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Blood test may spot hidden nerve damage behind chronic constipation

NCT ID NCT05016700

Knowledge-focused Sponsor: Evangelisches Klinikum Köln Weyertal gGmbH Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This study investigates whether a blood test can identify nerve damage in the bowel wall that may cause chronic constipation and defecation disorders. Researchers will compare blood samples and tissue from 100 adults undergoing surgery for obstructive defecation disorder to see if certain markers correlate with the degree of nerve cell loss. The goal is to find a less invasive way to diagnose this neuropathic cause, potentially leading to new treatments that address the root problem.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
blood sample
What this could lead to
If successful, this could lead to a simple blood test to identify patients with nerve damage in the bowel, enabling more targeted treatments.
What could go wrong
This is an early exploratory study, and the blood test may not reliably reflect nerve damage. The findings may not apply to all patients with defecation disorders.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

100 people

The number who actually took part.

Started

Mar 2019

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with severe defecation disorders, both in terms of colonic transit disorder and obstructive defecation disorder, and combinations of both, who have been managed conservatively and require a full-wall bowel biopsy or bowel resection for medical indication.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * obstructive defecation disorder scheduled for surgery * must be able to undergo surgery * \> 18 years of age * informed consent Exclusion Criteria: * no defecation disorder * no surgery needed * unable to undergo surgery * ≤ 18 years * no consent

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Conditions

The condition(s) this trial relates to.

autoimmune disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Autoimmune diseases Defecation disorder Neuropathology

Contacts and locations

Locations

  • Evangelisches Klinikum Koeln Weyertal

    Cologne, North Rhine-Westphalia, 50931, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.