Type 2 diabetes mellitus

Researchers are testing whether home-delivered medically tailored meals help older adults with type 2 diabetes improve their blood sugar, diet, and mental health. The trial compares three approaches: meals dropped off without interaction, meals delivered in person with human cont…

This early study looks at whether taking tirzepatide (Mounjaro) after sleeve gastrectomy surgery helps people lose more weight and improve conditions like diabetes and high blood pressure. About 42 adults with obesity will be split into two groups: one gets surgery alone, the oth…

This study tests an experimental oral medication, KAI-7535, taken once daily to help people with obesity or overweight lose weight. About 320 adults with at least one weight-related condition (like high blood pressure or sleep apnea) will receive either the drug or a placebo for …

This study is checking if a new insulin pump (NMX8) and continuous glucose monitor (DS5/Simplera Sync) are safe for people with type 1 or type 2 diabetes. About 400 participants, ages 7 to 85, will first wear the sensor for up to 40 days, then use the pump for about 90 days while…

This trial tests whether a traditional Chinese herbal formula, Huangqi Gegen Decoction, can improve blood vessel function in adults with type 2 diabetes who are at very high risk for heart disease. Participants will take either the herbal granules or a placebo for 12 weeks, along…

This study looks at the safety and performance of the Endogenex System in 50 adults with type 2 diabetes. Participants previously received a sham (fake) procedure in an earlier study. The main goal is to track any serious side effects related to the device or procedure.

This Phase 3 trial tests whether a cell therapy called REACT (rilparencel) can slow kidney decline in 685 adults with type 2 diabetes and chronic kidney disease. Participants receive either two injections of their own kidney cells or sham procedures. The study measures changes in…

This study tests three different non-drug approaches to help older adults in nursing homes manage their type 2 diabetes. One group uses a device that sends mild electrical pulses to the leg muscles, another does supervised exercise, and the third receives health education. The ma…

This study tests a device called ReCET that delivers gentle electric pulses to the first part of the small intestine. The goal is to trigger cell regeneration and improve blood sugar control in people with type 2 diabetes who are not on insulin. Participants are randomly assigned…

This Phase 1 study tests retatrutide, a new injectable drug, in 95 adults with type 2 diabetes who already take metformin. The goal is to see if retatrutide improves insulin sensitivity and beta-cell function better than placebo or semaglutide over 28 weeks. Participants will rec…

This study tests whether combining an AI smartphone app, intermittent fasting (16 hours of fasting daily), and resistance training can improve blood sugar control and physical fitness in people with type 2 diabetes. Sixty adults with diabetes will either follow this program or re…

This early-stage trial tests whether a drug called RO7204239 can improve how the body uses insulin and affects muscle composition in 30 adults with type 2 diabetes who are overweight or obese. Participants will receive either the drug or a placebo, and researchers will measure ch…

This Phase 2 study tests a new once-daily pill called RO7795081 for people with type 2 diabetes. About 240 adults whose diabetes is not well controlled will take the drug, a placebo, or an existing medication (semaglutide) for 30 weeks. The main goal is to see if RO7795081 lowers…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This early-stage study tests a new drug, maridebart cafraglutide, to see if it helps people with type 2 diabetes use insulin better. About 56 adults on metformin will receive either the drug or a placebo. The main goal is to measure changes in insulin sensitivity after 25 weeks.

This study looks at whether 10 weeks of regular exercise (on land or in water) can lower blood sugar and blood pressure in people aged 60 and older who have several health conditions like diabetes, high blood pressure, and arthritis. 63 volunteers will be split into two exercise …

This early-stage trial is studying whether an experimental drug called AZD6793 changes how the common diabetes medicine metformin works in people with type 2 diabetes. About 28 participants will take both AZD6793 and a placebo alongside their usual metformin to compare effects on…

This study tests whether semaglutide (Wegovy), a once-weekly injection, can preserve the pancreas's ability to produce insulin and reduce liver fat in 60 obese youth with prediabetes or early type 2 diabetes and fatty liver disease. Participants receive either semaglutide or a pl…

This study is testing the safety of the FreeStyle Libre 2, a device that continuously checks blood sugar levels, in 550 children and young adults aged 4 to 30 with type 1 or type 2 diabetes. The goal is to see if using this monitor reduces severe low blood sugar events that need …

This study was designed to test whether a program called Lifestyle MIND can help people with serious mental illness (like schizophrenia or bipolar disorder) prevent or manage type 2 diabetes. The program includes group exercise and health classes twice a week for 10 weeks. Howeve…

This study compares two different three-drug combinations for people newly diagnosed with type 2 diabetes. 110 adults aged 30-55 will take one of the combos daily for 90 days. Researchers will check blood sugar, weight, and safety over 6 months to see which combo works better.

This study tests a new way for cancer doctors and primary care doctors to work together to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one of these conditions will …

This study tests if weight-loss surgery (sleeve gastrectomy) can help people with newly diagnosed type 2 diabetes and a BMI of 30-42 achieve diabetes remission without medication. About 30 adults will be randomly assigned to either surgery or standard medical care and followed fo…

This study tests whether adding omega-3 supplements to standard diabetes treatment can improve blood sugar control and cholesterol levels in people with type 2 diabetes. About 66 adults aged 25-75 will take either omega-3 or a placebo twice daily for 12 weeks. Researchers will mo…

This study compares two different doses of vitamin D supplements in 108 adults with type 2 diabetes who also have low vitamin D levels. Researchers will measure changes in blood sugar and HbA1c over time to see if higher doses improve diabetes control. Participants must be aged 4…

This study tests whether sending text message reminders and education to pregnant women with diabetes helps them follow their care plan—like keeping appointments, tracking blood sugar, and taking medications. About 185 participants will be randomly assigned to receive texts or st…

This study tests a snack bar made from red beans and tomatoes, called GlycoBite, in 100 people with type 2 diabetes. Participants eat one 40-gram bar daily for three weeks. Researchers check if it helps lower fasting blood sugar and HbA1c levels. The goal is to see if this simple…

This study tests a new insulin called GZR4 that is given once a week, compared to a standard daily insulin, in adults with type 2 diabetes who have never used insulin before. About 580 participants will receive either the weekly shot or daily insulin, along with their usual diabe…

This study tests a new insulin (GZR4) given just once a week, compared to a standard daily insulin (glargine), in 580 adults with type 2 diabetes who already use mealtime insulin. The goal is to see if the weekly shot controls blood sugar as well or better, with fewer injections …

This phase 3 study tests a new insulin called GZR4 that is injected just once a week, compared to the standard daily insulin degludec. About 620 adults with type 2 diabetes who already use basal insulin will take part. The goal is to see if the weekly shot controls blood sugar ju…

This study tests a new medication, SHR-3167, against a standard long-acting insulin (insulin degludec) in people with type 2 diabetes who already use basal insulin. The goal is to see which one controls blood sugar better and is safer. About 173 adults aged 18-65 with type 2 diab…

This phase 3 trial compares two doses of an experimental drug called JY09 against the approved drug dulaglutide in 600 adults with type 2 diabetes not well controlled by metformin alone. Participants receive either JY09 every two weeks or dulaglutide once a week for 54 weeks. The…

This phase 3 trial tests a new drug called JY09 in 270 adults with type 2 diabetes whose blood sugar is not well controlled by diet and exercise alone. Participants receive either JY09 or a placebo injection every two weeks for up to 54 weeks. The main goal is to see if JY09 lowe…

This study is looking at whether enavogliflozin, a diabetes medication, can help people with type 2 diabetes lose weight. Researchers will track 200 adults over 24 weeks in regular doctor visits. The main goal is to see changes in body weight and BMI, along with safety.

Researchers are testing whether a device called ANSiScope Plus can identify autonomic dysfunction by measuring heart rate variability. Participants include healthy adults and people with prediabetes or type 2 diabetes, some with complications like nerve, kidney, or eye damage. Ea…

This study tests a new way to screen for type 2 diabetes by measuring sugar levels in fingernails. Researchers will compare results from 100 adults (half with known diabetes, half without) to standard blood tests. The goal is to see if this simple, non-invasive method can accurat…

This study is testing a mixed meal test to better diagnose a specific type of diabetes (type 3c) that occurs in people with pancreatic cancer or chronic pancreatitis. Researchers will enroll 775 adults aged 30 to 84 who have new-onset diabetes and one of these pancreatic conditio…

This study tests a new device called LabPatch that measures blood sugar from fluid just under the skin. About 60 adults with type 1 or type 2 diabetes who use insulin will wear the patch for 6 hours. Researchers will compare its readings to standard lab tests and two commercial g…

This study tests two behavioral programs—Appetite Awareness Training and the Diabetes Prevention Program—to see if they can reduce binge eating and prevent weight gain in Black women aged 18-25 who are at risk for type 2 diabetes. Participants will attend 16 core sessions over si…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This study compares high-effort versus low-effort resistance exercise sessions to see which better controls blood sugar in people with prediabetes or type 2 diabetes. Fifteen participants will complete both types of sessions plus a no-exercise control day, with blood sugar monito…

This trial tests whether blood flow restriction (BFR) training—exercising with a cuff that partially limits blood flow—can improve blood sugar control, nerve function, pain, and quality of life in people with type 2 diabetes and peripheral neuropathy. Participants will be randoml…

This study tests whether linaclotide (Linzess) can improve bowel movement frequency in people with type 2 diabetes who have chronic constipation. About 23 participants will receive either the drug or a placebo for two weeks, then switch after a break. The goal is to see if the dr…

This study checks if a Turkish version of a questionnaire about managing low blood sugar (hypoglycemia) is accurate and reliable. Researchers will ask 200 adults with type 2 diabetes who have had low blood sugar to fill out the questionnaire. The goal is to make sure the scale wo…

This completed study observed 40 people with type 2 diabetes to find blood markers that could identify those at risk for a serious liver condition called NASH. Researchers measured liver stiffness and calculated scores like FIB-4 and ELF to see which patients might have liver sca…

This study follows over 4,800 Dutch heart attack survivors aged 60-80 to understand how diet, lifestyle, blood markers, and genetics relate to their long-term health. Researchers are tracking cardiovascular deaths, major heart events, and other conditions like diabetes and cognit…

This study reviews medical records of 1200 Indian adults with chronic kidney disease and type 2 diabetes who started finerenone between August 2022 and April 2024. Researchers will analyze how doctors prescribed the drug, dose changes, and lab results like kidney function and pot…

This study looks at whether two common diabetes drug combinations (SGLT2 inhibitors plus metformin vs. DPP-4 inhibitors plus metformin) affect memory and depression risk in older adults with type 2 diabetes. Researchers will track 300 participants over time using memory tests and…

This study looks at how SGLT-2 inhibitors, a common class of diabetes drugs, affect lower urinary tract symptoms such as frequent urination, urgency, and nighttime trips to the bathroom. Researchers will follow adults with type 2 diabetes who are starting an SGLT-2 inhibitor for …

This observational study follows 150,000 people with chronic kidney disease and type 2 diabetes to see how finerenone (Kerendia) works in everyday medical care. Researchers will compare those taking finerenone to those not taking it, looking at rates of heart attacks and heart fa…

This observational study follows over 4,600 adults with chronic kidney disease and type 2 diabetes who are starting finerenone, a drug that helps slow kidney damage. Researchers will collect data from routine doctor visits over 12 months to understand why doctors prescribe it, ho…

This study looks at how the liver burns fat and makes sugar in people with NASH (a serious liver disease linked to obesity) who are planning to have weight-loss surgery. Researchers will use special scans to measure liver function before and after surgery in 30 adults. The goal i…

This study looks at over 1,200 adults with type 2 diabetes and heart muscle problems to see if diabetic cardiomyopathy is a unique condition. Researchers will use detailed medical tests, imaging, and biological data to find patterns. The goal is to better understand and diagnose …

This study aimed to learn more about using a CT scan to check for calcium buildup in the heart arteries of people with diabetes. The goal was to improve screening and treatment decisions. However, the study was withdrawn before enrolling any participants, so no new information wa…

This study looks at how being overweight and having type 1 or type 2 diabetes may change genetic markers in sperm. Researchers will test if a 3-month lifestyle or blood sugar program can improve these markers. About 40 men will provide sperm samples before and after the program.

This study looks at how the sugars, fats, and proteins in breast milk change from mother to mother and over time. Researchers want to see how these differences, along with the mother's diet and health, affect the development of the baby's gut bacteria. About 395 pregnant women wh…

This study looks at how low blood sugar (hypoglycemia) affects blood vessel function in people with type 2 diabetes and healthy adults. Researchers want to learn if a natural gut hormone called GLP-1 can change these effects. The study involves 28 participants and measures change…

This study looks at whether 6 months of aerobic exercise can improve blood vessel health and cell function in older veterans with impaired glucose tolerance, a pre-diabetic condition. Researchers will measure changes in endothelial progenitor cells and muscle blood flow. The goal…