Can a diabetes drug also protect the heart? new study tests liraglutide
NCT ID NCT04866667
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study screened 316 people with type 2 diabetes who were at high risk for heart disease. Researchers tested whether adding the drug liraglutide to standard care could reduce new heart problems like heart attacks, strokes, and hospitalizations. The goal was to see if this approach could better control blood sugar, cholesterol, and blood pressure while preventing cardiovascular events.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- liraglutide (a GLP-1 receptor agonist drug)
- What this could lead to
- If successful, this could show that liraglutide helps prevent heart attacks, strokes, and other cardiovascular problems in people with type 2 diabetes.
- What could go wrong
- This is a completed study with 316 participants, but results are not yet widely reported. The benefit may be modest and not apply to all diabetes patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
316 people
The number who actually took part.
- Started
-
May 2021
- Finished
-
May 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Type 2 diabetes patients over 18 years old with high risks of atherosclerotic cardiovascular disease
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Type 2 diabetes * HbA1c ≥7.0% * Prior CVD cohort: age ≥50 and ≥1 of the following criteria. * Prior MI * Prior stroke or TIA * Prior coronary, carotid or peripheral arterial revascularization * N50% stenosis of coronary, carotid, or lower extremity arteries * History of symptomatic CHD documented by Positive exercise stress test or any cardiac imaging or Unstable angina with ECG changes * Asymptomatic cardiac ischemia Documented by positive nuclear imaging test, exercise test or dobutamine stress echo * Chronic heart failure NYHA class II-III * Chronic renal failure, eGFR \<60 mL/min per 1.73m2 MDRD eGFR \<60 mL/min per Cockcroft-Gault formula * No Prior CVD group: Age ≥60 y and ≥1 of the following criteria. * Microalbuminuria or proteinuria * Hypertension and left ventricular hypertrophy by ECG or imaging * Left ventricular systolic or diastolic dysfunction by imaging * Ankle-brachial index b0.9 Exclusion Criteria: * Type 1 diabetes * other type diabetes * Calcitonin ≥50 ng/L * Use of a GLP-1 receptor agonist (exenatide, liraglutide or other) or pramlintide or any DPP-4 inhibitor within the 3 months prior to screening * Use of insulin other than human NPH insulin or long-acting insulin analogue or premixed insulin within 3 months prior to screening. Shortterm use of other insulin during this period in connection with intercurrent illness is allowed, at Investigators discretion * Acute decompensation of glycemic control * An acute coronary or cerebrovascular event in the previous 14 d * Currently planned coronary, carotid, or peripheral artery revascularization * Chronic heart failure (NYHA class IV) * Current continuous renal replacement therapy * End-stage liver disease * History of solid organ transplant or awaiting solid organ transplant * Malignant neoplasm * Family or personal history of multiple endocrine neoplasia type 2 (MEN2) or familial medullary thyroid carcinoma (FMTC) * Personal history of non-familial medullary thyroid carcinoma
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Zhejiang provincial people's hospital
Hangzhou, Zhejiang, 310014, China
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