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Can a diabetes drug also protect the heart? new study tests liraglutide

NCT ID NCT04866667

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study screened 316 people with type 2 diabetes who were at high risk for heart disease. Researchers tested whether adding the drug liraglutide to standard care could reduce new heart problems like heart attacks, strokes, and hospitalizations. The goal was to see if this approach could better control blood sugar, cholesterol, and blood pressure while preventing cardiovascular events.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
liraglutide (a GLP-1 receptor agonist drug)
What this could lead to
If successful, this could show that liraglutide helps prevent heart attacks, strokes, and other cardiovascular problems in people with type 2 diabetes.
What could go wrong
This is a completed study with 316 participants, but results are not yet widely reported. The benefit may be modest and not apply to all diabetes patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

316 people

The number who actually took part.

Started

May 2021

Finished

May 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Type 2 diabetes patients over 18 years old with high risks of atherosclerotic cardiovascular disease

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Type 2 diabetes * HbA1c ≥7.0% * Prior CVD cohort: age ≥50 and ≥1 of the following criteria. * Prior MI * Prior stroke or TIA * Prior coronary, carotid or peripheral arterial revascularization * N50% stenosis of coronary, carotid, or lower extremity arteries * History of symptomatic CHD documented by Positive exercise stress test or any cardiac imaging or Unstable angina with ECG changes * Asymptomatic cardiac ischemia Documented by positive nuclear imaging test, exercise test or dobutamine stress echo * Chronic heart failure NYHA class II-III * Chronic renal failure, eGFR \<60 mL/min per 1.73m2 MDRD eGFR \<60 mL/min per Cockcroft-Gault formula * No Prior CVD group: Age ≥60 y and ≥1 of the following criteria. * Microalbuminuria or proteinuria * Hypertension and left ventricular hypertrophy by ECG or imaging * Left ventricular systolic or diastolic dysfunction by imaging * Ankle-brachial index b0.9 Exclusion Criteria: * Type 1 diabetes * other type diabetes * Calcitonin ≥50 ng/L * Use of a GLP-1 receptor agonist (exenatide, liraglutide or other) or pramlintide or any DPP-4 inhibitor within the 3 months prior to screening * Use of insulin other than human NPH insulin or long-acting insulin analogue or premixed insulin within 3 months prior to screening. Shortterm use of other insulin during this period in connection with intercurrent illness is allowed, at Investigators discretion * Acute decompensation of glycemic control * An acute coronary or cerebrovascular event in the previous 14 d * Currently planned coronary, carotid, or peripheral artery revascularization * Chronic heart failure (NYHA class IV) * Current continuous renal replacement therapy * End-stage liver disease * History of solid organ transplant or awaiting solid organ transplant * Malignant neoplasm * Family or personal history of multiple endocrine neoplasia type 2 (MEN2) or familial medullary thyroid carcinoma (FMTC) * Personal history of non-familial medullary thyroid carcinoma

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Zhejiang provincial people's hospital

    Hangzhou, Zhejiang, 310014, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.