TYPE 2 DIABETES MELLITUS

This study compares weight-loss surgery (sleeve gastrectomy) with standard medical treatment for people newly diagnosed with type 2 diabetes who are obese (BMI 30-42). The goal is to see if surgery can lead to diabetes remission—meaning normal blood sugar without medication—for u…

This study looks at how retatrutide, a once-weekly injection, affects recovery from low blood sugar in people with type 2 diabetes. About 78 adults who manage their diabetes with diet, exercise, and metformin will take part. Researchers will measure how quickly blood sugar return…

This study tests a new medicine called SHR-3167 against a standard insulin (insulin degludec) in people with type 2 diabetes who already use basal insulin. The goal is to see which one controls blood sugar better and is safer. About 173 adults aged 18-65 will take part, and the m…

This study tests three different 12-week programs to help older adults (60+) with type 2 diabetes who live in nursing homes better manage their blood sugar. The programs are: electrical muscle stimulation, supervised exercise (aerobic and resistance), and a health education class…

This study tracks 200 adults with type 2 diabetes who are prescribed enavogliflozin (alone or with other diabetes drugs) to see how much weight they lose over 24 weeks. Researchers measure changes in body weight and BMI at 12 and 24 weeks. The goal is to understand the drug's rea…

This study tests whether three common diabetes medications—liraglutide, empagliflozin, and linagliptin—can help reverse mild cognitive impairment (early memory and thinking problems) in people with type 2 diabetes. About 396 adults aged 40 to 75 will take one of the drugs for 48 …

This study aimed to see if a lifestyle program called Lifestyle MIND could help people with serious mental illness manage or prevent type 2 diabetes. Participants would have been randomly assigned to join the program right away or later. The study was withdrawn before any partici…

This study tests a new medicine called JY09 in 270 adults with type 2 diabetes whose blood sugar is not well controlled by diet and exercise alone. Participants receive either JY09 or a placebo for up to 54 weeks. The main goal is to see if JY09 safely lowers blood sugar levels (…

This early-stage study tests whether the drug RO7204239 can improve how the body uses insulin in people with type 2 diabetes who are also overweight or obese. About 30 participants will receive either the drug or a placebo for 24 weeks. The main goal is to measure changes in insu…

This phase 2 study tests whether semaglutide, a once-weekly injection, can help preserve insulin-producing cells and reduce liver fat in 60 obese youth with prediabetes or early type 2 diabetes and fatty liver disease. Participants receive semaglutide or placebo for 6 months, wit…

This study compares two different three-drug combinations for adults newly diagnosed with type 2 diabetes. 110 people aged 30-55 will take one of the combos daily for 90 days. Researchers will check blood sugar, weight, and safety at regular visits to see which combo works better…

This study tests a new once-daily medicine called RO7795081 to see if it helps lower blood sugar in adults with type 2 diabetes. About 240 participants will take the study drug, a placebo (inactive pill), or an approved diabetes medicine (semaglutide) for 30 weeks. The main goal …

This study looks at whether the amount of effort during weightlifting changes blood sugar levels in people with prediabetes or type 2 diabetes. Fifteen adults will try a high-effort workout, a low-effort workout, and a rest day to compare blood sugar and how they feel. The goal i…

This study looks at how a new medicine called AZD6793 changes the way metformin (a common diabetes drug) works in the body. Researchers want to see if AZD6793 affects blood sugar levels and how much metformin stays in the blood. The study was planned for 28 adults with type 2 dia…

This study looks at how exercise affects special cells that help repair blood vessels in older veterans who have higher-than-normal blood sugar. Researchers want to see if aerobic exercise can improve the number and function of these repair cells, which may lead to better blood f…

This study reviews medical records of 1200 Indian adults with chronic kidney disease and type 2 diabetes who started finerenone between 2022 and 2024. Researchers will describe how doctors prescribed the drug, dose changes, and effects on kidney function and potassium levels. The…

This study looks at health records from 150,000 people with chronic kidney disease and type 2 diabetes to see how safe and effective the drug finerenone is in everyday medical care. Researchers will compare those who take finerenone with those who do not, focusing on heart attack…

This study looks at how low blood sugar (hypoglycemia) affects blood vessel function in people with type 2 diabetes and healthy adults. Researchers want to understand if a natural gut hormone called GLP-1 can change these effects. The goal is to learn more about how low blood sug…

This study observes over 4,600 adults with chronic kidney disease and type 2 diabetes who are already taking finerenone as part of their routine care. Researchers will collect data from medical records and doctor visits for 12 months to see how the drug is used, why it might be s…

This study looks at whether improving metabolic health through a 3-month lifestyle or blood sugar program can change epigenetic marks in the sperm of overweight men with type 1 or type 2 diabetes. Researchers will measure sperm concentration and DNA methylation patterns before an…

This study observes how the sugars, fats, and proteins in breast milk differ among mothers and change over time. It also looks at how these components, along with the mother's diet and health, affect the development of the baby's gut bacteria. About 395 pregnant women who plan to…