New study tracks heart inflammation in teens after pfizer vaccine

NCT ID NCT05295290

Ongoing Knowledge-focused Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 319 people under 21 who developed heart inflammation (myocarditis or pericarditis) within 21 days of receiving the Comirnaty (Pfizer) COVID-19 vaccine. Researchers will monitor their heart function with imaging tests for up to 5 years to see if there are lasting effects. The goal is to better understand the risks and recovery from this rare side effect.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could clarify the long-term heart health risks after COVID-19 vaccination in young people, helping guide future vaccine safety recommendations.
What could go wrong: This is an observational study, not a treatment trial, so it won't offer new therapies. The findings may be limited by the small number of participants (319) and the lack of a comparison group.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 myocarditis pericarditis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYOCARDITIS

Contacts and locations

Locations

Boston Children's Hospital

Boston, Massachusetts, 02115, United States
Children's Healthcare of Atlanta - Arthur M. Blank Hospital

Atlanta, Georgia, 30329, United States
Children's Hospital

New Orleans, Louisiana, 70118, United States
Children's Hospital of Michigan

Detroit, Michigan, 48201, United States
Childrens Hospital Los Angeles

Los Angeles, California, 90027, United States
Childrens Mercy Kansas City

Kansas City, Missouri, 64108, United States
Childrens National Hospital

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Columbia University Medical Center

New York, New York, 10032, United States
Connecticut Children's Medical Center

Hartford, Connecticut, 06106, United States
Indiana University School of Medicine

Indianapolis, Indiana, 46202, United States
MUSC Summey Medical Pavilion

North Charleston, South Carolina, 20406, United States
Memorial Healthcare System

Hollywood, Florida, 33021, United States
Northwell Health-Cohen Children's Medical Center

New Hyde Park, New York, 11042, United States
Riley Hospital for Children at IU Health

Indianapolis, Indiana, 46202, United States
The Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
University of Michigan Health Center

Ann Arbor, Michigan, 48109, United States
Valley Children's Hospital

Madera, California, 93636, United States

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