Which diabetes pill combo works best? new study pits three options Head-to-Head
NCT ID NCT06759922
First seen Nov 21, 2025 · Last updated Jun 22, 2026 · Updated 35 times
Summary
This completed study tested different combinations of diabetes drugs (glimepiride, empagliflozin, or sitagliptin) taken with metformin in 172 adults newly diagnosed with type 2 diabetes. Participants were split into four groups and took their assigned pills once daily for 90 days. Researchers measured blood sugar control (HbA1c), weight, cholesterol, and side effects to see which combination worked best and was safest.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for TYPE 2 DIABETES MELLITUS are added.
Genom att skicka in godkänner du våra Användarvillkor
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
Genom att skicka in godkänner du våra Användarvillkor
Locations
-
National Medical Center
Karachi, Sindh, 75500, Pakistan
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Metformin combined with glimepiride, empagliflozin, or sitagliptin
What this could lead to
If successful, this could help doctors choose the most effective and safe two- or three-drug combination for managing blood sugar in newly diagnosed type 2 diabetes patients.
What could go wrong
This is a small, completed Phase 4 trial, so results may not apply to all patients. Side effects like diarrhea, weight gain, or urinary infections are possible with these drugs.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.