h…

This study tests a personalized health pathway for 400 people with persistent COVID-19 symptoms lasting more than 12 weeks. Participants receive nurse follow-up and can choose workshops on disease management, anxiety, and fatigue. The goal is to see if this approach improves qual…

This study looks at whether online psychotherapy, a physical activity program, or a combination of both can reduce fatigue in people with Post-COVID syndrome. 195 adults with fatigue will be assigned to one of three groups for 3 months of treatment. The goal is to find which appr…

This study looks at whether joining community drum circles and mindfulness programs can help reduce anxiety and depression in Black and other marginalized groups who faced extra stress during COVID-19. About 90 people aged 16 and older will take part. Researchers will measure how…

This study tests whether a virtual, community-based program combining music and mindfulness can help reduce stress, anxiety, and depression in people of African descent. About 300 participants aged 16 and older will take part. The goal is to see if these culturally relevant activ…

This study tests a short, acceptance-based therapy (ABBT) to help LGBTQ+ adults with mild anxiety or depression worsened by the COVID-19 pandemic. 240 participants will either receive the therapy or standard care. The goal is to see if ABBT can reduce symptoms and improve social …

This study planned to test TADIOS, a blend of three herbs used in traditional Asian medicine, as an add-on treatment for adults hospitalized with mild to moderate COVID-19. Participants would have received TADIOS or a placebo for up to 10 days. The goal was to see if TADIOS could…

This study follows nearly 1,900 cancer patients who tested positive for COVID-19. Researchers collect blood samples, medical records, and images to see how the virus impacts their cancer treatment and overall health. The goal is to learn which factors make COVID-19 more severe in…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study asks over 1,600 African American women aged 23-35 about their experiences during the COVID-19 pandemic. Participants fill out a short online or paper survey covering infection, vaccination, childcare, job loss, and emotional stress. The goal is to understand how the pa…

This study tests a new AI-powered toolkit designed to help public health officials at local CDC offices respond more quickly to emerging infectious diseases such as COVID-19, mpox, influenza, and dengue. The toolkit combines data analysis, risk assessment, decision support, and e…

This early-stage study is testing a new tablet version of the COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how much of the drug gets into the blood when taken as a whole tablet, dispersed in water, or with food. The goal is to compare the new tablet to…

This study investigates whether hospital caregivers working in COVID-19 patient areas are more likely to get infected than those in non-COVID areas. Researchers will take blood samples from participants on day 0, day 15, and day 30 to check for antibodies that signal past infecti…

This study tests whether training primary care providers on how to talk to patients about vaccines can increase flu and COVID-19 vaccination rates. Over 24,500 patients and their doctors at multiple clinics will take part. Doctors in some clinics will receive special communicatio…

This study looks at how the immune system of patients in the intensive care unit (ICU) responds to severe infections caused by viruses or bacteria. Researchers will take extra blood samples from 38 adults to analyze immature granulocytes, a type of immune cell. The goal is to see…

This pilot study tracks 24 adults who were hospitalized for COVID-19. Researchers use diaphragm ultrasound to see how well the main breathing muscle works 3 and 6 months after leaving the hospital. The goal is to describe long-term breathing changes, not to test a treatment.

This study tracks 56 follicular lymphoma patients to see how long their COVID-19 and other vaccine immunity lasts while they receive chemotherapy and maintenance therapy. Researchers will collect blood samples at several time points to measure immune responses. The goal is to und…

This study aimed to see if the antibiotic doxycycline could protect people from severe COVID-19. Researchers planned to analyze health records of patients who took doxycycline for acne during the pandemic. However, the study was withdrawn before enrolling any participants, so no …

This study examines whether senescent cells—sometimes called 'zombie cells' that accumulate with age—contribute to Long-Hauler Syndrome, a condition where COVID-19 symptoms persist long after the initial infection. Researchers at Mayo Clinic will compare markers of cellular aging…

This study follows 583 adults who recovered from COVID-19 or were close contacts. Researchers will track their health, mental well-being, and immune responses over 3 years to understand long-term effects and whether prior infection prevents reinfection. Participants undergo regul…

This study uses a special bronchoscopy technique called narrow band imaging to look at blood vessel patterns in the airways of people with COVID-19. Researchers will compare images from three groups: patients with COVID-19, patients with other lung infections, and patients with l…

This study looks at how COVID-19 impacts people with hepatocellular carcinoma, a type of liver cancer. Researchers will track infection rates and see how the virus affects liver function, cancer treatment, and overall health. About 23 participants from a French national liver can…

This study follows 98 elderly residents in French nursing homes to see how long their COVID-19 antibodies last. Researchers will also measure immune markers linked to aging to understand why some older people have weaker immune responses. The goal is to learn how to better protec…

This study tracked 81 critically ill COVID-19 patients admitted to a French intensive care unit. Researchers compared factors like age, medical history, and treatments to understand who becomes severely ill. The goal is to improve care for future patients.

This study examines whether the COVID-19 pandemic increased frailty and muscle loss (sarcopenia) in people waiting for a liver transplant. Researchers will compare data from 208 patients assessed before and during the pandemic. The goal is to understand how the pandemic affected …

This study follows 300 families with children aged 2 to 6 years over three years to understand how ongoing stress might lead to weight gain. Researchers will measure stress hormones and behaviors to see what role they play. The goal is to learn, not to test a treatment, so no new…

This study planned to test telemonitoring for older adults (75+) in nursing homes with confirmed or probable COVID-19. The goal was to see if remote monitoring could improve healthcare management and reduce deaths within 30 days. However, the study was withdrawn before enrolling …

This study is testing whether a computer can automatically measure how much lung tissue is damaged in patients with severe breathing problems from COVID-19 or after surgery. Researchers will compare the computer's lung measurements to standard severity scores in 500 patients. The…

This study follows 1,520 mostly Black and Latino individuals and their households who had COVID-19 in New York City. Researchers will use surveys and medical records to track long-term health problems, and for 500 hospitalized patients, they will collect nasal swabs and blood sam…

This study examines tissue from people who died after a COVID-19 infection to understand why some develop Long COVID. Researchers will look for signs of inflammation, scarring, blood clots, and tissue death in the body. The goal is to learn more about the long-term effects of the…

This study follows 90 people who survived severe COVID-19 pneumonia and needed intensive care. Researchers will check their physical health, mental health, and quality of life at 3 months, 6 months, 1 year, and 5 years after leaving the ICU. The goal is to better understand the l…

This study collects blood samples and medical information from 201 adults diagnosed with COVID-19. The goal is to create a resource that researchers can use to study the virus and improve understanding of the disease. Participants provide samples and allow their health data to be…

This study was designed to track how many healthcare workers at Lille University Hospital caught COVID-19 over 10 weeks. Researchers planned to test 100 workers every two weeks using nasal swabs and blood tests, along with questionnaires about their work and home exposures. The g…

This study aimed to collect medical information from people who developed unusual blood clots within four weeks of receiving a COVID-19 vaccine. The goal was to better understand any possible link between the vaccine and these rare events. However, the study was withdrawn before …

This study was designed to track how COVID-19 infection might worsen the condition of people with inherited metabolic diseases (IMD). Researchers planned to collect information from French patients with IMD who had or had COVID-19 to see how often their metabolic disease got wors…

This study was designed to compare how often patients with severe COVID-19 developed lung infections while on a ventilator during the first and second waves of the pandemic. It was an observational study that would have looked back at patient records across European ICUs. However…

This study is creating a biobank of blood samples and health data from 100 people who have recovered from COVID-19. Researchers will use this information to better understand recovery and long-term effects. No new treatments are being tested; the goal is to provide resources for …

This study looks at whether cancer patients feel their doctors show more empathy during in-person visits with protective gear (PPE) or during video calls without it. About 107 adults from MD Anderson's emergency center will share their views after a conversation with their doctor…

This study follows 300 pregnant women who had respiratory infections to see if RSV can pass from mother to baby before birth. Researchers will test blood from mothers and umbilical cords for RSV antibodies and viruses. Babies will be tracked for up to 4 years to monitor respirato…

This study is a medical registry that follows over 21,000 adults hospitalized in 2021 at a Russian hospital. Researchers will analyze their health records, including chronic conditions, COVID-19 history, and outcomes like heart attacks or strokes, over five years. The goal is to …

This study looks at heart problems in adults hospitalized with COVID-19. Researchers will review medical records to see how often heart issues like heart failure, inflammation, or arrhythmias occur. No new treatments are tested; the goal is to learn more about the virus's effects…

This study aims to understand why people who use drugs in Baltimore may be hesitant to get a COVID-19 vaccine. Researchers will interview 40 participants about their views and barriers to vaccination. The goal is to improve vaccine access and acceptance in this community.

This study follows 549 children, teens, and young adults with cancer to see how their immune systems respond to COVID-19 vaccines. Researchers collect blood samples to measure protective antibodies. The goal is to learn how cancer and its treatment affect vaccine effectiveness, a…

This study follows 319 people under 21 who developed heart inflammation (myocarditis or pericarditis) within 21 days of receiving the Comirnaty (Pfizer) COVID-19 vaccine. Researchers will monitor their heart function with imaging tests for up to 5 years to see if there are lastin…

This study tests whether AI-powered X-ray analysis and portable molecular tests can help find tuberculosis (TB) and COVID-19 cases in African communities where many cases go undetected. Over 26,000 adults will be screened using these tools, and researchers will measure how quickl…

This study compares how well two FDA-approved COVID-19 vaccines—Novavax (a protein-based vaccine) and Pfizer (an mRNA vaccine)—trigger the immune system. Researchers will measure antibody levels against several virus variants in 54 healthy adults aged 18-79 who have risk factors …

This study follows 500 children under 18 who tested positive for flu, RSV, or COVID-19. Each child takes a daily nose swab for 14 days to measure how the virus levels change over time. Researchers also check if family members get sick. The goal is to understand when kids are most…

This study looks at why more than half of people who recover from COVID-19 still feel very tired. Researchers are measuring fatigue in 398 adults using questionnaires and muscle tests. The goal is to better understand who is most affected and how severe the fatigue can be.

This study looks at how the COVID-19 pandemic impacted the quality of life of 274 cancer patients who also have neuropathy (nerve pain). All participants had taken part in earlier clinical trials. Researchers want to see if there are differences between those who received a brain…

This study intentionally exposes healthy adults aged 18-40 who have had a COVID-19 vaccine or prior infection to the Omicron BA.5 virus via nasal drops. The goal is to find the safest dose that causes a mild, controlled infection in 50-75% of participants, while monitoring side e…

This study uses special MRI scans with inhaled gases to see how lungs work in people with asthma, COPD, or COVID-19. Researchers will follow up to 160 participants over several years to track changes in lung function. The goal is to better understand why some patients struggle wi…

This study aims to create a test that predicts how hospitalized COVID-19 patients will fare in the short and long term (up to one year). Researchers will enroll 600 adults from hospitals and Veterans' facilities, using medical records and lab data to forecast risks like frailty, …

This study looks at 57 people who received a COVID-19 vaccine to understand why some develop heart injury or myocarditis. Researchers use advanced heart scans (PET/MRI) and blood tests to find early warning signs. The goal is to better identify those at risk and improve follow-up…

This study is monitoring the safety of the Pfizer-BioNTech COVID-19 vaccine (BNT162b2) in 12,000 people in South Korea who received the vaccine as part of routine care. Researchers are tracking side effects like sore arms or fever within a week of each dose, as well as any other …

This study tracks over 4,200 people in South Korea who received a SPIKEVAX COVID-19 vaccine to see if any side effects occur over time. Participants are aged 12 or older depending on the vaccine version. The goal is to gather real-world safety data, not to test if the vaccine wor…

This study looks at whether temporarily reducing immunosuppressive medication can help kidney transplant recipients mount a stronger immune response to a third dose of the COVID-19 mRNA vaccine. Fourteen participants with low or no antibodies will have their antimetabolite dose l…

This study follows about 1,000 adults in the U.S. who test positive for COVID-19 or influenza. Participants fill out surveys about their symptoms and quality of life over six months. The goal is to understand how these illnesses affect daily activities and whether COVID-19 vaccin…

This study looks at organ changes in people recovering from COVID-19, comparing those with and without type 2 diabetes. Researchers will use scans to measure organ size and volume. The goal is to learn more about how COVID-19 affects the body long-term in diabetic patients.

This study collected data from 7,500 adults admitted to Swedish ICUs with COVID-19 during the first two years of the pandemic. Researchers looked at patient characteristics, treatments, and survival rates at 30 days and one year. The goal is to understand the disease's impact and…

This study tests whether changing how people interact in online social networks can improve their attitudes and intentions toward COVID-19 vaccination. Over 4,400 adults in the US with internet access will be placed into different online groups and answer health questions while s…

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This trial is studying a device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works and its safety. Participants will be monitored closely. The study sponsor and current status are not publicly available.

This study was designed to learn how the protein calprotectin might change blood stem cells in people with severe COVID-19 or certain blood cancers. Researchers planned to compare cells from patients and healthy donors in the lab. However, the study was withdrawn before any parti…

This study was designed to investigate whether new skin lesions on fingers or toes were linked to COVID-19. It planned to test adults with these lesions for the virus using PCR and antibody tests. However, the study was withdrawn before enrolling any participants, so no results a…

This study looks at how adults feel after getting either the Novavax or the mRNA COVID-19 booster vaccine. Researchers will track symptoms like fever, fatigue, and headache for a week after vaccination. The goal is to help people understand which vaccine might cause fewer reactio…

This study surveys over 1,200 cancer patients who previously took part in behavioral trials to learn how the COVID-19 pandemic impacted their quality of life, mental health, and daily routines. Participants fill out questionnaires about stress, sleep, diet, exercise, and social s…

This study explores whether listening to recordings of communal drumming, combined with mindfulness, can reduce stress and improve mental health in People of African Descent. Researchers will measure feelings of connection and synchrony in 30 adults. The goal is to see if cultura…

This study looks at how doctors and nurses in radiation oncology used telehealth instead of in-person visits during the COVID-19 pandemic. Researchers will survey 1,000 healthcare providers at Duke Cancer Center to understand their experiences and challenges. They will also track…

This study follows over 2,000 people and their pets in the Canton of Bern to learn how infections like COVID-19 spread and what social and environmental factors influence transmission. Participants provide samples and answer questionnaires over time. The goal is to improve pandem…

This study aimed to understand how undergraduate students and teaching staff at Misr International University in Egypt felt about online learning during the COVID-19 pandemic. Over 9,000 participants were asked about their satisfaction and knowledge through questionnaires. The go…

This study follows 200 ICU patients with severe COVID-19 to see how often they develop lung scarring (pulmonary fibrosis). Researchers will use blood tests and CT scans to find early signs of scarring and identify risk factors. The goal is to understand how scarring affects recov…

This study looks at how the COVID-19 pandemic impacted the well-being and quality of life of over 13,000 cancer patients and survivors. Researchers used questionnaires to gather information on experiences like exposure, isolation, and financial disruptions. The goal is to underst…

This study follows 500 adults who had COVID-19 to see what health problems they face months later. Researchers will track symptoms like tiredness, breathing trouble, and lung damage. The goal is to learn how common these long-term issues are and who is most likely to have them.

This study monitors the safety of the Comirnaty (Bretovameran) COVID-19 vaccine in 660 Korean participants aged 12 and older. Researchers will track side effects like injection site reactions and serious adverse events for up to 28 days after each dose. The goal is to identify an…

This study looks at blood samples from 83 adults in Maryland who have recovered from COVID-19. Researchers want to understand how specific immune cells called CD8 T cells respond to the virus and how this changes with age. The goal is to gather knowledge that could help create be…

This study follows 1,000 Australians to see how well they follow COVID-19 rules like quarantine and distancing. Researchers also track the social, economic, and mental health effects of these measures. No treatment or vaccine is tested—the goal is to learn how to make public heal…

This study will safely give a small dose of the Delta COVID-19 virus to 20 healthy adults aged 21-30 in Singapore. The goal is to see if the virus causes infection and to check for side effects. This 'human challenge' model could help test future vaccines and treatments faster.

This study gathers information from cancer patients and their household members to better understand COVID-19 infections. Participants fill out online questionnaires about their health and lifestyle. The goal is to create a registry that helps researchers see how COVID-19 affects…

This study looks at how the COVID-19 pandemic changed the number of new cancer cases in Bavaria, Germany. Researchers analyzed data from 438,000 adults diagnosed with cancer between 2018 and 2023 to see if certain regions or cancer types were more affected. The goal is to underst…

This large observational study is following about 15,000 children and young adults (ages 0-25) across the U.S. to learn more about long COVID, also called PASC. Researchers will track symptoms, infections, and health over time using surveys and medical records. The goal is to ide…

This Pfizer study aimed to check if new combination tablets of nirmatrelvir/ritonavir (the drug in Paxlovid) work the same as the current marketed version. About 28 healthy adults were to receive single doses of different tablet forms under fasting conditions. However, the study …

This study planned to check how the COVID-19 quarantine affected people who were already seeing a psychiatrist. Researchers wanted to measure PTSD and other mental health symptoms during quarantine and a few months later. However, the study was withdrawn before enrolling anyone, …

This registry enrolls people who have recovered from COVID-19 to create a pool of volunteers for future studies on immunity, vaccines, and plasma donation. Over 5,000 participants are included. No treatment is given; it is purely for research.

This study follows 500 ICU patients to compare long-term mental and physical health between those with and without COVID-19. Researchers use surveys and tests to measure quality of life, thinking skills, and emotional well-being. The goal is to identify specific problems caused b…

This study follows 200 hospital employees who received the AstraZeneca COVID-19 vaccine. Researchers measure their antibody levels at 6 weeks, 6 months, and 12 months after the second dose to see how long protection lasts. The goal is to understand the immune response and help gu…

This study looks at how the immune systems of younger and older adults respond to Pfizer or Moderna COVID-19 vaccines. Researchers will collect blood samples from 78 healthy volunteers over two years to measure specific T-cell responses. The goal is to understand if age changes h…

This study is testing a tiny camera called micro OCT that can take detailed pictures of cells inside the lungs and nose. Researchers want to see if it works well in people with cystic fibrosis and other lung conditions. The goal is to eventually use this imaging to detect early d…

This study looks at how having intestinal worms (helminths) and COVID-19 antibodies changes the immune system and gut bacteria. Researchers will collect blood and stool samples from 1500 people in India to measure infections and immune markers. The goal is to understand these int…

This study tests whether temperature sensors placed inside a Venturi mask can monitor breathing patterns in 82 patients hospitalized with pneumonia and respiratory failure. The goal is to see if these patterns can detect early signs of deterioration before patients need a breathi…

This study collects blood plasma from people who have recovered from COVID-19 to learn more about the antibodies it contains. Researchers will give this plasma to people currently sick with COVID-19 and track how their health changes. The goal is to understand which antibody prof…

This study is building a large group of people living in the US who are willing to be contacted about future research, especially on COVID-19. Participants sign up online and share health information through surveys. The goal is to create a ready pool of volunteers for upcoming s…

This small pilot study looks at how the gut microbiome might be linked to lingering symptoms after severe COVID-19. Researchers will measure changes in gut bacteria, immune markers, and lung function in 20 adults who had severe COVID in the past year. The goal is to find better w…

This study looks at how well the yearly updated Pfizer COVID-19 vaccine works in adults and children. Instead of giving anyone the vaccine, researchers will analyze existing insurance claims and state vaccine records. They will compare people who got the vaccine to those who did …

This study aimed to see if COVID-19 makes asthma worse or harder to control. Researchers planned to compare asthma patients who had COVID-19 with those who did not, tracking lung function and symptoms for a year. However, the study was withdrawn before enrolling anyone, so no res…

This study looks at how COVID-19 changes the bacteria in the gut of hospitalized patients. Researchers will collect stool samples from 15 patients to measure the virus in feces and see if these changes relate to how sick patients become. The goal is to better understand the link …

This study looks at immune cells from people with autoimmune diseases (like lupus), people with infections, and healthy volunteers. Researchers want to understand how these cells differ and what makes them attack the body in autoimmune conditions. The study involves blood and bon…

This study examines whether people with certain blood cancers (myeloproliferative neoplasms) have autoantibodies that block a key immune protein called type I interferon. These autoantibodies may increase the risk of severe COVID-19. Researchers will test blood samples from 219 p…

This study looks at how having a penicillin allergy record affects treatment and antibiotic resistance in patients hospitalized with COVID-19. Many people labeled as allergic to penicillin are not truly allergic, leading to use of less effective antibiotics that can drive resista…

This study planned to track patients who had been in the intensive care unit for severe COVID-19, checking for long-term health problems like breathing, heart, kidney, and nerve issues. Researchers would have used questionnaires and doctor visits over 12 months. However, the stud…

This study looks at whether people can reliably collect their own blood and saliva samples at home to measure how well COVID-19 vaccines work. About 4,000 adults who recently got a COVID-19 vaccine will either do everything remotely or visit a clinic. Researchers will compare the…

This study looks at whether problems with blood vessels in the lungs cause ongoing shortness of breath in people who had COVID-19. Researchers will use heart and lung tests, including exercise and imaging, in 200 adults. The goal is to better understand why some people feel breat…

This study planned to test a powder made from organic rice and honey as a treatment for COVID-19. It was withdrawn before enrolling any participants. The main measurements were things like humidity and levels of heavy metals in the powder, not how well it worked against the virus…

This study examines how the COVID-19 pandemic affected syphilis cases and their interaction with HIV. Researchers will review medical records of 240 adults diagnosed with syphilis in Italy between 2017 and 2025. The goal is to see if pandemic restrictions led to delayed diagnoses…