Major trial aims to settle best approach for precancerous esophagus condition
NCT ID NCT05753748
First seen Nov 01, 2025 · Last updated Jun 21, 2026 · Updated 31 times
Summary
This study compares two standard approaches for Barrett's esophagus with low-grade dysplasia: regular monitoring with biopsies (surveillance) versus a procedure to remove or burn away precancerous cells (endoscopic eradication therapy). Researchers want to find out which method is safer and more effective at preventing progression to cancer. About 680 adults with this condition will take part across multiple U.S. hospitals.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Locations
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Baylor University Medical Center
RECRUITINGDallas, Texas, 75246, United States
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Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02215, United States
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Cleveland Clinic Foundation
RECRUITINGCleveland, Ohio, 44195, United States
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Columbia Universtiy
RECRUITINGNew York, New York, 10032, United States
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Dartmouth-Hitchcock Medical Center
RECRUITINGLebanon, New Hampshire, 03756, United States
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Florida Digestive Health Specialists
RECRUITINGSarasota, Florida, 34239, United States
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Indiana University Melvin & Bren Simon Cancer Center
RECRUITINGIndianapolis, Indiana, 46202, United States
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Johns Hopkins Universtiy
RECRUITINGBaltimore, Maryland, 21205, United States
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Kaiser Permanente
RECRUITINGSan Jose, California, 95119, United States
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Kaiser Permanente Oakland Medical Center
RECRUITINGOakland, California, 94611, United States
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Long Island Jewish Medical Center
RECRUITINGManhasset, New York, 11030, United States
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
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Northwestern Memorial Hospital
RECRUITINGChicago, Illinois, 60611, United States
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The University of Texas MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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University Hospitals Cleveland Medical Center Case Western University
RECRUITINGCleveland, Ohio, 44106, United States
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University of California, Los Angeles
RECRUITINGLos Angeles, California, 90095, United States
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University of Colorado
RECRUITINGAurora, Colorado, 80045, United States
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
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University of North Carolina School of Medicine
RECRUITINGChapel Hill, North Carolina, 27599, United States
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University of Pennsylania, Perelman School of Medicine
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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University of Pittsburgh Medical Center
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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University of Rochester Medical Center
RECRUITINGRochester, New York, 14642, United States
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Washington University in St. Louis
RECRUITINGSt Louis, Missouri, 63110, United States
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Endoscopic eradication therapy (removal or burning of precancerous cells) and endoscopic surveillance (biopsy monitoring)
What this could lead to
If successful, this trial could show that one approach is safer and more effective at preventing esophageal cancer in people with Barrett's esophagus and low-grade dysplasia.
What could go wrong
This is a large, well-designed trial, but low-grade dysplasia often does not progress to cancer, so the benefit of aggressive treatment may be small. Endoscopic therapy also carries risks like bleeding or narrowing of the esophagus.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.