Can 'Zombie Cell' drugs strengthen aging bones?
NCT ID NCT06018467
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial tests whether a combination of three drugs—dasatinib, quercetin, and nicotinamide riboside—can improve bone health in 120 adults aged 60-90 with osteopenia or osteoporosis. The goal is to see if these 'senolytic' drugs can clear aging cells from the skeleton and reduce bone loss. Participants take the drugs for a short period, and researchers measure changes in bone turnover markers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dasatinib, Quercetin, and Nicotinamide Riboside
What this could lead to
If successful, this could point toward a new way to treat osteoporosis by targeting aging cells in the bone, potentially reducing fracture risk.
What could go wrong
This is an early Phase 2 trial with only 120 participants, so results may not apply to everyone. The combination therapy may cause side effects or fail to improve bone health significantly.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Odense University Hospital
Odense, 5000, Denmark