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Could a blood flow cuff help MS patients walk better?

NCT ID NCT04633759

Symptom relief Sponsor: University of Colorado, Denver Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether 8 weeks of low-load leg exercises with a blood flow restriction cuff is safe and doable for people with multiple sclerosis who have moderate to severe walking problems. Sixteen adults with MS took part, doing exercises like knee extensions and hip lifts while wearing a cuff that partially blocks blood flow. The goal was to see if this method could improve leg strength and balance without needing heavy weights.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
blood flow restriction exercise
What this could lead to
If this approach works, it could offer a gentler way for people with MS to strengthen leg muscles and improve mobility without heavy weights.
What could go wrong
This is a very small feasibility study with only 16 participants and no control group, so results may not apply widely. The exercise requires special equipment and may not be comfortable for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

16 people

The number who actually took part.

Started

Feb 2021

Finished

Oct 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults ages 18-70 * Neurologist-confirmed diagnosis of multiple sclerosis * Expanded Disability Status Scale (EDSS) 6.0 to 7.0 * EDSS 6.0: unilateral assistance (cane or crutch) required to walk at least 100 meters with or without resting * EDSS 6.5: Bilateral assistance (cane or crutch) required to walk at least 20 meters with or without resting * EDSS 7.0: unable to walk 5 meters even with aid, essentially restricted to wheelchair; wheels self and transfers alone; up and about in wheelchair some 12 hours a day Exclusion Criteria: * EDSS 7.5 or greater: Restricted to wheelchair for all mobility, unable to walk more than a few steps, even with walking aid * EDSS 5.5 or less: Able to walk more than 100 meters without walking aid or rest * Unable to provide consent or follow simple directions * Prior history of Deep Venous Thrombosis/ Pulmonary Embolism * History of peripheral vascular disease, thrombophilia or other clotting disorders * Patient report of easy bruising * Any comorbid conditions or pain that substantially affects physical function or would interfere with the participant's ability to safely complete rehabilitation (e.g. neurologic, vascular, cardiac problems, orthopedic, or ongoing medical treatments) as determined by a neurologist of physical therapist * Severe lower extremity spasticity as defined as Modified Ashworth scale \> 2 * Currently undergoing supervised resistance training with a physical therapist or other exercise professional * Use of Blood Flow Restriction currently or in the previous 3 months prior to enrollment * MS-related exacerbation or changes to their disease-modifying drug therapy in the month prior to enrollment * Inability to tolerate pressure cuff during baseline assessment

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Conditions

The condition(s) this trial relates to.

multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Multiple sclerosis

Contacts and locations

Locations

  • University of Colorado

    Aurora, Colorado, 80045, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.