University Of Colorado, Denver

This study is testing whether giving a third dose of the Shingrix shingles vaccine to people who have had a stem cell transplant is safe and helps their immune system fight the virus. Researchers want to see if the timing of the vaccine after the transplant affects how well it wo…

This study is testing whether a 12-week program using a Fitbit activity tracker and personalized text messages can help people with type 2 diabetes. Researchers want to see if this approach is practical and acceptable for 36 sedentary adults. The goal is to see if this technology…

This study is testing whether a drug called sargramostim, already approved for stimulating bone marrow, is safe and might help people with mild-to-moderate Alzheimer's disease. Over six months, 42 participants will receive injections to see if the drug can slow or stop their cogn…

This study is testing whether a combination of two drugs, mirvetuximab soravtansine and olaparib, can help keep cancer from growing back in women whose ovarian, peritoneal, or fallopian tube cancer has returned but responded well to platinum-based chemotherapy. The goal is to see…

This is a small, early-stage study to see if a 6-month program that combines standard weight loss coaching with specific strategies to improve sleep is practical and acceptable to participants. The researchers will enroll about 25 overweight or obese adults who also have poor sle…

This study is testing whether freezing testicular tissue is a safe and practical option for men and boys who face infertility due to medical conditions or treatments like chemotherapy. Researchers will enroll 60 participants of any age who are at high risk of losing their fertili…

This study is testing whether a device called the iLet Bionic Pancreas can be successfully used by regular primary care doctors to help adults with type 1 or type 2 diabetes. Researchers want to see if using this automated insulin delivery system for 13 weeks leads to better bloo…

This study is testing a school-based program designed to help children from low-income communities better manage their asthma. The program, called BACK, uses school nurses and asthma navigators to educate kids and connect families with resources to reduce asthma attacks. Research…

This early-stage trial is testing the safety and best dose of a new type of CAR-T cell therapy. The therapy uses a patient's own modified immune cells to target two proteins (CD19 and CD22) on lymphoma cells. It is for adolescents and adults whose B-cell non-Hodgkin lymphoma has …

This study is testing whether placing a special dissolvable gel between a metal plate and wrist tendons can improve healing after wrist fracture surgery. Researchers will compare 50 patients who receive the gel during surgery to those who do not. They will measure how well the te…

This early-stage trial is testing whether combining two existing drugs—losartan and sunitinib—is safe and might help control osteosarcoma that has returned or stopped responding to other treatments. The study will first find the highest dose patients can tolerate without severe s…

This study is testing whether delivering extra radiation directly inside the rectum can help patients avoid surgery. It's for adults with rectal cancer who still have some tumor left after completing standard chemotherapy and radiation. Participants receive three outpatient treat…

This study aims to find the best approach for managing Barrett's esophagus with low-grade dysplasia, a condition that can sometimes lead to esophageal cancer. Researchers are comparing two common strategies: regular monitoring with camera exams and biopsies versus procedures that…

This study is testing whether adding two newer immunotherapy drugs to a standard chemotherapy drug (doxorubicin) can help control advanced soft tissue sarcoma for longer. It will enroll about 65 adults with specific types of this cancer who have not had certain prior treatments. …

This study is testing if teaching hospital staff to aim for a specific, slightly lower oxygen level (90-96%) in adult ICU patients on breathing machines helps them recover faster. The main goal is to see if this approach reduces the number of days patients need the ventilator. It…

This study is testing if adding the diabetes drug metformin to standard lifestyle advice helps men with prostate cancer who are also overweight or have slightly high blood sugar. Researchers want to see if metformin improves weight, blood sugar control, and possibly affects the p…

This study is testing whether freezing gonadal tissue (ovarian or testicular tissue) is a safe and effective way to preserve fertility or future hormone function. It is for young people under 30 with a disorder of sex development (DSD) who are at risk of infertility or need their…

This study is testing whether a support program called CARES helps rural cancer patients start treatment sooner and complete it faster. The program provides navigation help and counseling sessions alongside usual cancer care. Researchers will compare outcomes for 320 patients who…

This early-stage trial is testing the safety of a new CAR T-cell therapy for adults with B-cell acute lymphoblastic leukemia (B-ALL). It is for patients who are in their first remission but still have tiny, hard-to-detect amounts of cancer cells. The main goal is to find a safe d…

This early-stage study is testing the safety and best dose of two oral drugs, CC-486 and venetoclax, for adults with acute myeloid leukemia (AML) that has come back or hasn't responded to prior treatment. The main goal is to find the highest dose patients can tolerate without sev…

This study is testing a new nutrition and exercise program designed for cancer survivors who are overweight or obese. The goal is to find the best combination of support—like one-on-one counseling, group sessions, and skill-building—to help participants manage their weight and im…

This study is testing a new drug called NT219 in combination with two existing cancer drugs (pembrolizumab or cetuximab) for people with advanced head and neck cancer that has returned or spread. The main goal is to see if these combinations can shrink tumors and control the dise…

This study aims to understand why teens and young adults respond differently to weight loss surgery and to see if adding the medication semaglutide can help those who don't lose enough weight after surgery. It will enroll 40 people aged 12-24. Researchers will first observe body …

This study is testing if a single dose of a supplement called equol, which comes from soy, can quickly improve blood vessel function in postmenopausal women. It aims to see if this could be a potential way to help lower the high risk of heart disease in women with chronic kidney …

This study is testing whether a short, intensive brain stimulation treatment can help people with moderate to severe methamphetamine addiction. Researchers will give 20 participants either real or fake magnetic stimulation to the brain over 5 days during a brief hospital stay. Th…

This study is testing whether a common allergy drug (clemastine) combined with specially designed sounds can help middle-aged adults hear better in noisy environments. Researchers believe this combination may help repair the brain's hearing pathways. About 344 participants aged 4…

This study is testing whether a 12-week behavioral training program can change how the brain responds to food, reduce the desire to eat, and help with weight control in adults with obesity. Researchers will use brain scans and measure food intake to see if the training works. The…

This study is testing whether giving a lower dose of the chemotherapy drug doxorubicin weekly, instead of the standard higher dose every few weeks, can help control advanced sarcoma in patients aged 65-100 while causing fewer side effects. Researchers will see if this gentler sch…

This study is testing if it's safe and effective for people with stable relapsing multiple sclerosis (MS) to switch from powerful infusion/injection therapies (anti-CD20 drugs) to a daily pill called ozanimod. The goal is to see if the milder pill can maintain disease control whi…

This early-stage study is testing whether combining two drugs, Cirtuvivint and Olaparib, is safe and tolerable for women with a specific type of ovarian cancer that has stopped responding to standard platinum-based chemotherapy. The trial will enroll about 50 women who have alrea…

This study is testing whether the medication semaglutide can improve heart and kidney health in adults with type 1 diabetes. Researchers want to see if it reduces artery stiffness and improves how the body uses insulin, similar to benefits seen in type 2 diabetes. The trial will …

This study is testing whether a combination of two drugs, cladribine and venetoclax, can help control acute myeloid leukemia (AML) in adults when a similar previous treatment has stopped working. The trial is for people whose AML has a specific pattern (monocytic) and has come ba…

This study is testing a new type of CAR-T cell therapy that targets two proteins (CD19 and CD22) on leukemia cells. It aims to find a safe dose and see if it can help children and young adults (3 months to 30 years old) whose B-cell acute lymphoblastic leukemia has come back or h…

This early-stage trial is testing whether combining two chemotherapy approaches—one delivered directly into the abdomen and another into the bloodstream—is safe and effective for adults with pancreatic cancer that has spread to the abdominal lining. Researchers want to see if thi…

This early-stage study is testing whether adding the drug mitoxantrone to a standard leukemia treatment can help patients whose cancer has returned or stopped responding. It will enroll about 30 adults with a specific type of acute myeloid leukemia. The main goals are to find a s…

This study is testing a special type of ultrasound that uses a contrast dye to see if it helps brain surgeons better distinguish tumor tissue from healthy brain tissue during surgery. The goal is to help surgeons remove as much of the brain tumor as possible while protecting norm…

This study is testing a new, single-use camera scope designed to help doctors during procedures on the bile ducts. It will be used in up to 75 people who have hard-to-remove bile duct stones or unclear blockages. The main goals are to see if the camera helps doctors break up ston…

This study is testing whether a new at-home urine pregnancy test is as accurate as a standard blood test for monitoring early pregnancies when the location is unknown. Researchers will enroll 35 women to compare the home test results with blood test results over several days. The…

This study is testing whether an asthma medication called Advair HFA can help prevent high-altitude pulmonary edema (HAPE), a dangerous lung condition that can occur when climbing to high elevations. Researchers will give the drug or a placebo to 60 healthy volunteers and people …

This study is testing whether a telehealth program can help prevent older adults from falling again after they visit the emergency room for a fall. Participants will have video calls with a physical therapist and a pharmacist while still in the ER, followed by phone check-ins for…

This study is testing whether a special educational program can help more young people and their parents in underserved communities get the full series of HPV vaccines. The program uses videos and informational materials to explain HPV, related cancers, and the importance of vacc…

This study is testing a one-hour therapy session designed to prevent anxiety, depression, and trauma symptoms in mothers after a cesarean delivery. The session involves education about anxiety and a brief, guided visit to the operating room before the surgery. Researchers are rec…

This study is testing whether placing free naloxone (a medication that can reverse opioid overdoses) in community vending machines helps get this life-saving treatment to more people who need it. Researchers will work with three communities to install machines in locations sugges…

This study is testing if starting the HPV vaccine at age 9-10, instead of the recommended 11-12, leads more parents to get their children fully vaccinated. Researchers believe earlier timing might reduce parental hesitation and ensure protection before potential exposure to the v…

This study is testing whether a 12-week telehealth exercise program can reduce severe fatigue in rural breast and prostate cancer survivors. Researchers will enroll 134 participants, who will either start the program immediately or after a 12-week wait. The program includes virtu…

This study is creating a new mindfulness program called 'MIND-Together' to help couples where one partner has metastatic colorectal cancer. Researchers are interviewing patients, their partners, and clinicians to design a 4-session video program that addresses their specific emot…

This study is testing a minimally invasive procedure called genicular artery embolization (GAE) to see if it can reduce knee pain and inflammation in adults with osteoarthritis. Researchers will measure changes in pain scores, knee fluid, and MRI scans before and after the proced…

This study is testing whether gentle electrical stimulation applied to the ear can improve thinking skills like decision-making and problem-solving. Researchers want to see if this non-invasive stimulation helps both healthy adults and people with Parkinson's disease. Participant…

This study is testing whether a liquid cannabis medicine taken by mouth can help people with long-term back or neck pain. Researchers want to see if it can safely reduce pain and help patients lower their use of prescription opioid painkillers. The trial will involve 157 adults w…

This study is testing a digital exercise program designed to help older family members who care for someone with heart failure. Participants will use a Fitbit activity tracker and receive coaching to increase their physical activity. The goal is to see if this approach reduces ca…

This study is testing whether a 12-week home exercise program can help people with Long COVID feel better and improve their ability to do daily activities. Researchers will compare a group doing the exercise program to a group receiving their usual care. The goal is to see if thi…

This study is testing whether a high-intensity exercise program can be safely done at home by people with Parkinson's disease, and whether a special headband can effectively track their sleep. Researchers want to see if these home-based tools are easy to use and acceptable to par…

This study aims to find the best way to manage pain after a cesarean delivery (C-section). Researchers are comparing two groups: one receives a continuous infusion of a local numbing medicine (bupivacaine) at the incision site, and the other receives a harmless saltwater solution…

This study is testing whether a 12-session parent training program can help reduce anger outbursts and irritable moods in children aged 10-14. Parents will learn new skills during weekly sessions while their children's behavior is monitored before, during, and after the program. …

This study is testing if adding a specific type of electrical muscle stimulation to standard physical therapy helps people recover better after knee replacement surgery. It will involve over 3,000 patients across two major healthcare systems. The goal is to see if this stimulatio…

This study is testing whether a psychological therapy called Pain Reprocessing Therapy (PRT) can help adults who still have knee pain months after knee replacement surgery. Participants will be randomly assigned to receive either eight weekly video therapy sessions (PRT) or conti…

This study is testing a new type of exercise using a special machine to see if it helps people with knee arthritis climb stairs more easily and safely. Researchers will compare 60 adults with arthritis to healthy adults, measuring muscle health and movement patterns. The goal is …

This research study aims to understand why people move their eyes differently when searching for things visually. Researchers will measure participants' attention and ability to control impulses through simple computer tasks while tracking their eye movements. The goal is to lear…

This study aims to create a detailed map of the very early cellular changes in the lungs that can lead to cancer. Researchers will follow 240 high-risk current or former smokers over 2-3 years, performing regular lung exams (bronchoscopies) to collect tissue samples. The goal is …

This study aims to understand how the stiffness of a prosthetic foot affects people with below-knee amputations. Researchers will compare two groups—those using a bone-anchored prosthetic limb and those using a standard socket prosthesis—as they walk with feet of different stiffn…

This study aims to learn how the right side of the heart responds to exercise in people with chronic obstructive pulmonary disease (COPD). Researchers will measure heart function at rest and during different exercise intensities in 60 participants with COPD. The goal is to identi…

This study is testing whether people taking medication for HIV treatment or prevention can collect their own blood samples at home and mail them in. The goal is to see if these home-collected samples give the same drug level results as samples taken at a clinic. About 150 partici…

This study aims to understand how alcohol and different ways of communicating affect the risk of sexual violence between intimate partners. Researchers will observe 240 couples from the Denver area in a laboratory setting, where some will drink alcohol and others will not, and co…

This study aims to understand why lung cancers stop responding to targeted drug therapies. Researchers will analyze tumor tissue samples from 500 adults with lung or other chest cancers, both before treatment and when the cancer starts growing again. The goal is to identify genet…

This study is a community partnership, not a treatment trial. Its purpose is to understand how to better involve specific communities in health research and improve health-related behaviors. It will enroll 1,500 adults from specific racial/ethnic groups and regions in Colorado. T…

This study aims to learn how a woman's pregnancy history might influence her immune system's response to breast cancer. Researchers will compare samples from women who developed breast cancer during or after pregnancy with those who did not. The goal is to understand these differ…

This study aims to understand how poor blood flow in small vessels might contribute to heart and muscle problems in people with type 2 diabetes. Researchers want to see if a 15-week exercise program can improve how the body uses insulin and increase blood flow to the heart and mu…

This study aims to understand how restricted growth during pregnancy affects babies' long-term health. Researchers will follow 200 babies who are smaller than expected during pregnancy, using advanced ultrasound and MRI scans to monitor their brain, heart, and development. The go…

This study is creating a collection of tissue samples from people with lung cancer to support future research. Participants are those undergoing testing or treatment for lung cancer who consent to donate samples. The goal is to help scientists discover ways to detect lung cancer …

This study aims to understand how lung cancer cells survive during the first weeks of targeted drug therapy. Researchers will take tumor samples and blood from 100 adults with specific genetic mutations before and after starting treatment. By comparing these samples, they hope to…

This study aims to understand if using a menstrual cup can accidentally move or expel an intrauterine device (IUD). Researchers will measure IUD position in 80 women before and after they insert and remove a menstrual cup, following the manufacturer's instructions. The goal is to…

This study aims to find out if exercising in the morning or the evening is more effective for weight loss. Researchers will compare how the timing of exercise affects body weight, appetite, and daily energy use in 128 adults who are overweight or obese. Participants will be assig…

This study aims to understand if changes in the natural bacteria in our mouth and gut (the microbiome) play a role in causing head and neck cancers. Researchers will collect saliva and stool samples from 60 people, including those with and without oral cancer, to analyze the bact…

This study is testing a new, radiation-free imaging system called EIT to see how well it can show lung function in people with breathing problems. Researchers will use it on children and adults with conditions like chronic lung disease or muscle weakness, as well as healthy volun…

This study is testing whether two advanced imaging techniques—shear-wave elastography (SWE) and MRI—can reliably detect and measure scarring (fibrosis) in the uterus caused by pelvic radiation therapy. Researchers will recruit up to 22 women under 45 who received pelvic radiation…

This online study aims to find the best way to talk to women about breast cancer screening. Researchers are testing different explanations of mammogram benefits and risks to see which ones reduce skepticism and encourage screening. Nearly 2,000 women aged 39-49 will participate i…

This study aims to collect placenta and blood samples from 1,250 women during delivery to create a research bank. Researchers will use these samples to learn how the placenta works in both healthy pregnancies and those with complications like preterm birth or diabetes. The goal i…

This study aims to create and test Spanish-language educational videos about pediatric cancer topics. Researchers are partnering with Spanish-speaking parents, medical interpreters, and doctors to develop these videos. The goal is to see if these videos can help improve knowledge…

This study aims to understand how the brain controls thinking skills by recording brain cell activity during awake Parkinson's surgery. Researchers will insert a special probe into the brain of 15 patients who are already undergoing deep brain stimulation surgery. The goal is to …

This study aims to understand why pregnant women living at high altitudes have higher rates of fetal growth restriction and preeclampsia. Researchers will compare tissue samples from women giving birth in Denver versus Summit County, Colorado, to see if altitude affects blood ves…

This study aims to learn more about how lung diseases develop in babies and children by using a new, safe imaging machine that doesn't use radiation. Researchers will compare lung images from children with chronic breathing problems to images from healthy children. The goal is to…

This study is creating a large collection of biological samples and health information from people with and without Down syndrome. The goal is to provide approved researchers with materials to study conditions linked to Down syndrome, like heart defects, Alzheimer's, and leukemia…

This study aims to find out if using common pain relievers called NSAIDs for a short time after surgery is safe for children who already have mild-to-moderate kidney disease. Researchers will follow 80 children after urology surgery to see if these medications increase their risk…

This study aims to understand if two common chemotherapy drugs, vincristine and doxorubicin, cause long-term bladder problems in children who have survived cancer. Researchers will observe 152 survivors, aged 5-13, who finished chemo at least a year ago. They will compare bladder…

This study aims to understand and improve communication and support for Spanish-speaking families of children with leukemia or lymphoma. Researchers will interview families to learn about their experiences, needs, and the barriers they face in getting care. The goal is to gather …

This study aims to understand how cancer treatment affects a patient's ability to work and their overall well-being. It will follow 400 low-income men, many of whom are Latino, who are newly diagnosed with solid tumors. Researchers will track their work status, hours, financial s…

This is a research study, not a treatment trial. It aims to build a large database of health information, blood, and tissue samples from people with cancer or at risk of cancer. Researchers will use this collection over many years to learn more about cancer and help design better…

This study aims to identify biological markers (biomarkers) in tissue and sputum samples that could signal the development of lung, head, neck, or esophageal cancers. Researchers are enrolling 700 participants who either have precancerous cell changes, a history of these cancers,…