Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Scientists probe hidden memory system that might survive brain damage

NCT ID NCT04846764

Knowledge-focused Sponsor: Rennes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at how people learn and remember associations, like names or where you met someone. Researchers compared healthy young and older adults with patients who have memory problems from Alzheimer's or semantic dementia. They used memory tests and brain scans to uncover a learning system that may work even when the hippocampus is damaged.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could reveal a hidden memory system that might one day be used to help people with memory loss from aging or brain disease.
What could go wrong
This is an observational study, not a treatment trial. It aims to understand memory, not to test a therapy, so direct patient benefits are far off and uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

97 people

The number who actually took part.

Started

Apr 2021

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Healthy Volunteers * aged 18 to 40 years old and aged 60 to 80 years old * native French speaker * right-handed * with a level of education greater than or equal to the Certificate of Primary Education * free of any medical or psychiatric condition that may interfere with cognition Neurological patients * patients with mild neurocognitive impairment due to Alzheimer's disease * patients with semantic dementia syndrome * right-handed patients with a right or left unilateral surgical lesion of the anterior temporal lobe as a result of pharmaco resistant temporal epilepsy, with no seizures in the last 6 months, with a memory quotient greater than 75, and free of internal extra temporal lesions on MRI * patients with autoimmune limbic encephalitis who have been seizure-free for one month * 1 KA patient, suffering from the rare syndrome of developmental amnesia Exclusion Criteria: All participants * MRI contraindications * sensory deficit interfering with experimental tests * protected major (safeguard justice, trusteeship and guardianship) and persons deprived of liberty Healthy volunteers \- deficit score on the MoCA scale according to current calibrations Neurologic patients * 7-items modified Hachinski ischemic score \>2 * dementia * epileptic seizure in the month prior to inclusion for epileptic patients undergoing surgery and limbic encephalitis patients

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Autoimmune limbic encephalitis are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Alzheimer disease autoimmune limbic encephalitis central nervous system disorder nervous system disorder semantic dementia temporal lobe epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Central nervous system Neurological diseases

Contacts and locations

Locations

  • CHU Rennes

    Rennes, 35033, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.