Bone resorption disease

This study looks at whether giving the osteoporosis drug romosozumab in two separate 6-month blocks, with breaks for another drug called zoledronate, can build more bone than the standard 12-month course. It involves 270 postmenopausal women with osteoporosis and a recent fractur…

This study compares two surgical techniques—ridge splitting and the sausage technique—to widen a narrow lower jawbone and place dental implants at the same time. Thirty adults with mild to moderate bone loss will be treated and followed for at least three months. The goal is to s…

This study tests a device called Vessel-X® that uses a special container to deliver bone cement into fractured vertebrae caused by osteoporosis. The goal is to reduce cement leakage and improve safety compared to standard procedures. About 146 adults aged 40 to 95 with spinal fra…

This study compares two treatment schedules for postmenopausal women with severe osteoporosis. One group gets romosozumab for 12 months then denosumab for 12 months. The other group cycles between the two drugs every 6 months for 2 years. Researchers will measure bone density and…

This study looks at ways to prevent bone loss when older adults lose weight. It will test if a combination of resistance exercise and a bone-strengthening drug (alendronate) can protect bone density. About 900 overweight or obese older adults with low bone mass will take part for…

This Phase 2 study tests whether a Traditional Chinese Medicine (TCM) herbal formula can improve muscle strength and bone health in pre-frail adults aged 65 and older, compared to the nutritional supplement HMB. Over 24 weeks, 90 participants will take either the TCM powder or HM…

This study tests a new drug called SAL056 in postmenopausal women with osteoporosis. The goal is to find the safest and most effective dose. About 200 women aged 45 to 80 will receive different doses of the drug or a control treatment for around 10 weeks. The study focuses on sid…

This study tests whether a special exercise program that combines rhythm and multitasking (called RYMA) can reduce falls, fractures, and heart problems in people aged 65 and older with type 1 or type 2 diabetes. Participants will be screened for fall risk, bone health, nerve func…

This study aims to see how well two different FDA-approved medication regimens improve bone density in postmenopausal women with osteoporosis who are at high risk of fractures. About 50 women aged 45 and older will receive one of the two treatments for 12 months. The main goal is…

This study tests whether a weekly dose of everolimus (a drug similar to rapamycin), resistance training three times a week, or both together can improve bone formation in women aged 60-75 with low bone mass. Researchers will measure bone markers, density, and muscle function over…

This study tests whether adding platelet-rich fibrin (PRF), made from a patient's own blood, to standard surgery improves healing of bone and gum damage around dental implants. Forty adults with peri-implantitis will be randomly assigned to receive either surgery with PRF or surg…

This study tests a special medical food containing probiotics and prebiotics to see if it can help slow or reverse bone loss in older women. Researchers will measure changes in bone density and strength over 18 months. The goal is to find a safe, dietary approach to manage osteop…

This study tests whether a single dose of either zoledronic acid or denosumab can prevent bone loss in older adults who have been in the intensive care unit (ICU). The trial will include 450 women aged 50+ and men aged 70+ who spent at least 2 days in the ICU. Participants will r…

This study tests whether blocking a hormone called LH can improve bone health in menopausal women. 192 women with moderate-to-severe hot flashes will receive either a GnRH analog, estrogen, testosterone, or a placebo for 8 weeks. The goal is to find a safer alternative to estroge…

This study tests custom-made, 3D-printed hip implants for 15 adults whose previous hip replacements failed due to severe bone loss or infection. The implants are designed from CT scans to fit each person's unique bone damage. Researchers will track complications, pain, mobility, …

This study compares drinking dairy milk, pea-based, or almond-based beverages after resistance training sessions for 12 months. It includes 150 postmenopausal women and men aged 50 and older. The goal is to see which drink best improves bone density and strength, helping prevent …

This study tests a new, less invasive surgical technique to rebuild bone in the upper jaw near the sinuses. The procedure uses a small window in the bone to lift the sinus membrane and add bone graft material, aiming to create enough bone for dental implants. The trial will enrol…

This study tests whether a dietary fiber supplement (soluble corn fiber) can help older men absorb more calcium and improve bone health. Thirty male veterans aged 60 and older will take the fiber supplement and then have their calcium absorption measured. The goal is to see if ch…

This study tests whether a monthly pill called risedronate can reduce bone and muscle loss after sleeve gastrectomy, a common weight-loss surgery. About 200 adults who have had the surgery will take either risedronate or a placebo for 6 months and be followed for a year. The goal…

This study tests whether Denosumab, a drug used for osteoporosis, can help preserve muscle strength and mobility in frail adults aged 65 and older living in nursing homes or assisted living. Participants will receive either Denosumab or Zoledronic Acid, and researchers will measu…

This study tests a program called OPTIONS that helps older adults recover after breaking a hip or leg. The program provides information on exercise, healthy eating, and bone-strengthening medications to patients in nursing homes and after they go home. Researchers will include ab…

This study looks at how well a full set of dental implants (All-on-X) works for people with bone loss in the upper jaw. Researchers will check implant survival and gum health over 2 years using special stackable guides for surgery. The goal is to see if this method helps patients…

This study tests whether doing Pilates exercises three times a week for 12 weeks can improve bone density in breast cancer survivors aged 40-60 who are taking hormone therapy (aromatase inhibitors). These women are at higher risk for bone loss and osteoporosis. The trial will mea…

This study compares two treatment plans for people with osteoporosis who have already had a fracture. One group receives a bone-building drug (teriparatide) for 6 months followed by a bone-strengthening drug (denosumab), while the other group takes denosumab alone. The goal is to…

This study compares three different gum graft methods used right after a tooth implant to see which one best prevents bone loss. Fifty-four adults needing a front tooth implant will be randomly assigned to one of the three techniques. The main goal is to check if the graft can st…

This study looks at women with postmenopausal osteoporosis who have been on denosumab for at least two years and are now stopping it. Stopping denosumab can cause a rapid bone loss and increase fracture risk. The trial compares two strategies using zoledronic acid infusions: one …

This study tests whether adding a growth factor (rhPDGF) to a standard bone graft helps rebuild jawbone better than using saline alone. About 44 adults who need dental implants but have thin jawbone will receive one of the two treatments. Researchers will measure new bone formati…

This study looks at two surgical methods to fix the spine in people with osteoporosis (weak bones). It compares screws that are reinforced with bone cement to regular hollow screws. The goal is to see which method provides better stability, pain relief, and recovery, with fewer c…

This study is testing a fracture liaison service (FLS) combined with medication management for people with osteoporosis in a rural area. The program provides education, monitoring, and follow-up to help patients take their medications as prescribed. Researchers will enroll 200 ad…

This study tests whether denosumab, a drug used for osteoporosis, can also improve muscle mass, strength, and insulin sensitivity in postmenopausal women with type 2 diabetes. About 40 women will receive either denosumab or a placebo for 12 months. The goal is to see if the drug …

This study tests whether a gradual reduction of denosumab (Prolia) combined with zoledronic acid (Aclasta) can prevent bone loss after long-term osteoporosis treatment. 44 postmenopausal women and men over 50 who have taken denosumab for at least 3 years will be randomly assigned…

This study tests whether combining two osteoporosis drugs (romosozumab and denosumab) works better than either drug alone for postmenopausal women with weak bones. About 90 women will receive one of three treatments for 6 months. The goal is to see which approach improves bone de…

This study tests whether adding vitamin K, α-lactalbumin, and D-chiro-inositol to standard calcium and vitamin D supplements can improve bone health in women with breast cancer who are on hormone therapy. These women are at higher risk for bone loss and fractures. The trial will …

This study looks at placing a dental implant and temporary crown right after tooth removal in the upper front jaw, using guided surgery and bone grafting. Fifty adults with bone loss will be followed for five years to check bone thickness, healing, and esthetics. The goal is to s…

This study tests whether taking a daily supplement of lutein, zeaxanthin, and fish oil for six months can improve thinking skills, eye health, and bone density in healthy adults. Researchers will enroll 80 people with low levels of a key eye pigment. Participants will take either…

This study looks at whether eating a small amount of Jarlsberg cheese every day, along with calcium and vitamin D supplements, can improve bone density and bone health markers in people with weak bones (osteopenia or osteoporosis). About 60 adults over 55 will be randomly assigne…

This study looks at a new way to place dentures in the lower jaw using computer-guided surgery. The goal is to see if these implant-supported dentures help keep the jawbone healthy and last for at least 3 years. 40 adults aged 40-75 with no teeth in the lower jaw and enough bone …

This study is following 425 people who receive Teknimed bone substitutes during surgeries like bone grafting or spinal fusion. The goal is to confirm the safety and performance of these products in everyday medical practice. Researchers will track how well the bone heals, pain le…

This study tests whether an AI system (VeriOsteo OP) can help doctors find osteoporosis earlier in adults aged 40 to 80 who are at high risk. About 1,180 participants will be randomly assigned to get either AI-guided screening or usual care. The goal is to see if AI leads to bett…

This study is testing a new blood-based method to diagnose osteoporosis and predict fracture risk. Researchers will analyze the vitality and behavior of certain blood cells from 120 healthy, osteopenic, and osteoporotic adults aged 40 and older. The goal is to see if this approac…

This study checks if a computer tool called BBCT-hip can accurately predict the risk of breaking the thigh bone (femur) when a person falls. Researchers will enroll 300 postmenopausal women with osteoporosis—150 who have already had a fracture and 150 who have not. All will get a…

This study will test whether an AI program can find vertebral fractures (broken spine bones) that might be missed on CT scans done for other reasons. Researchers will look at scans from 250 men aged 50 or older to see how common these fractures are. The goal is to improve detecti…

This study is testing an artificial intelligence system that reads medical images like X-rays and MRIs to diagnose and stage osteoporosis and osteoarthritis. Researchers aim to make diagnosis more accurate and consistent. The trial will enroll 2,000 adults who have already had im…

This study tests an artificial intelligence software called Osteo Signal that analyzes chest X-rays to detect signs of osteoporosis or osteopenia in adults aged 50 and older. Researchers will compare the AI's accuracy against the standard DXA bone density scan using data from 595…

This study tests whether a generative AI tool can help doctors diagnose complications and co-existing diseases in people with rheumatoid arthritis. The AI reviews patient records and suggests possible issues like lung or heart problems. Doctors then decide if the AI's suggestions…

This study uses artificial intelligence to look at CT scans that people already had for other reasons. The goal is to create a tool that can estimate bone age and catch early signs of osteoporosis without needing extra tests or radiation. Researchers will study 3,000 adults to se…

This study is testing a portable ultrasound device called POROUS R4C that measures bone in the lower leg without radiation. Researchers want to see if it can estimate bone mineral density as accurately as the standard X-ray method (DXA). The study will include 350 healthy men and…

This study compares a new ultrasound technology called REMS with the standard DXA scan for measuring bone density. Researchers will enroll 296 women aged 30-80 to see if REMS is as accurate and reliable as DXA, but without using radiation. If it works, it could offer a faster, sa…

This study tests a procedure called LOEP that strengthens the hip bone to prevent a second fracture in women over 65 with osteoporosis who have already broken one hip. About 2400 women will either receive the procedure or standard care and be followed for at least 5 years. The go…

This study tests whether a patient navigator—someone who contacts you after a fracture and connects you to a bone health specialist—can help older adults avoid future fractures. Over 2,600 people aged 50 and older who recently had a fragility fracture will be assigned to either t…

This study tests whether eating 5-6 prunes daily for 18 months can prevent the rapid bone loss that often happens during menopause. Researchers will compare bone density, inflammation, and gut health in 124 women aged 44-55 who either eat prunes or avoid them. If successful, this…

This study tests whether vitamin K2 supplements can prevent bone loss in children with nephrotic syndrome who are on long-term steroid therapy. Steroids are effective but can weaken bones, increasing fracture risk. The trial will enroll 60 children under 16 and measure changes in…

This study tests whether using a positive expiratory pressure (PEP) device before and after hip fracture surgery can prevent hospital-acquired pneumonia. About 566 patients will either receive the PEP therapy plus standard care or standard care alone. The goal is to see if this s…

This study tests a medical device called VCFix to treat broken vertebrae (spinal bones) from compression fractures. The goal is to reduce pain and improve movement in 103 adults aged 21-85 with a single recent fracture. The device is placed into the bone to restore height and sta…

This study tests a walking program called Walk-BEST for people aged 70+ with osteoporosis. The program uses a sensor to improve walking and aims to reduce falls and fractures. Researchers want to see if it's practical and acceptable for 28 participants.

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study is testing whether a technique called EMG biofeedback—which uses sound and visual cues to help people control muscle activity—can improve balance in people aged 65–75 with osteoporosis. Sixty participants will receive biofeedback combined with balance and strength trai…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study tests whether virtual reality exercise games can improve balance, reduce fall risk, and boost quality of life in postmenopausal women aged 50–75 with osteoporosis. Fifty participants will either do VR exercises or standard care. The goal is to see if fun, interactive g…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests whether a virtual chiropractor program is practical for people over 50 who have had a spine fracture from osteoporosis. Participants will receive 12 online sessions over 8 weeks covering pain management, safe movement, exercise, and nutrition. The goal is to see …

This study tests a gentle exercise program combining Baduanjin (a traditional Chinese mind-body practice) with resistance training for older adults with osteoporosis and a slipped disc in the lower back. Researchers want to see if it can reduce pain, improve muscle strength, and …

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study investigates whether a protein called lumican, found in the blood, can identify postmenopausal women who have fragile bones but normal bone density scans. About 100 women will have their bone density, muscle strength, and blood lumican levels measured. The goal is to s…

This study looks at a new tool called the Functional Muscle-Bone Incongruity Index (FKUI) that combines handgrip strength and bone density measurements. Researchers want to see if this combined approach gives a fuller picture of muscle and bone health than looking at each measure…

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study aims to collect information and bone samples from up to 1,000 people with bone or mineral disorders, such as tumor-induced osteomalacia or familial tumoral calcinosis. Participants receive standard medical evaluations and may provide bone tissue from surgery or a biops…

This study looks at whether a standard shoulder X-ray can detect bone loss in the weak arm of people who have had a stroke. Researchers will measure bone thickness on X-rays from 65 stroke survivors and compare those measurements to the gold-standard DXA bone density scan. If the…

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study is creating a collection of blood, urine, and leftover surgical tissue from 350 patients with bone, calcium, and growth plate disorders. The goal is to better understand how these diseases progress and to find markers that could predict outcomes. No new treatments are …

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study is testing a robotic system called Epione to help doctors place needles or instruments into the bones of the pelvis and spine. The goal is to see if the robot makes these procedures more feasible, safe, and accurate compared to doing them by hand. Sixty adults who are …

This study aims to find small molecules called microRNAs in the blood that can predict how well two osteoporosis drugs (romosozumab and abaloparatide) work in postmenopausal women. Researchers will measure bone density and blood markers over 12 months in 42 women. The goal is to …

This study is looking at what happens to muscle and bone when people lose weight using the drug tirzepatide. Researchers want to see if adding protein shakes and resistance exercise can protect muscle and bone. The study will enroll 50 adults with obesity and track changes over 6…

This study looks at how endurance exercise (like walking or cycling) and resistance exercise (like lifting weights) affect bone health in older veterans aged 60 and over. Researchers want to see if either type of exercise causes bone breakdown and how the body adapts over time. T…

This study is recruiting 100 people who need hip replacement surgery after a fragility fracture (a break from a minor fall) and comparing them to patients having hip replacement for arthritis. Researchers will use a simple questionnaire (SARC-F) and analyze bone and muscle tissue…

This study looks at how different brain regions communicate in women with and without osteoporosis. Researchers will use MRI scans and blood tests to compare brain connectivity and bone markers in 60 postmenopausal women. The goal is to better understand the link between the brai…

This study looks at whether a new scoring system (called the OF score) helps doctors choose the best treatment for people with spine fractures due to osteoporosis. About 648 adults over 50 will be observed to see if following the score's advice leads to faster return to normal mo…

This study is building a registry of 300 people in Ontario who have had a rare type of thigh bone fracture called an atypical femur fracture. Researchers want to learn more about what causes these fractures, which have been linked to long-term use of osteoporosis drugs called bis…

This study is not testing a new drug or treatment. Instead, researchers want to make sure their lab tests and equipment give accurate and repeatable results when studying conditions like obesity, diabetes, heart disease, and bone loss. Up to 100 healthy volunteers and people with…

Researchers are testing a 14-question survey to see if it can help detect rare genetic bone diseases (like osteogenesis imperfecta) in adults with osteoporosis. The study will enroll 58 participants who will fill out the online questionnaire. The goal is to see if the questionnai…

This study investigates whether blocking a protein called RANKL can help eggs mature and improve fertility treatments. Researchers will use denosumab, a drug already approved for osteoporosis, in lab studies with human and mouse eggs. The goal is to understand if RANKL manipulati…

This study looks at bone density in 100 pregnant women (ages 30-45) with either one baby or twins during the third trimester. Researchers use a special ultrasound-like scan and questionnaires to check bone health and fracture risk. The goal is to see if carrying twins leads to gr…

This study is developing an AI model to predict complications like lymphedema, pain, and shoulder problems after breast cancer surgery. Researchers will collect data from 133 women before and after surgery to train the AI. The goal is to create a tool that helps doctors identify …

This study collects bone marrow from 24 adults aged 65+ having hip surgery to understand how common aging-related blood cell mutations (called CHIP) change cell metabolism. Researchers will compare gene activity in mutated versus normal stem cells. The goal is to learn more about…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study tests whether digital education or in-person classes help people over 50 with osteoporosis take better care of themselves. Six hundred participants will be split into three groups: one gets standard information, another attends three group sessions with a physiotherapi…

This study is creating a biobank of blood and tissue samples from 2,000 people with rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, or osteoporosis. Researchers will analyze these samples to find biomarkers that predict how well a patient responds to treatment. The …

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study uses two special scanners (HR-pQCT and pQCT) to take detailed pictures of bone and muscle in 1,000 people with conditions that raise the risk of bone loss, like osteoporosis, arthritis, or kidney disease. The goal is to see if these scanners can spot tiny changes in bo…

This study compares bone density in 84 stroke patients at different recovery stages (1 week to 6 months, or over 1 year) to understand osteoporosis risk. Researchers will also look at factors like muscle strength and vitamin D levels. The goal is to identify high-risk patients wh…

This study tests a new, radiation-free ultrasound technology called REMS to measure bone density in children aged 5 to 18 who have conditions that weaken bones, such as brittle bone disease or osteoporosis. The goal is to see if REMS can work as well as the standard X-ray method …

This study looks at how much older adults (women 65+ and men 70+) know about osteoporosis and their overall health literacy. Researchers will use surveys to measure awareness and understanding, aiming to find gaps that could lead to better education and prevention. No treatments …

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study looks at bone samples from 52 adults having hip replacement surgery to understand how osteoporosis causes tiny damage that leads to fractures. Researchers will use CT scans and computer models to compare healthy and osteoporotic bones. The goal is to create better ways…

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study interviews 15 doctors in Alsace, France, who treat elderly patients with osteoporosis and have used a practical guide on the condition. The goal is to find out what helps or prevents them from using the guide in their daily practice. By understanding these factors, res…

This study looks at how vitamin D levels are connected to genes, proteins, and other molecules in people newly diagnosed with primary osteoporosis. Researchers will collect blood samples from 120 adults to analyze these molecular profiles. The goal is to better understand the dis…

This study looks at how the drug romosozumab affects bone-making cells in postmenopausal women with osteoporosis. Researchers will take small bone samples to count these cells early and late in treatment. The goal is to understand why the drug works, not to test a new treatment. …

This study looks at how mechanical loading, like standing or vibrating, affects spinal reflexes in postmenopausal women with and without osteoporosis. Researchers will measure nerve signals (H-reflex) under different loads to see if bone loss changes these responses. The goal is …

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study looks at whether blood tests called bone turnover markers can quickly show if osteoporosis drugs are working in postmenopausal women. Forty women will receive either bone-strengthening or bone-building medications for six months. The goal is to see if these blood tests…

This study is building a registry of people with rare bone diseases (skeletal dysplasias) in Italy. Researchers will collect medical history, genetic data, and treatment details over time to better understand how these conditions progress. No experimental treatments are given; th…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This study looks at how estrogen and other hormones affect bone development in teenage and young adult women with cystic fibrosis (CF). It has two parts: an observational study that tracks bone health in women using different types of birth control, and a small feasibility study …

This study looks at whether having a surgeon send patients with osteoporosis to a bone specialist after hip or knee replacement leads to fewer implant problems and broken bones. About 2,000 adults over 50 with confirmed osteoporosis will be observed for two years. The goal is to …

This study looks at whether donepezil, a common Alzheimer's medication, can improve bone density and reduce fracture risk in older adults with mild to moderate Alzheimer's. Researchers will compare donepezil to another drug, memantine, over 12 months in 45 participants. The goal …

This study compares two different ways of placing dental implants to see which one leads to less bone loss after one year. Sixty adults with missing back teeth will be split into three groups, each receiving a slightly different implant procedure. Researchers will measure bone ch…