Pancreas disorder

Researchers are testing two experimental gene therapies, VV-14299 and VV-14300, in adults with long-standing type 1 diabetes whose blood sugar remains poorly controlled despite using an automated insulin pump. The therapies are injected into muscle and are designed to work togeth…

Researchers are testing a gene therapy called VV-14300 in adults with long-standing type 1 diabetes whose blood sugar remains poorly controlled despite using an automated insulin delivery system. The therapy uses a harmless virus to deliver the glucokinase gene into muscle, where…

This phase 1 trial tests whether injecting RGB-5088 islet cells under the abdominal muscle can safely help people with type 2 diabetes. The study enrolls 10 adults aged 18 to 65 who have had diabetes for at least 5 years and currently use insulin. Researchers will monitor safety …

Researchers are testing whether combining albumin-bound paclitaxel with gemcitabine helps people with metastatic pancreatic cancer who have not yet received systemic treatment. The study enrolls about 59 adults aged 18 to 75 with confirmed metastatic pancreatic adenocarcinoma. Pa…

Researchers are testing whether a carbohydrate drink before gastrointestinal surgery can reduce insulin resistance and improve blood sugar stability in adults with type 2 diabetes. Participants are randomly assigned to one of three groups: standard fasting without a carb drink, a…

This study will test whether a nutrition supplement with different forms of certain nutrients works better than standard supplements for adults with cystic fibrosis. Sixty participants will take the supplement for six weeks, and researchers will measure nutrient levels in their b…

Researchers are testing UrDiaCare, an Urdu-language app that gives diabetes self-management education and support through WhatsApp or Android. The trial includes 406 adults aged 30 to 70 in Pakistan who have type 2 diabetes and higher-than-recommended blood sugar levels. Particip…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

Researchers are testing whether waiting until 41 weeks to induce labor leads to fewer cesarean deliveries than inducing at 40 weeks in first-time mothers with diet-controlled gestational diabetes. The trial enrolls 1,500 women who manage their blood sugar through diet and exercis…

This study tests a combination of four drugs (epalrestat, HAIC, donafenib, and tislelizumab) as a first treatment for people with advanced liver cancer that cannot be removed by surgery and who also have diabetes. The goal is to see if this approach can control the cancer for at …

This study tests an experimental pill (cadisegliatin) taken alongside insulin in people with type 1 diabetes who already use a hybrid closed-loop insulin pump. The goal is to see if the pill helps keep blood sugar in a healthy range more consistently. About 40 adults will receive…

Researchers test whether a short course of targeted radiation followed by the immunotherapy drug adebrelimab and NALIRIFOX chemotherapy can shrink locally advanced pancreatic cancer enough to allow surgery. The trial enrolls 36 adults with previously untreated pancreatic ductal a…

This study looks at the safety and effectiveness of Rybelsus, a pill for type 2 diabetes, in everyday medical practice in Korea. About 600 adults will take the medicine as their doctor prescribes, and researchers will track side effects and blood sugar control for 26 weeks. The g…

Researchers are testing whether seltoplasmid, a gene therapy injected into the calf muscle, can improve outcomes for people with type 2 diabetes who have poor blood flow to the foot and a non-healing ulcer. All participants first undergo a standard procedure to restore blood flow…

This study tests whether a continuous glucose monitor (CGM) is better than standard finger-prick tests for managing blood sugar in 100 pregnant women with gestational diabetes. Participants will either wear a small sensor or continue finger-pricking. The goal is to see if CGM is …

Researchers are testing a chemotherapy combination built around albumin-bound paclitaxel (II) for people with pancreatic cancer. The study has three groups: one for advanced cancer that cannot be removed by surgery, one for cancer that may be removable and receives treatment befo…

Researchers at the University of Oklahoma are testing whether adding pentamidine, an antiparasitic drug, to standard modified FOLFIRINOX chemotherapy is safe and helps shrink tumors in people with advanced or metastatic pancreatic cancer. Up to 30 adults with confirmed locally ad…

Researchers are testing a new immunotherapy called Lm-LLO-TT in adults with advanced pancreatic ductal adenocarcinoma that has already been treated with chemotherapy. Lm-LLO-TT uses a weakened form of Listeria bacteria engineered to carry a tetanus toxoid antigen, aiming to spark…

Researchers are testing whether adding two oral drugs, avutometinib and defactinib, to standard chemotherapy (mFOLFIRINOX) is safe and can slow or shrink pancreatic ductal adenocarcinoma. The trial has two parts: one for people whose cancer has spread, and one for people whose ca…

Researchers are testing whether measuring specific proteins in tumors can help match patients with advanced pancreatic or breast cancer to antibody-drug conjugates that are more likely to work for them. The trial enrolls 225 adults whose cancer has progressed after prior treatmen…

Researchers test whether coconut oil pulling or a moringa mouthwash can reduce gingivitis in children with diabetes, compared with chlorhexidine. Thirty children aged 6 to 12 with mild to moderate gingivitis use one of the three rinses. The team measures gum inflammation and leve…

This trial is testing whether a combination of drugs—inavolisib plus fulvestrant, with or without palbociclib—is safe for people with a specific type of advanced breast cancer (HR+, HER2-negative) that has a PIK3CA mutation, and who also have type 2 diabetes. The main focus is on…

Researchers are testing whether a combination of four experimental oral drugs, AD-233A, AD-233B, AD-233C and AD-233D, can improve blood sugar control in adults with type 2 diabetes. The Phase III trial enrolls about 354 participants and compares the drug combination against an ac…

Researchers are running a first-in-human study of MGC030, an antibody-drug conjugate, in people with advanced solid tumors that have come back or stopped responding to standard treatment. The trial includes participants with urothelial, colorectal, gastric, gastroesophageal, esop…

Researchers are testing whether giving chemotherapy before surgery helps people with pancreatic cancer that can be removed. The trial compares two drug combinations, gemcitabine plus nab-paclitaxel and FOLFIRINOX, in adults with resectable pancreatic adenocarcinoma. After treatme…

This study will enroll 20 severely obese adults scheduled for metabolic surgery. Half will use a continuous glucose monitor (CGM) and half will use standard finger-stick testing to track blood sugar. Researchers want to see if the CGM leads to steadier blood sugar levels and fewe…

The HARVEST study is testing whether eating a special low-glycemic, high-protein rice instead of regular white rice can improve blood sugar control in people with prediabetes or type 2 diabetes. Over 16 weeks, 225 adults in Singapore will replace their usual rice with one of thre…

This trial tests whether eating almonds as an evening snack improves overnight blood sugar in pregnant women with gestational diabetes. About 156 women will either eat 43 grams of whole almonds daily or a nut-free snack for 28 days. Researchers will measure blood sugar levels ove…

Many people live with heart disease, kidney disease, and type 2 diabetes at the same time, but care often focuses on each condition separately. This trial tests a primary care model that brings these conditions together under one coordinated plan. Primary care centers receive tra…

This trial investigates whether adding a once-weekly injection of tirzepatide to standard diabetes pills can improve blood sugar control and promote weight loss in obese adults with type 2 diabetes. Over six months, researchers will compare changes in HbA1c and body weight betwee…

Researchers are testing whether a digital behavioral therapy app, added to standard diabetes care, can improve blood sugar control and lower the risk of liver fibrosis in adults with type 2 diabetes. The trial enrolls 180 adults with type 2 diabetes who are at low to moderate ris…

Researchers are testing how safely and comfortably people with type 2 diabetes can switch from semaglutide to CagriSema, a weekly injection that combines cagrilintide and semaglutide. About 210 adults who have taken a stable dose of branded semaglutide for at least three months w…

Pancreatic and other biliopancreatic cancers often block the bile duct, causing jaundice and serious infections. Doctors use endoscopic procedures to place stents that restore bile flow, but several techniques exist and it is unclear which works best. This study follows 300 patie…

Researchers are testing whether combining retlirafusp alfa, famitinib, and AG chemotherapy (nab-paclitaxel plus gemcitabine) can slow cancer growth in people with unresectable pancreatic cancer. The trial enrolls about 88 adults with locally advanced or metastatic pancreatic duct…

This study tests whether a smartphone app that shows real-time blood sugar and activity data can help adolescents and young adults with type 2 diabetes improve their glucose control. Participants use a continuous glucose monitor and Fitbit, and some receive prompts to reflect on …

Researchers are testing a wafer called EF-009 that surgeons place directly onto pancreatic tumors during a minimally invasive operation. The trial enrolls adults with borderline resectable or unresectable pancreatic cancer, meaning tumors that surgery may or may not be able to re…

Researchers at El Katib Hospital are testing a procedure called endoscopic band ligation on the upper part of the small intestine in people with type 2 diabetes. The goal is to reshape the duodenal lining so it may release more gut hormones that help control blood sugar. Ten adul…

Researchers are testing whether a multidisciplinary care model helps people with type 2 diabetes and chronic kidney disease start and adjust five classes of heart and kidney protective medicines within four months. The trial enrolls about 570 adults at high or very high risk of k…

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

Researchers are testing an investigational drug called SKB571 in adults with advanced or metastatic pancreatic cancer. The trial aims to see how well the drug shrinks tumors and how safe it is. Participants receive SKB571 every three weeks, and doctors track their response using …

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

Researchers are observing how tirzepatide works in routine care for adults in Pakistan who have obesity, prediabetes, or type 2 diabetes. The study follows 330 people starting the medicine as part of their normal treatment at ten diabetes and endocrinology centres. Doctors decide…

This trial tests whether the GX-01S continuous glucose monitoring system helps adults with type 1 or type 2 diabetes improve their blood sugar control. Participants wear the sensor for about 4.5 months, with the first 15 days blinded to establish a baseline, then full access to r…

Researchers in Oman are testing whether a structured education program that combines diabetes and oral health advice can improve blood sugar control and gum health in adults with type 2 diabetes. The trial enrolls 290 adults aged 35 and older who have had type 2 diabetes for at l…

This trial tests whether an experimental drug called HRS-7172, when combined with other antitumor therapies, can safely shrink or control advanced pancreatic cancer that has RAS mutations or amplifications. The study includes adults aged 18 to 70 with locally advanced or metastat…

This trial tests whether individualized nursing care can help adults with diabetes feel more confident and capable in managing their condition. Participants receive structured, personalized sessions that include education, goal-setting, and self-monitoring guidance. The study mea…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This trial tests whether an automated insulin delivery system, the DEKA TWIIST pump with Tidepool Loop software, can safely manage glucose levels in pregnant people with type 1 diabetes. The system adjusts insulin automatically and can be set to pregnancy-specific glucose targets…

This trial tests whether two moderate low-carbohydrate diets, one higher in protein and one higher in fat, improve blood sugar, blood fats, and weight more than a standard diet. Adults with type 2 diabetes, high triglycerides, and overweight or obesity will follow one of the thre…

This study tests two common methods for calculating mealtime insulin doses in hospitalized adults with type 2 diabetes. One method, carbohydrate counting, adjusts the insulin dose based on the grams of carbs a patient actually eats. The other uses a fixed dose that changes only w…

This early-stage trial tests an investigational drug called ABBV-253 in adults with advanced solid tumors, including lung, colorectal, and pancreatic cancers. The study aims to find safe doses and see whether the drug can shrink tumors. Participants receive the drug by infusion, …

This trial tests an experimental drug called SGC001 in people who are likely to develop severe acute pancreatitis, a painful inflammation of the pancreas that can lead to organ failure. Participants receive either SGC001 or a placebo as a single intravenous infusion alongside sta…

This phase III trial tests an experimental drug called YL201 against standard chemotherapy in people with metastatic pancreatic cancer that has progressed after gemcitabine-based treatment. YL201 is designed to deliver a toxin directly to cancer cells that carry a specific marker…

This study tests a 12-week digital program led by a nurse to help young adults (ages 18-45) with type 2 diabetes better manage their condition. Participants use a web or mobile app for education, goal-setting, and direct messaging with a nurse. The goal is to see if this approach…

This trial tests whether adding an experimental immunotherapy (SHR-1701) and a targeted drug (apatinib) to standard chemotherapy (gemcitabine and nab-paclitaxel) can help people with advanced pancreatic cancer. The study enrolls adults aged 18 to 75 who have not yet received trea…

This phase 2 trial tests whether choosing treatment based on the genetic changes in a person's pancreatic cancer works better than standard chemotherapy. Adults with advanced pancreatic cancer that has progressed after first-line treatment may join if their tumor has a genetic ch…

This trial tests whether a special cooling tube placed near the pancreas can help people with acute pancreatitis recover faster. Participants are randomly assigned to receive either standard care alone or standard care plus the cooling device for up to three days. The study measu…

This study looks at whether a preventive endoscopic procedure (sphincterotomy) can lower the risk of future bile duct problems in frail patients who cannot have their gallbladder removed after a bout of pancreatitis caused by gallstones. About 92 adults will be randomly assigned …

This early study tests if injecting a person's own stem cells into the upper gut is safe and feasible for treating type 2 diabetes. The stem cells are taken from belly fat and processed before being injected during a scope procedure. Only 15 people will take part, and the main go…

This trial compares two surgical approaches for people with pancreatic cancer in the left side of the pancreas. One method removes the spleen along with the tumor, which is standard practice. The other preserves the spleen, potentially reducing complications and avoiding lifelong…

This trial tests whether continuous glucose monitoring (CGM) can improve blood sugar control and reduce complications in hospitalized adults with type 2 diabetes, compared to standard finger-prick testing. Participants are randomly assigned to either CGM with a sensor-guided insu…

This 8-week pilot trial tests whether eating at least 56 grams of almonds daily can raise blood levels of vitamin E and improve overall diet quality in adults taking GLP-1 medications like semaglutide or tirzepatide for obesity or type 2 diabetes. Participants are split into two …

This trial tests whether giving hydrocortisone during and right after pancreatic surgery can lower the risk of a postoperative pancreatic fistula, a serious leak of digestive fluids. About 20 adults with pancreatic, duodenal, or bile duct cancer will be randomly assigned to recei…

This Phase 2 trial tests an investigational once-weekly injection called SYH2069 in adults with type 2 diabetes whose blood sugar is not well controlled by diet, exercise, or metformin alone. Researchers compare several doses of SYH2069 against a placebo and an existing diabetes …

This trial tests whether a specially designed smartphone app can improve self-management and blood sugar control in adults with type 2 diabetes. Participants use the app for daily tracking, video health lessons, and guidance from a team of doctors, nurses, dietitians, and pharmac…

This trial is testing whether a new oral drug called HRS-2329, which blocks multiple RAS proteins, can shrink tumors or slow disease when combined with other anti-cancer therapies. It is enrolling adults with advanced pancreatic cancer that has RAS mutations or amplifications and…

This phase II trial is testing whether an experimental oral medication, DA-302168S, can help people with type 2 diabetes control their blood sugar. The study will compare the drug against a placebo in about 272 adults who are already taking metformin. Researchers will measure cha…

This trial tests whether a daily supplement of calcium-HMB plus vitamin D3 can help adults aged 65 to 85 with type 2 diabetes keep their muscle mass and metabolism while starting semaglutide, a common weight-loss and diabetes medication. Participants take the supplement or a plac…

This study will give 100 adults with prediabetes a continuous glucose monitor (CGM) called Stelo, which tracks blood sugar every few minutes. The goal is to see if seeing real-time sugar levels helps people make better food and activity choices, lowering their A1c and improving h…

This trial compares fungal-based pancreatic enzymes to standard pig-derived enzymes in people with chronic pancreatitis and digestive insufficiency. Participants take either the fungal or porcine enzyme for 12 weeks to see if the fungal version works just as well. The goal is to …

This pilot trial tests a personalized AI platform called PIPE-AI, enhanced by DiabetesGPT, to see if it can help adults with prediabetes or type 2 diabetes improve their self-management and knowledge. Participants are randomly assigned to either use the AI platform for three mont…

This trial is testing whether an investigational drug called AZD6234, given as a weekly injection, can help adults with type 2 diabetes and excess weight lose more weight than a placebo. Participants will receive either AZD6234 or a placebo for 68 weeks, and researchers will meas…

This trial tests whether clazakizumab, an experimental anti-inflammatory drug, can lower a blood marker of inflammation called hsCRP in adults who have elevated levels and are at increased risk for heart problems. Participants must have conditions like established heart disease, …

This trial tests a 12-week community program for older stroke survivors who also have high blood pressure or type 2 diabetes. Participants take part in physical activities like exercise and nutrition education, plus cognitive games on an AI-enabled large screen. The goal is to se…

This trial tests whether a weight-loss procedure called endoscopic sleeve gastroplasty (ESG) can improve blood sugar control and reduce the need for insulin in adults with obesity and type 2 diabetes. Participants have poorly controlled diabetes despite taking standard medication…

This trial is testing whether adding dapagliflozin to metformin can improve levels of a growth-related hormone (IGF-1) in men with type 2 diabetes and fatty liver disease. The study will include 84 men aged 30-60 who are already taking metformin. Half will continue metformin alon…

This trial aims to find out whether a standard exercise program (Otago) or a specialized balance training that engages multiple senses (multisensory integration) is more effective at improving balance and walking in older adults with type 2 diabetes. Participants, aged 65 to 75, …

This study looks at whether supervised exercise and the diabetes drug semaglutide, alone or together, can improve thinking and brain health in older adults with type 2 diabetes. About 164 people aged 65 and older will take part. They will be assigned to exercise training, a contr…

This study tests a new once-daily oral pill called orforglipron against a weekly injection (dulaglutide) in 170 teens aged 10-18 with type 2 diabetes. The goal is to see if the pill works better at controlling blood sugar and is safe. Participants will be followed for about 61 we…

This trial tests whether a wearable device and a personalized prehabilitation program can help adults recover better after surgery for pancreatic cancer or related conditions. Participants will wear a monitor to track vital signs and activity, and follow a program of exercise, nu…

This trial is testing an experimental procedure called pulsENDO therapy for adults with type 2 diabetes whose blood sugar is not well controlled with current medications. The procedure uses a thin tube to deliver gentle electric pulses to the lining of the small intestine, aiming…

This trial tests a new laparoscopic procedure called SIBS, which combines sleeve gastrectomy with a side-to-side connection between the duodenum and ileum, without cutting the duodenum. The goal is to see if the surgery is safe and technically feasible in adults with obesity and …

This phase 2 trial is testing whether combining two immunotherapy drugs—vilastobart and retifanlimab—can shrink tumors in people with metastatic pancreatic cancer that has a BRCA1, BRCA2, or PALB2 gene mutation. Participants receive both drugs by IV infusion over several months. …

This trial is testing whether taking a daily Ceylon cinnamon supplement, combined with a structured educational program, can improve blood sugar control, cholesterol levels, and nerve pain in adults with type 2 diabetes and painful diabetic peripheral neuropathy. About 900 partic…

This trial tests whether a culturally tailored, Spanish-language onboarding and support program helps Latino youth aged 10–20 with type 1 diabetes adopt and consistently use the Medtronic MiniMed 780G automated insulin delivery system. Participants receive one-on-one nutrition su…

This trial tests whether open-source automated insulin delivery (AID) systems can control blood sugar as well as commercial systems in adults with type 1 diabetes, even when meals are not announced. Participants will use both types of systems for four weeks each, with a focus on …

This phase 2 trial is testing whether pirfenidone, a drug already used for lung scarring, can help people with chronic pancreatitis—a long-term inflammation of the pancreas that causes severe pain. The study will enroll 60 adults with chronic pancreatitis and moderate-to-severe p…

This study tests NeoMayor, a smartphone app that gives personalized advice on exercise, diet, sleep, and mood to improve heart health. Researchers will enroll 240 adults aged 55 to 75 in Chile who are at risk for heart problems. Participants use the app for 4 months, and some als…

This trial tests whether extending a 6-month exercise coaching program to 12 months helps people with type 2 diabetes maintain a healthier activity level. Participants will be randomly assigned to either the standard 6-month program or an extended version with sessions every two …

This trial explores whether starting transdermal estradiol (a skin gel or patch) soon after menopause can protect the heart and brain in women who have hot flashes and at least one cardiovascular risk factor. One hundred women will be randomly assigned to receive the hormone ther…

This pilot study tests whether a voice-activated smart speaker can help adults aged 50 and older with poorly controlled type 2 diabetes improve their blood sugar levels. Participants receive weekly diabetes education and skills training calls through the smart speaker for 12 week…

This trial compares two simple diet strategies — eating only during early hours or cutting staple foods like rice and bread in half — each combined with an app-guided exercise program, against exercise alone. Researchers want to see which approach helps adults with obesity and pr…

This study looks at whether a wearable insulin patch pump, guided by a continuous glucose monitor, can better control high blood sugar caused by high-dose steroids in people with sudden hearing loss and diabetes or prediabetes. About 44 participants will be randomly assigned to e…

This study tests four nutrition programs—meal kits, ready-to-eat meals, cooking classes, and motivational texts—in 400 adults with overweight or obesity who use food pantries. The goal is to see which approach best improves diet quality and food security, with the aim of reducing…

This trial investigates whether raising the body's core temperature to 41.5°C for 4 hours, called whole-body hyperthermia, can improve outcomes when added to standard chemotherapy for people with metastatic pancreatic cancer that has progressed after initial treatment. The study …

This pilot study tests whether a family-based, culturally tailored diabetes management program can help Native Hawaiian and Pacific Islander adults with type 2 diabetes. Participants attend group education sessions with a family member and receive help connecting to social servic…

This study tests a smart computer system that helps primary care doctors screen for and manage diabetic kidney disease in adults with type 2 diabetes. The tool automatically calculates kidney function, reminds doctors to order urine tests, and gives personalized treatment advice.…

This study tests a program where social workers screen families of youth with type 1 diabetes for social challenges like food insecurity, then connect them to community resources. The goal is to see if this approach is practical and acceptable, and whether it can improve diabetes…

This clinical trial tests whether adding focused ultrasound (IMD10) to standard chemotherapy can help people with borderline resectable or locally advanced pancreatic cancer. The study will enroll 136 adults aged 18-85 with confirmed pancreatic ductal adenocarcinoma. Half will ge…

This trial investigates whether tirzepatide, a medication already used for diabetes and weight loss, can help repair nerve damage in people with diabetic peripheral neuropathy. The study includes 40 adults with diabetes and nerve pain or numbness. Researchers will measure nerve h…

This study tests whether a home-based balance and strength program called Otago exercises can improve mobility, balance, and quality of life in adults with type 2 diabetes. Participants do the exercises 5 days a week for 4 weeks, plus walking. The trial measures how quickly they …

This study tests whether an AI-powered intensive lifestyle program can help people with obesity and newly diagnosed type 2 diabetes lose weight and control blood sugar as well as the drug tirzepatide. Adults aged 18 to 65 with a BMI of 28 to 40 and recent diabetes diagnosis are r…

This study explores whether eating durian daily for two weeks changes the gut microbiome, metabolism, and blood sugar levels in adults with type 2 diabetes. Forty participants will eat fresh durian pulp and undergo blood and stool tests, plus continuous glucose monitoring. The go…

This study tests a new combination drug called TriGlytza-01 in overweight adults with type 2 diabetes whose blood sugar is not well controlled by metformin alone. The trial compares TriGlytza-01 to standard metformin over 16 weeks, measuring safety, blood sugar levels, and body w…

This study tests whether a mobile app that provides structured diabetes education can help adolescents with type 1 diabetes improve their blood sugar control, confidence, and self-care habits. Participants aged 10 to 19 with type 1 diabetes and an HbA1c of 7% or higher will use t…

This study tests whether an integrated digital health platform—combining a continuous glucose monitor, activity and sleep tracker, and food log—can improve blood sugar control in adults with type 2 diabetes. Some participants also receive weekly feedback from a healthcare provide…

This study investigates whether regular blood tests can detect liver cancer earlier in people with type 2 diabetes who also have significant liver scarring. Participants are randomly assigned to either a surveillance group receiving specialized blood tests every six months or a s…

This study tests an experimental drug, TAX2, in adults with advanced or metastatic solid tumors that have not responded to standard treatments. The trial has two parts: first, finding a safe dose, and then testing that dose in more people. Researchers will monitor side effects, h…

This study will test whether eating a diet rich in whole fruit (up to 50% of daily calories) for 17 weeks can improve blood sugar control, reduce liver fat, and lower heart disease risk in adults with type 2 diabetes who do not use insulin. Participants will eat fruit prepared in…

This study tests whether montelukast, a common allergy medication, can reduce damage to the kidneys, eyes, and blood vessels in adults with type 2 diabetes and early kidney disease. The drug works by blocking inflammatory chemicals called leukotrienes, which are linked to diabete…

This study tests whether adding blood flow restriction (BFR) training to standard exercise helps adults aged 50-60 with type 2 diabetes improve balance, muscle strength, and physical function. Participants wear compression cuffs on their limbs during low-intensity resistance exer…

This study tests whether an artificial intelligence (AI) tool can help doctors choose better diabetes medicines for patients with type 2 diabetes. Many patients are treated by doctors who are not diabetes specialists, so the AI provides real-time suggestions and predictions about…

This trial investigates whether flushing the bile duct opening with ice-cold water after an ERCP procedure can reduce the chance of developing pancreatitis, a frequent complication. Researchers will compare patients who receive the flush to those who do not, looking at pancreatit…

This Phase 3 study tests SAB-142, an antibody that targets immune cells, in 108 people aged 5 to 40 with type 1 diabetes. The goal is to see if it can preserve the body's ability to produce insulin over 12 months. Participants receive either the drug or a placebo alongside standa…

This study tests whether replacing missing back teeth with dental implants can help people with uncontrolled type 2 diabetes improve their blood sugar levels. The idea is that better chewing leads to healthier eating, which may lower HbA1c. 140 adults will either get implants plu…

This study tests a new, simpler weight training program called D-STORM for adults with type 2 diabetes. The program uses easier exercises to build muscle and improve blood sugar control. Over 12 weeks, 56 participants will either do the training plus usual care or just usual care…

This study tests whether a personalized online lifestyle program, with or without a virtual AI coach, can help people with type 2 diabetes improve their blood sugar control. 160 adults will use continuous glucose monitors and attend online group sessions over 12 months, with foll…

This study tests a new drug called samuraciclib added to standard chemotherapy for people with a specific type of advanced pancreatic cancer (basal-like). The goal is to find the safest dose and see if the combination helps shrink tumors or slow the cancer. About 67 adults with n…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This trial tests whether a procedure called EUS-guided gallbladder drainage can prevent future gallbladder attacks in people who are too sick or frail for surgery. Participants are randomly assigned to receive either the drainage procedure or standard medical care. The study will…

This trial investigates whether a diet rich in polyphenols—including daily cocoa and extra fruits and vegetables—can reduce oxidative stress and improve blood vessel function in pregnant women. Researchers will randomly assign 60 pregnant women to receive dietary counseling and c…

This phase II trial tests whether a genetic signature can personalize chemotherapy for people with borderline resectable pancreatic cancer. About 110 participants will receive either a standard chemo regimen or one chosen based on their tumor's genetic profile. The goal is to see…

This study tests whether an interactive educational video, added to standard diabetes education, helps children aged 8 to 14 with type 1 diabetes improve their blood sugar control. The video lets kids make decisions in everyday situations and see the results. Researchers will mea…

This pilot study in Colombia will test whether a nursing program that tailors education and counseling to each patient's needs can help people with high blood pressure or type 2 diabetes stick to their medications and achieve better disease control. About 100 to 200 adults alread…

This study tests a modified oral rehydration salts (ORS) drink designed for diabetic pilgrims at risk of heat stress and dehydration during the Hajj. The modified ORS has adjusted electrolytes and carbohydrates to avoid raising blood sugar. Researchers will compare it to standard…

This study tests whether the shingles vaccine Shingrix and the diabetes drug semaglutide, alone or together, can help preserve the body's ability to make insulin in adults recently diagnosed with type 1 diabetes. The goal is to slow the immune attack on insulin-producing cells an…

This study tests whether a daily prebiotic drink (containing inulin) can improve blood sugar control in 30 postmenopausal women with prediabetes. Participants will consume the drink or a placebo for 4 weeks. The goal is to see if this simple dietary supplement can help reduce the…

This early-phase trial tests a three-step immune treatment for people recently diagnosed with Type 1 diabetes (within 6 months). The goal is to preserve the body's remaining insulin production by calming the immune attack and teaching the immune system to tolerate insulin. Sixty …

This study tests a new way to deliver insulin for type 2 diabetes: a spray applied to the skin instead of an injection. Thirty adults who already use insulin will try the spray for 21 days. Researchers will check if it keeps blood sugar in a safe range and causes less skin irrita…

This study tests whether a newer, shorter metal stent works better than a standard plastic stent for opening blocked bile ducts in people with pancreatic cancer who need surgery. About 116 adults with operable or locally advanced pancreatic cancer and high bilirubin levels will b…

This study will test an automated insulin delivery system (the Medtronic 780G pump with continuous glucose monitoring) in 20 pregnant women with type 2 diabetes. Participants join before 16 weeks of pregnancy and use the device until delivery. The main goal is to see how much tim…

This study tests whether a 3-month support program, led by a nurse and a community health worker and guided by an AI tool called MEDBRIDGE, can help people with type 2 diabetes manage their medications after leaving the hospital. The program aims to reduce confusion about medicat…

This study compares two glucose monitoring methods—continuous glucose monitors (CGM) and traditional finger-prick tests—in adults with type 2 diabetes who are taking the drug dapagliflozin. The 120 participants will be split into two groups and followed for 12 weeks to see which …

This early-stage trial tests a personalized cancer vaccine called ODI-2001 in 77 people with advanced colon or pancreatic cancer that has spread or cannot be removed. The vaccine is custom-made for each patient's tumor and is given along with a drug that boosts the immune system.…

This phase 3 trial tests whether adding chemotherapy after surgery can prevent aggressive pancreatic neuroendocrine tumors from coming back. About 300 patients will either receive active surveillance alone or 6 cycles of capecitabine-temozolomide pills plus surveillance. The stud…

This study tests a new treatment for people with advanced pancreatic cancer that has not been treated before. It combines a hedgehog inhibitor (NLM-001) with standard chemotherapy and two immunotherapy drugs. The goal is to see if this combination shrinks tumors better than chemo…

This study will test a program based on WHO guidelines to improve diabetes screening and care in 10 primary health centers in Nigeria. About 2,800 adults with or at risk for diabetes will take part. The goal is to see if the program helps more people get diagnosed and treated.

This early-stage trial tests a new therapy called MT-601, which uses a patient's own immune T-cells trained to recognize multiple cancer-related targets. It is for people with advanced pancreatic cancer that cannot be removed by surgery or has spread. The study will check safety …

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study tests a community-to-facility care model to help control type 2 diabetes in Bangladesh. Researchers will compare the new integrated approach with usual care in 20 city wards involving 5,000 adults. The goal is to see if linking community health workers with clinics imp…

This pilot study tests whether starting four approved kidney disease medicines quickly (over about 8 weeks) is safe and effective for people with type 2 diabetes and chronic kidney disease. Researchers will compare this rapid approach to usual care, where medicines are started on…

This pilot study tests whether a home-based high-intensity interval training (HIIT) program can help people who have reversed their type 2 diabetes keep it from returning. Twenty adults who completed the NHS Path to Remission programme will either do HIIT three times a week or co…

This study tests a special education program designed to boost confidence in managing type 2 diabetes. About 400 adults will either receive this program or standard care. The goal is to see if the program improves blood sugar monitoring, diabetes knowledge, and quality of life.

This study tests a new lab-made enzyme called NHS7108 in people with exocrine pancreatic insufficiency (EPI), a condition where the pancreas doesn't make enough enzymes to digest food. About 66 adults will take either NHS7108 or the standard enzyme Zenpep for 14 days each, while …

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This study tests a new automated insulin delivery system (NMX8) in 230 adults with type 1 diabetes who are not meeting their blood sugar goals. Participants will use either the NMX8 system or another approved system to see which helps keep blood sugar in the target range more oft…

This study looks at whether a 12-week Mediterranean diet can lower oxidative stress and improve blood sugar control in girls aged 10-18 with type 1 diabetes who have high HbA1c levels. Researchers will measure changes in blood markers and glucose levels. The goal is to see if thi…

This study tests whether a 3-month video-based lifestyle program works better when delivered by a patient's own primary care doctor versus an unfamiliar doctor. The program covers healthy eating, physical activity, and behavior change. Researchers will measure blood sugar control…

This study tests whether five virtual sessions with a trained pharmacist can improve blood sugar, diabetes knowledge, medication adherence, and quality of life in adults with uncontrolled type 2 diabetes. Participants are randomly assigned to receive the tele-education program pl…

This study tests whether changing the order of steps during a Whipple surgery for pancreatic head cancer can help surgeons remove the tumor more completely and lower the chance of cancer coming back. About 150 adults with operable pancreatic cancer will be randomly assigned to ei…

This study looks at whether a program called HEARTS can help people who have both high blood pressure and diabetes get better care. About 1,440 adults in Guatemala will take part, and clinics will either use the HEARTS program or continue their usual care. The program includes tr…

This study tests a new way of managing care for older adults (ages 60-74) who have both high blood pressure and type 2 diabetes. About 960 people from rural community health centers will either receive the new integrated care package or continue with standard care. The goal is to…

This study looks at whether people with type 1 diabetes can safely start using an advanced hybrid closed-loop insulin pump system at home instead of in the hospital. Researchers will track blood sugar levels, quality of life, and costs over 12 months in 80 adults. Participants re…

This study tests whether a mobile app can help people with diabetes better manage their condition after leaving the hospital. The app provides education, reminders, and monitoring tools for 90 days. Researchers will compare self-care behaviors, blood sugar control, and hospital r…

This study tests whether adding artificial intelligence to an automated insulin delivery system can improve blood sugar control for people with type 1 diabetes. The AI learns each person's meal patterns and automatically gives insulin boluses without requiring them to announce me…

This study looks at whether using a continuous glucose monitor (CGM) can help manage high blood sugar better than standard finger-prick tests in people with type 2 diabetes who have had a stroke. High blood sugar after a stroke can lead to worse outcomes. The study will involve 8…

This early-phase trial tests whether delivering the chemotherapy drug gemcitabine directly into the artery feeding the tumor can improve surgical outcomes for people with borderline resectable pancreatic cancer. Ten participants will receive standard chemo and radiation, followed…

This early-phase trial tests whether adding the migraine drug rimegepant to standard chemotherapy can help people with metastatic pancreatic cancer. About 30 adults who have not had prior treatment will receive the combination. Researchers will track how long the cancer stays und…

This study will test whether applying a special heat-reflecting coating to roofs can improve the health and well-being of 800 households in Colima, Mexico. The coating is designed to keep homes cooler indoors, which may help lower heart rate, improve blood sugar control, reduce d…

This Phase 3 trial tests a new once-weekly injection, NNC0487-0111, against the approved drug semaglutide in 1000 adults with overweight or obesity and type 2 diabetes. Participants receive two weekly shots (active drug plus placebo) to see if the new drug is safe and leads to gr…

This study compares two diabetes medications—imeglimin and metformin—in 176 adults newly diagnosed with type 2 diabetes. Participants will take one of the two drugs for 12 weeks. The main goal is to see which drug better improves mitochondrial function, measured by a blood test c…

This study tests whether a 9-month lifestyle coaching program (individual and group sessions with a dietician) helps obese male firefighters lose weight and improve metabolic health. Fifty participants will be randomly assigned to coaching or usual care. The main outcomes are cha…

This study tests a new approach to managing type 2 diabetes that combines an AI smartphone app with support from family doctors. About 1200 adults in China will use the app to track their meals and get personalized feedback, while also receiving regular check-ins from their docto…

This study tests whether a home-based vibrating calf device can help adults with type-2 diabetes improve blood sugar control. 305 participants in Saudi Arabia will be assigned to active vibration, a sham device, or usual care for 12 weeks. The main goal is to see if vibration-ass…

This study tests whether an automated insulin delivery system (the Omnipod 5) can help people with type 2 diabetes who are on dialysis achieve better blood sugar control. Half of the 84 participants will use the automated system, while the other half will continue their usual ins…

This study tests whether domperidone, a drug that speeds up stomach emptying, can help people with type 1 diabetes keep their blood sugar in a healthy range. About 70 adults with type 1 diabetes who have slow stomach emptying but no digestive symptoms will take either domperidone…

This study tests whether a special education plan using continuous ketone monitoring can lower the risk of diabetic ketoacidosis (DKA) in people with type 1 diabetes who also take SGLT2 inhibitors, a drug class that raises DKA risk. About 75 adults with type 1 diabetes will be en…

This study tests a temporary device placed in the upper small intestine to help control type 2 diabetes and obesity. The implant stays for 6 months and is then removed. Researchers will check if it lowers blood sugar (HbA1c), helps with weight loss, and improves liver health in p…

This study will enroll 120 children and teens with type 1 diabetes who use automated insulin pumps. Participants will be randomly assigned to follow either the standard blood sugar target (70-180 mg/dL) or a tighter target (70-140 mg/dL) for 12 months. Researchers want to see if …

This study tests whether taking melatonin daily can help pregnant women with gestational diabetes better control their blood sugar. Researchers will compare melatonin to a placebo in 150 women. Participants take the supplement or placebo from diagnosis until delivery and have reg…

This study compares two different drug combinations for people with type 2 diabetes whose blood sugar is not well controlled with metformin and sitagliptin. About 200 adults will receive either empagliflozin or glimepiride added to their current treatment. The goal is to see whic…

This early-stage trial tests whether adding ATRA, SDK002, and an immunotherapy drug to standard chemotherapy is safe for people with advanced pancreatic cancer that cannot be removed by surgery. Ten participants will receive all five drugs together. The study will also track how …

This study looks at two common diabetes pills—henagliflozin and metformin—to see how they affect muscle mass and blood sugar in older adults (ages 60-85) who are newly diagnosed with type 2 diabetes. About 116 participants will take one of the two medicines daily for 24 weeks. Th…

This study tests whether taking a daily supplement made from bitter melon extract and snakehead fish powder can help lower blood sugar in adults with type 2 diabetes. About 80 participants will take either the supplement or a placebo for 4 weeks. The goal is to see if this natura…

This study tests a program that combines online diabetes education videos with help connecting to social services for low-income Chinese and Latino/a immigrants with type 2 diabetes. The goal is to improve blood sugar control and see if people find the program useful and easy to …

This study tests whether an AI-powered app called 'Smart family doctor' can help people who have had heart surgery (bypass or stent) better control their blood pressure, blood sugar, and cholesterol. About 951 participants from 10-20 hospitals will use the app for personalized he…

This study tests a mobile app called Diactive-1 that provides personalized resistance training and education for children and adolescents with type 1 diabetes. Over 12 weeks, participants follow a tailored exercise program (like strength training or high-intensity intervals) and …

This Phase 3 trial will test whether glimepiride, a standard diabetes pill, can reduce the risk of heart-related death, heart transplant, or worsening heart failure in people with type 2 diabetes and chronic heart failure. About 1,484 participants will receive either glimepiride …

This study looks at whether actively treating diabetes with drugs like metformin or insulin can help people with metastatic pancreatic cancer live longer when they also receive standard chemotherapy. About 210 adults with both pancreatic cancer and diabetes will be enrolled. The …

This phase 2 trial tests whether adding nimotuzumab, a targeted antibody, to standard chemotherapy can help people with high-risk pancreatic cancer that can still be surgically removed. About 156 participants will receive either the drug combo or a placebo before and after surger…

This study tests a 12-week program that uses WhatsApp to teach people with type 2 diabetes and their family members how to manage the disease better. Participants get videos, quizzes, and weekly phone calls to improve self-care and blood sugar levels. The goal is to see if this a…

This study tests whether adding ganagliflozin tablets to standard care can slow kidney disease progression in 1,244 adults with type 2 diabetes and chronic kidney disease. Participants will take either ganagliflozin or a placebo daily for 120 weeks. The main goal is to measure ch…

This study tests whether using a continuous ketone monitor with a lower alarm threshold (1.0 vs 1.5 mmol/L) can reduce the risk of diabetic ketoacidosis in people with type 1 diabetes who take dapagliflozin, a drug typically used for type 2 diabetes. 115 adults will wear a dual g…

This study tests whether a specific sequence of two different chemotherapy combinations, each paired with an immunotherapy drug (PD-L1 antibody), can shrink borderline resectable or locally advanced pancreatic cancer enough to allow surgical removal. About 77 adults with this typ…

This study tests whether a personalized diet, exercise, sleep, and counseling program can help adults with type 2 diabetes achieve remission. 120 participants will follow the program for 6 months, then be monitored for another 12. The goal is to see if blood sugar levels can retu…

This study tests whether adding WhatsApp-based education and counseling to standard care helps stroke patients with type 2 diabetes improve their lifestyle, blood sugar control, and disease knowledge. 84 participants will be split into two groups: one gets routine education, the …

This study will compare two diabetes medications, cofrogliptin and linagliptin, when added to insulin therapy in Chinese adults with type 2 diabetes. About 594 participants will take either a biweekly or daily pill alongside their usual insulin. Researchers will track blood sugar…

This study compares two types of foot pads—siliconepads and felted foam—to see which one better reduces pressure under the ball of the foot in people with diabetes who are at high risk for foot ulcers. Researchers will measure pressure relief and ask participants about comfort an…

This study tests whether a 12-week virtual health coaching program powered by artificial intelligence can improve blood sugar control in adults with type 2 diabetes. 206 participants in Indonesia will be randomly assigned to use the DIACOACH app or receive standard diabetes educa…

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized lifestyle advice, and long-term support. Researchers will …

This study tests whether eating four GlucoBites cookies daily for 12 weeks can improve blood sugar control and reduce the risk of diabetic foot ulcers in adults with type 2 diabetes. The cookies contain an herb called Gynura procumbens. Researchers will compare blood sugar, insul…

Many people with diabetes skip regular eye exams, even though early treatment can prevent vision loss. This pilot study tests whether offering retinal photography during routine occupational health visits makes screening easier to access. Workers with diabetes attend one visit wh…

Researchers are studying whether immune markers in a blood sample taken before pancreatic cancer surgery can predict a serious complication called postoperative pancreatic fistula, where digestive fluids leak from the surgical connection. Adults scheduled for curative-intent panc…

Researchers at Assiut University are studying whether two ultrasound measures of fetal heart function and blood flow can predict poor outcomes in pregnancies complicated by diabetes or preeclampsia. The study enrolls 69 pregnant women, including those with gestational diabetes, p…

Researchers at Gaziantep City Hospital are using bedside ultrasound to measure stomach volume in pregnant women right before a scheduled cesarean section. They compare women who have gestational diabetes with those who do not, to see whether diabetes affects how much food or flui…

Many cancer trials require patients to have specific molecular markers, so researchers test large numbers of people to find the few who qualify. This study evaluates FATHOM, an AI system that reads clinical trial records and routine tumor slides to predict which patients carry th…

This study compares two needle devices used to take tissue samples from pancreatic lesions during an endoscopic ultrasound. The goal is to see which device provides better quality tissue for diagnosis with fewer needle sticks. About 30 adults with pancreatic solid lesions larger …

Researchers test a new endoscopic device called the loop brush fine needle aspiration (lbFNA) to sample pancreatic cysts in people scheduled for surgery. The pilot study enrolls 8 adults with cysts that require surgical removal. Doctors use the device to puncture, brush, and aspi…

Researchers at Assiut University are studying whether two types of routine blood measurements can help predict how quickly kidney disease worsens in people with diabetes. The first is the Triglyceride-Glucose index, a calculation from standard cholesterol and blood sugar tests. T…

Researchers are testing whether a previously validated artificial intelligence model can help identify high-grade dysplasia or pancreatic cancer in real time during a procedure called digital per-oral pancreatoscopy. The study enrolls 60 adults who need this procedure for suspect…

Pancreatic cancer is hard to catch early, and screening guidelines for high-risk people remain uncertain. Researchers at UNC are testing an electronic decision support tool that guides patients and doctors through a shared conversation about whether to screen. The pilot study enr…

This registry study follows 400 people at increased risk for pancreatic ductal adenocarcinoma who receive PancreaSure, a blood test designed to detect early-stage disease. Researchers track whether the test results lead doctors to change surveillance plans, such as scheduling mor…

This study tests whether using an AI program to screen for diabetic eye disease during regular primary care visits can get more people to follow up with an eye specialist. It will include 4,000 adults with diabetes who have Medicaid and haven't had an eye exam in the past year. T…

This study tests whether community pharmacies can help find undiagnosed type 2 diabetes and prediabetes in adults living in Irbid, Jordan. Participants without a diabetes diagnosis will fill out a risk questionnaire and, if their score is high, receive a quick finger-prick HbA1c …

This trial tests whether measuring glucose in umbilical cord blood, already collected at birth, can screen newborns for congenital hyperinsulinism, a condition that causes dangerously low blood sugar and can lead to brain damage if missed. Researchers will check the test's accura…

This study looks at whether a special ultrasound technique called detective flow imaging (DFI) can help doctors tell the difference between benign and malignant solid pancreatic lesions. Researchers will examine the blood vessel patterns seen with this technique and compare them …

This study investigates whether specific proteins found in tiny particles in the blood (called small extracellular vesicles) can help identify obese individuals who are at risk for developing type 2 diabetes. Researchers will measure levels of two proteins, integrin-β2 and ECM1, …

This pilot study tests whether a structured case-finding pathway can help detect pancreatic cancer earlier in Swiss primary care. Adults aged 60 or older with warning signs like new-onset diabetes, unexplained weight loss, or a family history of pancreatic cancer are invited to u…

This study aims to find molecular clues that could predict whether certain pancreatic growths will turn into cancer. Researchers will analyze tissue from patients having pancreatic surgery, using advanced genetic and protein tests on both the original tissue and lab-grown 3D cell…

This study tests a new imaging tracer called [18F]FAPI-74, which attaches to a protein found on cells in tumors and scarred or inflamed tissue. Researchers want to see if it can show these areas more clearly than current scans. About 770 adults with various cancers or non-cancer …

This study investigates whether a new ultrasound technology called Superb Microvascular Imaging (SMI) can accurately analyze material inside pancreatic cysts (PIMPTs) without using a contrast agent. Currently, doctors inject a contrast dye during endoscopic ultrasound to assess c…

This study will screen about 2,200 children aged 2-10 for autoantibodies that signal early type 1 diabetes. The goal is to find the disease before symptoms appear and test if educational programs help families. Researchers will also check if this screening is practical and cost-e…

This study tests a new blood test that combines genetic sequencing and immune response analysis to quickly tell if dead pancreatic tissue has become infected. Researchers will enroll 200 patients with severe pancreatitis across four hospitals. If accurate, this test could help do…

Pancreatitis is a painful inflammation of the pancreas that can happen after an ERCP procedure. Doctors often give rectal indomethacin around the time of ERCP to lower that risk, but it still occurs. This trial randomly assigns adults having ERCP to receive either rectal indometh…

Researchers are testing an AI chatbot that gives personalized, culturally tailored advice on nutrition, physical activity, and goal setting to adults at risk for type 2 diabetes. About 30 adults aged 18 to 55 will use the chatbot for 6 weeks. The study will check whether the chat…

This study tests whether an enhanced version of the Intensive Diabetes Prevention Program (IDPP) works better than the standard program at recruiting and keeping participants in district health centres. Researchers will compare the two approaches in 170 adults with prediabetes, l…

Researchers are testing whether an intensive Mediterranean diet program started in the first trimester of pregnancy lowers the chance of developing gestational diabetes in women at high risk. The trial enrolls about 1,200 pregnant women aged 18 to 50 with a single, unassisted pre…

Researchers in South Savo, Finland, invite residents turning 45, 50 or 55 to take a blood test that measures many small molecules at once. The test estimates each person's 10-year risk of type 2 diabetes, heart attack, stroke, chronic kidney disease and fatty liver disease. Peopl…

Researchers are testing whether adding family health history and family participation to the standard Diabetes Prevention Program helps adults with prediabetes. The trial enrolls 400 adults with prediabetes and a family member who joins them. Participants are assigned to either t…

Researchers at New York University are testing whether a package of online tools can help low-income families with teens at risk for type 2 diabetes buy and eat more fruits, vegetables, and legumes. The trial enrolls 200 households that receive SNAP or have low incomes and includ…

This study tests whether delivering prepared meals or boxes of unprepared food to pregnant people at risk of gestational diabetes is practical and acceptable. Researchers will give participants either ready-to-heat meals from a diabetes-friendly menu or boxes with fresh produce a…

This trial tests whether giving semaglutide (Wegovy) to women shortly after a pregnancy affected by gestational diabetes can reduce their risk of developing metabolic syndrome, a cluster of conditions that raise the chance of heart disease and diabetes. About 226 postpartum women…

This phase 3 trial tests whether orforglipron, a daily oral medication, can help overweight adults reduce their risk of developing obesity-related complications such as type 2 diabetes, high blood pressure, and high cholesterol, as well as progression to class 1 obesity. Particip…

This trial tests whether a single intravenous dose of tacrolimus, given just before an ERCP procedure, can lower the chance of developing post-ERCP pancreatitis (PEP) in adults at moderate-to-high risk. Participants receive either tacrolimus or a placebo infusion, along with stan…

This trial tests whether combining time-restricted eating (eating only within a 10-hour window each day) with moderate-to-high intensity exercise can improve heart and metabolic health in women who recently had gestational diabetes. Participants are randomly assigned to either an…

This trial tests a family-focused program for women diagnosed with gestational diabetes in northern Vietnam. The program includes nutrition advice, physical activity guidance, breastfeeding support, and digital tools, delivered from pregnancy through two years after birth. The go…

This study investigates whether drinking kefir, a fermented dairy drink rich in live bacteria and yeasts, from around 14 weeks of pregnancy until routine diabetes screening can improve blood sugar control and reduce the risk of gestational diabetes. Pregnant individuals are rando…

This study tests whether eating all meals within an 8-hour window (between early morning and early afternoon) combined with morning exercise can prevent sarcopenia—age-related muscle loss—in postmenopausal women with obesity and type 2 diabetes. Forty-five women will follow eithe…

This study tests whether semaglutide (Ozempic/Wegovy) can prevent repeat episodes of acute pancreatitis caused by very high triglycerides. About 396 adults who recently had such an attack will receive either semaglutide injections or a placebo for 18 months, alongside standard ca…

This study tests whether two types of fish oil, EPA and DHA, can improve metabolic health in people at high risk for type 2 diabetes. Over 12 weeks, 84 participants will take daily capsules of EPA, DHA, or a placebo (corn oil) and undergo specialized tests to measure insulin func…

This study tests whether combining continuous glucose monitors (CGMs) with group lifestyle sessions can help people with prediabetes lower their blood sugar and prevent type 2 diabetes. Twenty adults with prediabetes will attend regular group meetings on diet, exercise, and stres…

This study tests a 12-session virtual program to help adults with prediabetes in the UAE prevent type 2 diabetes. The program covers diet, physical activity, sleep, and stress management, and is led by a health coach from the same cultural background. Thirty participants will att…

This study tests whether a virtual health community can help people with prediabetes improve blood sugar control and prevent type 2 diabetes. Participants will receive lifestyle support through a digital platform, including education, guidance, and group interaction. The trial wi…

Researchers at MD Anderson Cancer Center are studying whether routine electronic symptom monitoring improves quality of life and care experience for patients with pancreatic adenocarcinoma receiving chemotherapy or radiation before surgery. About 200 adults with operable or local…

Researchers are testing a program that combines mindful eating and yoga-based movement for adults with type 2 diabetes. The trial enrolls 60 people aged 40 and older who have had diabetes for at least six months. Half receive the mindfulness program and half receive standard diet…

Researchers are testing whether intermittent fasting improves quality of life for adults with acute or chronic pancreatitis. Participants follow a daily 16-hour fast or receive standard calorie guidance. The study measures pancreas-related quality of life, pain, opioid use, weigh…

Researchers are studying whether a procedure called fluoroscopy-guided transdiscal splanchnic nerve neurolysis can safely reduce severe upper abdominal pain in adults with pancreatic, gastric, or hepatobiliary cancer. Participants first receive a diagnostic nerve block with local…

Researchers are testing whether a digital nutrition app called STRONG, paired with remote dietitian counseling, is practical and helpful for adults with pancreatic ductal adenocarcinoma who are starting chemotherapy or radiation. About 80 participants join the study and are assig…

Researchers are testing whether personalised nutritional care from a trained dietitian improves quality of life for people aged 65 and older with pancreatic ductal adenocarcinoma. About 250 participants will be randomly assigned to either six months of individualised nutrition su…

This trial tests whether a traditional Chinese music therapy, called Ziwu Liuzhu Five-Element Music Therapy, can reduce anxiety in people with pancreatic cancer who are undergoing chemotherapy. The study will enroll 320 patients with mild-to-moderate anxiety and randomly assign t…

Researchers are testing a diabetes education program that combines standard self-management lessons with hands-on activities involving miniature horses. Children and teens ages 8 to 20 with type 1 or type 2 diabetes, along with their caregivers, attend four sessions led by a diab…

Diabetic foot ulcers heal in only about half of patients, even with standard care. Researchers are testing a turmeric-derived nanoparticle hydrogel applied to the wound alongside usual treatment, such as medication, insulin, or surgery. The trial enrolls adults with type 1 or typ…

Researchers at Mayo Clinic are running a pilot study to see whether clearing a blocked pancreatic duct improves how the pancreas makes insulin in people with chronic pancreatitis. Participants are adults with minimally symptomatic chronic pancreatitis and a duct blockage. The stu…

Researchers are testing DiaFootCare, a mobile app that teaches foot self-care, sends medication and care reminders, guides users through taking wound photos, and shares information with pharmacists. The trial enrolls 139 adults aged 40 to 60 with diabetes and an active foot ulcer…

This pilot study tests whether delivering pain medication directly to the spinal cord via an implanted pump can better control severe pain in people with pancreatic cancer. The trial enrolls adults whose pain is not well managed by standard treatments or who cannot take typical p…

Researchers are testing whether foot care education delivered with digital tools helps people with type 2 diabetes take better care of their feet. Ninety participants are randomly assigned to either a structured education program or standard care. The program includes two face-to…

This study tests whether taking vitamin D supplements can reduce nerve pain, improve sleep, and boost quality of life in people with type 2 diabetes who have nerve damage. Researchers will give vitamin D to 150 adults with low vitamin D levels and track their pain and sleep over …

This trial tests whether a structured, one-on-one educational session led by a nurse before an endoscopic retrograde cholangiopancreatography (ERCP) can reduce patient anxiety and improve knowledge about the procedure. Sixty adults scheduled for elective ERCP will be randomly ass…

This trial tests whether a lidocaine gel applied to the feet can ease painful diabetic neuropathy as well as the oral drug duloxetine. Adults with type 2 diabetes and moderate-to-severe nerve pain will be randomly assigned to one of the two treatments for 8 weeks. Researchers wil…

This trial tests whether a traditional Chinese exercise called Baduanjin can improve quality of life and emotional well-being in people with pancreatic cancer who are receiving chemotherapy. Researchers will enroll 96 patients and randomly assign them to either a 12-week Baduanji…

This trial tests whether a virtual reality version of Mindfulness-Based Stress Reduction (MBSR-VR) can be delivered to young adults aged 16 to 20 with type 1 diabetes who report high stress. Participants will attend group sessions that teach meditation, body awareness, and mindfu…

This trial tests whether a structured art therapy program, grounded in positive psychology, can improve self-compassion and hope in children aged 8 to 12 who are staying in a hospital ward. Half of the 80 participants will receive the art therapy sessions alongside standard nursi…

This study tests whether a 4-week rehabilitation program is practical and helpful for patients who experience severe complications after pancreatic surgery. The program includes personalized exercise, nutritional guidance, and techniques to reduce anxiety, and can be done at home…

This pilot study tests a software tool called NEXT that gives personalized advice on insulin and carbohydrate adjustments before and after exercise for adults with type 1 diabetes. Twenty participants will try three different approaches to managing their blood sugar around exerci…

This early-stage study tests whether the drug sodium phenylbutyrate (NaPB) can improve blood pressure and blood vessel function. It will include 30 healthy volunteers and people with diabetes. The goal is to see if NaPB might help ease vascular problems linked to diabetes.

This study investigates whether a device called FREMS, which delivers rhythmic electrical pulses to the legs, can improve blood flow, reduce nerve pain and numbness, and enhance quality of life in people with type 2 diabetes who have peripheral neuropathy and poor leg circulation…

This study tests whether a thoracic epidural block—a numbing injection near the spine—can help people with severe acute pancreatitis avoid or shorten the need for intensive care support like breathing machines and kidney dialysis. Participants are randomly assigned to receive eit…

This trial tests whether a short course of precisely targeted radiotherapy can safely reduce severe pain in people with advanced pancreatic cancer. The radiation is aimed at the coeliac plexus, a network of nerves in the abdomen that often causes pain when affected by the tumor. …

This study tests whether an AI-powered educational platform can help parents of children with type 1 diabetes count carbohydrates more accurately and manage diabetes better. About 80 parents will either use the AI platform plus usual care or usual care alone for 12 weeks. The goa…

This study tests whether individualized video consultations can help adults with type 1 diabetes manage exercise and blood sugar more confidently. Sixty participants will receive up to three 30-minute sessions with a doctor or exercise specialist. The goal is to improve self-mana…

This study looks at whether morning or evening exercise is better for controlling blood sugar in men with type 2 diabetes. Sixty men aged 40-60 will do high-intensity interval and resistance training for 12 weeks, either in the morning or evening. Researchers will measure changes…

This study will test a mindfulness-based education program for adults with type 2 diabetes. The goal is to see if it reduces diabetes-related distress and helps people feel more empowered to manage their condition. 70 participants will take part in group sessions that combine min…

This study tests whether a specially designed, better-tasting liquid diet can be used for two weeks by adults with chronic pancreatitis who have bothersome stomach symptoms. The diet is an easy-to-absorb formula that replaces all food for 14 days. Researchers want to see if peopl…

This study tests whether a home-based exercise program can help people with gastrointestinal or lung cancer handle chemotherapy better. Up to 120 participants will be randomly assigned to either an aerobic and resistance exercise group or a stretching group. All activities are do…

This pilot study tests an 8-week program called DREAM that uses AI-powered text messages to encourage physical activity in adults with type 2 diabetes. Twenty participants will receive twice-weekly messaging and set weekly activity goals. The study focuses on whether the program …

This study will test whether a single dose of beetroot juice can improve blood pressure and heart rate recovery after light cycling in adults with type 2 diabetes. About 20 participants aged 40-65 will receive either beetroot juice or a placebo in random order. The goal is to see…

This study tests if a gentle electrical stimulation on the outer ear can activate the vagus nerve and reduce nausea, vomiting, and stomach discomfort in people with diabetes and gastroparesis. Sixty adults with both conditions will receive the treatment and report symptom changes…

This pilot study tests a virtual program called STRIDE, designed for adults aged 21-44 who have type 2 diabetes and are raising children. The program includes three online sessions focused on self-care, healthy eating, and family activity. Researchers will measure changes in diab…

This study tests whether a 12-week supervised strength training program can help people with advanced pancreatic cancer maintain muscle mass and improve their quality of life. Ten participants who are receiving chemotherapy or immunotherapy will be randomly assigned to either the…

This study compares pain after root canal therapy done in one visit versus two visits for people with diabetes. 200 patients aged 12-60 with a single-rooted tooth needing root canal will be randomly assigned to either a single session or two sessions. The main goal is to see whic…

This study tests a single injection of CIL001 (Paliroden) into the ear to repair nerve damage that causes hearing problems in people with type 2 diabetes. The trial includes 135 adults aged 45-75 with diabetes for at least 5 years. Researchers will check safety and whether the in…

This study tests a structured psycho-social program (PSP) for adults aged 30-40 with type 2 diabetes who have mild-to-moderate mental health issues. Over 6-8 sessions, participants learn to manage stress, challenge negative thoughts, and improve daily habits. The goal is to reduc…

This study tests whether a probiotic called Clostridium butyricum CBM588 can reduce diarrhea and improve quality of life in people who have had their pancreas removed due to cancer or other growths. About 158 patients will take either the probiotic or a placebo for three months a…

This study will test if a program combining supervised exercise and perineal massage during pregnancy can help prevent problems like urinary incontinence, depression, and gestational diabetes. About 2000 healthy pregnant women will be randomly assigned to either the program or us…

This pilot study will test whether five weekly sessions of Swedish massage can reduce stress and improve blood sugar control in 20 adults with type 1 diabetes. Researchers will measure stress hormones, inflammation, and glucose levels before and after the massage program. The goa…

This study will test three approaches to reduce painful nerve damage in people with type 2 diabetes. Sixty adults aged 35-85 with moderate to severe neuropathy will receive either a special massage-like therapy (INF), a diet guided by a food sensitivity test (NVIf), or both toget…

This study will follow 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or have metabolic issues. Researchers will collect blood, saliva, urine, and stool samples during routine clinic visits, along with questionnaires about diet, sleep, and mood. The goal is …

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

This pilot study will check if it's possible to collect useful nutrition and health information from 30 adults with diabetic foot ulcers. Researchers want to see if they can recruit enough people and gather complete data. The goal is to learn about patients' diet, body compositio…

This study will test whether combining continuous glucose monitor (CGM) data with information from a smartwatch and a phone app (like meals and activity) can better predict blood sugar levels in people with type 2 diabetes. Thirty-six adults will wear a CGM and smartwatch and log…

This study will test if an AI chatbot can give helpful nutrition advice to pregnant women. About 100 women will either use the chatbot or get standard care. The goal is to see if the chatbot is easy to use and if it helps improve diet and knowledge about conditions like gestation…

Researchers at Assiut University Hospitals are studying whether a simple calculation from two routine blood tests, the leukocyte glucose index, relates to how severe diabetic ketoacidosis becomes in adults with diabetes. The index multiplies white blood cell count by blood sugar …

People with type 2 diabetes often have high lactate levels, which researchers link to heart failure and thinking problems. This early study uses a carbon-13 MRI contrast agent called hyperpolarized pyruvate to watch how the heart and brain process pyruvate, lactate, and bicarbona…

Researchers at Al-Azhar University are studying whether type 2 diabetes is linked to changes in women's hair and scalp. The study compares 130 women aged 20 to 60, half with diabetes for at least a year and half healthy controls matched by age. Participants undergo clinical hair …

Researchers at Kırıkkale University are studying how GLP-1 receptor agonists, drugs prescribed for type 2 diabetes and obesity, affect saliva and oral health. Fifty adults aged 18 to 65 who are newly prescribed these drugs provide saliva samples and undergo dental exams at the st…

This study will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brains of 100 people who had a stroke and underwent endovascular therapy (clot removal). The goal is to see if TCD readings can predict complications like bleeding or brain swelling in the days…

Researchers are studying whether extracellular vesicles released by pancreatic islets can indicate islet quality and be used to improve their fitness before transplantation. The trial involves adults with type 1 diabetes who are on the waiting list for an islet transplant. The go…

This study looks at children and teenagers with type 1 diabetes to see how many have abnormal liver function tests. Researchers will check blood samples for signs of liver stress and try to find patterns or risk factors. The goal is to understand whether liver issues are common i…

Researchers at Mass General Brigham are testing whether genetic information can help identify people who might benefit from early screening for type 1 diabetes, even before they feel sick. The study involves 150 adults from the MGB Biobank who agreed to be recontacted. Participan…

This phase 1 trial asks whether a single dose of tirzepatide changes how quickly the stomach empties in adults with type 1 diabetes who are overweight or have obesity. Researchers will give participants either tirzepatide or a placebo injection, then measure stomach emptying usin…

This observational study tests whether artificial intelligence can predict how well pancreatic cancer responds to chemotherapy and how the disease may progress. Researchers will analyze data from 700 patients, including endoscopic ultrasound images, CT/MRI scans, lab results, and…

This study will watch how doctors use a special camera (endoscopic ultrasound) to diagnose suspected pancreatic or bile duct diseases in 2500 adults across Lombardy, Italy. The goal is to see how accurate the procedure is, how safe it is, and how quickly patients get a final diag…

Researchers are testing whether standard blood tests can indicate the quality of stem cells taken from the heel bone during foot or ankle surgery. The study includes adults aged 40 to 80, some with type 2 diabetes and diabetic foot ulcers. Before surgery, participants give blood …

Doctors in the ICU often check blood gases through an arterial line, but that carries risks like clots and infection. This study asks whether blood drawn from a central venous line, which is already in place for other care, gives equally useful information. Researchers will compa…

This study looks at whether routine blood test results can help predict which patients with acute pancreatitis will develop severe disease or die within 28 days. Researchers will track 109 adults admitted with acute pancreatitis and compare their blood cell ratios, such as neutro…

This study enrolls 150 adults with suspected or confirmed pancreatic cancer who are scheduled for chemotherapy. Researchers will collect tumor samples via endoscopic ultrasound before and during treatment to analyze gene activity. They aim to understand how the cancer changes acr…

This study investigates how different genetic pathways affect the body's response to food and to a short course of orforglipron, an oral GLP-1 drug used for weight management and blood sugar control. Researchers will enroll about 100 adults, with or without type 2 diabetes, who a…

This study investigates whether the speed at which blood sugar falls after starting a new diabetes medicine affects small blood vessels in the eye. Adults with type 2 diabetes who are beginning a GLP-1 receptor agonist or an SGLT2 inhibitor will undergo advanced eye scans and blo…

This study follows 100 adults with diabetes who are on peritoneal dialysis or about to start it. Researchers use a continuous glucose monitor to track blood sugar levels over time. They will look for links between glucose patterns and health events like hospitalizations, heart pr…

This study looks at how to safely use a type of diabetes drug (SGLT1&2 inhibitor) in people with type 1 diabetes and mild to moderate chronic kidney disease. The goal is to find out what increases the risk of a serious condition called diabetic ketoacidosis (DKA). About 80 adults…

This study tests a remote education program to help people at higher risk for pancreatic cancer learn about genetic testing and a blood test that screens for multiple cancers. The program targets Black, Latino/a, and Medicaid-enrolled individuals in Massachusetts who may have had…

This study looks at whether showing patients a short educational video before they sign consent for Whipple surgery (a complex operation for pancreas cancer) helps them understand the procedure better and feel more satisfied. About 60 adults will be split into two groups: one get…

This study explores the real-life experiences of adults with type 2 diabetes who have used a continuous glucose monitoring (CGM) device daily for at least a year. Through in-depth interviews, researchers aim to uncover the benefits and challenges people face with these devices. T…

This study looks at how children and teens with type 1 diabetes use the Omnipod 5, a tubeless insulin pump that automatically adjusts insulin based on glucose readings. Researchers will track how quickly families adopt the system, who chooses it, and how it affects blood sugar co…

This study looks at anonymized health records from about 100,000 people in a Turkish hospital network to see how common cardiometabolic conditions—like obesity, type 2 diabetes, heart disease, fatty liver, and kidney disease—are and how often they occur together. By tracking thes…

This observational study will follow 1,500 adults with chronic pancreatitis for several years, collecting health data and biological samples like blood, stool, and bile. The goal is to track how the disease changes over time, especially in those undergoing ERCP treatment, and to …

This study tests whether continuous glucose monitors (CGMs) like the Dexcom G7 can be safely and effectively used in intensive care units. The monitors provide real-time blood sugar readings and alarms for dangerously high or low levels, potentially reducing the need for frequent…

This observational study looks at how pancreatic cancer changes immune cells in the blood. Researchers will compare blood samples from 50 people with newly diagnosed, untreated pancreatic cancer to 50 age-matched people with a non-cancerous pancreatic condition. They aim to ident…

This study tracks blood sugar changes after an epidural steroid injection for back or leg pain. Researchers will compare 36 adults with and without type 2 diabetes using a continuous glucose monitor worn for 15 days. The goal is to see if the injection causes higher or longer-las…

This study looks at how the hormone glucagon works with insulin in the liver to manage blood sugar. Researchers want to understand glucagon's multiple, sometimes opposite, roles to create better diabetes medicines. Forty healthy adults aged 18-45 will have two 5-hour sessions whe…

This study looks at whether a new blood test can find tiny bits of tumor DNA left behind after pancreatic cancer surgery. About 30 adults who had their cancer removed will give blood samples at three key times over six months. The goal is to see if this test can detect remaining …

This study will test two new non-invasive devices (HEMI and SPG-NINOX) that measure small blood vessel function in 165 adults. Participants include healthy volunteers and people with high blood pressure, type 2 diabetes, or chronic kidney disease. The goal is to see if these devi…

This observational study looks at whether the total antioxidant capacity of a person's diet is linked to levels of inflammation and nutritional health in adults with type 2 diabetes. Researchers will compare people with well-controlled blood sugar to those with poorly controlled …

This study looks at whether levels of a protein called Neuregulin-4 (NRG4) in the blood are linked to obesity, insulin resistance, and different diabetes treatments in people with type 2 diabetes. Researchers will compare NRG4 levels across groups including obese and non-obese pa…

This observational study is investigating whether vitamin D levels are linked to cholesterol and other blood fats in obese adults with type 2 diabetes. Researchers will measure vitamin D status and lipid profiles in 150 participants from a diabetes clinic in Cairo. No treatments …

This observational registry study follows 2,250 adults with cardiovascular-kidney-metabolic syndrome (CKMS) at five hospitals in India. Researchers aim to understand how the condition progresses over 12 months, how it affects quality of life, and what treatments doctors prescribe…

This study investigates whether blocking GLUT1, a protein that helps immune cells use sugar, can reduce the autoimmune attack that destroys insulin-producing cells in type 1 diabetes. Researchers will analyze stored blood samples from adults with type 1 diabetes and test immune c…

This pilot study tests a new continuous glucose monitor (CGM) called SAVA in 20 adults with Type 1 Diabetes. Participants wear three SAVA sensors and one standard sensor for 15 days to check how well the SAVA measures blood sugar compared to lab tests. The study also looks at com…

This study will include about 2,748 people with breast, gynecologic, or pancreatic cancer. Researchers want to see if adding patient-reported outcomes—like symptoms, preferences, and travel distance—to tumor board discussions helps doctors make better treatment decisions. The goa…

This study looks at how menopause and poor sleep change heart structure and function in women aged 48-58 with type 2 diabetes. Researchers will use heart ultrasounds to measure early signs of heart strain. No treatment is given; the goal is to better understand these risks.

This study screens adults aged 18 and older in suburban and peri-urban areas of Faisalabad, Pakistan, for four major noncommunicable diseases: diabetes, hypertension, obesity, and high cholesterol. Participants who are found to have these conditions are referred to doctors for st…

This study will follow 5,500 first-time pregnant women to see if blood tests and eye scans can predict complications like preeclampsia, fetal growth restriction, and gestational diabetes. Researchers will collect samples and images at different points during pregnancy and compare…

The EXPAND study is a research project that will enroll 440 adults with and without pancreatic conditions to understand why type 2 diabetes varies so much from person to person. Researchers will collect data on metabolism, genetics, and pancreas health to identify distinct diabet…

This study aims to identify newborns with a high genetic risk of developing type 1 diabetes. Researchers will screen 50,000 infants using a simple genetic test to find those with a greater than 10% risk. The goal is not to treat diabetes, but to find eligible babies for future pr…

This study will examine whether certain workplace chemicals or tasks increase the risk of biliary tract and pancreatic cancers. Researchers will compare detailed work histories of 210 cancer patients from two earlier trials with healthy volunteers. The goal is to identify occupat…

This study compares two ways of inviting people to screen for type 1 diabetes at home: a simple email or letter versus a personal phone call. Researchers want to see which method leads more people to complete and return a home screening kit. Participants are adults and children a…

This study will test whether a therapeutic patient education program is acceptable and useful for adults living with obesity and related conditions like diabetes or joint problems. About 42 participants will take part in a one-day group session and follow-up workshops, then answe…

This study tests whether a digitally supported prehabilitation program is feasible for patients awaiting major surgery for cancers of the pancreas, liver, stomach, or esophagus. The program includes supervised exercise, nutritional counseling, psychological support, and digital t…

This study will follow 200 people with colorectal cancer and healthy controls to explore how genes, blood sugar, and immune responses are connected. Researchers will analyze blood and tissue samples to find shared genetic factors that may influence both cancer and diabetes. The g…

This study will test whether smelling a pleasant food odor (madeleine scent) before drinking a sugary solution changes how the body handles blood sugar. Twenty adults, some with obesity and mild insulin resistance and some without, will each undergo two sessions: one with the sce…

This study looks at two scoring systems, NEWS-2 and NEWS-Calcium, to see which better predicts the risk of dying in the hospital for people aged 65 and older with acute pancreatitis. Researchers will review medical records of 350 patients to compare the scores. The goal is to hel…

This study follows 500 people with a type of heart failure called HFpEF, where the heart pumps normally but doesn't fill properly. Researchers will use heart ultrasounds, blood tests, and medical history to group patients into different subtypes. The goal is to better understand …

This study tests whether adding health messages to lab reports can reduce serious heart and kidney problems in people with both diabetes and chronic kidney disease. Over 125,000 participants will be randomly assigned to receive either routine care or extra health messages in thei…

This study looks at why some patients develop blood clots after pancreatic surgery that also involves removing a piece of a major vein. Researchers will collect information from over 1,000 patients across many hospitals to see how surgical techniques and blood-thinning medication…

This study looks at how removing part or all of the pancreas changes blood sugar control in adults who already have diabetes and need pancreatic surgery. Researchers will track 408 patients over time to see if diabetes gets worse depending on how much pancreas is removed. The goa…

This study tests whether special amino acid-enriched drinks can help people on GLP-1 weight-loss drugs maintain muscle and prevent weight regain. Eight adults aged 30-65 who recently started GLP-1 medication will drink different supplement beverages, and researchers will measure …

This study tests whether a new real-time imaging method can make radiation therapy more accurate for cancer patients. About 40 adults with various cancers will receive their normal radiation treatment while the new imaging tracks the tumor in real time. The goal is to see if the …

This study aims to see if using a patient's genetic signature to choose chemotherapy can improve outcomes for people with borderline resectable pancreatic cancer. About 367 participants will receive standard chemotherapy, and researchers will track how long they live without majo…

This 5-year study will follow 2,800 overweight or obese Chinese adults aged 18-60 to see how their health changes over time. Participants will use a smartphone app to track their data and get lifestyle support. The goal is to understand who develops diabetes or complications, and…

This observational study will check if diathermy, a tool used during surgery to stop bleeding, affects the accuracy of continuous glucose monitors in people with Type 1 Diabetes. About 126 adults and children will have their glucose readings compared before and after diathermy us…

This study looks at how a diet high in acid-forming foods (like meat, cheese, and grains) affects kidney function and blood sugar in people with type 2 diabetes and chronic kidney disease. Researchers will ask 80 participants to follow either a high- or low-acid diet for 8 weeks …

This study tracks physical activity in 175 pregnant women with type 1 or type 2 diabetes to see how it relates to blood sugar control and mental health. Participants wear an activity monitor for a week each trimester and complete questionnaires. The goal is to understand current …

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study looks for genetic differences that might explain a rare form of diabetes that is not caused by the immune system. Researchers will study 118 adults of African or Indian ancestry in the French West Indies who have this atypical diabetes. The goal is to find gene changes…

This study looks at whether tumor DNA found in blood or peritoneal fluid can predict the spread of digestive cancers (stomach, colon, pancreas) to the lining of the abdomen. Researchers will follow 300 patients with early-stage tumors to see if those with positive DNA markers are…

This study looks at whether wearing a continuous glucose monitor (CGM) and receiving education can help teenagers with prediabetes improve their blood sugar levels and adopt healthier behaviors. Twenty-five teens aged 13-17 will take part in a 20-week program, first receiving sta…

This study tests whether using MRI scans to plan radiotherapy is better than using CT scans alone. Researchers will work with up to 150 cancer patients and 15 healthy volunteers to see if MRI can make treatment more precise and reduce side effects. The goal is to improve how tumo…

This study looks at whether a blood test can predict how well certain cancer drugs (PARP inhibitors) work in people with advanced breast, prostate, ovarian, or pancreatic cancer. Researchers will collect blood and tumor samples from 300 adults to analyze cancer cells and their DN…

This study will look at health records of 10,000 patients in Qatar who were hospitalized for heart problems and have diabetes or prediabetes. Researchers will use artificial intelligence to find patterns that predict future heart attacks, strokes, or death. The goal is to create …

This study follows 450 adults with diabetes who were part of an earlier study. Researchers want to see if levels of a nutrient called glutamine in the blood are linked to future heart problems. No new treatments are given—just observation and data collection over time.

This study looks at whether fear of hypoglycemia (low blood sugar) affects the heart, physical activity, and exercise ability in children and teens with type 1 diabetes. About 67 participants aged 10-18 will answer questionnaires and have their heart rate, blood pressure, and oxy…

This study looks at whether people with pancreatic cysts (IPMN) also have trouble digesting food due to poor pancreatic function. Researchers will follow 600 adults to see if this digestive problem is linked to cyst growth or cancer risk. The goal is to find a simple test that he…

This study will check 100 adults with chronic pancreatitis or who had part of their pancreas removed. Even though they take enzyme pills, they still have stomach pain, bloating, or diarrhea. Researchers will use breath tests to see if a condition called SIBO (too much bacteria in…

This early-stage study tests a new medicine called efsubaglutide alfa (YN-011) in 48 healthy adults in Brazil. The goal is to check the drug's safety, how the body processes it, and its effects. Participants receive a single injection of either the drug or a placebo and are monit…

This study looks at whether a polygenic risk score—a measure based on many small genetic variations—can help predict who might develop pancreatic ductal adenocarcinoma (PDAC). Researchers will compare the genetic profiles of about 1,140 people with and without the disease. The go…

The SIRENA study will follow 300 children and adults who have tested positive for islet autoantibodies, which are early markers of type 1 diabetes. Over up to 10 years, researchers will track how their blood sugar, immune system, and metabolism change. The goal is to better predi…

This study will test a two-step screening program for advanced liver fibrosis in people with type 2 diabetes. About 1,714 patients will first get a blood test (FIB-4), and if that suggests risk, they will receive a liver stiffness measurement (transient elastography). The goal is…

This study tests a companion mobile app that wirelessly collects real-time glucose readings from Dexcom G7 continuous glucose monitors (CGMs) used by children with diabetes in the hospital. The app sends the data to a central hospital database, making it accessible to care teams …

This study aims to detect and measure microplastics in pancreas tissue from 10 patients having pancreatic surgery. Researchers will also check fat tissue and blood samples. The goal is to see if microplastics are present and whether they might be linked to metabolic problems or c…

This study looks at how different temperatures—cold, normal, and hot—affect blood sugar levels and insulin absorption in adults with type 1 diabetes. Thirty participants will sit in a special room at each temperature for two hours while researchers monitor their blood sugar, hear…

This study will check how often fatty liver disease and liver scarring happen in adults with type 1 diabetes or LADA in Quebec. About 100 participants will get a special liver scan (FibroScan) during one visit. The goal is to find hidden liver problems that current checkups might…

This study looks at how the amount of fat in a meal and a woman's menstrual cycle affect blood sugar after eating in people with type 1 diabetes. Fifty adults (25 women, 25 men) will eat standardized low-fat and high-fat meals while wearing continuous glucose monitors. The goal i…

This study will test whether a new e-learning app can help school nurses feel more confident and knowledgeable about diabetes devices like insulin pumps and continuous glucose monitors. About 86 school nurses in Pennsylvania will use the app over 16 weeks and complete surveys bef…

This study will follow 1300 women with type 1 diabetes who had a pregnancy. Researchers want to see if a high risk of preeclampsia (a dangerous pregnancy complication) in the first trimester is linked to hidden heart disease years later. Participants will have an ultrasound to ch…

This observational study looks at how having type 2 diabetes impacts quality of life in cancer patients receiving immunotherapy. Researchers will compare changes in well-being over six months between patients with and without diabetes. About 920 adults with solid tumors will fill…

This study will check if low vitamin D levels are linked to higher insulin resistance in 165 adults with type 2 diabetes. Researchers will use a simple blood test called the triglyceride-glucose index. The goal is to better understand how vitamin D might affect diabetes control.

This study looks at whether using a continuous glucose monitor (CGM) can help find and manage low blood sugar in newborns whose mothers had insulin-treated gestational diabetes. About 120 babies will be monitored for the first 72 hours after birth. The goal is to see if CGM catch…

This study looks at how gut bacteria are linked to obesity and type 2 diabetes in New Caledonia, where these conditions are very common. Researchers will collect blood, urine, and stool samples from 270 adults to analyze their gut microbes and related chemicals. The goal is to be…

This study will look at 3000 young Asians in Singapore who do not have diabetes yet. Researchers will use blood tests, glucose monitors, food diaries, and body measurements to find better ways to detect diabetes early. The goal is to create new risk tools to identify young people…

This study looks at whether it's practical to screen close relatives of people with type 1 diabetes for early signs of the disease. About 1,000 adults in Quebec will have blood tests and answer questionnaires. If they show early markers, they will be monitored either by the resea…

This study looks at whether draining a blocked bile duct before surgery for pancreatic cancer changes the tumor's behavior or patient survival. Researchers will review medical records of 90 patients who had their pancreatic tumor removed over 8 years. They will compare those who …

This study looks at whether a moldable silicone toe divider (Otoform) can help people with diabetes who have had a lesser toe amputated. Researchers want to see if it is possible to run a larger trial by testing how well patients accept the device and how it affects walking and f…

This study looks at whether doing broad gene testing early, instead of later, helps find more effective treatments for people with advanced pancreatic, liver, or triple-negative breast cancer. About 360 adults with poor-prognosis cancers will be randomly assigned to early or stan…

This study will analyze medical records of 400 adults with type 2 diabetes or obesity to see how semaglutide affects blood sugar, heart, and kidney health over three years. Researchers will compare those taking semaglutide to those on other diabetes medications. The goal is to un…

This study looks at how healthy people without diabetes respond to sitagliptin, an FDA-approved diabetes medication. Researchers want to understand why some people's bodies process sugar differently after taking the drug. About 400 healthy Amish adults will take part in two clini…

This study will give 10 overweight men a daily pill called ATR-258 for 8 weeks to see how it changes signaling pathways in their muscles. Researchers will take small muscle samples and measure blood sugar control and body composition. The goal is to understand the biology, not to…

This pilot study tests whether fecal microbiota transplantation (FMT) can change the gut microbiome in 30 people with type 2 diabetes and stable coronary artery disease. Participants receive processed stool from healthy donors via colonoscopy. The goal is to see if this alters gu…

This study looks at how well ankle numbing (ankle block) works in people with and without diabetes during foot or ankle surgery. Researchers will measure how fast the numbing starts, how much pain medicine is needed afterward, and if blood sugar control plays a role. The goal is …

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study aims to understand how dry eye disease and diabetic macular edema (a swelling in the back of the eye) are related in people with diabetes. About 50 adults with diabetes for over 8 years will have their eyes tested using questionnaires, tear measurements, and imaging. T…

This study looks at how fasting during Ramadan impacts treatment adherence, emotional well-being, and blood sugar levels in adults with type 2 diabetes. Researchers will compare those who fast and those who do not, using surveys and HbA1c tests before and after Ramadan. The goal …

This study will follow 3000 adults with chronic heart failure to see how often they also have kidney disease, diabetes, fatty liver, or clogged arteries. Researchers want to understand how these conditions interact and affect patient outcomes over two years. No new treatments are…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This early-stage study looks at how three popular statins (atorvastatin, rosuvastatin, simvastatin) affect blood sugar levels in 100 healthy volunteers. Participants will take the medicine for two days, and researchers will measure changes in blood glucose, insulin, and C-peptide…

This study looks at how artificial sweeteners (saccharin, sucralose) and a natural one (erythritol) affect blood sugar control, blood clotting, and heart disease risk in 80 adults with prediabetes. Participants will be randomly assigned to take one sweetener or water for two week…

This study compares two ways to reconnect the digestive tract after pancreatic cancer surgery (Whipple procedure). The goal is to see which method reduces delayed stomach emptying, a common complication. About 124 adults having this surgery will be randomly assigned to one of the…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study will give 50 women who had gestational diabetes a continuous glucose monitor (Stelo) to wear after giving birth. The goal is to learn how their blood sugar levels change during daily life and how well the device works. Participants will use the monitor for up to 6 week…

This study looks at ways to help VA medical centers put proven health programs into practice for women Veterans in midlife. The programs focus on heart health, weight management, diabetes, mental health, and menopause care. Researchers will test two support strategies at 18 VA si…

This study will compare two different schedules for removing pancreatic stents placed during ERCP to prevent pancreatitis. One group will have the stent removed after 1-3 months, while the other will have it removed within 10 days. The goal is to see which timing leads to fewer c…

This study will screen up to 10,000 adults aged 18-75 who are overweight or have metabolic issues like high blood sugar or cholesterol. Researchers will use questionnaires, blood tests, and liver ultrasounds to find out how common fatty liver disease is and what factors increase …

This study compares two ways of making treatment decisions for people with diabetes and severe blockages in all three main heart arteries. One group gets a real-time online discussion among heart specialists during an angiogram, while the other gets usual care. The goal is to see…

This study looks at whether training general practitioners to better monitor and manage kidney health can slow the loss of kidney function in people with type 2 diabetes. About 360 patients aged 50 and older with early kidney problems will take part. Doctors in the intervention g…

This observational study will measure how well the body breaks down blood clots in 150 cancer patients (with blood cancers or solid tumors) who also have clotting issues. Researchers will take extra blood samples during routine care to look for markers that might predict bleeding…

This study will use a safe ultrasound test to look for early signs of artery hardening in 96 adults who have both type 2 diabetes and stage 3 chronic kidney disease. Many patients with these conditions develop heart problems without symptoms. The goal is to find out how common th…

This study looks at how the bacteria in the gut and mouth relate to nutrition in 150 adults with digestive cancer starting chemotherapy. Researchers will collect stool and saliva samples, along with questionnaires and tests, before and after the first chemo cycle. The goal is to …

This study will use a special eye scan called OCT to look for early signs of retinal damage in people with diabetes who have no vision problems. Researchers want to see if these scans can detect changes before symptoms appear. About 112 participants will get a detailed eye exam, …

This study looks at how diabetes affects small blood vessels and nerves in the eyes and brain. Researchers will use advanced imaging to detect damage and test a traditional Chinese herbal medicine called Tangshen'an Granules to see if it can help. 160 adults with diabetes will ta…

This study will follow 100 adults with diabetes and foot ulcers to see how non-vascular factors like nerve damage, infection, and poor blood sugar control affect ulcer severity and healing. Researchers hope to find which risk factors can be changed to prevent ulcers from coming b…

This observational study tests a new bedside device that measures nucleosome levels in the blood of critically ill ICU patients. Researchers want to see if these levels can predict which patients are likely to die within 30 days. The study will enroll 130 adults with conditions l…