New mRNA vaccines aim to shield healthy 50-64 year olds from COVID-19

NCT ID NCT07266558

Ongoing ⭐️ VACCINE ⭐️ Sponsor: ModernaTX, Inc. Source: ClinicalTrials.gov ↗

First seen Dec 26, 2025 · Last updated May 20, 2026 · Updated 23 times

Summary

This study tests two updated mRNA COVID-19 vaccines (mRNA-1283 and a variant version of mRNA-1273) in 30,000 healthy adults aged 50 to 64 who are not at high risk for severe COVID-19. The goal is to see if these vaccines can prevent symptomatic COVID-19 compared to a placebo. Researchers will also monitor for side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

AMR Clinical

Kansas City, Missouri, 64116, United States
AMR Clinical Mobile

Mobile, Alabama, 36608, United States
Accel Clinical Research

Birmingham, Alabama, 35216, United States
Accel Research Sites

Maitland, Florida, 32751, United States
Accel Research Sites - Neurostudies

Decatur, Georgia, 30030, United States
ActivMed Practices & Research, LLC

Methuen, Massachusetts, 01844, United States
Annapolis Internal Medicine

Annapolis, Maryland, 21401, United States
Artemis Institute for Clinical Research

Riverside, California, 92503, United States
Artemis Institute for Clinical Research

San Diego, California, 92103, United States
Atlanta Center for Medical Research

Atlanta, Georgia, 30331, United States
Avacare

Colton, California, 92324, United States
Avacare

Kenner, Louisiana, 70065, United States
Avacare

Fort Worth, Texas, 76135, United States
Avacare Research/Methodist Physicians Clinic

Fremont, Nebraska, 68025, United States
Avacare/Midwest Regional Health Services

Omaha, Nebraska, 68144, United States
Be Well Clinical Studies

Round Rock, Texas, 78681, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
CTI Clinical Research Center

Cincinnati, Ohio, 45212, United States
CenExel CNR

Garden Grove, California, 92845, United States
CenExel Research Centers of America

Hollywood, Florida, 33024, United States
CenExel iResearch, LLC

Decatur, Georgia, 30030, United States
Centennial Medical Group

Columbia, Maryland, 21045, United States
Charlottesville Medical Research, LLC

Charlottesville, Virginia, 22911, United States
Clay-Platte Family Medicine Clinic

Kansas City, Missouri, 64151, United States
Clinical Research Atlanta

Stockbridge, Georgia, 30281, United States
Clinical Research Partners, LLC

Richmond, Virginia, 23226, United States
Clinical Research Professionals

Chesterfield, Missouri, 63005, United States
Coastal Carolina Research Center, LLC

North Charleston, South Carolina, 29405, United States
Cope Family Medicine / Avacare

Bountiful, Utah, 84010, United States
Critical Care, Pulmonary and Sleep Associates, P.LLP/Avacare

Lakewood, Colorado, 80228, United States
Cullman Clinical Trials

Cullman, Alabama, 35055, United States
DM Clinical Research - Albuquerque

Albuquerque, New Mexico, 87106, United States
DM Clinical Research - Brookline

Brookline, Massachusetts, 02446, United States
DM Clinical Research - Houston

Houston, Texas, 77065, United States
DM Clinical Research - Houston

Houston, Texas, 77081, United States
DM Clinical Research - Jersey City

Jersey City, New Jersey, 07306, United States
DM Clinical Research - Melrose Park

Melrose Park, Illinois, 60160, United States
DM Clinical Research - Philadelphia

Philadelphia, Pennsylvania, 19107, United States
DM Clinical Research - San Antonio

San Antonio, Texas, 78207, United States
DM Clinical Research - Southfield

Southfield, Michigan, 48076, United States
DM Clinical Research - Sugar Land

Sugar Land, Texas, 77478, United States
DM Clinical Research - Tomball

Tomball, Texas, 77375, United States
DelRicht Research

Atlanta, Georgia, 30329, United States
DelRicht Research

Louisville, Kentucky, 40205, United States
DelRicht Research

Mandeville, Louisiana, 70471, United States
DelRicht Research

New Orleans, Louisiana, 70115, United States
DelRicht Research

Prairieville, Louisiana, 70769, United States
DelRicht Research

Springfield, Missouri, 65807, United States
DelRicht Research

Town and Country, Missouri, 63017, United States
DelRicht Research

Tulsa, Oklahoma, 74133, United States
DelRicht Research

Charleston, South Carolina, 29407, United States
DelRicht Research

Hendersonville, Tennessee, 37075, United States
DelRicht Research

Prosper, Texas, 75078, United States
Desert Clinical Research

Mesa, Arizona, 85213, United States
Eximia Research - NC, LLC

Raleigh, North Carolina, 27607, United States
Fiel Family and Sports Medicine / Avacare

Tempe, Arizona, 85283, United States
Foothills Research Center/Avacare

Phoenix, Arizona, 85044, United States
ForCare Clinical Research

Tampa, Florida, 33613, United States
Global Health Research Center, Inc.

Miami Lakes, Florida, 33016, United States
Global Health Research Center, Inc.

Tampa, Florida, 33615, United States
Hatboro Medical Associates/Avacare

Horsham, Pennsylvania, 19044, United States
Headlands Research Detroit

Southfield, Michigan, 48034, United States
Headlands Research Orlando

Orlando, Florida, 32819, United States
Headlands Research Scottsdale

Scottsdale, Arizona, 85260, United States
Health Awareness Inc.

Jupiter, Florida, 33458, United States
Hillcrest Medical Research, LLC

DeLand, Florida, 32720, United States
Indago Research & Health Center, Inc

Hialeah, Florida, 33012, United States
Innovation Medical Research Center

Palmetto Bay, Florida, 33157, United States
J. Lewis Research, Inc/Jordan River Family Medicine

South Jordan, Utah, 84095, United States
JBR Clinical Research

Salt Lake City, Utah, 84107, United States
Javara Inc. and Mankato Clinic, Ltd.

Mankato, Minnesota, 56001, United States
Javara Inc. and PRIVIA Medical Group of Georgia, LLC

Albany, Georgia, 31707, United States
Javara Inc. and Privia Medical Group - North Texas

Stephenville, Texas, 76401, United States
Javara Inc. and Privia Medical Group Gulf Coast, PLLC

Conroe, Texas, 77384, United States
Javara Inc. and Privia Medical Group Gulf Coast, PLLC

San Marcos, Texas, 78666, United States
Javara Inc. and Privia Medical Group Gulf Coast, PLLC

Sugar Land, Texas, 77478, United States
Javara Inc. and Privia Medical Group of Georgia, LLC

Fayetteville, Georgia, 30214, United States
Johnson County Clin-Trials

Lenexa, Kansas, 66212, United States
Lenzmeier Family Medicine - Avacare

Glendale, Arizona, 85308, United States
Mountain View/Avacare

Pleasant View, Utah, 84404, United States
New England Research Associates

Bridgeport, Connecticut, 06606, United States
NextPhase Research Florida

Hollywood, Florida, 33024, United States
Olympus Clinical Research

Sugar Land, Texas, 77479, United States
Olympus Family Medicine/Avacare

Salt Lake City, Utah, 84117, United States
Papillion Research/Avacare

Papillion, Nebraska, 68046, United States
Peninsula Research Associates

Rolling Hills Estates, California, 90274, United States
Rochester Clinical Research

Rochester, New York, 14609, United States
Sandhill Research, LLC d/b/a Accel Research Sites - Lakeland Clinical Research Unit

Lakeland, Florida, 33803, United States
Sandhill Research, LLC d/b/a Accel Research Sites- St. Pete-Largo Clinical Research Unit

Largo, Florida, 33777, United States
Santa Rosa Medical Centers of Nevada

Las Vegas, Nevada, 89119, United States
South Ogden Family Medicine/ Avacare

South Ogden, Utah, 84405, United States
Stamford Therapeutics Consortium

Stamford, Connecticut, 06905, United States
Summit Headlands LLC

Portland, Oregon, 97210, United States
Suncoast Clinical Research

New Port Richey, Florida, 34652, United States
Suncoast Research Associates, LLC

Doral, Florida, 33172, United States
Sundance Clinical Research, LLC

St Louis, Missouri, 63141, United States
TMA Headlands LLC d/b/a Trial Management Associates

Wilmington, North Carolina, 28403, United States
Tekton Research, LLC

Denver, Colorado, 80238, United States
Tekton Research, LLC

Fort Collins, Colorado, 80525, United States
Tekton Research, LLC

Longmont, Colorado, 80501, United States
Tekton Research, LLC

Wichita, Kansas, 67218, United States
Tekton Research, LLC

Edmond, Oklahoma, 73013, United States
Tekton Research, LLC

Moore, Oklahoma, 73160, United States
Tekton Research, LLC

Yukon, Oklahoma, 73099, United States
Tekton Research, LLC

Austin, Texas, 78745, United States
Tekton Research, LLC

Beaumont, Texas, 77706, United States
Tekton Research, LLC

San Antonio, Texas, 78229, United States
University Clinical Research-Deland, LLC d/b/a Accel Research Sites - Deland Clinical Research Unit

DeLand, Florida, 32720, United States
Velocity Clinical Research

Lincoln, Nebraska, 68510, United States
Velocity Clinical Research - Albuquerque

Albuquerque, New Mexico, 87107, United States
Velocity Clinical Research - Austin

Austin, Texas, 78759, United States
Velocity Clinical Research - Boise - ERN - PPDS

Meridian, Idaho, 83642, United States
Velocity Clinical Research - Cleveland

Beachwood, Ohio, 44122, United States
Velocity Clinical Research - Columbia

Columbia, South Carolina, 29204, United States
Velocity Clinical Research - Covington

Covington, Louisiana, 70433, United States
Velocity Clinical Research - Dallas

Dallas, Texas, 75230, United States
Velocity Clinical Research - East Greenwich

East Greenwich, Rhode Island, 02818, United States
Velocity Clinical Research - Los Angeles

Los Angeles, California, 90017, United States
Velocity Clinical Research - Medford

Medford, Oregon, 97504, United States
Velocity Clinical Research - Phoenix

Phoenix, Arizona, 85006, United States
Velocity Clinical Research - Salt Lake City (West Jordan)

West Jordan, Utah, 84088, United States
Velocity Clinical Research - San Diego - ERN - PPDS-Site Number:8400010

La Mesa, California, 91942, United States
Velocity Clinical Research - Sioux City

Sioux City, Iowa, 51106, United States
Velocity Clinical Research - Suffolk

Suffolk, Virginia, 23435, United States
Velocity Clinical Research -- Banning

San Bernardino, California, 92408, United States
Velocity Clinical Research Gulfport

Gulfport, Mississippi, 39503, United States
Velocity Clinical Research Norfolk

Norfolk, Nebraska, 68701, United States
Velocity Clinical Research Omaha

Omaha, Nebraska, 68134, United States
Velocity Clinical Research Savannah

Savannah, Georgia, 31406, United States
Velocity Clinical Research Spartanburg

Spartanburg, South Carolina, 29303, United States
Velocity Clinical Research Springdale

Cincinnati, Ohio, 45246, United States
Velocity Clinical Research Union

Union, South Carolina, 29379, United States
Velocity Clinical Research Valparaiso

Valparaiso, Indiana, 46383, United States
Velocity Clinical Research, Abilene

Abilene, Texas, 79606, United States
Velocity Clinical Research, Anderson

Anderson, South Carolina, 29621, United States
Velocity Clinical Research, Durham

Durham, North Carolina, 27701, United States
Velocity Clinical Research, Grand Island

Grand Island, Nebraska, 68803, United States
Velocity Clinical Research, Hallandale Beach

Hallandale, Florida, 33009, United States
Velocity Clinical Research, Huntington Park

Huntington Park, California, 90255, United States
Velocity Clinical Research, Lafayette

Lafayette, Louisiana, 70508, United States
Velocity Clinical Research, Mobile

Mobile, Alabama, 36608, United States
Velocity Clinical Research, New Orleans

New Orleans, Louisiana, 70119, United States
Velocity Clinical Research, Rockville

Rockville, Maryland, 20854, United States
Velocity Clinical Research, Spokane

Spokane, Washington, 99218, United States
Velocity Clinical Research-Baton Rouge

Baton Rouge, Louisiana, 70809, United States
Velocity Clinical Research-Hampton

Hampton, Virginia, 23666, United States
Velocity Clinical Research-Mt. Auburn

Cincinnati, Ohio, 45242, United States
Velocity Clinical Research-Washington, DC

Washington D.C., District of Columbia, 20016, United States
Versailles Family Medicine - CCT Research

Versailles, Kentucky, 40383, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States

Conditions

Explore the condition pages connected to this study.

SARS-COV-2