New combo pill aims to boost Insulin's power against diabetes
NCT ID NCT02220920
First seen Jan 11, 2026 · Last updated Jun 19, 2026 · Updated 23 times
Summary
This study tested whether adding canagliflozin, a diabetes pill, to insulin therapy helps people with type 2 diabetes control their blood sugar better. 146 adults who were already on a stable insulin dose took either canagliflozin or a placebo for 16 weeks. Researchers measured changes in blood sugar levels, weight, and blood pressure, and monitored for side effects like low blood sugar.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Reserch site
Chugoku, Japan
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Reserch site
Chūbu, Japan
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Reserch site
Hokkaido, Japan
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Reserch site
Kanto, Japan
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Reserch site
Kinki, Japan
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Reserch site
Kyushu, Japan
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Reserch site
Tōhoku, Japan
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Canagliflozin
What this could lead to
If it works, this could provide an additional treatment option for people with type 2 diabetes who need better blood sugar control despite using insulin.
What could go wrong
This is a completed Phase 4 trial with only 146 participants, so results may not apply to everyone. Canagliflozin can increase the risk of hypoglycemia (low blood sugar) when combined with insulin.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.