TYPE 2 DIABETES MELLITUS

This study tested a new medicine called HTD1801 in 551 adults with type 2 diabetes whose blood sugar was not well controlled by metformin alone. Participants received either HTD1801 or a placebo for 24 weeks to see if the drug could lower blood sugar levels safely. The main goal …

This study tested a new drug, TA-7284, in 61 adults with type 2 diabetes. Participants took the pill once daily for 15 days at different dose levels to check safety and how the body processes it. The goal was to see if the drug can help control blood sugar.

This study looked at whether testosterone therapy can improve bone health in men who have both type 2 diabetes and low testosterone. About 92 male veterans aged 35-70 with these conditions received testosterone for one year. Researchers measured bone strength using special scans …

This study screened 316 people with type 2 diabetes who were at high risk for heart disease. Researchers tested whether the drug liraglutide could help prevent new heart problems like chest pain, stroke, or heart attack. The goal was to better identify and manage heart disease ri…

This study tested whether a once-weekly injection of exenatide (a diabetes drug) could improve heart and kidney health in 57 adults with type 2 diabetes, mild kidney disease, and early heart stiffness. Participants received either the drug or a placebo for 38 weeks. Researchers m…

This study tested whether adding canagliflozin to insulin helps people with type 2 diabetes control their blood sugar better. 146 adults on stable insulin therapy took either the drug or a placebo for 16 weeks. Researchers measured changes in blood sugar, weight, and blood pressu…

This study looked at how a single dose of a new medicine, LY3209590, moves through the bodies of children with type 2 diabetes. Fifteen children took part, and the study lasted about 100 days. The goal was to measure how much medicine gets into the blood and how long it takes to …

This study tested a long-acting insulin called Gla-300 in 228 adults with type 2 diabetes whose blood sugar was not well controlled by oral medications. Participants had never used insulin before. The main goal was to check safety, including side effects and low blood sugar event…

This early-stage study tested an oral tablet called ecnoglutide in 87 healthy adults to see if it is safe and how the body processes it. The drug is designed to help manage type 2 diabetes and obesity by mimicking a natural hormone that controls blood sugar and appetite. Particip…

This study tested different starting doses of insulin using an automated delivery system (Omnipod M) in 56 adults with type 2 diabetes. The goal was to see if a simplified onboarding process is safe and helps control blood sugar levels. Participants used the system for up to 12 w…

This study tested a new medication called XW003 in 211 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. Participants received either XW003 or a placebo to see if the drug could safely lower blood sugar levels. The main goal was to …

This early-stage study tested an experimental oral drug called XW014 in 127 healthy volunteers and people with type 2 diabetes. The main goal was to check if the drug is safe and how the body processes it. Researchers gave single or multiple doses and looked for side effects, cha…

This study tested the Omnipod M System, a wearable insulin pump, in 40 adults aged 18-75 with type 2 diabetes. The goal was to see if the system helps keep blood sugar levels in a safe range and reduces dangerous highs and lows. Participants used the system for 6 weeks while rese…

This study tested four different doses of an experimental drug called MP-513 in 448 adults with type 2 diabetes who were already taking metformin. The goal was to see if adding MP-513 could safely improve blood sugar levels over 24 weeks, with an optional extension up to 52 weeks…

This study tested whether adding the drug JW0201 to two other diabetes medications helps lower blood sugar in people with type 2 diabetes. 196 adults whose blood sugar was not well controlled on their current treatment took part. The main goal was to see if JW0201 reduced HbA1c l…

This study tested whether adding teneligliptin to metformin helps Chinese adults with type 2 diabetes control their blood sugar better than metformin alone. 247 participants took either the combination or a placebo for 24 weeks. The main goal was to see changes in HbA1c, a key bl…

This study tested a long-acting insulin called Insulin Glargine U300 in 570 Chinese adults with type 2 diabetes whose blood sugar was not well controlled. Some participants had never used insulin before, while others switched from another basal insulin. The main goal was to see h…

This study tested an experimental drug called CT-868 in 103 overweight or obese adults with type 2 diabetes. The goal was to see if the drug could lower blood sugar levels and help with weight loss over 26 weeks. Participants received either the drug or a placebo, and researchers…

This study tested a lifestyle program designed for Native Hawaiian and Pacific Islander adults with conditions like diabetes, high blood pressure, and obesity. Community health workers delivered the program, which included support for social needs like housing and food access. Th…

This study tested a once-daily combination pill (teneligliptin and canagliflozin) in 153 Japanese adults with type 2 diabetes whose blood sugar was not well controlled on teneligliptin alone. Over 52 weeks, researchers monitored safety and changes in blood sugar levels. The goal …

This study tested a drug called ertugliflozin in 166 teenagers (ages 10-17) with type 2 diabetes who were already taking metformin. The goal was to see if adding this drug could lower blood sugar levels more than a placebo. After 24 weeks, the drug helped reduce HbA1C, a key bloo…

This study tested whether adding JW0201 to two standard diabetes medications helps lower blood sugar more effectively in people with type 2 diabetes. About 200 adults whose blood sugar was not well controlled on their current drugs took either JW0201 or a placebo for 24 weeks. Th…

This study tested a new drug called MP-513 (Teneligliptin) combined with a standard diabetes medicine (pioglitazone) in 204 Japanese adults with type 2 diabetes. The goal was to see if the combination improved blood sugar levels over 12 weeks, with a follow-up up to 52 weeks. Par…

This study tested a new medicine called TG103, given as a weekly shot, in 465 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. The goal was to see if TG103 could lower blood sugar levels and help with weight loss. The study is now …

This study tested a new weekly injection called CagriSema (a mix of two medicines) to help people with overweight or obesity and type 2 diabetes lose weight. About 1,200 adults took part, receiving either CagriSema or a placebo for around 1.5 years. The main goals were to see how…

This study looked at how well a triple combination of diabetes drugs (zemidapa and metformin) works and how safe it is for people with type 2 diabetes. Over 2,000 adults who were already on certain diabetes medicines took part. The main goal was to see if their blood sugar levels…

This study tested a new treatment called REACT (rilparencel) for people with type 1 or type 2 diabetes who also have chronic kidney disease. The treatment uses a person's own kidney cells to try to slow down kidney damage. 53 adults aged 30 to 80 took part, and the study looked a…

This study tested a new drug, MP-513 (Teneligliptin), added to standard sulfonylurea treatment in 194 Japanese adults with type 2 diabetes. The goal was to see if the combination improved blood sugar levels more than sulfonylurea alone over 12 weeks, with a follow-up up to 52 wee…

This study looked at whether weight-loss surgery (vertical sleeve gastrectomy) can improve diabetes and kidney health in teens aged 12-21 with type 2 diabetes. Researchers measured how well the pancreas and kidneys worked before and after surgery. The goal was to see if surgery c…

This study tested whether adding the pill teneligliptin to insulin helps Japanese adults with type 2 diabetes control their blood sugar better. 148 people took the combination for 16 weeks, with some continuing up to 52 weeks. The main goal was to see if HbA1c (a measure of avera…

This study tested a new diabetes medication called MP-513 (Teneligliptin) in 203 Japanese adults with type 2 diabetes. Participants took the drug or a placebo for 12 weeks to see if it safely lowered blood sugar levels. The goal was to control the disease, not cure it.

This study tested a personalized approach to see if some people with type 2 diabetes who take multiple daily insulin injections could safely stop their mealtime insulin. 239 participants wore a continuous glucose monitor and had blood tests to measure C-peptide (a marker of natur…

This study tested a new drug called MP-513 in 99 Japanese adults with type 2 diabetes. The goal was to see how well it controls blood sugar levels over 24 hours after 4 weeks of treatment. Participants were not on other diabetes drugs before the study. The results help understand…

This study tested three different drug combinations (glimepiride, empagliflozin, or sitagliptin) with metformin in 172 adults newly diagnosed with type 2 diabetes. Participants took one pill daily for 90 days. Researchers measured changes in blood sugar (HbA1c), weight, and chole…

This study tested two ways of taking insulin in 218 adults with type 2 diabetes. One group took a mixed insulin twice a day; the other took it once a day plus extra rapid-acting insulin. After 16 weeks, researchers compared blood sugar control and safety to see which routine was …

This study tested whether adding teneligliptin to canagliflozin helps Japanese adults with type 2 diabetes who still have high blood sugar despite taking canagliflozin alone. Over 24 weeks, 154 participants took both drugs once daily. The main goal was to see if the combination l…

This study tested a personalized dietary program for 30 adults with type 2 diabetes. The program aimed to improve blood sugar levels and support diabetes remission by helping participants follow a healthier diet. Researchers measured changes in HbA1c and other health markers to s…

This study tested two injectable diabetes drugs, iGlarLixi and IDegAsp, in 582 Chinese adults with type 2 diabetes whose blood sugar was not well controlled by oral medications. The goal was to see which drug worked better at lowering blood sugar over 24 weeks. Both drugs are des…

This study followed 262 adults with type 2 diabetes and obesity for up to 13 years to see if bariatric surgery or medical/lifestyle management works better over time. Researchers measured blood sugar levels and how many people achieved diabetes remission without needing medicatio…

This study looked at the long-term safety and effectiveness of adding canagliflozin to insulin treatment in 139 adults with type 2 diabetes. Participants had already completed a 16-week study. The goal was to see if the combination helped control blood sugar and weight over time.…

This study tested whether a personalized meal plan (IDP) is practical and helpful for adults with type 2 diabetes. 122 participants were randomly assigned to either receive customized diet advice or standard care for 10 weeks. Researchers measured blood sugar (HbA1c), cholesterol…

This study tested a drug called teneligliptin in 254 Chinese adults with type 2 diabetes. Participants received either the drug or a placebo for 24 weeks. The main goal was to see if the drug lowered blood sugar levels (HbA1c) better than placebo. The study was completed and prov…

This study tested a surgery that combines a sleeve gastrectomy (stomach reduction) with a rerouting of the small intestine to help people with obesity and type 2 diabetes lose weight and control blood sugar. 18 adults aged 19-65 with a BMI between 35 and 50 and stable diabetes to…

This study tested whether empagliflozin, a diabetes medication, lowers blood pressure more than other oral diabetes drugs in people with type 2 diabetes and high blood pressure. 300 adults took either empagliflozin or another diabetes pill for 12 weeks. Researchers measured blood…

This study tested a new medication called TA-7284 in 272 adults with type 2 diabetes. The goal was to see if the drug safely lowers blood sugar levels over 24 weeks compared to a placebo. Participants took the pill alone without other diabetes medicines.

This study tested a new medication called TA-7284 in over 1,200 Japanese adults with type 2 diabetes. The goal was to see if the drug is safe and helps control blood sugar over 52 weeks, either alone or with other diabetes medicines. Researchers measured side effects, blood sugar…

This study tested the long-term safety of the drug MP-513 (Teneligliptin) in 240 Japanese adults with type 2 diabetes. Some participants took MP-513 alone, while others took it with another diabetes medicine called sulfonylurea. The study lasted 52 weeks and tracked side effects …

This study looked at the long-term safety and effectiveness of adding canagliflozin to an existing GLP-1 treatment in 71 adults with type 2 diabetes. Over 52 weeks, researchers tracked side effects, blood sugar control, weight, and blood pressure. The goal was to see if the combi…

This study tested three different doses of a new drug, AMG 133, against a placebo in 592 adults with overweight or obesity. Some participants also had type 2 diabetes. The main goal was to see how much weight people lost after 52 weeks of treatment. The drug aims to help control …

This study tested a new daily pill, BMF-219, in healthy adults and people with type 2 diabetes. The goal was to check its safety and how well it controls blood sugar over 26 weeks. About 443 participants took either the drug or a placebo. The results will help decide if larger st…

This study tested whether the drug dapagliflozin works better than standard treatments for people with type 2 diabetes whose blood sugar is not well controlled on metformin alone. Over 600 adults took part, and researchers looked at improvements in blood sugar, weight loss, and s…

This early-stage study tested a new drug called ZT002 in 32 healthy adults to see if it is safe and how the body processes it. The goal is to develop a treatment for type 2 diabetes. Participants received either the drug or a placebo, and researchers monitored for side effects. T…

This study looked at whether Soliqua 100/33, a combination insulin, can help people with very uncontrolled type 2 diabetes (HbA1c 9% or higher) spend more time in a healthy blood sugar range. 124 adults who were already on at least two diabetes pills took part. They used a contin…

This study tested an experimental daily pill (TA-7284) in 383 adults with type 2 diabetes to see if it safely lowers blood sugar and helps with weight. Participants took either the drug or a placebo for several weeks. The main goal was to measure changes in HbA1c (average blood s…

This study tested a new weekly medicine called CagriSema, which combines two drugs (semaglutide and cagrilintide), in over 2,700 adults with type 2 diabetes. The goal was to see if the combo lowers blood sugar and body weight better than either drug alone or a placebo. Participan…

This study tested whether adding canagliflozin to teneligliptin helps Japanese adults with type 2 diabetes who are not well controlled on teneligliptin alone. 138 participants took the combination daily for 24 weeks. The main goal was to see if it lowered blood sugar levels (HbA1…

This study tested the long-term safety and effectiveness of the drug MP-513 (Teneligliptin) in 462 Japanese adults with type 2 diabetes. Participants took the drug alone or with other diabetes pills for 52 weeks. The main goal was to track side effects, and researchers also measu…

This study tested a new injectable drug called TG103, taken with the common diabetes pill metformin, in 632 adults with type 2 diabetes. The goal was to see if TG103 helps lower blood sugar better than an existing drug (dulaglutide) over 28 weeks. Participants had poorly controll…

This study looked at whether shivering from cold temperatures can improve blood sugar levels over 24 hours in people with pre-diabetes or type 2 diabetes. Researchers had 24 participants experience different intensities of cold-induced shivering and measured their glucose continu…

This study looked at whether giving a carbohydrate-rich drink before abdominal surgery helps diabetic and non-diabetic patients recover better. Traditionally, patients fast before surgery, which can stress the body and slow recovery. 120 adults were split into three groups to tes…

This study looked at whether taking bitter melon, blueberry, or cranberry powder twice a day for 12 weeks could improve blood sugar control and reduce diabetes symptoms in 120 adults with type 2 diabetes. Participants took the powder mixed with yogurt or water alongside their usu…

This study tested a 12-week intensive aerobic and resistance exercise program in 58 adults aged 40-85 with type 2 diabetes and thinking problems. The goal was to see if exercise could improve memory, metabolism, inflammation, and physical function. Participants were grouped by ri…

This study looked at whether interacting with a live turtle or watching turtle videos could help adults with type 2 diabetes lower their blood sugar levels (HbA1c) and feel more confident about taking their diabetes medication. Fifty-one participants were split into groups that e…

This study tested whether the incremental shuttle walk test (a timed walking test) is a valid and reliable tool for people with type 2 diabetes. 120 adults with diabetes completed the test twice, one week apart, along with a standard 6-minute walk test. The goal was to see if the…

This study looked at how four different diabetes medicines (HRS-1780, henagliflozin, metformin, and HRS-7535) affect each other in the body. It involved 24 healthy men aged 18 to 50. The goal was to measure drug levels and check for side effects, not to treat diabetes. This helps…

This early-stage study enrolled 24 healthy adults to see how different manufacturing methods and food intake affect the absorption of HRS-7535, an experimental drug for type 2 diabetes. Participants took the drug under fasting and fed conditions, and researchers measured drug lev…

This study looked at how the diabetes drug metformin might change gut bacteria and thinking abilities in older adults with type 2 diabetes. Fifty participants were followed for a year, with some taking metformin for six months. Researchers measured memory, attention, and other co…

This study looked at how a diabetes medicine called TA-7284 works in people with type 2 diabetes who also have moderate kidney problems. Twenty-four adults took a single dose of the drug, and researchers measured how much drug got into their blood and how it affected blood sugar.…

This study looked at whether a short therapy program for depression could help prevent type 2 diabetes in teenage girls at high risk. The girls were ages 12-17, overweight, had mild to moderate depression, and a family history of diabetes. Researchers compared the therapy group t…

This study looked at whether continuous glucose monitors (CGMS) can help predict low blood sugar (hypoglycemia) in adults with type 2 diabetes. 41 participants wore either a regular or a hidden monitor for a short time while continuing their usual care. The goal was to find new w…

This study tested whether a special education program could help people with diabetic foot feel more prepared for disasters and take better care of their feet. 68 adults with type 2 diabetes and diabetic foot took part. One group received the education, while the other got usual …

This study looked at whether a generative AI simulation can improve how medical students communicate a type 2 diabetes diagnosis. 120 students were split into two groups: one used the AI platform DIALOGUE-DM2, and the other followed traditional teaching. Their communication skill…

This study looked at how increasing ketone levels in the blood affects heart function in 41 adults with type 2 diabetes and heart failure. Researchers used heart scans to measure how well the heart pumps blood and how it uses sugar for energy. The goal was to understand the body'…

This study tested whether gentle reminders in electronic health records could help doctors avoid tests and treatments that may do more harm than good in older adults. Researchers focused on three common examples: unnecessary urine tests, prostate cancer screening in very elderly …

This study looked at whether using a blood test called glycated albumin (GA) to guide diabetes treatment helps people with newly diagnosed type 2 diabetes achieve better blood sugar control. About 200 adults in China were split into two groups: one where doctors used GA levels to…

This study looked at 186 pregnant women with type 1 or type 2 diabetes to understand how fats (lipids) in the mother's and baby's blood relate to birth weight. Even when blood sugar is well-controlled, babies of diabetic mothers are often larger than average, which can cause deli…

This study looked at data from 348 people with type 2 diabetes in Germany who use the myTherapy app. The goal was to see how many have elevated levels of albumin in their urine, which is an early sign of kidney disease. Researchers tracked these levels over about a year to unders…

This study looked at nearly 242,000 adults with type 2 diabetes to find out which glucose-lowering medications are best for heart health and other important outcomes. Researchers also examined whether benefits differ by age, sex, race, or kidney function. The goal is to help pati…

This study observed over 6,500 Chinese adults with chronic kidney disease and type 2 diabetes who started taking the drug finerenone. Researchers looked at patient health records to understand how the drug is used in real life, including its effects on kidney function and potassi…

This study looked at whether people with type 2 diabetes who show signs of premature aging are more likely to develop heart muscle disease. Researchers measured aging markers in blood and used heart imaging in 150 adults aged 40-55 with diabetes but no heart symptoms. The goal wa…

This study followed 24 adults with type 2 diabetes who use insulin pumps. Over 14 days, researchers used continuous glucose monitors to track blood sugar levels and linked them to insulin doses and meals. The goal was to understand real-life patterns, not to test a new treatment.