Immune system disorder

This trial tests a treatment strategy for adults with acute myeloid leukemia (AML) that did not respond to standard induction chemotherapy. Participants receive clofarabine and intermediate-dose Ara-C chemotherapy, followed by a reduced-intensity allogeneic stem cell transplant u…

Researchers test a reduced-intensity conditioning regimen before allogeneic stem cell transplant in adults with high-risk AML, MDS, or ALL who cannot tolerate standard intensive treatment. The regimen combines clofarabine, busulfan, and thymoglobulin. The trial measures relapse r…

Researchers are testing a vaccine called 3D189 in adults with blood cancers such as acute leukemia, multiple myeloma, non-Hodgkin lymphoma, and higher-risk myelodysplastic syndrome. Participants must be in remission after standard treatment and unable to receive a stem cell trans…

Researchers are testing whether adding tofacitinib to prednisone works better than prednisone alone for people with active IgG4-related disease. The trial enrolls 58 adults with active disease and assigns them to either tofacitinib plus prednisone or prednisone alone. The main go…

This study tests a drug called leniolisib in 20 people with common variable immunodeficiency (CVID), a condition that weakens the immune system. All participants will receive the drug for 6 months, starting at a low dose and increasing. The main goal is to check safety and tolera…

This phase III trial tests whether adding low-dose methotrexate to standard corticosteroid treatment works better than steroids alone for adults who develop acute graft-versus-host disease after a stem cell transplant. Participants receive either methotrexate or a placebo alongsi…

Ulcerative colitis causes ongoing inflammation in the colon and rectum, and current treatments do not work for everyone. Researchers are testing whether adding pentoxifylline, a drug with anti-inflammatory and antioxidant effects, to standard care can reduce disease activity. The…

This study tested a smart cap that attaches to insulin pens to help people with type 1 diabetes track their injections and glucose data. 42 adults used the device or a blinded version for comparison. The goal was to see if it reduces time spent with high blood sugar and improves …

Researchers are testing a combination of rituximab, acalabrutinib, and durvalumab in adults with primary central nervous system lymphoma, a rare cancer that starts in the brain or spinal cord. The trial enrolls people whose disease has returned or worsened after earlier treatment…

Researchers are testing whether lucitanib, an oral drug, can slow the growth of advanced thymic carcinoma that has worsened after at least one round of chemotherapy. The trial enrolls adults with recurrent or metastatic thymic carcinoma. In one part, participants receive lucitani…

This trial tests whether an experimental antibody called 611, given as a shot alongside a topical corticosteroid, can improve moderate-to-severe atopic dermatitis (eczema) better than the steroid alone. Adults aged 18 to 75 with a history of inadequate response to topical treatme…

This study looks at the long-term safety of filgotinib, a drug for ulcerative colitis, in over 1,100 adults who already took part in a filgotinib trial. The main goal is to track side effects and lab test changes over time. Participants must have completed a prior filgotinib stud…

Researchers are testing whether continuous glucose monitoring, alone or combined with a family behavioral program, helps children under 8 with type 1 diabetes keep their blood sugar in a healthy range. The trial compares these approaches to standard home blood glucose monitoring.…

This early-phase study tests a new drug called ERAS-601, alone or with other cancer treatments, in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find safe doses and check for side effects. About 90 participants will take pa…

This early-phase study tested a new approach for people whose B-cell cancers (like lymphoma or leukemia) came back after a donor stem cell transplant. Researchers took white blood cells from the original donor, genetically modified them to recognize and attack cancer cells, and g…

Researchers are studying whether trained community workers can safely deliver HIV treatment outside clinics in Cambodia. The trial enrolls about 4,000 people living with HIV who have stable treatment and no complications. Community action workers receive training to dispense drug…

This early-phase study tested the safety of rituximab, a drug that targets faulty white blood cells, in 7 adults with rare immune diseases like pulmonary alveolar proteinosis and severe candidiasis. Participants received several doses over 6 months and were monitored for 18 month…

Researchers are testing a combination of L-DEP chemotherapy (aspargase, liposomal doxorubicin, etoposide, and methylprednisolone) and a PD-1 antibody as initial treatment for people with Epstein-Barr virus-positive lymphoma-associated hemophagocytic lymphohistiocytosis, a rare an…

This study tests whether a substance produced by umbilical cord cells can help control moderate rheumatoid arthritis. Participants receive weekly injections of either the cell substance or a placebo for six weeks, alongside their usual medication. The goal is to see if it improve…

This study tested whether the drug ritlecitinib could prevent intestinal damage and symptoms when people with celiac disease ate gluten. 62 adults with well-controlled celiac disease (on a gluten-free diet) took either the drug or a placebo along with a daily gluten challenge. Th…

Adults with B-cell acute lymphoblastic leukemia that has come back or stopped responding to treatment have few options. This phase 2 trial tests whether adding epratuzumab, an antibody that attaches to the CD22 protein found on most of these leukemia cells, to standard chemothera…

Researchers at Nantes University Hospital are testing a computer model that describes how glucose and insulin interact in people with type 1 diabetes. The model aims to help doctors choose insulin pump settings, including basal rate, insulin sensitivity, and carbohydrate ratios. …

Researchers compare two three-drug combinations, VTD and VCD, as initial treatment for people newly diagnosed with multiple myeloma who are eligible for a stem cell transplant. Participants receive four cycles of either combination. The trial measures how well each combination re…

Researchers are testing whether adding tocilizumab, a drug that blocks an inflammation signal called IL-6, to standard chemotherapy helps adults with high-risk acute myeloid leukemia. Participants receive idarubicin and cytarabine, the usual induction chemotherapy, plus a single …

Researchers are testing a combination of three drugs, obinutuzumab, ibrutinib, and GDC-0199, in people with mantle cell lymphoma. The trial includes patients whose cancer has come back or stopped responding to treatment, as well as those who have not yet received treatment. The g…

This Phase 3 trial tests dazodalibep, a drug given by IV, in 651 people with moderate-to-severe Sjögren's syndrome. The goal is to see if it reduces disease activity and improves symptoms like dryness and fatigue. Participants receive either the drug or a placebo, and researchers…

This Phase II trial tests whether adding rituximab to standard first-line treatment with ciclosporine and corticosteroids improves remission rates in adults who develop chronic graft versus host disease after a stem cell transplant. Participants receive rituximab infusions once a…

This study is testing an experimental drug called povetacicept in adults with autoimmune cytopenias — conditions where the immune system mistakenly destroys blood cells, leading to low platelet counts (immune thrombocytopenia) or anemia (autoimmune hemolytic anemia and cold agglu…

Researchers are testing an experimental ointment called IN-A002 for mild to moderate atopic dermatitis, a common skin condition that causes itchy, inflamed skin. The trial enrolls healthy adult men and adults with atopic dermatitis to see how safe and tolerable the ointment is wh…

Researchers are testing whether a once-daily form of raltegravir can keep HIV suppressed in adults who already have the virus under control with standard antiretroviral therapy. The trial enrolls about 100 adults with HIV-1 who have been on stable treatment for at least six month…

Researchers are testing a combination of carfilzomib, melphalan, and prednisone in adults over 65 with newly diagnosed multiple myeloma. The trial first aims to find the highest dose of carfilzomib that people can tolerate without severe side effects. Then it will measure how wel…

Atypical hemolytic uremic syndrome (aHUS) is a rare disease that damages the kidneys by causing blood clots in small vessels. The drug eculizumab blocks the complement system and has greatly reduced kidney failure, but doctors do not know how long patients should stay on it. This…

Researchers are testing whether adding the experimental drug MLN9708 to lenalidomide and dexamethasone can help adults under 66 with newly diagnosed multiple myeloma. Participants receive three cycles of the triplet, then a stem cell transplant, followed by more triplet and maint…

Researchers are testing an experimental monoclonal antibody called OpSCF in adults with moderate to severe atopic dermatitis, also known as eczema. About 50 participants receive either OpSCF or a placebo injection every two weeks for 14 weeks. The main goal is to measure how much…

Researchers are testing whether apremilast helps people with early psoriatic arthritis that affects only a few joints. Participants have had symptoms for five years or less and still have joint pain and swelling despite stable treatment with NSAIDs or one conventional DMARD. The …

This study tests whether giving a probiotic (Saccharomyces boulardii) along with a common antibiotic can protect the gut bacteria of children aged 4 to 12 being treated for ear or sinus infections. The goal is to see if it reduces antibiotic-associated diarrhea and limits the spr…

This study followed 591 adults with eosinophilic granulomatosis with polyangiitis (EGPA) across Europe to see how well mepolizumab 300mg every 4 weeks works over the long term in everyday medical practice. Researchers looked at disease control, lung function, and safety by review…

This study tested whether eating less fat and more fiber can reduce the chance of a repeat Clostridioides difficile infection in cancer patients. Eight participants with leukemia, lymphoma, or other cancers followed a specific diet. Researchers tracked diarrhea and measured C. di…

Researchers are studying whether an enhanced package of care helps people with advanced HIV in Malawi stay in treatment and keep the virus suppressed. The package adds CD4 and TB-LAM tests and starts patients on TB preventive therapy, delivered through a hub-and-spoke system of c…

Researchers are testing whether a liposomal chemotherapy drug called CPX-351 works better than standard chemotherapy before an allogeneic stem cell transplant in adults with higher-risk myelodysplastic syndromes (MDS) or oligoblastic acute myeloid leukemia (AML). The trial enroll…

This Phase 3 trial tested netakimab, a biologic drug given as a shot, against a placebo in 202 Chinese adults with moderate-to-severe plaque psoriasis. The main goal was to see if netakimab could improve skin symptoms by at least 75% (PASI75) or achieve clear/almost clear skin (s…

This completed Phase 1 study tested a new fast-acting insulin called NNC0471-0119 in 43 adults with type 1 diabetes who use an insulin pump. The goal was to see how quickly the insulin enters the bloodstream, how long it works, and how safe it is compared to a standard insulin (i…

Researchers are studying a spinal implant called the EVOS Lumbar Interbody System, which uses PEEK-OPTIMA HA enhanced cages, in adults with degenerative disc disease or grade 1 spondylolisthesis in the lower back. The study follows participants who receive the device during spina…

This study is testing the long-term safety and effectiveness of bimekizumab, a drug that reduces inflammation, in 508 adults with active axial spondyloarthritis (including ankylosing spondylitis). Participants who completed earlier trials will receive the drug for an extended per…

This study follows people with moderate-to-severe plaque psoriasis who have already taken deucravacitinib in earlier trials. It aims to check the drug's long-term safety and how well it controls psoriasis over time. A smaller group will also test how the drug affects immune respo…

Researchers are testing whether combining ibrutinib and venetoclax can help people with previously untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. The trial assigns participants to either a fixed course of the two drugs or a course guided by a sensitive test…

Researchers are testing an experimental drug called sonelokimab in adults with active psoriatic arthritis, a condition that causes painful, swollen joints along with skin psoriasis. The trial compares sonelokimab injections with placebo injections, and also includes a third group…

This study tested a once-daily pill called ABX464 (obefazimod) in 639 people with moderate-to-severe ulcerative colitis who had not responded well to other treatments. The goal was to see if the drug could help bring about remission and improve bowel inflammation within 8 weeks. …

This study tested a new daily pill, ABX464, for people with moderate to severe ulcerative colitis who did not get better with other treatments. About 636 adults and teens took either 25 mg, 50 mg, or a placebo for 8 weeks. The main goal was to see if the drug could help achieve r…

This study tests whether adding metformin, a diabetes drug, to standard methotrexate therapy helps more people with rheumatoid arthritis achieve disease control. About 128 adults with active RA who have not recently taken methotrexate will receive either methotrexate plus metform…

This early-phase study tests whether Mozobil, a drug already used to boost stem cells for transplants, can safely raise white blood cell counts in people with WHIMS. WHIMS is a rare genetic condition that traps infection-fighting cells in the bone marrow, leading to frequent infe…

This phase III trial compares two consolidation treatments for people with relapsed or refractory follicular lymphoma whose cancer has shrunk after chemotherapy. Participants receive either a radioactive antibody called Zevalin or high-dose chemotherapy followed by an autologous …

This study tests whether gabapentin, an FDA-approved medication, can help restore the balance of key brain chemicals (GABA and glutamate) in people with bipolar disorder who also use cannabis. Participants are randomly assigned to receive either gabapentin or a placebo for 17 day…

Researchers test whether giving low-dose rituximab after an initial treatment can make the response last longer in adults with immune thrombocytopenia (ITP), a condition where the immune system attacks platelets. The trial enrolls adults whose ITP has not responded well to steroi…

Researchers are testing whether a combination of venetoclax and a three-day course of decitabine works better than the standard pairing of venetoclax and azacitidine for older or unfit adults newly diagnosed with acute myeloid leukemia. The trial enrolls 154 participants and comp…

This phase 2 trial tests a new COVID-19 booster vaccine (GEO-CM04S1) in 80 people with chronic lymphocytic leukemia (CLL). The goal is to see if this vaccine triggers a stronger immune response than standard mRNA boosters. Participants will receive either the new vaccine or a sta…

Researchers are testing a daily application of roflumilast cream 0.3% in people with chronic plaque psoriasis to see if it is safe and effective over 24 weeks. The study includes adults and children aged 2 and older, some who have used the cream before and some who have not. Part…

This study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) …

This completed trial tested whether a faster-acting insulin (Lyumjev) used with a special conversion factor in an automated insulin pump (Control-IQ) could improve blood sugar control in 11 adolescents with type 1 diabetes. Participants were randomly assigned to use Lyumjev with …

This study tests a chemotherapy drug called CPX-351 in people under 60 with secondary acute myeloid leukemia (AML), a type of leukemia that develops after other blood disorders or cancer treatments. The goal is to see how well the drug can make the cancer disappear or improve blo…

This study looked at the long-term safety and effectiveness of bimekizumab in adults with active psoriatic arthritis. Over 1,100 people who completed earlier studies received the drug and were monitored for side effects and disease symptoms. The goal was to see if bimekizumab rem…

This early-stage trial evaluates an experimental drug called ZB002, given as an injection under the skin. In the first part, healthy volunteers receive a single dose to check safety and how the drug moves through the body. In the second part, people with rheumatoid arthritis rece…

This Phase 3 trial tests an experimental injection called SHR-1819 in 652 adults with moderate to severe atopic dermatitis (eczema). Half get the drug, half get a placebo. The main goal is to see if it improves skin rash and itch after 16 weeks. If it works, it may offer a new wa…

This trial tests whether kidneys from deceased HIV-positive donors can be safely transplanted into people living with HIV. Researchers track major complications like graft failure, serious side effects, and HIV progression. The goal is to see if using these organs is a safe way t…

This Phase 2 trial tests three commonly used drugs—lorazepam, IVIG, and tofacitinib—in 66 people aged 8 to 30 with Down Syndrome Regression Disorder (DSRD). DSRD causes sudden severe symptoms like loss of speech, movement, and daily living skills. The study aims to see if these d…

This study tests two treatments for people with repeat C. diff infections: a lab-made bacteria mix called MTC01 and a fecal transplant (FMT) from a healthy donor. Both are given during a colonoscopy. The goal is to see which is safer and better at stopping the infection from comi…

This early-stage trial is testing whether a pill made from freeze-dried healthy donor stool (MTP-101P) is safe and can restore good bacteria in people having part of their colon removed. Forty adults aged 18-75 with colon polyps, early-stage cancer, or diverticulitis will take th…

This Phase 3b study is testing whether the drug benralizumab (Fasenra) can allow people with severe eosinophilic asthma to safely reduce their daily maintenance medications. About 504 participants aged 12-75 in China will try to step down from drugs like inhaled steroids or long-…

This early-phase trial tested the drug enasidenib in 17 people with low-risk myelodysplastic syndrome or a related leukemia who had anemia and did not have a specific gene mutation. The goal was to see if the drug could safely improve red blood cell counts and reduce the need for…

This study looks at how well different immunochemotherapy combinations, such as RCHOP, BR, and RCVP, work for people with small B-cell non-Hodgkin lymphoma. Researchers will track 206 adults with this type of lymphoma to see how many respond to treatment and how long they stay fr…

This study tests whether bimekizumab works better than risankizumab for adults with active psoriatic arthritis (PsA), a condition causing joint pain and skin lesions. About 684 participants will receive one of the two drugs for 16 weeks. The main goal is to see who gets at least …

This pilot study tested whether a butyrate supplement, a type of short-chain fatty acid, could change the gut microbiome and immune responses in people with rheumatoid arthritis who didn't respond well to methotrexate. Twenty participants took the supplement for up to two months.…

This early-stage trial tests the safety and tolerability of SOF-SKN, a cream applied to the skin, in healthy volunteers aged 18 to 64. The study has two parts: one applies a single dose, and the other applies daily doses for two weeks, with escalating strengths. Researchers monit…

This trial tests whether adding venetoclax to a standard chemotherapy pair (cytarabine and mitoxantrone) can help adults with acute myeloid leukemia that has relapsed or not responded to initial treatment. In the first phase, researchers find the highest safe dose of cytarabine w…

This study tests whether adding empagliflozin or semaglutide to insulin can improve blood sugar control in overweight or obese adults with type 1 diabetes. About 105 participants will take one of the two drugs or a placebo for 3 months. The goal is to see if these drugs help lowe…

This trial tests whether the probiotic Lactobacillus rhamnosus GG can ease atopic dermatitis, a chronic skin condition causing dry, itchy patches, in children aged 6 to 36 months. Half of the 100 participants receive the probiotic daily, while the other half get a placebo. Resear…

This phase 2 trial tests a combination of four drugs, selinexor, bortezomib, lenalidomide, and dexamethasone (SVRd), in people newly diagnosed with multiple myeloma whose disease has spread outside the bone marrow, called extramedullary disease. The study aims to see how well thi…

This study tested the drug RINVOQ in 69 adults with ankylosing spondylitis, a type of arthritis that mainly affects the spine. Participants took RINVOQ as prescribed by their doctor and were followed for up to a year. The goal was to see how safe and effective the drug is in real…

This study looked at whether it is safe for people with multiple sclerosis to receive their natalizumab (Tysabri) infusions at home instead of at a hospital. Researchers compared serious side effects, quality of life, and costs over one year in 295 patients. The goal was to see i…

This trial tests whether tulisokibart, an experimental drug given by IV infusion, can help people with moderate to severe ulcerative colitis achieve remission. About 178 participants will receive either tulisokibart or a placebo for 12 weeks, with the option to continue treatment…

This trial tests whether a nasal spray containing two probiotic bacteria strains can reduce allergy symptoms in children aged 6 to 12 with allergic rhinoconjunctivitis, a condition that causes sneezing, a runny nose, and itchy eyes. Researchers will compare the probiotic spray ag…

This study tests whether taking dexamethasone pills twice a week for 3 months can stop active vitiligo from spreading in children aged 4 to 9. Researchers will also monitor side effects, especially on growth and bone health. The goal is to control the disease, not cure it.

This study tested a daily medication called acalabrutinib in 552 adults with chronic lymphocytic leukemia (CLL), a type of blood cancer. Participants included those newly diagnosed, those whose cancer returned, and those who had previously taken a similar drug. The goal was to se…

This study is checking how safe and effective an updated insulin pump system (Control-IQ 1.5) is for children ages 2 to 6 with type 1 diabetes. About 144 kids will use the pump for a year while researchers track dangerous low blood sugar events and diabetic ketoacidosis. The goal…

Researchers are testing a smartphone game called MyGoals to see if it can help adolescents living with HIV in Kenya stay engaged in their care. The game includes role-playing, mini-games, and personal goal-setting to boost knowledge, attitudes, and confidence around treatment and…

This study tests a new insulin infusion set designed to last up to 7 days for people with type 1 diabetes. Twenty adults currently using a Tandem insulin pump and Dexcom CGM will try the SteadiSet at home. The goal is to see if the set can survive a full week without causing high…

This phase II trial tests whether the combination of lenalidomide and dexamethasone can help people with POEMS syndrome, a rare blood disorder that damages nerves and causes other symptoms. Participants receive the drug combo either before local radiation or intensive treatment, …

This trial tests whether adding a synbiotic supplement to a Mediterranean diet can improve quality of life and reduce disability in people with relapsing-remitting multiple sclerosis. Participants follow the diet for 12 weeks and take either a synbiotic or a placebo pill daily. R…

Many adults with type 1 diabetes don't get enough sleep, which can make blood sugar harder to control. This trial tests a 12-week program called Sleep-Opt that uses wearable sleep trackers, phone coaching, and educational materials to improve sleep habits. Researchers will measur…

This trial tests whether an oral medication called linsitinib can help people with active, moderate to severe thyroid eye disease, a condition that causes eye bulging and inflammation. Participants take either linsitinib or a placebo twice daily for 24 weeks. The main goal is to …

This study looks at whether dupilumab, an injectable medication, can improve lung function and reduce symptoms in adults with COPD who have a specific type of inflammation. The researchers are reviewing medical records from patients who received dupilumab as part of routine care,…

This trial tests whether a daily 10-gram dose of sea buckthorn extract, taken for 12 weeks, can improve blood sugar control and immune cell balance in adults with type 1 diabetes. Type 1 diabetes is an autoimmune condition where the body attacks insulin-producing cells. The study…

This trial is testing whether combining certolizumab pegol, an injectable biologic, with methotrexate, a standard oral medication, can help adults with early active rheumatoid arthritis achieve and maintain remission. Participants are newly diagnosed, have not yet taken disease-m…

This trial tests whether combining certolizumab pegol (Cimzia) with methotrexate can help adults with early, active rheumatoid arthritis achieve and maintain low disease activity without flare-ups. Participants who already responded well to this combination in a prior study conti…

This study tests a telehealth program called REAL-T, designed to help young adults with type 1 diabetes fit diabetes care into their daily habits and routines. Participants receive about 12 hours of virtual coaching from an occupational therapist over six months. The study compar…

This trial tests whether a skin patch delivering peanut proteins can safely desensitize children with peanut allergy. Children aged 5 to 17 will wear the patch daily for six months, and researchers will check if they can eat more peanut without symptoms. The goal is to see if thi…

This trial tests whether a topical medication called pentoxifylline, typically used to improve blood flow, can help restore skin color in people with stable vitiligo. It compares this approach to another topical drug, 5-fluorouracil, and to microneedling alone, with all patients …

This study looks at whether placing an antibiotic paste directly into the infected bone during surgery can cure foot bone infections. Adults with foot osteomyelitis will receive the paste instead of six weeks of intravenous antibiotics, followed by a short course of oral antibiot…

This trial explores whether it is possible to run a larger study of mirtazapine, an antidepressant, in people who have both major depression and inflammatory bowel disease (IBD). About 76 adults with IBD and depression will be randomly assigned to take either mirtazapine or a pla…

This early-stage trial is testing whether adding the targeted drug orelabrutinib to a standard chemotherapy regimen can safely treat newly diagnosed primary central nervous system lymphoma (PCNSL), a rare type of lymphoma that starts in the brain or spinal cord. The study will en…

This phase 2 trial is testing whether adding venetoclax, a pill taken daily for 12 months, can reduce the number of leukemia stem cells that remain in the bone marrow of people with chronic myeloid leukemia (CML) who are already in deep molecular remission on standard TKI therapy…

This phase III trial is testing whether taking oral azacitidine as a maintenance therapy after an allogeneic stem cell transplant can help prevent relapse in people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Participants are randomly assigned to receive…

This trial tests whether offering small cash payments to people living with HIV, when they attend counseling sessions and clinic visits, can help them stay engaged in care and achieve viral suppression. Participants are adults identified as high risk for dropping out of care at t…

This trial tests whether veligrotug, an antibody that blocks a receptor involved in inflammation, can reduce eye bulging and swelling in people with active thyroid eye disease. Participants receive five infusions of the drug or a placebo. The study measures how many people see a …

This trial tests a smart insulin pump algorithm designed to automatically adjust insulin delivery during the night to keep blood sugar levels in a safe range. The algorithm predicts when blood sugar might drop too low and pauses insulin, and when it might rise too high, it gives …

This study is testing whether a subcutaneous (under the skin) injection of ocrelizumab works as well as the standard intravenous (IV) infusion for people with relapsing or primary progressive multiple sclerosis. The trial will compare how the drug is absorbed, its safety, and its…

This phase III trial is testing whether adding selinexor to a standard two-drug regimen (bortezomib and dexamethasone) can help people with relapsed or refractory multiple myeloma—a blood cancer that has returned or stopped responding to treatment. About 154 adults with measurabl…

This trial tests whether a structured, pharmacist-led medication management program can help HIV patients at high risk of drug-related problems take their medications more consistently. Participants are randomly assigned to usual care, a basic program, or an enhanced program with…

This trial tests whether stem cells grown in the lab before being returned to the body can help blood counts recover faster after a stem cell transplant for multiple myeloma. Adults aged 18 to 65 with myeloma in first response will receive their own amplified stem cells. The main…

This early-phase trial tests a new type of immunotherapy for people who develop a rare blood cancer called post-transplant lymphoproliferative disease (PTLD) after a solid organ transplant. The treatment uses the patient's own immune cells (T-cells) that are engineered to resist …

This trial is testing whether a prebiotic supplement called 2'-FL, found in human milk, can safely ease gut symptoms in young people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Participants, aged 11 to 25, are in remission and already …

This study looks at how a shorter tuberculosis (TB) treatment regimen works for children and adolescents with non-severe TB in Zambia. It involves children, caregivers, health workers, and policymakers to understand how well the regimen is accepted, followed, and feasible in real…

This trial looks at whether children with juvenile spondyloarthritis who have stable, inactive disease can safely reduce or stop their TNFi medication without causing a flare. Participants are randomly assigned to continue their usual TNFi dose, take it less frequently, or stop i…

This study follows about 600 adults with Crohn's disease who are receiving ustekinumab (Stelara) as part of their routine care. The goal is to see how many achieve steroid-free remission after one year, using a standard symptom score. By including patients from both large researc…

This phase II trial is testing whether an experimental drug called MG-K10 can reduce the severity of moderate-to-severe atopic dermatitis, a chronic inflammatory skin condition. About 60 adults who have not responded well to topical treatments will receive either MG-K10 or a plac…

This trial tests whether a specially designed mealtime insulin, HDV-insulin lispro, can reduce nighttime low blood sugar (hypoglycemia) in adults with type 1 diabetes. Participants will use continuous glucose monitors and work with doctors to adjust doses. One group receives the …

This trial investigates whether drinking pomegranate juice for 12 weeks can reduce gut inflammation in people with Crohn's disease or ulcerative colitis who are in remission. Participants will drink either pomegranate juice or a placebo beverage twice daily, and researchers will …

This phase 2 trial is investigating whether adding the targeted drug copanlisib to the standard R-CHOP chemoimmunotherapy regimen can help people with previously untreated diffuse large B-cell lymphoma (DLBCL) live longer without their cancer progressing. The study enrolls adults…

This study tracks adults with relapsed or refractory multiple myeloma who are already receiving isatuximab as part of their routine care. Researchers will measure how many patients respond to treatment, how long the response lasts, and how the drug affects quality of life and sid…

This trial tests whether cladribine tablets change key immune cells and nerve damage markers in the spinal fluid of people with relapsing forms of multiple sclerosis. Participants take cladribine as prescribed and undergo up to two lumbar punctures to measure these biomarkers ove…

This phase 3 trial tests whether Jinhua Qinggan Granules, a traditional Chinese herbal medicine, can eliminate symptoms of acute upper respiratory infections (like fever, sore throat, and congestion) within three days. About 273 adults with early-stage cold or flu will receive ei…

This study tracks about 450 adults with active psoriatic arthritis who are prescribed upadacitinib (RINVOQ) by their doctor. Researchers will follow participants for up to 24 months to see how well the drug controls joint and skin symptoms when used alone or with methotrexate in …

This trial is testing the long-term safety and tolerability of the drug filgotinib in people with rheumatoid arthritis who have already completed an earlier filgotinib study. Researchers are monitoring side effects, lab abnormalities, and vital signs over an extended period. The …

This study looks at two surgical options for people with stage II Kümmell's disease, a condition where a spinal bone collapses after a minor injury. Researchers are comparing standard vertebroplasty (injecting bone cement) against a newer method that combines cement with small sc…

This study follows about 269 people with chronic lymphocytic leukemia (CLL) who are starting venetoclax, a targeted pill. Researchers will track how well the drug shrinks or controls the cancer over the first year, and how long it takes before patients need another treatment. The…

This study tested a new strategy: giving TB prevention medicine at the same time as TB testing to people with HIV starting or restarting antiretroviral therapy. The goal was to see if this approach gets more people on TB prevention quickly without missing active TB cases. The tri…

This study tests whether a specific diet, called the IBD-AID, can improve symptoms of inflammatory bowel disease (IBD) by changing the bacteria in the gut. Participants aged 15 and older with IBD will follow the diet for 8 weeks, with guidance from study staff and cooking classes…

This study looks back at health records from over 46,000 people in Denmark and Sweden with allergic rhinitis (hay fever), some of whom also have asthma. It compares those who used SQ sublingual immunotherapy (SLIT) tablets — a daily tablet placed under the tongue containing grass…

This study tests how different amounts of dietary carbohydrates affect insulin needs and blood sugar control in adults with type 1 diabetes. Participants are randomly assigned to one of three diets: a traditional diet with 50-60% of calories from carbs, a moderately low-carb diet…

This phase 3 trial tests whether risankizumab, an injectable biologic, can reduce joint pain and swelling in adults with moderately to severely active psoriatic arthritis who have not responded to or cannot tolerate other biologic treatments. Participants receive either risankizu…

This study tests whether adding the targeted drug venetoclax to standard chemotherapy helps more adults with acute myeloid leukemia (AML) achieve remission. It enrolls people aged 18 to 65 with intermediate- or high-risk AML who have not yet been treated. The main goal is to see …

This study tests whether lebrikizumab, an injectable biologic, can improve skin symptoms in adults and adolescents (aged 12 and older) with moderate-to-severe atopic dermatitis, also known as eczema. Participants receive lebrikizumab for 24 weeks, and doctors measure changes in e…

This study tests whether a peer coaching program delivered by phone and text can help adolescents and young adults (ages 16–22) with chronic conditions like sickle cell disease, diabetes, or cystic fibrosis improve their self-management skills. Participants are paired with a trai…

This study tests a new dissolving film called DESF that delivers epinephrine under the tongue. It is designed for children ages 7 to 17 who weigh at least 30 kg and have a history of allergic reactions that put them at high risk for severe episodes like anaphylaxis. The goal is t…

This study tests whether a low-carbohydrate diet (under 75 grams per day) can help adults with type 1 diabetes preserve their remaining insulin production. The idea is that the diet might calm the immune attack on insulin-making cells. Participants will follow the diet for a peri…

This study tracks the safety and effectiveness of bosutinib (Bosulif) in people with chronic myelogenous leukemia (CML) who are either newly diagnosed or have not responded to or tolerated prior treatments. Researchers will monitor side effects and how well the drug controls the …

This study compares the safety of baricitinib, an oral medication, against TNF inhibitors (injectable drugs like etanercept and adalimumab) in people with rheumatoid arthritis. The main focus is on the risk of venous thromboembolism (blood clots in veins). Participants include th…

This study tests a four-week virtual program designed to help teens aged 12-21 with type 1 diabetes use technology like insulin pumps and continuous glucose monitors. Participants complete surveys and interviews about their diabetes management and technology use. The goal is to u…

This study tracks 282 adults with moderate-to-severe ulcerative colitis who are taking mirikizumab as part of their routine care. Researchers will measure how many achieve clinical remission at 12 weeks and endoscopic remission at 24 and 52 weeks, along with changes in symptoms a…

This study tests whether using a continuous glucose monitor (CGM) — a small sensor that tracks blood sugar levels in real time — helps teens and young adults (ages 14 to under 25) with type 1 diabetes improve their blood sugar control compared to standard fingerstick testing. Par…

People with inflammatory bowel disease (IBD) have a higher risk of colorectal cancer and need regular colonoscopies to catch early warning signs. This study compares two techniques—narrow-band imaging (a special light) and an artificial intelligence (AI) system—to see which finds…

This study tests a software upgrade for an automated insulin pump system (Control-IQ) in adults with type 1 diabetes. The upgrade adds an adaptive biobehavioral control module that learns from the user's patterns to improve blood sugar management. Participants use the standard sy…

This phase 2 trial is testing whether combining two drugs, ponatinib and 5-azacitidine, can improve survival in people with advanced chronic myeloid leukemia (CML). The study includes adults whose CML has progressed to an accelerated phase or a more aggressive blast crisis. Parti…

This study tests whether adjusting the daily dose of the leukemia drug dasatinib based on a patient's blood levels can improve safety and effectiveness. Adults newly diagnosed with chronic phase chronic myeloid leukemia (CML) will receive either standard dosing or a dose tailored…

This phase 2 trial tests whether adding pioglitazone (a diabetes drug) to the standard leukemia medication imatinib can eliminate remaining cancer cells in people with chronic-phase chronic myeloid leukemia (CML). Participants must have been on imatinib for at least two years and…

This trial tests whether adding the targeted drug ponatinib to standard chemotherapy (cytarabine) can help prevent relapse in adults with a specific, high-risk genetic form of acute myeloid leukemia (FLT3-ITD AML) who are already in first remission. The study includes two age gro…

This trial investigates whether adjusting the dose of imatinib (Gleevec) based on the drug's level in the blood can improve outcomes for people newly diagnosed with chronic phase chronic myeloid leukemia (CML). Participants whose imatinib blood level is low after 28 days are rand…

This study tests whether a secure website with educational sessions, goal-setting, and tracking tools can help survivors of several cancers (including breast, prostate, colorectal, and others) improve their diet, increase physical activity, and manage weight. Participants are age…

This study tested whether Naderin, an immune-boosting drug, could prevent low white blood cell counts in 79 women with breast cancer receiving first-line chemotherapy. Participants either received Naderin alongside chemotherapy or chemotherapy alone. The results showed that only …

This study tests whether a nasal spray containing adelmidrol can reduce inflammation and shrink nasal polyps in people with chronic sinusitis. Participants are adults aged 18 to 70 who are scheduled for sinus surgery. Half receive standard care plus the adelmidrol spray, while th…

This study tested whether adding Naderin (sodium nucleinate) to standard treatment could reduce complications in 75 patients with cancer, tuberculosis, or hepatitis C. The main group received Naderin plus standard therapy, while the control group received standard therapy alone. …

This study investigates whether changing diet can reduce disease activity in people with psoriatic arthritis. Participants are randomly assigned to one of two diets: one focusing on which foods are eaten, and another limiting daily calorie intake. The trial lasts 24 weeks and inc…

This pilot study tested whether the multiple myeloma drug carfilzomib can be safely given at home instead of in a hospital. Seventeen patients received their first cycle in the clinic and later cycles at home, with nurses administering the short infusion. The main goal was to see…

This phase 3 study tested a drug called rocatinlimab in 726 adults with moderate-to-severe atopic dermatitis (eczema) that wasn't well controlled by creams. Participants received either the drug or a placebo as a shot under the skin for 24 weeks. The main goals were to see if the…

This study looked at whether taking oral azacitidine (Onureg) as maintenance therapy can help older adults with acute myeloid leukemia (AML) stay in remission longer after treatment with CPX-351 chemotherapy. The study included 100 patients aged 65 and older who had achieved remi…

This study tested whether adding ixazomib to the standard drug ibrutinib can help people with mantle cell lymphoma that has returned or not responded to prior treatment. Forty-three adults received both pills by mouth in cycles. Researchers looked for the best dose and measured h…

This phase 2 trial tests whether OSE-127, an antibody that blocks a key immune signal, can reduce disease activity in people with moderate to severe ulcerative colitis who have not responded to or cannot tolerate previous treatments. Participants are randomly assigned to receive …

This study tested a chemotherapy drug called CPX-351 in 59 adults aged 60 to 75 with a high-risk form of acute myeloid leukemia (AML). The goal was to see how well it could put the cancer into remission. Participants received the drug through an IV, and some also had a stem cell …

This completed Phase 4 study compared the safety of baricitinib (a daily pill) to TNF inhibitors (injections) in over 2,600 adults with rheumatoid arthritis. The main goal was to see if baricitinib had a higher risk of blood clots. Participants had to be at least 60, have a histo…

This study tests whether certolizumab pegol (Cimzia), a drug already used for arthritis, can reduce flares of anterior uveitis—a painful eye inflammation—in people with axial spondyloarthritis who have had uveitis before. About 89 adults with active axial spondyloarthritis and a …

This study tests whether adding the targeted drug inotuzumab ozogamicin to a milder chemotherapy regimen improves survival in adults over 55 with a specific type of acute lymphoblastic leukemia (ALL) that is Philadelphia chromosome-negative and CD22-positive. Participants receive…

This phase 3 trial tests whether a personalized cell therapy called bb2121 works better than standard drug combinations for people with relapsed and refractory multiple myeloma. About 386 participants were randomly assigned to receive either bb2121 or one of several standard regi…

This completed study tested whether a 6-week cardiac rehabilitation program (aerobic and resistance exercises) could improve heart disease risk, blood pressure, and arthritis activity in 40 people with both rheumatoid arthritis and high blood pressure. Participants were randomly …

This study tested whether taking two doses of sodium bicarbonate (baking soda) over 24 hours could reduce uric acid crystals in the urine of adults with type 1 diabetes. Uric acid crystals can harm the kidneys, so lowering them might help prevent diabetic kidney disease. The tria…

This study looked at 144 people with aggressive relapsing multiple sclerosis to compare two treatment plans over three years: monthly natalizumab infusions versus a six-month course of mitoxantrone followed by another immune-modulating drug. Researchers measured cost-effectivenes…

This study tested two drug combinations in 186 adults with multiple myeloma that came back or didn't respond after earlier treatment. One group got pomalidomide plus low-dose dexamethasone, and another got those two plus daratumumab. The goal was to see if the tumors shrank enoug…

This trial compares a standard mastectomy closure to a technique that adds padding stitches between the skin and chest muscle, aiming to reduce lymphoceles (painful fluid pockets). About 90 women with breast cancer undergoing mastectomy will be randomly assigned to one of the two…

This phase 2 trial investigates whether combining rituximab with lenalidomide works as well as standard rituximab-based chemotherapy for patients aged 75 and older with relapsed diffuse large B-cell lymphoma. The study focuses not only on controlling the cancer but also on mainta…

This study tested whether measuring oxygen levels in the blood (ScvO2) can help doctors decide when to give blood transfusions to anemic patients after heart surgery. 100 patients were randomly assigned to receive transfusions based on standard guidelines or only if their ScvO2 w…

This study tested a new drug called EQ001 in 30 people who developed acute graft-versus-host disease (aGVHD) after a stem cell transplant. aGVHD is a serious condition where donor immune cells attack the patient's body. The goal was to see if EQ001 is safe and can help control th…

This study tested whether adding rituximab to standard steroid treatment helps adults with IgA vasculitis (a disease causing inflamed blood vessels) achieve remission without needing steroids long-term. 75 participants with new or relapsing disease were randomly assigned to recei…

This early-phase trial tested a new treatment for relapsing-remitting multiple sclerosis (RRMS) that uses a patient's own red blood cells. The cells are coated with specific peptides and given back to the patient to teach the immune system to stop attacking the body. The study in…

This early-stage trial tested a drug called itolizumab (EQ001) in 52 adults with lupus, some of whom also had active kidney inflammation. The main goal was to check safety and find the right dose. Researchers also looked at how the drug behaves in the body and how it affects immu…

This study looked at 152 adults with systemic lupus erythematosus (SLE) who started taking anifrolumab during its first year on the market in Spain. Researchers tracked their disease activity, flare-ups, and remission rates using standard medical records. The goal was to see how …

This study tested the drug bosentan in 18 adults with systemic sclerosis who had reduced blood flow in their hands and a history of digital ulcers. The goal was to see if bosentan could improve hand blood flow measured by laser imaging and how blood flow relates to ulcer severity…

This study tested a new way to treat blood cancers like leukemia in 16 adults who did not have a standard bone marrow donor. Doctors used a single unit of cord blood that was grown in a lab to increase the number of stem cells before transplant. The goal was to see if this method…

This study tested whether adding a daily fiber supplement (inulin) to standard anti-IL-17 therapy could improve gut bacteria balance and treatment response in 76 adults with axial spondyloarthritis. Participants took either fiber or a placebo powder for three months. The main goa…

This study looked at how the drug abrocitinib affects the skin barrier in 20 adults with moderate to severe atopic dermatitis (eczema). Researchers measured water loss from the skin and changes in skin-related genes at 2 and 12 weeks. The goal was to see if the treatment helps re…

This study tested a new treatment for adults with a high-risk form of acute promyelocytic leukemia (APL). The experimental therapy combined arsenic trioxide, ATRA, and a low dose of idarubicin, aiming to improve survival and reduce side effects compared to the standard chemothera…

This study tested whether adding a smart, AI-powered insulin boost before meals could improve blood sugar control in adults with type 1 diabetes. Nineteen participants used either a standard automated insulin system or the same system with the AI boost during hotel stays and at h…

This study tested whether the drug rivaroxaban works as well as warfarin to prevent further brain damage in people who have had a stroke due to antiphospholipid syndrome (APS), a condition that causes abnormal blood clotting. About 40 participants took either rivaroxaban or warfa…

This completed Phase 3 trial tested the oral drug dimethyl fumarate (Tecfidera) against an injected interferon in 156 children aged 10 to 17 with relapsing-remitting multiple sclerosis. The main goal was to see if the drug could prevent new brain lesions and control the disease s…

Some people have a severe allergic reaction, called anaphylaxis, after a COVID-19 vaccine. This study checks whether those people can safely receive another dose. Researchers also run allergy tests to find out which vaccine ingredients, such as PEG2000 or PS80, might cause the re…

Researchers are studying whether cell-free RNA in saliva can work as a non-invasive liquid biopsy to help diagnose Sjögren's disease. The trial compares saliva from people with Sjögren's disease against saliva from people with dry-eye and dry-mouth symptoms who do not have the di…

Researchers compare PET scans and MRI to see which imaging method detects more myeloma lesions in adults under 65 with newly diagnosed multiple myeloma. Participants receive both scans at diagnosis, after three cycles of chemotherapy, and at the end of treatment. The study also t…

This study looked at whether certain proteins in saliva can help tell the difference between healthy gums, gingivitis (mild gum inflammation), and periodontitis (serious gum disease). Researchers collected saliva from 60 people and measured three specific biomarkers. The goal is …

Researchers at Izmir Katip Celebi University are testing a deep learning model called UNet to automatically outline bone sequestra, pieces of dead jawbone, on panoramic dental X-rays. The study uses 120 anonymized X-rays with 134 marked lesions from patients who had radiotherapy,…

This study tests a new MRI technique called ENRAGED FLAIR that aims to capture two types of brain images (T2-FLAIR and T1-weighted) in a single sequence, instead of the usual two separate scans. Researchers will compare the image quality and time savings against standard MRI in 1…

This study is testing whether a set of memory and thinking tests, usually done in person, can be given remotely over a video call. Researchers will compare results from in-person and remote versions to see if they match. If it works, it could make dementia assessments easier for …

This study tests whether a blood test can help doctors tell apart uveitis caused by lymphoma from other types of uveitis. Uveitis is an eye inflammation that can lead to vision loss, and in some cases it is a sign of a rare eye lymphoma that may spread to the brain. The researche…

This study tests whether chemicals in a person's breath, called volatile organic compounds, can signal inflammation in inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. Researchers will collect breath, blood, and stool samples from people wi…

Researchers at Lund University Hospital are testing a new MRI technique called DIVIDE to see if it can measure how sensitive brain metastases are to radiation. Today, doctors only see whether radiation worked by watching tumor size change on scans weeks or months later. This tria…

This trial tests whether a new imaging tracer, gallium-68-deferoxamine, can make Aspergillus fungus infections in the lungs visible on a PET/CT scan. The study involves 10 adults with suspected chronic pulmonary aspergillosis or allergic bronchopulmonary aspergillosis. The goal i…

This study investigates whether hearing problems are an under-recognized complication of diabetes. Researchers will screen 172 adults with type 1 or type 2 diabetes using hearing tests and a questionnaire. If a hearing issue is found, a more detailed assessment will be done to de…

This study tests whether an artificial intelligence system called GliomaAI-Astro23 can identify a specific type of brain tumor (IDH mutant astrocytoma) from routine MRI scans. Researchers are using existing MRI data from 1,372 patients to train and evaluate the AI. If accurate, t…

This study looked at nearly 500 patients who had a paracetamol (acetaminophen) allergy test over 22 years. The goal was to find the smallest dose that triggers a reaction, so future tests can be shorter and safer. By analyzing past data, researchers hope to create a simplified te…

This study tested how well a small, portable device (LumiraDx) measures blood clotting (INR) compared to standard lab tests. Researchers collected blood from 420 adults, some taking warfarin and some not, using both a fingerstick and a vein draw. The goal was to see if the device…

This study tested whether a thermal camera could detect intestinal inflammation in 43 children with Crohn disease. The camera measures heat patterns on the belly, which may reflect underlying inflammation. Researchers compared these readings to standard stool tests and symptom sc…

This study tested a non-invasive imaging device called dermal optical coherence tomography (D-OCT) to diagnose basal cell carcinoma (a common skin cancer) around the eye area. Researchers compared its accuracy to standard biopsy results in 210 adults with suspected lesions. The g…

Researchers are testing whether giving azacitidine, a chemotherapy drug, together with donor lymphocyte infusions after a stem cell transplant can prevent relapse in people with high-risk acute myeloid leukemia or myelodysplastic syndrome. About 30 patients will receive the combi…

Researchers at Stanford University are testing whether the Diabetes Body Project, a six-session group program, can reduce eating disorder symptoms and improve blood sugar control in young women with type 1 diabetes. The study enrolls 55 female-identifying participants aged 15 to …

This trial tests whether mobile phone communication helps HIV-positive pregnant women in Kenya complete the steps that prevent passing HIV to their babies. Twenty-six health facilities are assigned to either standard care or standard care plus phone-based support for mothers, mal…

Researchers at the University of Washington are adapting a brief narrative therapy session for use in a low-barrier primary care clinic that serves people experiencing homelessness in North Seattle. The study enrolls 64 adults who have had at least one therapy appointment at the …

This trial tests whether a single high dose of vitamin A, given before a donor stem cell transplant, can prevent gastrointestinal graft-versus-host disease (GVHD), a condition where donor cells attack the gut. Vitamin A deficiency is linked to a higher risk of this complication, …

This study is testing whether following a Mediterranean diet during pregnancy can reduce the chance of children developing allergies by age 2. Researchers are enrolling 276 healthy pregnant women (ages 20-35) who are at risk of having a baby with allergies. Participants receive p…

This trial tests a program designed for Latino fathers to help them reduce risky sexual behaviors, substance abuse, and domestic violence, and improve communication with their sons. The program combines two behavioral interventions: one that teaches fathers about HIV prevention a…

This study tests a culturally tailored program to prevent chronic diseases like diabetes, high blood pressure, and obesity in Latino men over 50 living with HIV. Participants meet with a community health worker, join group walking sessions three times a week, and discuss pleasant…

This study tests whether training influential members of social networks to talk about PrEP can encourage more African-American men who have sex with men to use it. Half of the recruited networks will have their leaders trained to share accurate PrEP information and counter misco…

Researchers are testing whether a combined exercise program can improve muscle thickness, balance, and fall risk in people with multiple sclerosis who also have sarcopenia, a condition involving loss of muscle mass and strength. Participants in the exercise group attend 60-minute…

Researchers are testing whether a 12-week Taekwondo training program can help adults with ankylosing spondylitis and axial spondyloarthritis. The trial enrolls 21 adults aged 19 to 59 who have stable treatment or no medication for at least three months. Participants join either a…

Researchers are comparing two diets to see whether either one reduces fatigue in people with relapsing-remitting multiple sclerosis. Participants follow their usual diet for 12 weeks, then are randomly assigned to the Swank low-saturated-fat diet or the Wahls Elimination modified…

This study tests whether a virtual exercise program can help children and young adults (ages 8-23) recover physical function and quality of life after a stem cell transplant. Participants will have twice-weekly, 30-minute online sessions with a physical therapist for 12 weeks. Th…

Researchers are testing whether injecting dexamethasone, a steroid, into the soft palate during tonsillectomy reduces uvula swelling and improves recovery. The study includes 74 adults aged 18 to 44 having tonsillectomy for recurrent tonsillitis. Half receive the steroid injectio…

This study looks at whether walking football—a low-impact, no-running version of soccer—is safe and helpful for people with axial spondyloarthritis, a long-term inflammatory spine condition. Twelve participants will play twice a week for 12 weeks. Researchers will measure pain, s…

Ataxia-telangiectasia is a rare, inherited disease that damages the nervous system, skin, and immune system, and it has no cure. Researchers are testing sirolimus, an immune-suppressing drug, in children under 17 with the condition. The six participants take sirolimus by mouth fo…

Researchers are comparing two ways of delivering exercise therapy to people with multiple sclerosis: supervised sessions with a physiotherapist and a program followed over the internet. The study enrolls 34 adults with moderate to severe disability, measured by an EDSS score of 5…

Researchers are testing whether propionic acid, a short-chain fatty acid, can slow nerve damage and ease fatigue in people with multiple sclerosis. The trial enrolls 101 adults aged 18 to 60 who have stable MS and signs of immune activity in their spinal fluid. Participants recei…

This study tested a video-based telemedicine program called REDCHiP for parents of young children (ages 2-6) with type 1 diabetes. The program uses education, behavior training, and therapy to reduce parents' fear of hypoglycemia (low blood sugar). 396 families participated, comp…

Researchers are testing whether an investigational eyelid emollient balm improves comfort and tolerance when used with tacrolimus 0.1% ointment in adults with atopic eyelid dermatitis. The study enrolls 33 people aged 18 to 65 with eczema on both eyelids. Each person applies the …

Researchers are testing whether milk and dairy products made with A2 beta-casein protein can improve gut symptoms, quality of life, sleep, and nutritional blood markers in adolescents with celiac disease. The trial enrolls 50 teens aged 10 to 18 who were diagnosed with celiac dis…

This early-stage study tests a new drug called ATTO1310 to see if it is safe and how the body processes it. It includes healthy adults, people with atopic dermatitis (eczema), and those with long-term itching. Participants receive either the drug or a placebo and are monitored fo…

This early-stage study tests a new drug called ATTO-3712 in healthy adults and people with atopic dermatitis (eczema). The main goal is to check if the drug is safe and how the body processes it. Participants receive either the drug or a placebo and are monitored with clinic visi…

Researchers compare alpha hydroxy acids, both with and without nanocarriers, against a standard calcipotriol plus betamethasone ointment for plaque psoriasis. The trial enrolls 80 adults with mild to moderate psoriasis who have not used psoriasis therapy for two months. Participa…

This study tests whether 80 sessions of a gentle brain stimulation technique called tDCS, given over 12 months, can improve attention, social skills, and language in 180 children aged 6 to 11 who have autism along with rare diseases, genetic problems, or PANDAS. The treatment is …

Fatigue is one of the most common problems in multiple sclerosis, and it can make walking, balance, and thinking harder. Researchers want to measure how fatigue changes these functions during a long walking test using wearable sensors. They are also testing whether a high-intensi…

Researchers at Ataturk University are testing whether watching nature videos through virtual reality glasses can improve sleep quality and mental well-being in people with multiple sclerosis. The trial enrolls 42 adults aged 18 to 80 who have MS and are not in an attack. One grou…

People with liver cirrhosis often have abnormal cholesterol and triglyceride levels. Researchers at Northern Jiangsu People's Hospital are following 150 cirrhosis patients who undergo laparoscopic splenectomy and azygoportal disconnection, a common operation for bleeding caused b…

This study tests whether a daily probiotic blend can improve quality of life for adults with persistent allergies to dust mites, cats, or dogs. For 12 weeks, 98 participants will take either the probiotic or a placebo and track their symptoms and antihistamine use. The goal is to…

This trial tests whether an 8-week Clinical Pilates program can improve balance and physical function in adults with multiple sclerosis. Participants are randomly assigned to Clinical Pilates, standard physiotherapy, or a control group with no structured exercise. Researchers mea…

Researchers are testing a nasal spray called PG-011 in adults with moderate to severe seasonal allergic rhinitis. The trial compares two strengths and dosing schedules of the spray against a placebo to see which might best reduce nasal symptoms like runny nose, sneezing, congesti…

Researchers at Rigshospitalet in Denmark are testing whether adults newly diagnosed with acute myeloid leukemia can safely measure their own blood counts and give themselves blood and platelet transfusions at home. The study trains and certifies 22 participants to use a home bloo…

Researchers are testing whether nicotinamide riboside, a form of vitamin B3 sold as a supplement, can reduce immune system activation in people with mild to moderate psoriasis. The trial enrolls adults aged 18 to 80 who are not on biologic therapy. Participants take either the su…

Researchers are testing a full-spectrum medicinal cannabis extract called NTI164, which contains 0.08% THC, in children with pediatric acute-onset neuropsychiatric syndrome (PANS). PANS causes sudden, severe obsessive-compulsive symptoms, restricted eating, and other psychiatric …

This study is testing a robotic lower-limb exoskeleton combined with functional electrical stimulation (FES) to help people with conditions like spinal cord injury, brain injury, or multiple sclerosis improve their walking. The device provides robotic support and electrical stimu…

This study tested a new drug called BLU-808 in 21 adults with ragweed allergies. The goal was to see if it is safe and helps reduce sneezing, runny nose, and itchy eyes caused by ragweed pollen. Participants were exposed to ragweed in a special chamber to measure the drug's effec…

This trial tests whether a self-management program can reduce lymphedema symptoms and improve quality of life in women with breast cancer who have developed arm swelling after mastectomy. Participants will learn exercises and receive education on lymphedema care, such as skin pro…

This study tests whether personalized nutritional counseling from a team of pediatricians, allergists, and dietitians can improve the quality of life for mothers of children with food allergies. Researchers will compare mothers already receiving this multidisciplinary care with t…

This pilot study tests whether a mindfulness program delivered through a web app can help hospitalized neurological patients and their caregivers cope with stress and anxiety. Participants learn mindfulness techniques in an initial face-to-face session, then practice via weekly o…

This study tests whether morning light therapy can improve sleep timing and reduce symptoms in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Sixty-eight adults with active IBD symptoms will either use a light therapy device at hom…

This Phase 2 trial tests whether an injection called DM-101PX can reduce nasal symptoms caused by birch pollen allergy. About 100 adults with birch pollen allergic rhinitis or rhinoconjunctivitis will receive either the drug or a placebo. The main goal is to see if the treatment …

This trial tests whether a bleaching gel fortified with tiny titanium oxide particles can whiten teeth better and cause less sensitivity than a standard gel. Sixty adults with tooth discoloration will receive either the nano-enriched gel or the conventional gel during a single se…

This trial tests a new 24-week program called COMFI that combines a cognitive behavioral approach with physical activity to help people with inflammatory arthritis manage fatigue. Participants attend group sessions, an optional individual session, and a booster session, and they …

This trial tests whether using a virtual reality headset during a rectosigmoidoscopy (a type of colonoscopy) can reduce pain and anxiety in people with ulcerative colitis. Participants will be randomly assigned to receive standard care or to wear a VR headset that provides medica…

This study tests whether blood flow restriction training (BFRT) — using pressure cuffs during low-load exercise — can help people with rheumatoid or psoriatic arthritis build muscle with less joint strain than conventional strength training. Adults with these conditions will be r…

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This study tested a 21-step enhanced recovery protocol for children aged 10-18 undergoing elective gastrointestinal surgery. The protocol included things like shorter fasting times, early eating and moving, and less use of opioids. The goal was to see if it could shorten hospital…

This trial tests whether practicing tai chi can increase overall physical activity in people with spondyloarthritis, a type of inflammatory arthritis. Participants will either take tai chi sessions for two or four months or receive no tai chi (control group). The study measures c…

This trial tests whether combining proprioceptive neuromuscular facilitation (a type of stretching that improves flexibility and strength) with core strengthening exercises can help people with Guillain-Barré syndrome recover balance, muscle strength, and the ability to perform d…

This study tests whether learning Argentine tango can increase overall physical activity in people with chronic inflammatory arthritis, such as rheumatoid arthritis or spondyloarthritis. Participants will take tango sessions that focus on body awareness, movement, and connection …

This study investigates how easy or hard it is for adults with inflammatory bowel disease (IBD) to follow three different eating plans: intermittent fasting, the Mediterranean diet, and the low FODMAP diet. Researchers will interview participants to understand what helps or hinde…

This trial compares two exercise programs—chin tuck against resistance (CTAR) and proprioceptive neuromuscular facilitation (PNF) neck stretches—for people with multiple sclerosis who have trouble swallowing. Over 8 weeks, participants perform supervised sessions three times a we…

This phase 3 trial tests whether a once-daily pill combining desloratadine (an antihistamine) and betamethasone (a corticosteroid) relieves nasal allergy symptoms better than desloratadine alone. About 70 adults with moderate-to-severe allergic rhinitis will take either the combo…

This trial tests whether a structured memory training program, called Strategy-Based Training to Enhance Memory (STEM), can improve learning and recall in people with multiple sclerosis who report memory difficulties. Participants attend eight training sessions over four weeks an…

This study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …

This study looked at whether touch-massage can reduce anxiety in people with blood disorders (like leukemia or lymphoma) who are hospitalized in a sterile, isolated room. Sixty-two patients received three massage sessions, and researchers measured their anxiety levels before and …

This study tests whether PG2, a compound from the astragalus root, can reduce fatigue and low white blood cell counts caused by chemotherapy in women with stage II or III breast cancer. Participants receive either PG2 or a placebo alongside their standard chemotherapy. The goal i…

This study tested a special lollipop containing the painkiller diclofenac to help children aged 4 to 12 manage pain after having their tonsils removed. Fifty children received a weight-adjusted dose every 8 hours for the first day after surgery. The goal was to see if the lollipo…

This study looked at whether placing a bridge device during loop ileostomy creation reduces complications like infections or stoma problems. 166 adults having elective colorectal surgery took part. The goal was to see if the device improves outcomes or just adds difficulty to car…

This study tested whether nurse-led consultations can help people with rheumatoid arthritis become more independent in managing their subcutaneous biotherapy. Many patients struggle to recognize warning signs and delay seeking help. The study enrolled 71 adults with rheumatoid ar…

This study tested a smartphone app called SNAQ that estimates the carbohydrate content of a meal from a single photo. The goal was to see if using the app helps people with type 1 diabetes keep their blood sugar in a healthy range. 44 adults who already use an automated insulin p…

This study looked at whether 8 weeks of low-load leg exercises with a blood flow restriction cuff is safe and doable for people with multiple sclerosis who have moderate to severe walking problems. Sixteen adults with MS took part, doing exercises like knee extensions and hip lif…

This study tested whether practicing Qi Gong, a gentle mind-body exercise, could improve quality of life in people with systemic lupus erythematosus (SLE). Thirty-three participants took part in weekly Qi Gong sessions for six months. Researchers measured changes in physical func…

This study tested a new, standardized process for providing assistive devices (like special tools) to help people put on and take off compression stockings. 220 adults who need these stockings long-term took part. The goal was to see if the new method improves how often people us…

This completed pilot study looked at whether a placebo treatment — sham TENS combined with positive verbal suggestions — could reduce fatigue in people with relapsing-remitting multiple sclerosis. 36 participants were enrolled. The main goal was to measure motor performance (numb…

This study tested whether roasted nux vomica capsules can help with nerve pain caused by the chemotherapy drug bortezomib in multiple myeloma patients. Twenty-two participants took the capsules for six weeks while continuing their regular chemo. Researchers measured changes in ne…

This study looked at whether high-intensity interval training (short bursts of hard exercise) can improve physical function and reduce fatigue in adults aged 50-80 living with HIV who are sedentary and tired. Participants were randomly assigned to either high-intensity training o…

This study compares two oral formulations of pranlukast, a drug used for asthma and allergic rhinitis, to see if they are equivalent. Sixty healthy adults will receive a single dose of each version in random order under fasting conditions. The main goal is to measure drug levels …

This early-phase study tested whether ferumoxytol, an iron-based contrast agent, can help MRI scans better detect inflammation in the brains of people with multiple sclerosis (MS). Fourteen participants (some with MS, some healthy) received a single IV dose of ferumoxytol and had…

This study is collecting blood, urine, and stool samples from 500 children with autoimmune diseases and healthy controls. Researchers will analyze these samples to find molecular patterns that could help diagnose these conditions and guide treatment decisions. The goal is to crea…

Researchers are studying how two types of ulcerative colitis treatment, tofacitinib and anti-TNF drugs, affect platelet function and the body's clotting system. The trial enrolls adults with ulcerative colitis and compares blood and tissue samples before and after they start trea…

This completed study looked at levels of a specific antibody (IgG4) to cow's milk and egg in 135 children, both with and without allergies. Researchers wanted to see if these levels could help tell which children have outgrown their allergy. The study involved a single blood draw…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This study looks at how the menstrual cycle changes blood sugar and energy use in women with type 1 diabetes. About 40 women will use a closed-loop insulin pump and continuous glucose monitor to track these changes. The goal is to understand how hormone shifts affect insulin need…

This study tests a new way to choose treatments for people with multiple myeloma or plasma cell leukemia that has returned or stopped responding to standard therapy. Researchers use a lab test that checks many drugs at once, along with genetic information, to find which drug or d…

Researchers at Giresun University are studying whether a blood protein called calprotectin changes in people with axial spondyloarthritis who complete a four-week pulmonary rehabilitation program. Thirty patients aged 25 to 65 will take part. The team will measure calprotectin al…

This study tested whether two light-based technologies, fNIRS and DCS, can safely measure brain activity in children with rare neurocognitive disorders like Niemann-Pick disease and Smith-Lemli-Opitz syndrome. 73 participants, including healthy volunteers, wore a cap with lights …

This completed study looked at 386 adults with psoriasis to understand how skin inflammation might be linked to heart and blood vessel diseases. Participants had up to seven visits over four years, including blood tests, heart scans, and optional skin biopsies. The goal was to se…

This study followed 1,377 people living with HIV in Liberia over three years to track how the disease progresses and affects their health. Researchers collected blood and urine samples, conducted physical exams, and asked about medications and risk behaviors. The goal was to gath…

This completed study analyzed genetic material from 1,340 patients with lymphoma, leukemia, or multiple myeloma. Researchers used DNA microarrays and other tools to find new molecular subtypes that could explain why some patients respond better to treatment than others. The goal …

This completed study analyzed leftover tissue samples from 130 people with lymphoma or related conditions. Researchers measured levels of histone and other proteins to find patterns linked to different lymphoma types. The goal was to better understand the biology of these cancers…

This study follows up to 5,000 people with autoinflammatory diseases (like NOMID, CANDLE, and juvenile dermatomyositis) and their healthy relatives. Researchers will collect medical history, blood samples, and imaging over 2-5 day visits to learn how these diseases work and find …

This study looks at people who have severe allergic reactions (anaphylaxis), especially when the cause is unknown. Researchers will do blood tests and bone marrow biopsies to find genetic or molecular clues. The goal is to understand what goes wrong in the body, not to test a new…

Researchers are studying whether a non-invasive skin imaging technique called reflectance confocal microscopy can predict how well people with moderate to severe atopic dermatitis respond to dupilumab. The trial enrolls 40 participants aged 6 months and older who are starting dup…

This study searched for genetic factors that may cause focal segmental glomerulosclerosis (FSGS), a kidney disease that can lead to kidney failure. Researchers compared DNA from 616 people, including African-Americans with FSGS, African-Americans with HIV but no FSGS, and non-Afr…

Researchers at Yale University are studying whether certain gut bacteria are linked to the autoantibodies that drive antiphospholipid syndrome, an autoimmune disorder that causes dangerous blood clots. The study follows 16 adults, including patients with the syndrome, people who …

Researchers are studying whether the lining of the small intestine shows signs of inflammation in people with Familial Mediterranean Fever (FMF), a genetic condition that causes recurring fevers and pain. The study compares intestinal biopsy samples from about 30 adults with FMF …

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for …

Researchers are studying natural killer (NK) cells in people who receive stem cell transplants for leukemia. The study follows 92 patients and their donors, looking at genes called KIR and HLA that control how NK cells work. By tracking NK cells during immune recovery, researcher…

Researchers want to learn what causes myeloproliferative neoplasms, a group of rare blood cancers. They are testing whether small incentives like pens, trolley tokens, or a £10 reimbursement encourage more people to join a case-control study. The trial includes about 100 patients…

This registry study follows 400 patients with a specific type of leukemia (non-high-risk APL) who are 70 or younger. It compares two standard treatments: ATRA plus chemotherapy versus ATRA plus arsenic trioxide. The goal is to see which approach leads to better long-term outcomes…

This pilot study tested whether PET-CT scans can detect leukemia that has spread outside the bone marrow in patients with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia (ALL). Ten participants received a PET scan before and after CAR T-cell therapy. The goal was to…

This study looks at 672 people with active ulcerative colitis to find the best treatment target. Participants are split into three groups: one aiming for symptom relief only, another for symptom plus endoscopic healing, and a third for symptom, endoscopic, and microscopic healing…

This completed study followed 945 people, mostly children and young adults with severe eczema or related allergic conditions, along with their relatives. Researchers observed how these diseases progress over up to a year, using tests like allergy skin pricks, blood draws, and lun…

This study aims to find the best way to share research results with people who have scleroderma, a rare autoimmune disease. About 128 participants will be randomly assigned to receive either an infographic or a plain-language summary of a study. They will then rate how complete, …

This completed study in Kazakhstan looked at 240 adults recently diagnosed with diabetes. Researchers measured blood sugar, insulin resistance, and immune markers to understand how different forms of diabetes develop. The goal is to help doctors diagnose and treat adult-onset dia…

This study investigates whether balance problems explain why fatigue leads to a greater fear of falling in people with multiple sclerosis (MS). Researchers will assess fatigue, balance, and fear of falling in 40 adults with MS who can walk independently or with a device. The goal…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study looked at how the virus that causes COVID-19 reduces the number of infection-fighting white blood cells (lymphocytes) in the blood. Researchers collected blood samples and medical records from 240 adults with or recovering from COVID-19. The goal was to learn more abou…

This study looks at how a new medicine (PF-08049820) is processed by the body when taken alone or with another drug (rabeprazole). It involves 18 healthy Chinese adults aged 18-65. Participants take both medicines by mouth, and blood samples are collected to measure drug levels. …

Researchers are collecting health records from young people with HIV in ten African countries who have taken the drugs darunavir, etravirine, or both. The study follows their demographics, clinical and laboratory profiles, and HIV drug resistance over time. The goal is to underst…

People with multiple sclerosis often do not report side effects from their oral disease-modifying drugs, which leaves safety monitoring incomplete. This trial compares two ways of encouraging reports: a nurse who trains the patient and follows up by phone over six months, versus …

This study checks whether the Four Square Step Test (FSST) is a good way to measure balance in people with rheumatoid arthritis. Researchers will test 50 adults aged 18-65 with RA, comparing FSST results to other measures like disease activity, pain, and muscle strength. The goal…

This study looks at how a new medicine called PF-08049820 changes the way birth control pills, a sedative, and a blood thinner move through the body. It involves 16 healthy adult women who will take the drugs alone and then with PF-08049820. The results will help plan future stud…

This study looked at 30 adults with Alpha-Gal syndrome, a condition where eating red meat causes allergic reactions. Participants ate cooked ground pork with or without a sugar called alpha-gal, then researchers checked for allergic reactions, gut symptoms, and changes in immune …

This study looked at 47 people with bullous pemphigoid, a blistering skin condition, who were treated with high-dose topical corticosteroids (clobetasol propionate) for 6 months. Researchers measured bone mineral density at the start, at 3 months, and at 6 months to see if the tr…

This study collected tissue samples from the tonsils, lymph nodes, bowel, and lungs of HIV patients and healthy volunteers. The goal was to measure the amount of virus and certain immune cells in these tissues during treatment. By comparing samples, researchers hoped to learn mor…

This early-stage study tests the safety of PF-08049820, a medicine being developed for eczema (atopic dermatitis), in about 71 healthy adults. Participants will take single or multiple doses of the drug or a placebo, and researchers will monitor how the body processes it and whet…

This trial tests whether rituximab, a drug used for ANCA-associated vasculitis, leaves patients with a weakened immune system. Researchers give pneumococcal vaccines to patients treated with rituximab, patients with the disease but not on rituximab, and healthy volunteers. They c…

This study looks back at health records from over 3,700 adults with immune thrombocytopenia (ITP), a condition where the immune system destroys blood platelets, raising bleeding risk. Researchers want to see which second-line treatments doctors prescribe after first-line steroids…

Researchers are studying 116 people with chronic watery diarrhea to see how many actually have microscopic colitis, a gut condition that standard tests often miss. Participants will give blood and stool samples and undergo a full colonoscopy with tissue biopsies from different pa…

This study looks at how changing sleep time affects the immune system and breathing in urban children with asthma. Researchers will ask some children to go to bed 90 minutes later for a week, while others keep their usual bedtime. They aim to understand if short sleep worsens ast…

This study looks at whether a common light treatment for vitiligo changes certain proteins in the skin. Researchers will measure two markers, CD63 and CD9, in skin samples from 20 people with vitiligo before and after three months of narrow-band ultraviolet B (NB-UVB) therapy. Th…

This study investigates whether people with multiple sclerosis experience kinesiophobia, a fear of movement, and how it relates to fatigue. Researchers will assess 352 adults with MS using scales for disability, spasticity, walking speed, pain, sleep, anxiety, and depression. The…

This observational study measures how often HPV infections and other sexually transmitted infections occur in transgender adults. Researchers will check for HPV at genital, anal, and oral sites, and also look for anal dysplasia, which can be a precursor to cancer. The study inclu…

This study follows children born moderately or late preterm (32-36 weeks) to age 9, measuring their thinking, movement, language, behavior, and growth. Researchers compare these kids to full-term peers to understand long-term effects. The goal is to learn how early development pr…

This study is testing whether two dietary supplements, Goodphyte IB Defense and Goodphyte Immunity, are acceptable and easy for adults with chronic diseases like IBD, hypertension, anemia, or multiple sclerosis to take. Researchers will also check if the supplements improve how w…

This study looked at how small differences in the COX-2 gene affect the balance of immune cells that play a role in allergies and asthma. Researchers analyzed blood and urine samples from 117 adults who were part of a larger genetic registry. No treatments were given; the goal wa…

This study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study investigates whether compounds found in ultra-processed foods, like advanced glycation end products (AGEs), might play a role in childhood eczema, also known as atopic dermatitis. Researchers will compare the diets of 100 children aged 6 months to 10 years, half with e…

This study tested a document called Voicing My CHOiCES, designed to help young adults (ages 18-39) with serious illnesses like cancer or HIV discuss their care preferences. Participants filled out questionnaires about anxiety, social support, and communication, then reviewed the …

This study aims to identify the unique molecular signature of immune cells called T cells that mistakenly attack the liver in autoimmune liver diseases like autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis. Researchers will analyze blood sampl…

This study screened up to 1,000 people with severe allergic conditions—like anaphylaxis, eczema, and asthma—along with their relatives to find genetic causes. Researchers collected blood samples and medical history to link specific gene mutations to these diseases. No treatment w…

Researchers are using wearable sensors and smartphone check-ins to track fatigue as it happens in people with myeloma, long COVID, heart failure, and healthy controls. Participants wear an ECG patch and a wrist sensor that measure heart rate, activity, and posture, and they rate …

This study will check 300 people living with HIV for oral HPV infection and mouth lesions using a simple swish-and-spit sample. Researchers will compare those who test positive and negative, and look at factors like age, sex, tobacco use, and HIV lab results to see what might pre…

Researchers are asking whether people with multiple sclerosis who have trouble reading emotions also face more difficulties in family life, friendships, and social integration. The study compares three groups: MS patients with emotional processing problems, MS patients without su…

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This study looks at whether two additional lab tests can better predict the risk of blood clots in people with antiphospholipid syndrome (APS), an autoimmune condition that can cause clots and pregnancy complications. Researchers will measure specific antibodies and thrombin gene…

This study looks at whether a protein in the blood, called soluble CD95 ligand, plays a role in ANCA-associated vasculitis, a rare group of diseases that cause inflammation of blood vessels. Researchers will collect blood and urine samples from 48 adults with the condition and tr…

This research program aims to deepen understanding of severe asthma by closely studying its clinical and biological features over time. Researchers will follow more than a thousand people with asthma, aged 6 and older, measuring lung function and tracking how often severe asthma …

This study looks at whether adrenaline, the body's stress hormone, triggers an immune reaction during low blood sugar (hypoglycemia) in people with and without type 1 diabetes. Researchers will lower participants' blood sugar and then give drugs that block adrenaline's effects to…

This completed study from Minia University looked at 200 patients with autoimmune thyroiditis (an inflamed thyroid) who had thyroid surgery. The goal was to see how often thyroid cancer is found by accident when examining the removed tissue. Researchers checked for cancer in pati…

This trial investigates whether combining group and individual educational sessions helps patients with chronic inflammatory rheumatism (like rheumatoid arthritis or spondyloarthritis) learn safety skills better than individual sessions alone. Participants are starting their firs…

This trial investigates whether gluten consumption affects digestive comfort, quality of life, and physical performance in non-celiac athletes who train intensively. Participants, who are healthy and free of digestive diseases, will be randomly assigned to a gluten-containing or …

This study follows people with relapsing-remitting multiple sclerosis who are starting immunosuppressant treatment. Researchers will track changes in cognitive abilities, fatigue, emotions, and overall quality of life over an extended period. The goal is to better understand how …

This study investigates whether a blood test can identify nerve damage in the bowel wall that may cause chronic constipation and defecation disorders. Researchers will compare blood samples and tissue from 100 adults undergoing surgery for obstructive defecation disorder to see i…

This study tests whether a French version of the Pain Sensitivity Questionnaire (PSQ) accurately measures a person's natural sensitivity to pain. The PSQ uses 17 questions about everyday situations that might cause pain. Researchers will compare answers from healthy volunteers an…

This study tests whether a smartphone-based digital assessment can measure rheumatoid arthritis activity as well as a standard doctor-performed exam. Adults with rheumatoid arthritis will complete a digital questionnaire, record guided videos of their joint movements, and then ha…

This study looks at how type 1 diabetes affects the heart, lungs, and overall fitness of children aged 6 to 17. It also measures their physical activity levels and quality of life. Researchers will compare these results with those of healthy children of the same age. The goal is …

This study aims to find the lowest concentrations of ragweed and birch pollen that cause allergy symptoms in people with seasonal allergic rhinitis. Participants sit in a special chamber where pollen levels are carefully controlled, and their nasal symptoms are measured. The goal…

Multiple myeloma, a common blood cancer, often causes bone lesions that lead to pain, fractures, and other serious events. This study reviews medical records of patients diagnosed between 2019 and 2021 to describe how often these bone complications occur and what rehabilitation s…

This study tests a data visualization tool called the Trial Enrollment Diversity Dashboard (TEDD) designed to help doctors see how diverse their clinical trial enrollments are. The goal is to overcome racial and ethnic disparities in leukemia trial participation. The study enroll…

This study investigates why some aggressive B-cell lymphomas stop responding to immunotherapy. Researchers are looking at tiny particles called exosomes that are released by tumor cells and may act as decoys, soaking up therapeutic antibodies before they can reach the cancer. By …

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…

This study investigates how women with type 1 diabetes manually adjust their automated insulin delivery (AID) systems to manage blood sugar changes during their menstrual cycle. Researchers will interview 69 women to catalog strategies like entering fake carbohydrates or changing…

This study investigates whether GHB is truly the most common drug used in chemical submission (drug-facilitated assault) or if its short detection window in blood and urine hides its real prevalence. Researchers will analyze hair samples from adult victims of suspected chemical s…

This study follows thousands of people with multiple sclerosis (MS) in the UK to see how COVID-19 affects them. Researchers track infections, hospital stays, and deaths using questionnaires and national health data. The goal is to understand the risks and outcomes for this group,…

This study investigates the genetic causes of pediatric Evans syndrome, a rare autoimmune condition where the immune system attacks blood cells. Researchers analyze blood samples from affected children and their families to find known or new mutations. The goal is to better under…

This study investigates how the immune system responds to COVID-19 in people with chronic lung conditions like asthma, COPD, or cystic fibrosis, compared to those without lung disease. Researchers collect blood, sputum, and nasal samples to measure immune signals and gene activit…

This study looks at how well existing risk models predict dangerous blood clots in people with diffuse large B-cell lymphoma (DLBCL), a common type of blood cancer. Researchers will review medical records from over 1,500 patients across multiple hospitals to see which factors are…

This study investigates why athletes with type 1 diabetes often experience higher blood sugar during competitions compared to regular training. Researchers will monitor 12 athletes with type 1 diabetes and 12 healthy athletes during a 5K race and a 5K training session, measuring …

This study looked at whether asking people with multiple sclerosis (MS) to do two things at once — like walking while thinking — can uncover balance problems that standard tests miss. Researchers studied 24 people with mild MS and low disability. The goal was to see if this dual-…

This completed study enrolled 6 adults with systemic lupus erythematosus (SLE) to collect blood, urine, saliva, stool, and tissue samples over time. The goal was to find biological markers that could predict when a patient's disease might flare up or how they might respond to tre…

This study looked at 54 people with primary Sjögren's syndrome who also had muscle inflammation. Researchers wanted to see how many met the official criteria for inflammatory myopathies. The goal was to better understand and classify muscle disease in Sjögren's patients.

This study tested a decision algorithm to help doctors diagnose the cause of eosinophilia (high levels of a type of white blood cell). The algorithm guides which tests to do and in what order. Researchers enrolled 53 patients and measured how many followed the algorithm correctly…

This study looked at how the drug adalimumab affects gene activity in the skin of people with chronic plaque psoriasis. Researchers compared skin samples from normal, non-lesional, and lesional areas before and after treatment. The goal was to understand the immune changes that h…

This study tests French versions of three questionnaires that measure fear of low blood sugar (hypoglycemia) in children with type 1 diabetes and their parents. The goal is to ensure these tools are reliable for French-speaking families. About 194 children aged 2 to 18 and their …

This study looked at how the heart fills and pumps blood when the body is tilted or exposed to lower body pressure. Researchers compared 30 people with type 1 diabetes and healthy volunteers. They used heart monitoring and ultrasound to measure changes, aiming to understand how d…

This study looked at how a protein called IL-22 binding protein (IL-22BP) affects gut healing in people with Crohn's disease or ulcerative colitis. Researchers compared samples from 52 patients and healthy volunteers to understand how IL-22BP is regulated during disease flares. T…

This study looked at 347 children and teens with type 1 diabetes who use the Medtronic MiniMed 780G insulin pump. Researchers tracked how much carbohydrate they ate each day and measured their blood sugar control over time. The goal was to understand the link between daily carb i…

This study looked at 107 people with severe food or insect allergies to measure the distance from skin to muscle in their thighs. The goal was to see if the needles on common epinephrine auto-injectors (like EpiPen) are long enough to deliver the medicine into the muscle, as reco…

This study tested whether children under 16 with a history of mild beta-lactam (like penicillin) allergies could safely take the drug again without first having skin tests. Researchers used a questionnaire to identify low-risk kids and then gave them an oral dose. The goal was to…

This study follows people newly diagnosed with psoriatic arthritis (PsA) to see how a 'treat to target' approach works in everyday clinics. Participants receive standard care, often starting with methotrexate, and their disease activity is tracked over time. The goal is to unders…

This study looked at how two types of exercise—high-intensity interval training (HIIT) and continuous moderate exercise—affect sleep and inflammation in 52 older adults with HIV. Participants exercised three times a week for 16 weeks. Researchers measured sleep quality through su…

This study follows children in France diagnosed with severe autoimmune cytopenia—conditions where the immune system attacks blood cells. Researchers will track their health over time to see who achieves remission and what factors influence their recovery. The goal is to better un…

This completed study looked at blood samples from 70 children and adults newly diagnosed with immune thrombocytopenic purpura (ITP), a condition that causes easy bruising and bleeding. Researchers wanted to see if certain immune and blood markers could predict whether the disease…

This study investigates whether stress hormone activity is linked to depression and brain changes in children with type 1 diabetes. Researchers will measure cortisol levels and use brain scans in children aged 6–12 who have had diabetes for at least a year, comparing them to thei…

This study investigates whether gut microorganisms and their byproducts play a role in triggering severe flare-ups of ulcerative colitis. Researchers will compare patients hospitalized with severe colitis to those with milder symptoms, analyzing stool and blood samples over three…

This study looked at how well two drugs, azathioprine and mycophenolate mofetil, work for people with myasthenia gravis in everyday medical practice. Researchers followed 82 adults with autoimmune MG for 2-3 years, measuring quality of life and side effects. The goal was to provi…

This completed study looked at how people learn and remember associations, like names or where you met someone. Researchers compared healthy young and older adults with patients who have memory problems from Alzheimer's or semantic dementia. They used memory tests and brain scans…

This study investigates whether spores from birch rust fungi trigger seasonal allergies in autumn. Researchers will compare 30 people with suspected birch rust allergy to 15 non-allergic controls, tracking symptoms and spore levels. The goal is to understand a possible cause of a…

This study looked at a type of immune cell called B regulatory cells in 100 people—some healthy and some with rheumatoid arthritis (RA). The goal was to understand how these cells differ between the two groups and how they might help control the disease. By identifying unique fea…

This study followed 115 people with relapsing-remitting multiple sclerosis for up to 5 years to see if early damage to the spinal cord could predict later walking difficulties. Researchers used MRI scans and walking tests to track changes. The goal was to better understand how ea…

This completed study from France examined whether a specific type of immune cell (innate CD8+ T cells) is linked to how quickly resistance mutations develop in patients with chronic myeloid leukemia or Philadelphia-positive acute lymphoblastic leukemia. Researchers analyzed blood…

This study looked at three ways to help people with rheumatoid arthritis take their methotrexate medication as prescribed: usual doctor visits, text message reminders, or a chat with a pharmacist. The goal was to see which method works best to improve adherence. The study include…

This study looks at whether people with chronic inflammatory rheumatism (like spondyloarthritis) or lupus who still have pain despite treatment have low vitamin C levels. Researchers will measure vitamin C in the blood and ask about pain, fatigue, and quality of life. The goal is…

This completed study looked at 340 people to understand how certain proteins in the lungs, called autoantibodies, might be linked to the start of rheumatoid arthritis (RA). Researchers collected sputum (mucus from the lungs) from people at risk for RA, those already diagnosed, an…

This study looked at 170 patients with aggressive B-cell lymphoma who received CAR-T cell therapy. Researchers used surveys to track how patients felt about their fatigue, symptoms, and daily functioning over time. The goal was to understand the real-world impact of the treatment…

This completed study enrolled 311 people with myasthenia gravis, a condition that causes muscle weakness. Researchers collected clinical information and blood samples to build a repository for future studies. The goal is to help scientists better understand the disease and potent…

This study tested whether wearable motion sensors can accurately measure spinal movement in people with ankylosing spondylitis (AS), a condition that causes back pain and stiffness. Forty participants (20 with AS and 20 healthy volunteers) wore sensors while performing everyday m…

This study followed 150 adults with systemic sclerosis (scleroderma) for two years to track their nutritional health. Researchers measured weight, diet, and disease severity every six months. If malnutrition was found, patients received dietary advice or supplements. The goal was…

This study followed 163 people with chronic inflammatory rheumatism (like rheumatoid arthritis) who had a recent COVID-19 infection. Researchers measured their antibody levels over two years to see how immunosuppressive drugs affect antibody persistence. The goal was to better un…

This study investigates whether analyzing bowel sounds with a computer can help measure disease activity in children with Crohn's disease. Researchers will record bowel sounds and compare them to a standard disease activity score. The goal is to find a noninvasive, painless way t…

This study aimed to create a detailed map of the cells in the human appendix and understand their genetic activity. Researchers analyzed appendix tissue from 5 patients undergoing colon cancer surgery. The goal was to learn more about the appendix's role in the immune system and …

This completed study took small tissue samples from the colons of 40 people during routine colonoscopies. Using advanced genetic techniques, researchers created a detailed map of the different cell types and their gene activity. The goal is to better understand how colon diseases…

This study looked at how people with multiple sclerosis and their natural caregivers (like family members) feel about the quality of care they receive. Researchers surveyed over 1,000 participants to understand their expectations and experiences. The goal was to create a tool tha…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This study used advanced MRI scans to look at energy use in the brains of 40 people with multiple sclerosis and 15 healthy volunteers. The goal was to see if energy problems in brain cells can predict nerve damage over two years. Researchers hope this will help understand how MS …

This completed study looked at 70 patients with myeloma or lymphoma who needed stem cell transplants. Researchers compared two drugs, Zarzio and Granocyte, used to stimulate stem cell production before collection. The goal was to see if one drug led to better stem cell grafts. Si…

This Phase 1 trial tested the safety and tolerability of INT-210 capsules in 86 healthy adults aged 18-45. Participants received single or multiple doses of the drug or a placebo, and researchers monitored side effects and how the drug moves through the body. The study also looke…

This study looked at 320 people whose brain scans showed signs that sometimes lead to multiple sclerosis (MS), even though they had no symptoms. Researchers analyzed blood and spinal fluid samples to find biological markers that could predict whether these silent signs would turn…

This study followed 307 people with relapsing multiple sclerosis in Germany who had recently switched to the drug Kesimpta (ofatumumab) from another treatment. Researchers collected information on why patients made the switch and how many doses they missed over one year. The goal…

This study tested whether a special heart ultrasound (speckle tracking strain echocardiography) can detect early heart muscle changes in 61 adults with type 1 diabetes, before symptoms appear. Researchers looked for links between these changes and small blood vessel damage (micro…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study tracked 204 patients with blood cancers or those on certain immune-suppressing treatments to see how often COVID-19 infection persists for 21 days or more. Researchers also looked for factors that make a long infection more likely. The goal was to better understand who…

This study aimed to find blood markers that can predict whether the drug adalimumab will successfully treat ankylosing spondylitis after 6 months. Researchers analyzed blood samples from 50 adults starting adalimumab for the first time. The goal was to create an algorithm to help…

This study looked at whether certain genes make people who are regularly around pigeons more likely to develop a type of lung disease called hypersensitivity pneumonitis. Researchers analyzed the DNA of 475 pigeon fanciers to find genetic markers linked to lung scarring. The goal…

This study looked at over 13,000 people with chronic inflammatory rheumatism or autoimmune diseases who had or were suspected to have COVID-19. Researchers tracked how many developed severe COVID-19 requiring intensive care or leading to death. They also examined risk factors lik…

This study looked at how the COVID-19 lockdown changed blood sugar control and self-care in 77 young people aged 13 to 25 with type 1 diabetes. Researchers used data from a glucose monitoring platform to compare blood sugar levels before, during, and after the two-month lockdown …

This study looked at 29 adults with severe bee or wasp sting allergies to understand why a fast, one-day desensitization treatment is safe. Researchers measured changes in immune cells (basophils and T cells) before and after the treatment. The goal was to learn the mechanism, no…