Gout drug shows promise for diabetic kidney protection in small trial
NCT ID NCT07177898
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This completed study tested whether adding allopurinol (a gout medication) to standard lisinopril treatment could better protect kidneys in people with type 2 diabetes. 80 patients with normal uric acid levels were split into two groups: one received both drugs, the other lisinopril alone. Researchers tracked kidney function over a year to see if urine albumin levels rose, a sign of kidney damage.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- allopurinol and lisinopril
- What this could lead to
- If adding allopurinol works, it could offer a simple, low-cost way to help protect kidneys in people with type 2 diabetes.
- What could go wrong
- This is a small, single-center study with only 80 participants. Results may not apply to everyone, and the benefit might be small or not confirmed in larger trials.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
80 people
The number who actually took part.
- Started
-
May 2023
- Finished
-
Nov 2024
- Lead sponsor
-
A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
35 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * patients with type 2 diabetes mellitus on oral hypoglycemic agents, serum creatinine levels less than 1.1 mg/dL, and serum uric acid levels between 5.5-6.5 mg/dL for males and 5-6 mg/dL for females Exclusion Criteria: * patients with tumor lysis syndrome, chronic kidney disease from other causes (e.g., hypertension, glomerulonephritis, polycystic kidney disease, or hydronephrosis), those on medications that could cause hyperuricemia (such as thiazide diuretics) or those on drugs that may induce proteinuria (e.g., NSAIDs, cyclosporine, penicillamine, or gold). Patients with uric acid levels exceeding 7 mg/dL were also excluded
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
King Edward Medical University
Lahore, Punjab Province, 54000, Pakistan
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