Bone resorption disease

This study tests whether a robotic exoskeleton called ReWalk can help people with complete spinal cord injury below T4 walk and improve their health. Fifty participants will either use the exoskeleton or receive standard physical therapy. The goal is to see if the device improves…

This trial tests a fracture liaison service (FLS) — a coordinated care program for people aged 50 and older who have had a hip or spine fracture. The program follows best-practice standards to ensure patients receive bone density tests and appropriate osteoporosis management. Res…

This study tests a new device called VCFix for treating a broken bone in the spine (vertebral compression fracture). Ten adults with a single recent fracture will receive the implant to see if the procedure is safe and works as intended. The goal is to gather early data to plan a…

This study tests a service designed to help people with osteoporosis take their medications as prescribed. Participants receive education, reminders, and regular follow-up calls. The goal is to see if this support improves medication adherence and reduces fracture risk over 18 mo…

This study looks at whether adding the drug abaloparatide (Tymlos) to the standard treatment denosumab (Prolia) can improve bone density more than denosumab alone in postmenopausal women with osteoporosis. Seventy women who have already been on denosumab will either continue with…

This study aimed to see if romosozumab (Evenity) could improve bone density and muscle mass in postmenopausal women with osteoporosis undergoing lumbar spine surgery. Participants would have received monthly injections of romosozumab or weekly alendronate pills for 12 months. How…

This study tests if Prolia can improve bone density in people whose bones have weakened from taking steroids (glucocorticoids). About 102 adults in China will receive the drug and be monitored for 12 months. The main goal is to see if bone mass in the lower spine increases.

This study tests whether a Fracture Liaison Service (FLS) helps people aged 50 and older who have had a hip or spine fracture. Half of the 400 participants get the FLS, which includes bone health checks, medication guidance, diet and exercise advice, and regular phone follow-ups …

This study tests a personalized treatment for age-related osteoporosis using the drug teriparatide. Researchers aim to match treatment to each patient's bone turnover rate using simple blood tests, avoiding the need for painful bone biopsies. The trial involves 60 adults aged 45 …

This study tests whether taking teriparatide (a bone-building drug) for one month before lumbar fusion surgery helps surgeons place screws more securely in patients with osteoporosis. About 192 participants will be randomly assigned to receive either the drug or no pretreatment. …

This study looks at whether taking teriparatide (Forteo) for 24 months can improve bone structure in 100 men and women with osteoporosis. Researchers will use a special CT scan to see changes in bone thickness and microarchitecture at the wrist and shin. The goal is to understand…

This Phase 2 trial tests whether a combination of three drugs—dasatinib, quercetin, and nicotinamide riboside—can improve bone health in 120 adults aged 60-90 with osteopenia or osteoporosis. The goal is to see if these 'senolytic' drugs can clear aging cells from the skeleton an…

This study looks at how teriparatide, a bone-building drug for severe osteoporosis, affects bone structure in postmenopausal women. Researchers will use a special scanner to see changes in bone thickness and tiny connecting rods at the wrist and ankle over 24 months. The goal is …

This study tests whether a patient's own stored tooth can be used as a graft to preserve jawbone after tooth extraction. About 21 adults needing at least two teeth pulled will receive this treatment. The goal is to maintain bone width and height for better future dental implant p…

This trial tests a nurse-led health program for women aged 45 to 64 in Hong Kong. The program uses a 5-step approach (ask, advice, assess, assist, arrange) to help women manage conditions like high blood pressure, anxiety, and menopause symptoms. Researchers will compare the prog…

This study tests whether a two-step drug treatment can improve bone density in people with long-term spinal cord injury who have bone loss. Participants receive either romosozumab (a bone-building drug) or a placebo for 12 months, followed by denosumab (a bone-strengthening drug)…

This study compares two FDA-approved medications, romosozumab and denosumab, for treating postmenopausal osteoporosis. Researchers will measure changes in hip bone density over 12 months in 50 women at high fracture risk. The goal is to see which drug works better to strengthen b…

This study compares two bone cements used to treat painful spinal fractures caused by osteoporosis. One cement includes a softener (V-Flex) to make it less rigid, while the other is standard cement (V-Steady). The goal is to see if the softer cement reduces the chance of new frac…

This study looks at 40 adults with osteoporosis who already completed a year of treatment with either Alendronate or Teriparatide. In this follow-up, participants will switch to the other drug for another year to see which works better for bone loss. The goal is to find a more pe…

This study compares two types of dental implant frameworks—PEEK (a plastic-like material) and titanium—to see which one causes less bone loss around the implants. Twenty adults with no lower teeth received a fixed set of four implants. Researchers measured bone loss and density a…

This study tests whether a monthly injection of romosozumab for one year, followed by another drug (denosumab) for another year, can safely increase bone density in 30 premenopausal women aged 18-48 who have osteoporosis without a known cause. The goal is to improve bone mass and…

This study compares two ways to place dental implants in people with bone loss. One technique places the implant at the gum level (tissue-level), while the other places it at the bone level and requires a second surgery to uncover it. Researchers will track bone changes, implant …

This study tests whether a year of monthly injections of romosozumab, followed by an infusion of zoledronic acid, can improve bone density and prevent fractures in women aged 65 and older with osteoporosis who live in long-term care facilities. The goal is to find a treatment tha…

This study looks at how well the drug Prolia works for men with osteoporosis in mainland China. About 102 men aged 30 to 90 with weak bones will receive Prolia injections. The main goal is to see if bone density in the lower spine improves after 12 months of treatment.

This early-stage trial is testing a new stem cell treatment called HMM910 in 9 postmenopausal women with osteoporosis who are at high risk of breaking a bone. The stem cells are given through an IV drip. The main goal is to see if the treatment is safe and tolerable, not yet to p…

This study tests an experimental drug called AGA2118 in postmenopausal women aged 55 to 80 who have low bone density but no history of fractures. The goal is to see if the drug can safely increase bone mineral density over 12 months compared to a placebo. About 379 women will par…

This study tests whether a new drug called SAL023 works like the approved osteoporosis medicine Evenity. It involves 118 healthy Chinese adults who get a single dose of either SAL023 or Evenity. The goal is to compare how the body processes the drug, its safety, and any immune re…

This early study tests a drug called romosozumab in 10 postmenopausal women who have both multiple myeloma and osteoporosis. The goal is to see if it safely improves bone formation and reduces bone breakdown caused by the cancer. Researchers will measure bone health markers and w…

This study tests a collagen-based bone graft material (Bio-Oss Collagen) for sinus augmentation in people with bone loss and missing teeth. The goal is to see if it helps grow enough bone to support a dental implant. The study involves 36 adults who need a single implant in the u…

This study looks at whether giving zoledronate infusions can prevent bone loss in postmenopausal women who have stopped taking denosumab for osteoporosis. About 200 women who took denosumab for at least two years will receive zoledronate at different times. The goal is to find th…

This phase 4 trial tests whether starting with romosozumab for 12 months and then switching to denosumab for another 12 months can better maintain bone density around the knee in people with recent spinal cord injury, compared to using denosumab alone. The study involves 40 adult…

This early-stage study tests a new injectable drug called LYN101 in 44 people. First, healthy volunteers get a single dose to check safety. Then, postmenopausal women with low bone mass get multiple doses to see how the drug affects bone turnover markers. The main goal is safety,…

This study was designed to see if a special bone scanner (bone mineral analyser) could predict how well osteoporotic women would respond to a zoledronic acid infusion. The plan was to measure bone texture and density before and one year after treatment. However, the study was wit…

This study tests a new ultrasound device that measures bone properties in the lower leg to predict fracture risk in adults over 55. It aims to see if it works as well as or better than standard DXA scans, without using radiation. Researchers will follow 1,600 participants for thr…

This study tests a handheld device called the Osteoprobe that measures bone strength by pressing on the shinbone. Researchers want to see if it can identify women at risk for hip and wrist fractures better than standard bone density scans. About 190 women with recent fractures an…

This trial investigates whether a daily effervescent supplement containing calcium, magnesium, and citrate can prevent bone loss, magnesium deficiency, and kidney damage in adults who take proton pump inhibitors (PPIs) long-term for conditions like heartburn or GERD. Participants…

This study tests whether a supervised resistance exercise program can reduce the risk of osteoporosis and osteoarthritis in women aged 50-70 who have gone through menopause. Participants will do leg and core exercises twice a week for 30-40 minutes. Researchers will measure chang…

This study tests whether a weekly dose of everolimus (a drug that targets aging pathways) and/or a fun exercise program called 'Football Fitness' can prevent the rapid bone loss that happens after menopause. 136 healthy women aged 45-60 will be assigned to one of four groups: exe…

This study compares three care models to prevent falls and fractures in older adults recovering from a broken bone in a skilled nursing facility. About 3,780 participants across 42 facilities will receive either medication reduction, bone health management, or both. The goal is t…

This study tests whether small meals containing dairy or banana can reduce bone breakdown in postmenopausal women with osteopenia (low bone density). Thirteen women will eat five different test meals or fast, then have blood samples taken over six hours to measure markers of bone…

This study tests a 32-week smart community resistance training program for adults aged 60 and older with primary osteoporosis. Participants use elastic bands and a smart bracelet to guide their workouts, while researchers measure changes in bone density and physical function comp…

This small, early study is testing a new device that uses low-frequency ultrasound waves in a bath to see if it can safely help heal knee osteoarthritis and reduce pain. Ten adults aged 40 and older with chronic knee pain will try the treatment every few days. The main goal is to…

This study explores whether a new type of resistance exercise is practical and safe for people with low bone mass, including those with osteopenia, osteoporosis, or sarcopenia. Over two months, one group performs progressive muscle-strengthening exercises while a control group co…

This study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…

This study looks at how bone contributes to citrate levels in urine, which may help explain why some people have low urine citrate. Researchers will study 25 adults with untreated osteoporosis, giving them potassium citrate and measuring changes in urine citrate and bone markers.…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This long-term study recruited over 12,000 non-pregnant women in Southampton, UK, and followed about 3,000 of them through pregnancy and their children's growth up to age 19. Researchers are tracking body composition, nutrition, asthma, and heart health to understand how a mother…

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This study is observing 60 people who received a special hip replacement cup (Plasmafit Revision Structan) during routine surgery. Researchers are checking how well the cup works and how long it lasts by tracking hip function and any need for repeat surgery. No new treatment is b…

This study tests whether sending information letters to doctors and patients after a fracture can improve osteoporosis care. Over 4,200 older adults in Manitoba who had a hip, spine, arm, or wrist fracture are included. The goal is to see if these notifications increase bone dens…

This study looks at whether two types of hormonal birth control pills (LF111 and drospirenone) affect bone density in women aged 14 to 45. Over 1,500 participants will have their bone density measured after 12 months and compared to women using non-hormonal birth control. The goa…

This study checks whether two easy-to-use risk calculators (OST and MORES) can accurately predict osteoporosis in Turkish men aged 50-75, compared to the standard DEXA bone density scan. Researchers will enroll 140 men to see how sensitive and specific these tools are. If they wo…

This study looks for a biomarker to identify people at risk of bone loss from glucocorticoid medications like prednisolone. 36 healthy volunteers will take either prednisolone or a placebo for seven days. Researchers will measure bone turnover markers in blood and collect bone, m…

This study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …

This study aimed to see if a mobile monitoring tool could accurately identify surgical site infections (SSIs) in orthopedic surgery patients, compared to the usual manual review. The study was withdrawn before enrolling any participants, so no results are available. It was design…

This study looks at whether common osteoporosis medications also improve muscle health in adults aged 65 and older. Researchers will measure changes in muscle mass, strength, and walking speed over time. The goal is to better understand the link between bone and muscle health in …

This study looks at 100 people who spent at least a week in the ICU and had kidney injury. Researchers will measure kidney function, muscle loss, and bone health to understand long-term effects. The goal is to improve follow-up care for ICU survivors.

This study tests whether placing a collagen matrix into the tooth socket right after extraction helps preserve bone and gum tissue better than letting the socket heal on its own. Twenty-four healthy adults with a single non-molar tooth that cannot be saved will be randomly assign…

This lab study compares how much growth factor (PDGF-BB) is released over time from two materials used in bone grafting: platelet-rich fibrin (PRF) from a patient's blood and a commercial product called GEM21S. Researchers will mix these with bone substitutes and measure growth f…

This study was designed to test whether adding arm exercises to a standard osteoporosis medication could improve bone density in the wrist. It was planned for postmenopausal women at high fracture risk. However, the study was withdrawn before enrolling any participants, so no res…

This study aimed to see if a web-based fracture liaison service (e-FLS) could help more older adults start osteoporosis treatment after a fracture compared to standard in-person services. It planned to include men and women over 60 in France who had a low-trauma fracture. However…

This study looks at how CFTR modulators, a type of cystic fibrosis treatment, affect bone strength and muscle mass in adults with CF. Researchers will measure changes in bone density and lean body mass over 12 to 24 months. The goal is to understand whether these treatments help …

This study tracks bone density and fracture risk in 1,230 pregnant and breastfeeding women using ultrasound scans and diet questionnaires. The goal is to catch early signs of pregnancy-related osteoporosis, a rare condition that can cause painful fractures. No drugs or treatments…