University Of Colorado, Denver

This study tests whether educational materials and a short video can help people who are underserved learn about the HPV vaccine and get it. The program is for Denver Health patients aged 9-26 who haven't started or finished the vaccine series. Researchers will measure changes in…

This study looks at how well the shingles vaccine (Shingrix) works in people who have had a stem cell transplant. Researchers want to find the best time to give the vaccine after transplant and whether a third dose helps. About 55 adults who already received two doses of Shingrix…

This study looks at how well the shingles vaccine (Shingrix) works and how safe it is in adults with kidney failure who are waiting for a kidney transplant. Some participants will get an extra dose of the vaccine after their transplant to see if it improves their immune protectio…

This study tests whether giving extra internal radiation (brachytherapy) to rectal cancer patients who still have some tumor after standard treatment can make the cancer disappear and avoid the need for surgery. About 44 adults will receive three weekly outpatient treatments. The…

This early-phase trial tests a combination of two drugs, losartan and sunitinib, in people aged 10 and older with osteosarcoma (a type of bone cancer) that has returned or stopped responding to standard treatments. The main goals are to find the safest dose and check for early si…

This study tests a combination of two drugs, cladribine and venetoclax, in adults with a specific type of acute myeloid leukemia (monocytic AML) that came back or didn't respond to standard treatment. About 20 participants will receive the new drug combo to see if it can shrink o…

This study looks at whether placing naloxone—a medication that can reverse an opioid overdose—in vending machines makes it easier for people to get it. Researchers will track how many naloxone kits are given out before and after the machines are installed in communities. Anyone i…

This study tests whether giving two drugs (pembrolizumab and axitinib) before surgery can shrink tumor clots in the main vein (inferior vena cava) for people with kidney cancer. About 17 adults with clear cell kidney cancer and a vein clot will receive the drugs for 12 weeks, the…

This study tests a drug called tofacitinib (XELJANZ) in 92 people with Down syndrome aged 6 to 22. The drug aims to calm the immune system and possibly improve thinking and daily skills. Participants receive either the drug or a placebo for 6 months, with close safety monitoring.

This study looks at whether giving people with type 2 diabetes a Fitbit and sending them personalized text messages can help them become more active and better manage their condition. Researchers will enroll 36 adults who are not very active. Participants will wear a Fitbit and r…

This study tests two school-based programs to help children aged 5-12 from low-income communities in Colorado better control their asthma. The goal is to reduce asthma attacks and missed school days by having school nurses and asthma navigators coordinate care with doctors and co…

This study is testing whether a medication called brexpiprazole can help people with alcohol use disorder drink less. Researchers want to see if a person's genes affect how well the drug works. The study involves 250 adults who are not seeking treatment for their drinking. Partic…

This study tests an accelerated form of transcranial magnetic stimulation (TMS) for people with moderate to severe methamphetamine use disorder. The goal is to see if this faster treatment is safe and can help reduce meth use and cravings. Twenty participants will receive either …

This study tests whether adding the drug ruxolitinib to a standard stem cell transplant can lower the chance of graft failure in children and young adults (ages 12-45) with severe sickle cell disease. About 24 participants will receive the treatment and be followed for 2 years. T…

This study tests whether combining two drugs, mirvetuximab soravtansine and olaparib, can effectively control recurrent ovarian, peritoneal, or fallopian tube cancer after initial treatment. About 53 women whose cancer responded to platinum-based chemotherapy will receive the dru…

This study tests whether sargramostim, a drug already approved for bone marrow stimulation, is safe and effective for people with mild-to-moderate Alzheimer's disease. Over six months, 42 participants will receive either the drug or a placebo. Researchers will track side effects …

This early-phase study is testing whether combining two drugs, Cirtuvivint and Olaparib, is safe for people with ovarian cancer that no longer responds to platinum chemotherapy. About 50 women with specific genetic markers (BRCA/HRD) will take the pills at different schedules. Th…

This study tests a new type of CAR-T cell therapy for children and teens with B-cell acute lymphoblastic leukemia (B-ALL) or B-cell non-Hodgkin lymphoma (B-NHL) that has come back or not responded to standard treatments. The therapy uses the patient's own immune cells, modified t…

This study tests a new, single-use digital scope (Dragonfly™) for treating bile duct stones and taking tissue samples. Up to 75 adults with bile duct stones or narrowings will use this scope during a standard ERCP procedure. The goal is to see how well it breaks up stones and col…

This study tests a new combination of drugs for people with acute myeloid leukemia (AML) whose cancer did not respond to or came back after standard treatment. About 30 adults will receive mitoxantrone along with venetoclax and azacitidine to see if this mix can shrink the cancer…

This study is for people aged 65-100 with advanced or metastatic leiomyosarcoma, a rare soft tissue cancer that cannot be removed by surgery. Researchers want to see if giving the standard chemotherapy drug doxorubicin at a lower dose every week (instead of a higher dose every fe…

This study is testing whether semaglutide, a drug already used for type 2 diabetes, can improve heart and kidney function in adults with type 1 diabetes. Researchers will measure artery stiffness and insulin sensitivity in 60 participants over time. The drug is not yet FDA-approv…

This early-phase study tests a new type of cell therapy (CD19x22 CAR T) for adolescents and adults with B-cell non-Hodgkin lymphoma that has come back or not responded to treatment. The therapy uses a patient's own immune cells, modified to target two proteins on cancer cells. Th…

This study tests whether cannabidiol (CBD), a non-psychoactive compound from the cannabis plant, can help people who regularly use high-potency cannabis concentrates reduce their use and cravings. About 120 adults aged 25-60 who use cannabis concentrates at least 4 times a week b…

This study tests a special gel (VersaWrap) placed between the metal plate and tendons during wrist fracture repair. The gel dissolves over time and aims to prevent tendons from sticking or rupturing. About 50 adults will be randomly assigned to get the gel or standard care. Resea…

This study looks at whether metformin, a common diabetes drug, can help prostate cancer patients who have high blood sugar or are overweight. About 100 men will either get metformin plus lifestyle tips or just lifestyle tips. The goal is to see if this approach is practical and i…

This study tests whether full-spectrum cannabidiol (CBD) can help people who regularly drink alcohol reduce their drinking. Researchers will measure how much participants drink in a lab setting and track their drinking habits over 12 weeks. The goal is to see if CBD can be a safe…

This study tests a new type of cell therapy (CD19x22 CAR T) in children whose B-cell acute lymphoblastic leukemia has come back or not responded to standard treatments. The therapy uses the patient's own immune cells, modified to attack two targets on leukemia cells. The main goa…

This study compares a smart insulin pump called the iLet Bionic Pancreas to usual diabetes care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the pump or continue their routine care for 13 weeks to see if the pump improves blood sugar …

This study tests a program called NAVIGATE-Kidney for 448 adults with advanced chronic kidney disease. The goal is to help patients start kidney replacement therapy (dialysis or transplant) in a planned way, avoiding emergency starts with a central venous catheter. The program in…

This study looks at whether people with stable relapsing multiple sclerosis (MS) can safely switch from a strong infusion therapy (anti-CD20) to a daily pill (ozanimod). The goal is to see if the pill can keep the disease under control with fewer serious infections. About 100 adu…

This study looks at whether a team-based mental health program can help pregnant and new mothers living with HIV in Kenya feel better and stay healthy. About 900 women will receive extra mental health support alongside their regular HIV care. The goal is to reduce depression and …

This early-stage trial tests a combination of two drugs, CC-486 and venetoclax, in people with acute myeloid leukemia (AML) whose cancer has returned or not responded to treatment, as well as some newly diagnosed patients. The main goal is to find the safest dose of CC-486 when g…

This early-phase trial tests whether adding chemotherapy directly into the abdomen (intraperitoneal paclitaxel) to standard vein chemotherapy (NALIRIFOX) is safe and effective for adults with pancreatic cancer that has spread to the lining of the belly. Ten participants will rece…

This study looks at whether a set of health interventions can help women going through menopause reduce inflammation, improve heart health, slow biological aging, and ease symptoms like hot flashes. Researchers will enroll 200 women aged 45-55 who are in late menopause transition…

This early-phase trial tests whether a new type of CAR T cell therapy (UCD19) is safe and can work in adults with B-cell acute lymphoblastic leukemia (B-ALL) who are in first remission but still have tiny amounts of cancer cells (minimal residual disease). About 29 participants w…

This study tests whether hemp-derived CBD can help young adults (ages 18-25) who use cannabis at least 5 days a week reduce their cannabis use and related harm. Participants are not trying to quit and will take either CBD or a placebo for 8 weeks. The study measures changes in ca…

This pilot study tests whether a home urine test can accurately measure pregnancy hormone (hCG) levels compared to standard blood tests. About 35 women with a pregnancy of unknown location (PUL) and non-pregnant controls will collect daily urine samples at home and have blood dra…

This study tests a telehealth program for older adults (65+) who came to the emergency room after a fall. Participants get physical therapy and pharmacy advice by video while still in the ER, plus phone follow-ups for 6 months. The goal is to see if this approach is practical and…

This study tests a program called ALERT-ED for older adults (65+) who are at high risk of falling. When they visit the emergency room, they get an automated message with their fall risk results and a link to local fall prevention programs. The goal is to reduce fall-related ER vi…

This study tests a new program to increase flu vaccination rates among children admitted to hospitals. Researchers will work with doctors, nurses, and families to create a simple process for offering flu shots during a hospital stay. The goal is to protect more kids from the flu …

This study tests a low-cost, one-hour program called CARE to prevent mood, anxiety, and trauma symptoms in pregnant people after a cesarean delivery. Researchers will work with patients and staff to improve the program, then test it with 80 participants at a large hospital. The g…

This study tests whether the asthma drug Advair HFA can prevent high altitude pulmonary edema (HAPE), a condition where fluid fills the lungs at high altitudes, causing breathing difficulty. Researchers will give the drug or a placebo to 60 healthy and HAPE-prone adults and measu…

This study tests if a short course of steroids given through a vein can reduce throat swelling and improve swallowing in people who recently had a breathing tube in the ICU. About 80 adults with confirmed throat swelling will be randomly assigned to receive either steroids or a p…

This study tests whether a one-month treatment combining the allergy drug clemastine fumarate with engineered sound can improve the ability to hear speech in background noise for people aged 45-65 with age-related central auditory processing disorder. Participants will be randoml…

This study compares a combination of ibuprofen and acetaminophen against ibuprofen alone or a placebo for managing pain after getting braces. It involves 375 people starting orthodontic treatment. The goal is to see if the combination provides better pain relief during the first …

After total knee replacement, many patients experience lasting leg weakness. This study tests whether adding neuromuscular electrical stimulation (NMES) to standard physical therapy can improve strength and mobility. Researchers will enroll 3,250 patients across two large healthc…

This study tests whether a special sleep program helps teens aged 10–19 recover from a concussion more quickly. About 54 participants will either get standard sleep advice or a detailed sleep plan. The goal is to see if better sleep leads to faster symptom relief, improved mood, …

This study tests a procedure called genicular artery embolization (GAE) to see if it can reduce knee pain and inflammation in adults with knee osteoarthritis. Researchers will compare knee fluid samples and MRI scans before and after the procedure to see if changes in inflammatio…

This study tests whether 12 weekly sessions of parent management training can reduce irritability, anger outbursts, and cranky moods in children aged 10-14. Parents attend the training while children complete assessments. The goal is to see if this approach works in a clinic sett…

This study tests whether Pain Reprocessing Therapy (PRT) helps veterans with chronic back or neck pain more than cognitive behavioral therapy (CBT) or their usual care. About 360 veterans will be randomly assigned to one of the three groups. Those in PRT or CBT will have nine wee…

This study tests whether a higher dose of aerobic exercise, started within two weeks of a concussion, helps teens recover faster. Researchers will measure symptom resolution, brain inflammation markers, and anxiety or depression changes. The goal is to create better rehabilitatio…

This study tests whether a Spanish-language program called Unstuck and On Target helps children ages 8-11 with autism or ADHD improve their planning and flexibility skills. About 40 Spanish-speaking families will either join the program right away or wait. The goal is to see if t…

This study tests whether a telehealth exercise program can reduce cancer-related fatigue in rural breast and prostate cancer survivors. About 134 participants will either start the program right away or wait 12 weeks before beginning. They will do virtual fitness assessments, col…

This study aims to help people with Parkinson's disease exercise safely at home and track their sleep using a special headband. Researchers will test if a high-intensity workout program, originally done in a lab, works well when done remotely. Sixteen participants in Colorado wil…

This study compares three types of archwires used in braces to see which one causes the least pain after the first wire is placed. About 126 healthy people getting braces will rate their pain over the first week. The goal is to help orthodontists choose a wire that makes treatmen…

This study looks at whether fenfluramine, a drug already approved for children 2 and older with Dravet syndrome, is safe for children under 2 years old. Dravet syndrome causes severe seizures starting in the first year of life. The study will enroll 5 children aged 12 to 23 month…

This study tests whether coating small screws used in braces (called miniscrews) with an antimicrobial substance called K21 can reduce redness and swelling around the screw and help it stay firmly in place. About 30 people who need at least two miniscrews as part of their orthodo…

This study tests whether socks made with a special semiconductor fabric can improve healing and reduce symptoms after an ankle sprain. About 100 adults with ankle injuries will wear either the special socks or regular compression socks and track their pain and function over time.…

This study is testing whether oral cannabis can safely reduce chronic back or neck pain and help people cut down on strong painkillers like opioids. About 157 adults with long-term spine pain will take cannabis capsules or a placebo. The goal is to see if cannabis works as a non-…

This study tests whether special behavioral programs can change how your brain reacts to food, helping you eat less and lose weight. About 228 adults with a BMI of 27 or higher will undergo 12 weeks of training and brain scans. The goal is to see if these programs reduce cravings…

This study tests a program called ALIGN, which provides virtual palliative care visits for older adults with advanced cancer who are moving from the hospital to a skilled nursing facility. The goal is to see if the program can be delivered successfully and help patients and their…

This study looks at whether a supervised exercise program (cardiac rehab) can improve daily function and quality of life in people with Long COVID. Researchers will also study how the heart, lungs, and nervous system are affected. The study needs 30 adults who have had Long COVID…

This study tests a digital program called TPA4You that uses a Fitbit to help older adults (50+) who care for a family member with heart failure become more physically active. The goal is to see if the program is practical and can improve daily activity, reduce sitting time, and e…

This study looks at whether a continuous pain pump delivering numbing medicine (bupivacaine) after a C-section can lower the need for stronger painkillers like opioids. About 100 pregnant adults having C-sections at a special care center will be randomly assigned to get either th…

This study tests a new approach called Pain Reprocessing Therapy (PRT) for adults with ongoing knee pain after knee replacement surgery. PRT teaches the brain to reinterpret pain signals, aiming to reduce pain without medication. About 110 participants will be randomly assigned t…

This study is testing a new exercise program for people with knee osteoarthritis. The program uses a special machine to strengthen muscles during the lengthening phase of movement. Researchers want to see if this training helps people climb stairs more smoothly and safely, and re…

This early-phase study tests whether a single dose of psilocybin, given with therapy, can reduce the intense fear of cancer returning in women who have completed treatment for early-stage breast or ovarian cancer and are now in remission. Twenty participants will receive preparat…

This study looks at whether exercising in the morning or evening helps overweight adults lose more weight and change their eating and sleeping habits. Researchers will track 128 people over 13 months to see how workout timing affects body weight, fat, and daily behaviors. The goa…

This study looks at 750 adults with rheumatoid arthritis (RA) who are at risk for interstitial lung disease (ILD). Researchers use CT scans and other tests to find early signs of lung damage and figure out who might get worse over time. The goal is to better understand the diseas…

This study tests a special smart underwear that measures gas produced by gut bacteria after eating different foods. About 25 healthy adults will wear the underwear during the day to track hydrogen sulfide levels. The goal is to see if the device can detect changes in gut gas base…

This study looks at how romantic partners who both smoke can work as a team to quit. Researchers will ask 250 couples to fill out daily surveys for two weeks while trying to stop smoking. The goal is to learn which types of support are most helpful, so better programs can be crea…

This study collects sputum and tissue samples from 700 people with precancerous lung changes or certain cancers (lung, head and neck, esophageal). Researchers look for genetic markers that might help detect cancer earlier. The goal is to build a tissue bank for future research, n…

This study is for teens and young adults aged 12 to 24 who are planning to have weight loss surgery (sleeve gastrectomy). Researchers want to understand how the body changes after surgery and why some people lose more weight than others. They will also test if adding a medication…

This study involves 205 teens and young adults (ages 15-24) who have or survived childhood cancer. Researchers want to see if a simple screening questionnaire helps doctors and patients talk about sexual health issues. The goal is to make it easier for young survivors to get the …

This study collects placenta tissue, umbilical cord blood, and maternal blood from 1,250 pregnant women at delivery. Researchers will use these samples to learn how the placenta changes in conditions like preterm birth, diabetes, and obesity. The goal is to better understand preg…

This study looks at whether people with HIV can collect their own blood samples at home using a simple finger prick. The goal is to see if these self-collected samples are as good as those taken in a clinic for measuring drug levels. About 150 adults already on HIV treatment or p…

This study looks at how different snacks (walnuts or pretzels) change brain activity related to food cravings and fullness during a 12-week weight-loss diet. Researchers will use brain scans to measure responses to food pictures. The goal is to understand which snack might help p…

This study looks at how the stiffness of a prosthetic foot affects people who have a leg amputation below the knee and use a bone-anchored limb or a standard socket. Researchers will measure bone stress, walking ability, pain, and fall risk as participants walk on different types…

This study aims to create a mindfulness program designed for couples dealing with metastatic colorectal cancer. Researchers will interview patients, their partners, and clinicians to understand their needs and preferences. The goal is to develop a program that helps reduce emotio…

This study looks at how the right side of the heart works in people with COPD, both at rest and during exercise. Researchers want to find different patterns of heart strain to help develop better treatments in the future. The study involves 60 adults aged 40 and older with COPD.

This study examines whether the suction created when removing a menstrual cup can cause an IUD to shift or be expelled. Researchers will ask 80 women who already have an IUD to insert and remove a menstrual cup as recommended, then check if the IUD moved more than 1 cm. The goal …

This study looks at why some lung cancers stop responding to targeted therapy. Researchers will take small tumor samples before and after treatment to find early signs of resistance. The goal is to develop better drug combinations that can overcome resistance. About 100 adults wi…

This study uses a new, safe imaging tool called Electrical Impedance Tomography (EIT) to look at the lungs of infants and children without using harmful radiation. Researchers will compare children with chronic lung diseases to healthy children to learn more about lung structure …

This study interviews Spanish-speaking families of children with leukemia or lymphoma to understand their experiences and satisfaction with care. The goal is to identify common needs and barriers caused by language differences, and to explore interest in a home telemedicine suppo…

This study is testing a program called CARES that provides advocacy, resources, education, and support to rural cancer patients. The goal is to see if it helps them start treatment sooner and finish it on time. About 320 adults with solid tumors like lung, breast, or colon cancer…

This study tests whether a special ultrasound dye can help brain surgeons tell the difference between tumor tissue and normal brain during glioma surgery. The goal is to remove as much tumor as safely possible. About 100 adults with suspected or recurrent glioma will take part. T…

This study looks at why people move their eyes differently when searching for something visually. Researchers will measure attention and self-control in 225 healthy adults aged 18-65, then see how these skills relate to eye movement patterns. The goal is to understand normal diff…

This study looks at whether giving non-steroidal anti-inflammatory drugs (NSAIDs), like ibuprofen, to children with mild-to-moderate chronic kidney disease after surgery increases their risk of acute kidney injury. About 80 children aged 18 months and older will be monitored. The…

This study is testing a 24-week program that combines nutrition counseling, exercise, sleep tips, and stress management for cancer survivors who are overweight. The goal is to see if the program is practical and helpful for improving sleep quality, reducing stress, and boosting i…

This study is not testing a new treatment. Instead, it aims to collect blood, tissue, and health information from 20,000 adults who have cancer or are at risk for it. Researchers will use this data to better understand cancer and improve standard care in the future.

This study tests whether a training program for hospital staff can improve how oxygen levels are managed in ICU patients on breathing machines. The goal is to keep oxygen saturation between 90-96% and reduce the time patients need a ventilator. About 3,600 adults in the ICU who n…

This study aims to develop a new ultrasound technique that uses tiny, safe bubbles to measure blood flow in the pancreas. Researchers want to see if this method can detect changes that happen before type 1 diabetes develops. The study will compare 50 healthy adults and people rec…

This study looks at how insulin resistance in type 2 diabetes harms blood flow to the heart and muscles, leading to poor exercise ability. Researchers will test if 15 weeks of exercise training can improve insulin sensitivity and restore blood flow. The study involves 150 sedenta…

This study tests a new imaging device called Electrical Impedance Tomography (EIT) that uses electrodes to create lung pictures without radiation. Researchers will compare EIT images to standard tests in children with chronic lung disease, neuromuscular disease, and healthy contr…

This study works with parents, interpreters, and doctors to create short educational videos in Spanish about key cancer topics. The goal is to help Spanish-speaking caregivers better understand their child's care and feel more supported. The project will test if these videos are …

This study looks at whether a single dose of equol, a substance made from soy, can improve blood vessel function in postmenopausal women. It includes women with and without chronic kidney disease (CKD). Researchers will measure changes in artery health over a few hours after taki…

This study looks at how the autonomic nervous system (which controls heart rate and blood pressure) works in people with Down syndrome. Researchers will measure heart rate, blood pressure, and stress hormones during activities like cold exposure, fear simulations, and exercise. T…

This study examines how two chemotherapy drugs, vincristine and doxorubicin, may affect bladder function and urine composition in children who have completed cancer treatment. Researchers will compare 152 children aged 5-13 who received these drugs with those who did not, using n…

This study collects blood and tissue samples from 2,000 people being tested or treated for lung cancer. The samples are stored in a bank for future research aimed at earlier detection, better treatments, and prevention strategies. Participants give consent and provide samples dur…

This study looks at two common ways to manage Barrett's esophagus with low-grade dysplasia—a condition where the lining of the esophagus has abnormal cells that rarely turn into cancer. One approach is regular check-ups with a camera and small tissue samples (surveillance). The o…

This study compares three different follow-up methods (phone calls, text messages, or both) to see which best helps people improve their diet, physical activity, stress, and sleep. About 1000 adults who already completed a health risk assessment will take part. The goal is to fin…

This study tests if a mild electrical pulse on the ear can improve decision-making and problem-solving. Researchers will include healthy adults, people with mild cognitive impairment, and those with Parkinson's disease. The goal is to understand how this stimulation affects brain…

This study tests a program called Pediatric Medication Therapy Management (pMTM) for children ages 2-18 with complex medical conditions who take 5 or more medications. The goal is to see if the program helps doctors and families find and fix medication-related problems, such as d…

This study collects tumor samples from 500 adults with lung or other chest cancers to learn why targeted therapies stop working. Researchers will look for genetic changes in the cancer cells. No new treatment is given; the goal is to gather information that may guide future care.

This study looks at how losing weight affects the fat stored inside your muscles, called IMAT. Researchers want to see if this fat sends out signals that make your muscles less responsive to insulin, and if weight loss can quiet those signals. About 70 adults with obesity will fo…

This study aims to improve health research participation among Black, Latino, and Native American communities in Colorado. Researchers will work with local organizations to address health issues like mental health, high blood pressure, and diabetes. About 1,500 adults aged 18-90 …

This study looks at how a woman's immune system reacts to breast cancer, especially if she has been pregnant before. Researchers will follow 800 young women with breast cancer to understand these interactions. The goal is to learn more, not to test a new treatment.

This study looks at how children and young adults (ages 10 to 25) do after having a joint replaced for reasons other than cancer. Researchers will collect information from medical records and surveys about quality of life. The goal is to understand how these surgeries affect dail…

This study looks at how fat levels (triglycerides) in a pregnant woman's blood affect her baby's body fat. Researchers will have 140 pregnant women with a higher BMI check their triglycerides and glucose at home during pregnancy. After birth, babies will have their total body fat…

This study looks at whether freezing ovarian tissue can help preserve fertility in people with disorders of sex development who are at high risk of infertility or cancer. Up to 50 participants under 30 will have their tissue frozen before their ovaries are removed. The goal is to…

This study is creating a large collection of biological samples (like blood, saliva, and urine) from people with and without Down syndrome, ages 6 months to 89 years. The goal is to help researchers better understand Down syndrome and the health problems that often come with it. …

This study aims to understand how the brain's outer layers handle thinking and decision-making in people with Parkinson's disease. Researchers will insert a thin, high-tech probe into the brain for a short time during awake deep brain stimulation surgery. The study involves 15 ad…

This study tests whether a new imaging technique (shear-wave elastography combined with MRI) can detect scarring or injury in the uterus caused by pelvic radiation. Researchers will enroll 22 women who received pelvic radiation before age 40 and compare their imaging results to h…

This study looks at whether giving extra coaching and support to primary care clinics helps them better identify and manage suicide risk in young people ages 12 to 24. About 360 youth who screen positive for suicide risk will take part. The goal is to see if this coaching leads t…

This study looks at whether freezing testicular tissue is a safe and acceptable way to preserve fertility in male patients of any age who face infertility due to disease or treatments like chemotherapy or radiation. Researchers will track how many eligible patients choose the pro…

This study looks at how the right side of the heart works in people with COPD, both at rest and during exercise. Researchers want to find different patterns of heart strain to help design better treatments in the future. About 60 adults aged 40 and older with COPD will take part.

This study tests whether psilocybin, the active ingredient in magic mushrooms, is safe and tolerable for healthy adults aged 65 to 85. About 40 volunteers will receive the drug and be monitored for side effects. The goal is not to treat any disease, but to gather safety informati…

This study looks at how drinking alcohol and the way couples talk about sex can lead to sexual violence between partners. Researchers will bring 240 couples to a lab, give some alcohol and some a non-alcoholic drink, and observe their reactions. The goal is to understand what inc…

This study follows 400 men with solid tumors to understand how cancer care impacts their ability to work and their overall well-being. It focuses on low-income and Latino men, who often face extra challenges. Researchers will track employment hours, mental health, and financial s…

This study follows 200 babies diagnosed with intra-uterine growth restriction (IUGR) using advanced imaging to track subtle changes in the brain, heart, and placenta over time. Researchers will link these findings to the babies' development after birth and in early childhood. The…

This study looks at whether an imbalance in the natural bacteria in your mouth and gut (called dysbiosis) plays a role in head and neck cancer. Researchers will collect stool and saliva samples from 60 adults—some with cancer and some without—to compare their microbiomes. The goa…

This study looks at why pregnant women living at high altitude have higher rates of poor fetal growth and preeclampsia. Researchers will collect tissue samples from 84 women having scheduled C-sections in Denver (low altitude) and Summit County (high altitude). By comparing blood…

This study is creating a detailed atlas of pre-cancerous spots in the lungs to understand how they turn into cancer. Researchers will collect tissue samples from 240 adults with these spots using a scope down the airway. The goal is to find clues that could help prevent lung canc…